One‐way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential
Identifieur interne : 000716 ( Istex/Curation ); précédent : 000715; suivant : 000717One‐way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential
Auteurs : Jason S. Long [Royaume-Uni] ; Camilla T. Benfield [Royaume-Uni] ; Wendy S. Barclay [Royaume-Uni]Source :
- BioEssays [ 0265-9247 ] ; 2015-02.
Abstract
We hypothesise that some influenza virus adaptations to poultry may explain why the barrier for human‐to‐human transmission is not easily overcome once the virus has crossed from wild birds to chickens. Since the cluster of human infections with H5N1 influenza in Hong Kong in 1997, chickens have been recognized as the major source of avian influenza virus infection in humans. Although often severe, these infections have been limited in their subsequent human‐to‐human transmission, and the feared H5N1 pandemic has not yet occurred. Here we examine virus adaptations selected for during replication in chickens and other gallinaceous poultry. These include altered receptor binding and increased pH of fusion of the haemagglutinin as well as stalk deletions of the neuraminidase protein. This knowledge could aid the delivery of vaccines and increase our ability to prioritize research efforts on those viruses from the diverse array of avian influenza viruses that have greatest human pandemic potential. Also watch the Video Abstract.
Adaptation of influenza viruses to poultry results in altered receptor binding, increased pH of fusion of the haemagglutinin and neuraminidase stalk deletions, which may compromise human‐to‐human transmission. We suggest a trade‐off exists between high pathogenicity and transmissibility since HA stability may confer greater susceptibility to control by IFITM‐3.
Url:
DOI: 10.1002/bies.201400133
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000716
Links to Exploration step
ISTEX:774FA899B9E4BF38E04316D141658EE37FC34C90Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">One‐way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential</title>
<author><name sortKey="Long, Jason S" sort="Long, Jason S" uniqKey="Long J" first="Jason S." last="Long">Jason S. Long</name>
<affiliation wicri:level="1"><mods:affiliation>Imperial College London, Department of Medicine, Section of Virology, London, UK</mods:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, Department of Medicine, Section of Virology, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benfield, Camilla T" sort="Benfield, Camilla T" uniqKey="Benfield C" first="Camilla T." last="Benfield">Camilla T. Benfield</name>
<affiliation wicri:level="1"><mods:affiliation>Royal Veterinary College, London, UK</mods:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Veterinary College, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S." last="Barclay">Wendy S. Barclay</name>
<affiliation wicri:level="1"><mods:affiliation>Imperial College London, Department of Medicine, Section of Virology, London, UK</mods:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, Department of Medicine, Section of Virology, London</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Wendy BarclayE‐mail:</mods:affiliation>
<wicri:noCountry code="no comma">Wendy BarclayE‐mail:</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: w.barclay@imperial.ac.uk</mods:affiliation>
<country wicri:rule="url">Royaume-Uni</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:774FA899B9E4BF38E04316D141658EE37FC34C90</idno>
<date when="2015" year="2015">2015</date>
<idno type="doi">10.1002/bies.201400133</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-76VHRLW7-R/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000716</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000716</idno>
<idno type="wicri:Area/Istex/Curation">000716</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">One‐way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential</title>
<author><name sortKey="Long, Jason S" sort="Long, Jason S" uniqKey="Long J" first="Jason S." last="Long">Jason S. Long</name>
<affiliation wicri:level="1"><mods:affiliation>Imperial College London, Department of Medicine, Section of Virology, London, UK</mods:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, Department of Medicine, Section of Virology, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Benfield, Camilla T" sort="Benfield, Camilla T" uniqKey="Benfield C" first="Camilla T." last="Benfield">Camilla T. Benfield</name>
<affiliation wicri:level="1"><mods:affiliation>Royal Veterinary College, London, UK</mods:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Royal Veterinary College, London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Barclay, Wendy S" sort="Barclay, Wendy S" uniqKey="Barclay W" first="Wendy S." last="Barclay">Wendy S. Barclay</name>
<affiliation wicri:level="1"><mods:affiliation>Imperial College London, Department of Medicine, Section of Virology, London, UK</mods:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Imperial College London, Department of Medicine, Section of Virology, London</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Wendy BarclayE‐mail:</mods:affiliation>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: w.barclay@imperial.ac.uk</mods:affiliation>
<country wicri:rule="url">Royaume-Uni</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">BioEssays</title>
<title level="j" type="alt">BIOESSAYS</title>
<idno type="ISSN">0265-9247</idno>
<idno type="eISSN">1521-1878</idno>
<imprint><biblScope unit="vol">37</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="204">204</biblScope>
<biblScope unit="page" to="212">212</biblScope>
<biblScope unit="page-count">9</biblScope>
<date type="published" when="2015-02">2015-02</date>
</imprint>
<idno type="ISSN">0265-9247</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0265-9247</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We hypothesise that some influenza virus adaptations to poultry may explain why the barrier for human‐to‐human transmission is not easily overcome once the virus has crossed from wild birds to chickens. Since the cluster of human infections with H5N1 influenza in Hong Kong in 1997, chickens have been recognized as the major source of avian influenza virus infection in humans. Although often severe, these infections have been limited in their subsequent human‐to‐human transmission, and the feared H5N1 pandemic has not yet occurred. Here we examine virus adaptations selected for during replication in chickens and other gallinaceous poultry. These include altered receptor binding and increased pH of fusion of the haemagglutinin as well as stalk deletions of the neuraminidase protein. This knowledge could aid the delivery of vaccines and increase our ability to prioritize research efforts on those viruses from the diverse array of avian influenza viruses that have greatest human pandemic potential. Also watch the Video Abstract.</div>
<div type="abstract">Adaptation of influenza viruses to poultry results in altered receptor binding, increased pH of fusion of the haemagglutinin and neuraminidase stalk deletions, which may compromise human‐to‐human transmission. We suggest a trade‐off exists between high pathogenicity and transmissibility since HA stability may confer greater susceptibility to control by IFITM‐3.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000716 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000716 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:774FA899B9E4BF38E04316D141658EE37FC34C90 |texte= One‐way trip: Influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential }}
This area was generated with Dilib version V0.6.33. |