Development of Novel Influenza Virus Vaccines and Vectors
Identifieur interne : 000F93 ( Istex/Curation ); précédent : 000F92; suivant : 000F94Development of Novel Influenza Virus Vaccines and Vectors
Auteurs : Peter Palese [Autriche, États-Unis] ; Fidel Zavala [Autriche] ; Thomas Muster [Autriche] ; Ruth S. Nussenzweig [Autriche] ; Adolfo García-Sastre [Autriche]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1997.
Abstract
Approaches to improve the efficacy of the current (killed) influenza virus vaccines include the generation of cold-adapted and genetically engineered influenza viruses containing specific attenuating mutations. It is hoped that these genetically altered viruses, in which the hemagglutinin and neuraminidase genes from circulating strains have been incorporated by reassortment, can be used as safe live influenza virus vaccines to induce a long-lasting protective immune response in humans. In addition, genetically engineered influenza viruses may provide a means for expressing foreign antigens. Immunization of mice with recombinant influenza and vaccinia viruses expressing specific antigens of Plasmodium yoelii resulted in a dramatic protective immune response against malaria in this model. Mice immunized with recombinant influenza viruses expressing human immunodeficiency virus (HIV) epitopes generated long-lasting HIV-specific serum antibodies and secretory IgA in the secretory nasal, vaginal, and intestinal mucosa. These results suggest that genetically engineered influenza viruses may be developed for use as live virus vaccines against influenza as well as other diseases.
Url:
DOI: 10.1086/514175
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Sinai School of Medicine, 1 Gustave Levy Pl., New York</wicri:cityArea></affiliation></author><author><name sortKey="Zavala, Fidel" sort="Zavala, Fidel" uniqKey="Zavala F" first="Fidel" last="Zavala">Fidel Zavala</name><affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Mount Sinai School of Medicine, and Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, Vienna, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Microbiology, Mount Sinai School of Medicine, and Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Muster, Thomas" sort="Muster, Thomas" uniqKey="Muster T" first="Thomas" last="Muster">Thomas Muster</name><affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Mount Sinai School of Medicine, and Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, Vienna, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Microbiology, Mount Sinai School of Medicine, and Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Nussenzweig, Ruth S" sort="Nussenzweig, Ruth S" uniqKey="Nussenzweig R" first="Ruth S." last="Nussenzweig">Ruth S. Nussenzweig</name><affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Mount Sinai School of Medicine, and Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, Vienna, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Microbiology, Mount Sinai School of Medicine, and Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, Vienna</wicri:regionArea></affiliation></author><author><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="García-Sastre">Adolfo García-Sastre</name><affiliation wicri:level="1"><mods:affiliation>Department of Microbiology, Mount Sinai School of Medicine, and Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, Vienna, Austria</mods:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Microbiology, Mount Sinai School of Medicine, and Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York, Vienna</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1997-08">1997</date><biblScope unit="vol">176</biblScope><biblScope unit="issue">Supplemet_1</biblScope><biblScope unit="page" from="S45">S45</biblScope><biblScope unit="page" to="S49">S49</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Approaches to improve the efficacy of the current (killed) influenza virus vaccines include the generation of cold-adapted and genetically engineered influenza viruses containing specific attenuating mutations. It is hoped that these genetically altered viruses, in which the hemagglutinin and neuraminidase genes from circulating strains have been incorporated by reassortment, can be used as safe live influenza virus vaccines to induce a long-lasting protective immune response in humans. In addition, genetically engineered influenza viruses may provide a means for expressing foreign antigens. Immunization of mice with recombinant influenza and vaccinia viruses expressing specific antigens of Plasmodium yoelii resulted in a dramatic protective immune response against malaria in this model. Mice immunized with recombinant influenza viruses expressing human immunodeficiency virus (HIV) epitopes generated long-lasting HIV-specific serum antibodies and secretory IgA in the secretory nasal, vaginal, and intestinal mucosa. These results suggest that genetically engineered influenza viruses may be developed for use as live virus vaccines against influenza as well as other diseases.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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