Diagnosis of influenza virus: Coming to grips with the molecular era
Identifieur interne : 000A20 ( Istex/Curation ); précédent : 000A19; suivant : 000A21Diagnosis of influenza virus: Coming to grips with the molecular era
Auteurs : Jeffery K. Taubenberger ; Scott P. LayneSource :
- Molecular Diagnosis [ 1084-8592 ] ; 2001.
English descriptors
- Teeft :
- Acute sample, Allantoic cavity, Amino acids, Antigen detection, Antigenic, Antigenic drift, Antigenic shift, Antiviral drugs, Aspirate, Assay, Average year, Avian, Bronchial wash, Cellular pathology, Clin, Clin microbiol, Clinical course, Clinical samples, Clinical specimens, Common causes, Culture isolation, Current methods, December, Diagnosis, Economic impact, Exceptional virulence, Excess deaths, Fields virology, Forces institute, Gene, Gene segment, Genetic structure, Global laboratory, Hemorrhagic bronchitis, High risk, Hong kong, Host range, Human viruses, Immunoassay, Immunocompromised individuals, Infectious diseases, Joseph henry, Large numbers, Last year, Layne, Matrix, Matrix gene, Microbiol, Molecular assays, Molecular diagnosis, Molecular pathology, Mortality rates, Mutation, Nasal, Nasal aspirate, Nasal wash, Nasopharyngeal swabs, Nonstructural protein, Novel subtype, Novel surface proteins, Novel viruses, Other groups, Outbreak, Pandemic, Pandemic strain, Pandemic strains, Pandemic viruses, Polymerase, Polymerase chain reaction, Positive samples, Primer, Probe hybridization, Proc natl acad, Public health, Pulmonary edema, Rapid detection, Rapid diagnosis, Respiratory disease, Respiratory syncytial virus, Respiratory syncytial viruses, Sample strains, Segmented genome, Sequence analysis, Sequence variation, Simultaneous detection, Single year, Small number, Spanish virus, Subbarao, Subtype, Subtypes, Subtyping, Such tests, Surface genes, Surface glycoproteins, Surveillance, Surveillance network, Surveillance studies, Swine, Taqman assay, Taubenberger, Temperate climates, Therapeutic intervention, Vaccine, Vaccine production, Vaccine strain selection, Vaccine strains, Viral, Viral antigens, Viral culture, Viral isolation, Viral strains, Virol, Virulence, Virus, Virus isolation, World health organization, Worst pandemic.
Abstract
Abstract: Influenza viruses continually circulate and cause yearly epidemics, which kill 20,000 people in an average year in the United States. Occasionally and unpredictably, pandemic influenza strains sweep the world, infecting 20% to 40% of the world's population in a single year. In 1918, the worst influenza pandemic on record caused 675,000 deaths in the United States and up to 40 million deaths worldwide. Despite the prevalence of this virus, molecular assays for influenza diagnosis, surveillance, vaccine strain selection, and research have lagged behind such assays for other common viral pathogens. The extreme genetic variability of influenza viruses makes the design of useful molecular-based assays challenging, but several different approaches have been successfully used. RT-PCR is effective for the initial diagnosis and has greater sensitivity than other available rapid assays. Molecular assays also can be used to subtype influenza isolates, and sequence analysis of hemagglutinin may assist greatly in surveillance studies and vaccine strain selection. RT-PCR for influenza also can be performed from tissue biopsy specimens for both retrospective diagnosis and research.
Url:
DOI: 10.1054/modi.2001.28063
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Jeffery K. Taubenberger<affiliation><mods:affiliation>From the *Department of Cellular Pathology and Genetics, Division of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, MD; and the [dagger]Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA.</mods:affiliation><wicri:noCountry code="subField">CA.</wicri:noCountry></affiliation><affiliation><mods:affiliation>From the *Department of Cellular Pathology and Genetics, Division of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, MD; and the [dagger]Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA.</mods:affiliation><wicri:noCountry code="subField">CA.</wicri:noCountry></affiliation>Le document en format XML
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Taubenberger</name><affiliation><mods:affiliation>From the *Department of Cellular Pathology and Genetics, Division of Molecular Pathology, Armed Forces Institute of Pathology, Rockville, MD; and the [dagger]Department of Epidemiology, School of Public Health, University of California, Los Angeles, CA.</mods:affiliation><wicri:noCountry code="subField">CA.</wicri:noCountry></affiliation></author><author><name sortKey="Layne, Scott P" sort="Layne, Scott P" uniqKey="Layne S" first="Scott P." last="Layne">Scott P. 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Occasionally and unpredictably, pandemic influenza strains sweep the world, infecting 20% to 40% of the world's population in a single year. In 1918, the worst influenza pandemic on record caused 675,000 deaths in the United States and up to 40 million deaths worldwide. Despite the prevalence of this virus, molecular assays for influenza diagnosis, surveillance, vaccine strain selection, and research have lagged behind such assays for other common viral pathogens. The extreme genetic variability of influenza viruses makes the design of useful molecular-based assays challenging, but several different approaches have been successfully used. RT-PCR is effective for the initial diagnosis and has greater sensitivity than other available rapid assays. Molecular assays also can be used to subtype influenza isolates, and sequence analysis of hemagglutinin may assist greatly in surveillance studies and vaccine strain selection. RT-PCR for influenza also can be performed from tissue biopsy specimens for both retrospective diagnosis and research.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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