Computational Prediction of the Epitopes of HA1 Protein of Influenza Viruses to its Neutralizing Antibodies
Identifieur interne : 000210 ( Main/Curation ); précédent : 000209; suivant : 000211Computational Prediction of the Epitopes of HA1 Protein of Influenza Viruses to its Neutralizing Antibodies
Auteurs : Xiaoyan Zeng ; Fiona S. Legge ; Chao Huang ; Xiao Zhang ; Yongjun Jiao ; Herbert R. Treutlein ; Jun ZengSource :
- Antibodies [ 2073-4468 ] ; 2018.
Abstract
In this work, we have used a new method to predict the epitopes of HA1 protein of influenza virus to several antibodies HC19, CR9114, BH151 and 4F5. While our results reproduced the binding epitopes of H3N2 or H5N1 for the neutralizing antibodies HC19, CR9114, and BH151 as revealed from the available crystal structures, additional epitopes for these antibodies were also suggested. Moreover, the predicted epitopes of H5N1 HA1 for the newly developed antibody 4F5 are located at the receptor binding domain, while previous study identified a region 76-WLLGNP-81 as the epitope. The possibility of antibody recognition of influenza virus via different mechanism by binding to different epitopes of an antigen is also discussed.
Url:
DOI: 10.3390/antib8010002
PubMed: 31544808
PubMed Central: 6640696
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Computational Prediction of the Epitopes of HA1 Protein of Influenza Viruses to its Neutralizing Antibodies</title><author><name sortKey="Zeng, Xiaoyan" sort="Zeng, Xiaoyan" uniqKey="Zeng X" first="Xiaoyan" last="Zeng">Xiaoyan Zeng</name><affiliation><nlm:aff id="af1-antibodies-08-00002">Institute of Pathogenic Microbiology, Jiangsu Provincial Center for Disease Prevention and Control, Key Laboratory of Enteric Pathogenic Microbiology, Ministry of Health, Nanjing 210009, China;<email>zengxiaoyan6164@sina.com</email> (X.Z.);<email>nestar1987@126.com</email> (C.H.);<email>yongjunjiao@jscdc.cn</email> (Y.J.)</nlm:aff></affiliation></author><author><name sortKey="Legge, Fiona S" sort="Legge, Fiona S" uniqKey="Legge F" first="Fiona S." last="Legge">Fiona S. Legge</name><affiliation><nlm:aff id="af2-antibodies-08-00002">MedChemSoft Solutions, Level 3, 2 Brandon Park Drive, Wheelers Hill, VIC 3150, Australia;<email>suelegge@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Huang, Chao" sort="Huang, Chao" uniqKey="Huang C" first="Chao" last="Huang">Chao Huang</name><affiliation><nlm:aff id="af1-antibodies-08-00002">Institute of Pathogenic Microbiology, Jiangsu Provincial Center for Disease Prevention and Control, Key Laboratory of Enteric Pathogenic Microbiology, Ministry of Health, Nanjing 210009, China;<email>zengxiaoyan6164@sina.com</email> (X.Z.);<email>nestar1987@126.com</email> (C.H.);<email>yongjunjiao@jscdc.cn</email> (Y.J.)</nlm:aff></affiliation></author><author><name sortKey="Zhang, Xiao" sort="Zhang, Xiao" uniqKey="Zhang X" first="Xiao" last="Zhang">Xiao Zhang</name><affiliation><nlm:aff id="af3-antibodies-08-00002">Key Laboratory of Antibody Technique, Ministry Health, Nanjing 210029, China;<email>zhangxiao@njmu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Jiao, Yongjun" sort="Jiao, Yongjun" uniqKey="Jiao Y" first="Yongjun" last="Jiao">Yongjun Jiao</name><affiliation><nlm:aff id="af1-antibodies-08-00002">Institute of Pathogenic Microbiology, Jiangsu Provincial Center for Disease Prevention and Control, Key Laboratory of Enteric Pathogenic Microbiology, Ministry of Health, Nanjing 210009, China;<email>zengxiaoyan6164@sina.com</email> (X.Z.);<email>nestar1987@126.com</email> (C.H.);<email>yongjunjiao@jscdc.cn</email> (Y.J.)</nlm:aff></affiliation></author><author><name sortKey="Treutlein, Herbert R" sort="Treutlein, Herbert R" uniqKey="Treutlein H" first="Herbert R." last="Treutlein">Herbert R. 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Legge</name><affiliation><nlm:aff id="af2-antibodies-08-00002">MedChemSoft Solutions, Level 3, 2 Brandon Park Drive, Wheelers Hill, VIC 3150, Australia;<email>suelegge@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Huang, Chao" sort="Huang, Chao" uniqKey="Huang C" first="Chao" last="Huang">Chao Huang</name><affiliation><nlm:aff id="af1-antibodies-08-00002">Institute of Pathogenic Microbiology, Jiangsu Provincial Center for Disease Prevention and Control, Key Laboratory of Enteric Pathogenic Microbiology, Ministry of Health, Nanjing 210009, China;<email>zengxiaoyan6164@sina.com</email> (X.Z.);<email>nestar1987@126.com</email> (C.H.);<email>yongjunjiao@jscdc.cn</email> (Y.J.)</nlm:aff></affiliation></author><author><name sortKey="Zhang, Xiao" sort="Zhang, Xiao" uniqKey="Zhang X" first="Xiao" last="Zhang">Xiao Zhang</name><affiliation><nlm:aff id="af3-antibodies-08-00002">Key Laboratory of Antibody Technique, Ministry Health, Nanjing 210029, China;<email>zhangxiao@njmu.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Jiao, Yongjun" sort="Jiao, Yongjun" uniqKey="Jiao Y" first="Yongjun" last="Jiao">Yongjun Jiao</name><affiliation><nlm:aff id="af1-antibodies-08-00002">Institute of Pathogenic Microbiology, Jiangsu Provincial Center for Disease Prevention and Control, Key Laboratory of Enteric Pathogenic Microbiology, Ministry of Health, Nanjing 210009, China;<email>zengxiaoyan6164@sina.com</email> (X.Z.);<email>nestar1987@126.com</email> (C.H.);<email>yongjunjiao@jscdc.cn</email> (Y.J.)</nlm:aff></affiliation></author><author><name sortKey="Treutlein, Herbert R" sort="Treutlein, Herbert R" uniqKey="Treutlein H" first="Herbert R." last="Treutlein">Herbert R. Treutlein</name><affiliation><nlm:aff id="af4-antibodies-08-00002">Sanoosa Pty Ltd., Level 30, 35 Collins Street, Melbourne, VIC 3000, Australia;<email>herbertin@gmail.com</email></nlm:aff></affiliation></author><author><name sortKey="Zeng, Jun" sort="Zeng, Jun" uniqKey="Zeng J" first="Jun" last="Zeng">Jun Zeng</name><affiliation><nlm:aff id="af2-antibodies-08-00002">MedChemSoft Solutions, Level 3, 2 Brandon Park Drive, Wheelers Hill, VIC 3150, Australia;<email>suelegge@gmail.com</email></nlm:aff></affiliation></author></analytic><series><title level="j">Antibodies</title><idno type="eISSN">2073-4468</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this work, we have used a new method to predict the epitopes of HA1 protein of influenza virus to several antibodies HC19, CR9114, BH151 and 4F5. While our results reproduced the binding epitopes of H3N2 or H5N1 for the neutralizing antibodies HC19, CR9114, and BH151 as revealed from the available crystal structures, additional epitopes for these antibodies were also suggested. Moreover, the predicted epitopes of H5N1 HA1 for the newly developed antibody 4F5 are located at the receptor binding domain, while previous study identified a region 76-WLLGNP-81 as the epitope. The possibility of antibody recognition of influenza virus via different mechanism by binding to different epitopes of an antigen is also discussed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Schafer, J R" uniqKey="Schafer J">J.R. Schafer</name></author><author><name sortKey="Kawaoka, Y" uniqKey="Kawaoka Y">Y. Kawaoka</name></author><author><name sortKey="Bean, W J" uniqKey="Bean W">W.J. Bean</name></author><author><name sortKey="Suss, J" uniqKey="Suss J">J. 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