Pilot Studies on Recombinant Cold-Adapted Live Type A and B Influenza Virus Vaccines
Identifieur interne : 001528 ( Istex/Curation ); précédent : 001527; suivant : 001529Pilot Studies on Recombinant Cold-Adapted Live Type A and B Influenza Virus Vaccines
Auteurs : Fred M. Davenport [États-Unis] ; Albert V. Hennessy ; Hunein F. Maassab ; Elva Minuse ; Larry C. Clark ; Gerald D. Abrams ; John R. MitchellSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1977.
Abstract
Recombinant live attenuated type A and B influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. The vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. Thirty-nine isolates that were recovered after a single passage in humans appeared genetically stable. The results of histopathologic studies in ferrets encourage development of an animal model for attenuation of the virus.
Url:
DOI: 10.1093/infdis/136.1.17
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Albert V. Hennessy<affiliation><mods:affiliation>Department of Epidemiology, School of Public Health, and the Department of Pathology, Medical School, University of Michigan, Ann Arbor, Lansing, Michigan></mods:affiliation>
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<affiliation><mods:affiliation>Department of Epidemiology, School of Public Health, and the Department of Pathology, Medical School, University of Michigan, Ann Arbor, Lansing, Michigan></mods:affiliation>
<wicri:noCountry code="subField">Michigan></wicri:noCountry>
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<affiliation><mods:affiliation>Department of Epidemiology, School of Public Health, and the Department of Pathology, Medical School, University of Michigan, Ann Arbor, Lansing, Michigan></mods:affiliation>
<wicri:noCountry code="subField">Michigan></wicri:noCountry>
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<affiliation><mods:affiliation>Department of Epidemiology, School of Public Health, and the Department of Pathology, Medical School, University of Michigan, Ann Arbor, Lansing, Michigan></mods:affiliation>
<wicri:noCountry code="subField">Michigan></wicri:noCountry>
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<front><div type="abstract">Recombinant live attenuated type A and B influenza virus vaccines derived from standardized cold-adapted parent strains were given singly and in combination to volunteers. The vaccine viruses were well tolerated, functioned as good antigens, and failed to spread to intimate household contacts. Thirty-nine isolates that were recovered after a single passage in humans appeared genetically stable. The results of histopathologic studies in ferrets encourage development of an animal model for attenuation of the virus.</div>
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