Natural and synthetic sialic acid‐containing inhibitors of influenza virus receptor binding
Identifieur interne : 000747 ( Istex/Curation ); précédent : 000746; suivant : 000748Natural and synthetic sialic acid‐containing inhibitors of influenza virus receptor binding
Auteurs : Mikhail Matrosovich [Allemagne, Russie] ; Hans-Dieter Klenk [Allemagne]Source :
- Reviews in Medical Virology [ 1052-9276 ] ; 2003-03.
English descriptors
- Teeft :
- Acid, Airway, Airway mucins, Amino, Analogue, Avian, Avian viruses, Biol, Bivalent, Bivalent sialosides, Bovin, Cell culture, Cellular receptors, Chem, Copyright, Determinant, Different virus strains, Embryonated eggs, Equine, Erythrocyte, Febs lett, Gambaryan, Globular head, Glycoprotein, Haemagglutination, Haemagglutination inhibition, Hemagglutinin, Horse serum, Human virus, Human viruses, Influenza virus receptor binding, Inhibitor, Inhibitory activity, Innate immunity, John wiley sons, Klenk, Ligand, Matrosovich, Moiety, Monovalent, Monovalent sialosides, Mucin, Mutation, Natural inhibitors, Neu5ac, Neuraminidase, Neutralisation, Paulson, Penultimate sugar, Polyvalent, Receptor, Receptor binding, Replication, Serum inhibitors, Sialic, Sialic acid, Sialic acid species, Sialic acids, Sialic inhibitors, Sialoside, Sialosides, Sialyloligosaccharide moieties, Surfactant, Surfactant protein, Synthetic inhibitors, Synthetic sialic inhibitors, Target cells, Tuzikov, Viral, Virol, Virology, Virus, Virus attachment, Virus binding, Virus hemagglutinin, Virus infection, Virus receptors, Virus replication, Virus strains, Whitesides.
Abstract
Influenza viruses attach to susceptible cells via multivalent interactions of their haemagglutinins with sialyloligosaccharide moieties of cellular glycoconjugates. Soluble macromolecules containing sialic acid from animal sera and mucosal fluids can act as decoy receptors and competitively inhibit virus‐mediated haemagglutination and infection. Although a role for these natural inhibitors in the innate anti‐influenza immunity is still not clear, studies are in progress on the design of synthetic sialic acid‐containing inhibitors of receptor binding which could be used as anti‐influenza drugs. Copyright © 2003 John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/rmv.372
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Soluble macromolecules containing sialic acid from animal sera and mucosal fluids can act as decoy receptors and competitively inhibit virus‐mediated haemagglutination and infection. Although a role for these natural inhibitors in the innate anti‐influenza immunity is still not clear, studies are in progress on the design of synthetic sialic acid‐containing inhibitors of receptor binding which could be used as anti‐influenza drugs. Copyright © 2003 John Wiley & Sons, Ltd.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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