Cross‐reactive humoral responses to influenza and their implications for a universal vaccine
Identifieur interne : 001120 ( Istex/Curation ); précédent : 001119; suivant : 001121Cross‐reactive humoral responses to influenza and their implications for a universal vaccine
Auteurs : Christopher Chiu [Royaume-Uni] ; Jens Wrammert ; Gui-Mei Li ; Megan Mccausland ; Patrick C. Wilson [États-Unis] ; Rafi Ahmed [États-Unis]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2013-04.
Abstract
Influenza remains one of the most important causes of respiratory infection despite the widespread availability of vaccines. As effective vaccines against influenza principally rely on the induction of strain‐specific neutralizing antibodies for their protective efficacy, drifted escape mutants and genetically reassortant pandemic strains can rapidly overcome them. Several groups have recently described cross‐reactive influenza antibodies in humans, some of which bind to the conserved hemagglutinin stem. If such antibodies could be consistently induced at high levels by vaccines, they might protect against both seasonal and pandemic influenza strains. Here we discuss the humoral responses to influenza infection and vaccination, with particular reference to the pandemic H1N1 2009 virus and induction of broadly cross‐reactive stem‐binding antibodies. Having shown that cross‐reactive antibodies are preferentially induced by a pandemic hemagglutinin, the challenge is now to design a vaccine that applies these principles to the induction of heterosubtypic immunity.
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DOI: 10.1111/nyas.12012
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Jens Wrammert<affiliation><mods:affiliation>Department of Pediatric Infectious Disease, Department of Hematology and Oncology, Emory University School of Medicine, Georgia, Atlanta</mods:affiliation><wicri:noCountry code="subField">Atlanta</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Microbiology and Immunology</mods:affiliation><wicri:noCountry code="no comma">Department of Microbiology and Immunology</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Microbiology and Immunology</mods:affiliation><wicri:noCountry code="no comma">Department of Microbiology and Immunology</wicri:noCountry></affiliation>Le document en format XML
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Wilson</name><affiliation wicri:level="3"><mods:affiliation>Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Illinois, Chicago</mods:affiliation><country>États-Unis</country><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName><wicri:orgArea>Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Illinois</wicri:orgArea></affiliation></author><author><name sortKey="Ahmed, Rafi" sort="Ahmed, Rafi" uniqKey="Ahmed R" first="Rafi" last="Ahmed">Rafi Ahmed</name><affiliation><mods:affiliation>Emory Vaccine Center</mods:affiliation><wicri:noCountry code="no comma">Emory Vaccine Center</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Microbiology and Immunology</mods:affiliation><wicri:noCountry code="no comma">Department of Microbiology and Immunology</wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: rahmed@emory.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:349438B24A0869D5AD9D881559B89AB9CC9D1589</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1111/nyas.12012</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-1S3H9HRS-4/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001120</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001120</idno><idno type="wicri:Area/Istex/Curation">001120</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Cross‐reactive humoral responses to influenza and their implications for a universal vaccine</title><author><name sortKey="Chiu, Christopher" sort="Chiu, Christopher" uniqKey="Chiu C" first="Christopher" last="Chiu">Christopher Chiu</name><affiliation><mods:affiliation>Emory Vaccine Center</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology and Immunology</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>Center for Respiratory Infection, National Heart and Lung Institute, Imperial College London, London, United Kingdom</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Respiratory Infection, National Heart and Lung Institute, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Wrammert, Jens" sort="Wrammert, Jens" uniqKey="Wrammert J" first="Jens" last="Wrammert">Jens Wrammert</name><affiliation><mods:affiliation>Emory Vaccine Center</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology and Immunology</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Pediatric Infectious Disease, Department of Hematology and Oncology, Emory University School of Medicine, Georgia, Atlanta</mods:affiliation><wicri:noCountry code="subField">Atlanta</wicri:noCountry></affiliation></author><author><name sortKey="Li, Gui Ei" sort="Li, Gui Ei" uniqKey="Li G" first="Gui-Mei" last="Li">Gui-Mei Li</name><affiliation><mods:affiliation>Emory Vaccine Center</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology and Immunology</mods:affiliation><wicri:noCountry code="no comma">Department of Microbiology and Immunology</wicri:noCountry></affiliation></author><author><name sortKey="Mccausland, Megan" sort="Mccausland, Megan" uniqKey="Mccausland M" first="Megan" last="Mccausland">Megan Mccausland</name><affiliation><mods:affiliation>Emory Vaccine Center</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology and Immunology</mods:affiliation><wicri:noCountry code="no comma">Department of Microbiology and Immunology</wicri:noCountry></affiliation></author><author><name sortKey="Wilson, Patrick C" sort="Wilson, Patrick C" uniqKey="Wilson P" first="Patrick C." last="Wilson">Patrick C. Wilson</name><affiliation wicri:level="3"><mods:affiliation>Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Illinois, Chicago</mods:affiliation><country>États-Unis</country><placeName><settlement type="city">Chicago</settlement><region type="state">Illinois</region></placeName><wicri:orgArea>Department of Medicine, Section of Rheumatology, The Committee on Immunology, The Knapp Center for Lupus and Immunology Research, The University of Chicago, Illinois</wicri:orgArea></affiliation></author><author><name sortKey="Ahmed, Rafi" sort="Ahmed, Rafi" uniqKey="Ahmed R" first="Rafi" last="Ahmed">Rafi Ahmed</name><affiliation><mods:affiliation>Emory Vaccine Center</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology and Immunology</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: rahmed@emory.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Annals of the New York Academy of Sciences</title><title level="j" type="alt">ANNALS OF THE NEW YORK ACADEMY OF SCIENCES</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><biblScope unit="vol">1283</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="13">13</biblScope><biblScope unit="page" to="21">21</biblScope><biblScope unit="page-count">9</biblScope><date type="published" when="2013-04">2013-04</date></imprint><idno type="ISSN">0077-8923</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0077-8923</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Influenza remains one of the most important causes of respiratory infection despite the widespread availability of vaccines. As effective vaccines against influenza principally rely on the induction of strain‐specific neutralizing antibodies for their protective efficacy, drifted escape mutants and genetically reassortant pandemic strains can rapidly overcome them. Several groups have recently described cross‐reactive influenza antibodies in humans, some of which bind to the conserved hemagglutinin stem. If such antibodies could be consistently induced at high levels by vaccines, they might protect against both seasonal and pandemic influenza strains. Here we discuss the humoral responses to influenza infection and vaccination, with particular reference to the pandemic H1N1 2009 virus and induction of broadly cross‐reactive stem‐binding antibodies. Having shown that cross‐reactive antibodies are preferentially induced by a pandemic hemagglutinin, the challenge is now to design a vaccine that applies these principles to the induction of heterosubtypic immunity.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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