Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model
Identifieur interne : 000057 ( Istex/Curation ); précédent : 000056; suivant : 000058Master donor viruses A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortants used in live attenuated influenza vaccine (LAIV) do not display neurovirulent properties in a mouse model
Auteurs : J. Theo M. Voeten [Pays-Bas] ; Irina V. Kiseleva [Pays-Bas, Russie] ; Harrie L. Glansbeek [Pays-Bas] ; Stephanie M. C. Basten [Pays-Bas] ; Sandra K. M. Drieszen-Van Der Cruijsen [Pays-Bas] ; Larisa G. Rudenko [Russie] ; Han Van Den Bosch [Pays-Bas] ; Jacco G. M. Heldens [Pays-Bas]Source :
- Archives of Virology [ 0304-8608 ] ; 2010-09-01.
Abstract
Abstract: Demonstration of the absence of neurovirulent properties of reassortant viruses contained in live attenuated influenza vaccine (LAIV) is a regulatory requirement. A mouse model was used to detect neurovirulent properties of the cold-adapted, temperature-sensitive and attenuated influenza master donor viruses (MDVs) A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortant influenza viruses. A/NWS/33 (H1N1), which is known to be neurovirulent in mice, was used as a positive control. Under conditions where the positive control virus induced symptoms of disease and showed viral replication in the upper respiratory tract as well as in the brain, replication of the influenza master donor viruses and reassortant influenza A and B viruses was limited to the upper respiratory tract where they were administered. None of the mice inoculated with MDVs or reassortant influenza viruses suffered from disease, and no virus or viral replication was observed in the brains of these mice. The results demonstrate the absence of neurovirulent properties of the MDVs and reassortant influenza viruses derived therefrom used in LAIV.
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DOI: 10.1007/s00705-010-0719-8
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Theo M." last="Voeten">J. Theo M. Voeten</name><affiliation wicri:level="1"><mods:affiliation>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer</wicri:regionArea></affiliation><affiliation><mods:affiliation>E-mail: theo.voeten@sp.nobilon.com</mods:affiliation></affiliation></author><author><name sortKey="Kiseleva, Irina V" sort="Kiseleva, Irina V" uniqKey="Kiseleva I" first="Irina V." last="Kiseleva">Irina V. Kiseleva</name><affiliation wicri:level="1"><mods:affiliation>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Institute of Experimental Medicine, 12 Acad. Pavlov Street, 197376, Saint Petersburg, Russia</mods:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Experimental Medicine, 12 Acad. Pavlov Street, 197376, Saint Petersburg</wicri:regionArea></affiliation></author><author><name sortKey="Glansbeek, Harrie L" sort="Glansbeek, Harrie L" uniqKey="Glansbeek H" first="Harrie L." last="Glansbeek">Harrie L. Glansbeek</name><affiliation wicri:level="1"><mods:affiliation>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer</wicri:regionArea></affiliation></author><author><name sortKey="Basten, Stephanie M C" sort="Basten, Stephanie M C" uniqKey="Basten S" first="Stephanie M. C." last="Basten">Stephanie M. C. Basten</name><affiliation wicri:level="1"><mods:affiliation>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer</wicri:regionArea></affiliation></author><author><name sortKey="Drieszen Van Der Cruijsen, Sandra K M" sort="Drieszen Van Der Cruijsen, Sandra K M" uniqKey="Drieszen Van Der Cruijsen S" first="Sandra K. M." last="Drieszen-Van Der Cruijsen">Sandra K. M. Drieszen-Van Der Cruijsen</name><affiliation wicri:level="1"><mods:affiliation>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer</wicri:regionArea></affiliation></author><author><name sortKey="Rudenko, Larisa G" sort="Rudenko, Larisa G" uniqKey="Rudenko L" first="Larisa G." last="Rudenko">Larisa G. Rudenko</name><affiliation wicri:level="1"><mods:affiliation>Institute of Experimental Medicine, 12 Acad. Pavlov Street, 197376, Saint Petersburg, Russia</mods:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Experimental Medicine, 12 Acad. Pavlov Street, 197376, Saint Petersburg</wicri:regionArea></affiliation></author><author><name sortKey="Van Den Bosch, Han" sort="Van Den Bosch, Han" uniqKey="Van Den Bosch H" first="Han" last="Van Den Bosch">Han Van Den Bosch</name><affiliation wicri:level="1"><mods:affiliation>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer</wicri:regionArea></affiliation></author><author><name sortKey="Heldens, Jacco G M" sort="Heldens, Jacco G M" uniqKey="Heldens J" first="Jacco G. M." last="Heldens">Jacco G. M. Heldens</name><affiliation wicri:level="1"><mods:affiliation>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Nobilon Schering-Plough, Wim de Körverstraat 35, 5831 AN, Boxmeer</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="sub">Official Journal of the Virology Division of the International Union of Microbiological Societies</title><title level="j" type="abbrev">Arch Virol</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer Vienna</publisher><pubPlace>Vienna</pubPlace><date type="published" when="2010-09-01">2010-09-01</date><biblScope unit="volume">155</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1391">1391</biblScope><biblScope unit="page" to="1399">1399</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Demonstration of the absence of neurovirulent properties of reassortant viruses contained in live attenuated influenza vaccine (LAIV) is a regulatory requirement. A mouse model was used to detect neurovirulent properties of the cold-adapted, temperature-sensitive and attenuated influenza master donor viruses (MDVs) A/Leningrad/134/17/57 (H2N2) and B/USSR/60/69 and derived reassortant influenza viruses. A/NWS/33 (H1N1), which is known to be neurovirulent in mice, was used as a positive control. Under conditions where the positive control virus induced symptoms of disease and showed viral replication in the upper respiratory tract as well as in the brain, replication of the influenza master donor viruses and reassortant influenza A and B viruses was limited to the upper respiratory tract where they were administered. None of the mice inoculated with MDVs or reassortant influenza viruses suffered from disease, and no virus or viral replication was observed in the brains of these mice. The results demonstrate the absence of neurovirulent properties of the MDVs and reassortant influenza viruses derived therefrom used in LAIV.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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