Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?
Identifieur interne : 000549 ( Istex/Curation ); précédent : 000548; suivant : 000550Does prenatal exposure to influenza in mice induce pyramidal cell disarray in the dorsal hippocampus?
Auteurs : David Cotter [Irlande (pays)] ; Noriyoshi Takei [Royaume-Uni] ; Michael Farrell [Irlande (pays)] ; Pak Sham [Royaume-Uni] ; Peter Quinn [Royaume-Uni] ; Conall Larkin [Irlande (pays)] ; John Oxford [Irlande (pays)] ; Robin M. Murray [Royaume-Uni] ; Eadbhard O'Callaghan [Irlande (pays)]Source :
- Schizophrenia Research [ 0920-9964 ] ; 1995.
English descriptors
- Teeft :
- Abnormality, Adult schizophrenia, Animal studies, Apical dendrite, Asian influenza, Basal side, Bilateral phenomenon, Cell body, Cell disarray, Cell layer, Cell nucleus, Cell orientation, Clear pattern, Complement fixation test, Congenital malformations, Control group, Control groups, Coronal section, Cotter, Critical periods, Disarray, Disarray scores, Dorsal, Dorsal hippocampus, Epidemiological evidence, Fifth month, Genetic vulnerability, Gestation, High degree, Hippocampal, Hippocampal development, Hippocampal formation, Hippocampus, Influenza, Influenza epidemic, Influenza epidemics, Influenza group, Influenza infection, Influenza infections, Influenza virus, Inoculation, Interface, Interface zone, Interface zones, Intranasal route, Junctional area, Kovelman, Litter size, Long axis, Maternal infection, Maternal influenza, Maternal influenza infection, Monozygotic twins, Morphometric study, Neural tube defects, Neuron, Neuron formation, Neuronal migration, Normal saline, Other days, Overall effect, Polymorphic cell layers, Postnatal mortality, Pregnant mice, Prenatal, Prenatal exposure, Prospective study, Psychiatry, Pyramidal, Pyramidal cell, Pyramidal cell disarray, Pyramidal cell nucleus, Pyramidal cell orientation, Pyramidal cells, Reference axis, Scheibel, Schizophr, Schizophrenia, Schizophrenic patients, Second trimester, Sham, Similar placental unit, Specific vulnerability, Subsequent development, Such studies, Takei, Temporal window, Vaginal plug.
Abstract
Abstract: Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9–16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.
Url:
DOI: 10.1016/0920-9964(94)E0082-I
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Murray</name><affiliation wicri:level="1"><mods:affiliation>Department of Psychological Medicine, King's College Hospital and Institute of Psychiatry, London, UK</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Psychological Medicine, King's College Hospital and Institute of Psychiatry, London</wicri:regionArea></affiliation></author><author><name sortKey="O Callaghan, Eadbhard" sort="O Callaghan, Eadbhard" uniqKey="O Callaghan E" first="Eadbhard" last="O'Callaghan">Eadbhard O'Callaghan</name><affiliation><mods:affiliation>Corresponding author.</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co Dublin, Ireland</mods:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Cluain Mhuire Family Centre, Newtownpark Avenue, Blackrock, Co Dublin</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Schizophrenia Research</title><title level="j" type="abbrev">SCHRES</title><idno type="ISSN">0920-9964</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">16</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="233">233</biblScope><biblScope unit="page" to="241">241</biblScope></imprint><idno type="ISSN">0920-9964</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0920-9964</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abnormality</term><term>Adult schizophrenia</term><term>Animal studies</term><term>Apical dendrite</term><term>Asian influenza</term><term>Basal side</term><term>Bilateral phenomenon</term><term>Cell body</term><term>Cell disarray</term><term>Cell layer</term><term>Cell nucleus</term><term>Cell orientation</term><term>Clear pattern</term><term>Complement fixation test</term><term>Congenital malformations</term><term>Control group</term><term>Control groups</term><term>Coronal section</term><term>Cotter</term><term>Critical periods</term><term>Disarray</term><term>Disarray scores</term><term>Dorsal</term><term>Dorsal hippocampus</term><term>Epidemiological evidence</term><term>Fifth month</term><term>Genetic vulnerability</term><term>Gestation</term><term>High degree</term><term>Hippocampal</term><term>Hippocampal development</term><term>Hippocampal formation</term><term>Hippocampus</term><term>Influenza</term><term>Influenza epidemic</term><term>Influenza epidemics</term><term>Influenza group</term><term>Influenza infection</term><term>Influenza infections</term><term>Influenza virus</term><term>Inoculation</term><term>Interface</term><term>Interface zone</term><term>Interface zones</term><term>Intranasal route</term><term>Junctional area</term><term>Kovelman</term><term>Litter size</term><term>Long axis</term><term>Maternal infection</term><term>Maternal influenza</term><term>Maternal influenza infection</term><term>Monozygotic twins</term><term>Morphometric study</term><term>Neural tube defects</term><term>Neuron</term><term>Neuron formation</term><term>Neuronal migration</term><term>Normal saline</term><term>Other days</term><term>Overall effect</term><term>Polymorphic cell layers</term><term>Postnatal mortality</term><term>Pregnant mice</term><term>Prenatal</term><term>Prenatal exposure</term><term>Prospective study</term><term>Psychiatry</term><term>Pyramidal</term><term>Pyramidal cell</term><term>Pyramidal cell disarray</term><term>Pyramidal cell nucleus</term><term>Pyramidal cell orientation</term><term>Pyramidal cells</term><term>Reference axis</term><term>Scheibel</term><term>Schizophr</term><term>Schizophrenia</term><term>Schizophrenic patients</term><term>Second trimester</term><term>Sham</term><term>Similar placental unit</term><term>Specific vulnerability</term><term>Subsequent development</term><term>Such studies</term><term>Takei</term><term>Temporal window</term><term>Vaginal plug</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Epidemiological studies point to an association between prenatal exposure to influenza and later schizophrenia. Such studies are consistent with neuropathologic reports demonstrating cytoarchitectural abnormalities in the hippocampus and parahippocampal gyrus suggestive of second trimester developmental anomalies. The hypothesis that prenatal exposure to influenza in the second trimester may induce hippocampal pyramidal cell disarray in mice was investigated. Between days 9–16 of pregnancy, 35 Balb/c mice were intranasally inoculated with either a mouse-adapted or non mouse-adapted pool of Influenza A/Singapore/1/57 (H2N2), and 10 controls were inoculated with normal saline. Offspring were sacrificed on day 21 postpartum. Microscopic examination of the CA1-CA2 junctional areas in the offspring of mice exposed to influenza failed to demonstrate excess pyramidal cell disarray when compared with influenza-free, age matched controls. There was evidence that disarray was greater among those exposed on day 13 of pregnancy. Analyses of the data by sex and severity of maternal infection failed to reveal any significant effects.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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