Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring
Identifieur interne : 000D29 ( Istex/Curation ); précédent : 000D28; suivant : 000D30Synthesis and Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclobutane Ring
Auteurs : M. José Figueira [Espagne] ; J. Manuel Blanco [Espagne] ; Olga Caama O ; Franco Fernández [Espagne] ; Xerardo García-Mera [Espagne] ; Carmen L Pez [Espagne] ; Graciela Andrei [Belgique] ; Robert Snoeck [Belgique] ; Elisabeth Padalko [Belgique] ; Johan Neyts [Belgique] ; Jan Balzarini [Belgique] ; Erik De Clercq [Belgique]Source :
- Archiv der Pharmazie [ 0365-6233 ] ; 1999-10.
English descriptors
- Teeft :
- Acoh, Amino, Anal, Analogue, Analytical sample, Antiviral, Carbocyclic, Carbocyclic nucleosides, Cdcl3, Chem, Chromatographed, Compound concentrations, Crude product, Exch, Guanosine analogues, Herpes simplex virus type, Meoh, Mmol, Nucleoside, Parallel tests, Pharm, Recrystallization, Reference drugs, Reflux, Room temperature, Silica, Tumor cell lines.
Abstract
Five new carbocyclic nucleosides were prepared by constructing a guanine (compounds 3, 5) or 8‐azaguanine (compounds 4, 6, and 7) base on the amino group of (1′S,3′R)‐3‐(3′‐amino‐2′,2′‐dimethylcyclobutyl) propan‐1‐ol (8), and their activities against a variety of viruses and tumor cell lines were determined. Only compounds 3 and 7 showed a detectable activity at subtoxic concentrations against some viruses tested.
Url:
DOI: 10.1002/(SICI)1521-4184(199910)332:10<348::AID-ARDP348>3.0.CO;2-H
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<front><div type="abstract" xml:lang="en">Five new carbocyclic nucleosides were prepared by constructing a guanine (compounds 3, 5) or 8‐azaguanine (compounds 4, 6, and 7) base on the amino group of (1′S,3′R)‐3‐(3′‐amino‐2′,2′‐dimethylcyclobutyl) propan‐1‐ol (8), and their activities against a variety of viruses and tumor cell lines were determined. Only compounds 3 and 7 showed a detectable activity at subtoxic concentrations against some viruses tested.</div>
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