Reactogenicity and Immunogenicity of Whole and Ether-Tween-Split Influenza A Virus Vaccines in Volunteers
Identifieur interne : 001520 ( Istex/Curation ); précédent : 001519; suivant : 001521Reactogenicity and Immunogenicity of Whole and Ether-Tween-Split Influenza A Virus Vaccines in Volunteers
Auteurs : R. Jennings [Royaume-Uni] ; A. Clark [Royaume-Uni] ; J. S. Oxford [Royaume-Uni] ; D. J. Hockley [Royaume-Uni] ; C. W. Potter [Royaume-Uni]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1978.
Abstract
Two separate, double-blind studies were carried out in volunteers to compare the reactogenicity of, and serum antibody responses to, whole or ether-Tween-split inactivated influenza virus vaccines. In both studies the ether-Tween-split vaccines induced a lower rate of reactions. The serum hemagglutination-inhibiting (HAl) antibody response of volunteers to the A/Scotland/74 component of the split vaccine used in the first study was significantly greater than that following inoculation of A/Scotland/74 whole-virus vaccine. The neuraminidase-inhibiting (NI) antibody responses of the volunteers to each vaccine were similar. In the second study, a markedly better NI antibody response to the influenza A virus component was seen following immunization with split-virus vaccine, but the HAl antibody response to both split and whole vaccines was the same. In both studies the serum HAl antibody responses to the B/Hong Kong/73 component of the vaccines were similar. Challenge of the volunteers with attenuated influenza viruses homologous to the influenza A component of the vaccines showed both types of vaccines to be protective.
Url:
DOI: 10.1093/infdis/138.5.577
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<affiliation wicri:level="2"><mods:affiliation>Please address requests for reprints to Dr. R. Jennings, Department of Virology, University of Sheffield Medical School, Beech Hill Road, Sheffield SIO 2RX, England.</mods:affiliation>
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<front><div type="abstract">Two separate, double-blind studies were carried out in volunteers to compare the reactogenicity of, and serum antibody responses to, whole or ether-Tween-split inactivated influenza virus vaccines. In both studies the ether-Tween-split vaccines induced a lower rate of reactions. The serum hemagglutination-inhibiting (HAl) antibody response of volunteers to the A/Scotland/74 component of the split vaccine used in the first study was significantly greater than that following inoculation of A/Scotland/74 whole-virus vaccine. The neuraminidase-inhibiting (NI) antibody responses of the volunteers to each vaccine were similar. In the second study, a markedly better NI antibody response to the influenza A virus component was seen following immunization with split-virus vaccine, but the HAl antibody response to both split and whole vaccines was the same. In both studies the serum HAl antibody responses to the B/Hong Kong/73 component of the vaccines were similar. Challenge of the volunteers with attenuated influenza viruses homologous to the influenza A component of the vaccines showed both types of vaccines to be protective.</div>
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