Evaluation of the Infectivity, Immunogenicity, and Efficacy of Live Cold-Adapted Influenza B/Ann Arbor/1/86 Reassortant Virus Vaccine in Adult Volunteers
Identifieur interne : 001828 ( Istex/Corpus ); précédent : 001827; suivant : 001829Evaluation of the Infectivity, Immunogenicity, and Efficacy of Live Cold-Adapted Influenza B/Ann Arbor/1/86 Reassortant Virus Vaccine in Adult Volunteers
Auteurs : Mary Lou Clements ; Mark H. Snyder ; Stephen D. Sears ; Hunein F. Maassab ; Brian R. MurphySource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1990.
Abstract
A cold-adapted (ca) influenza B reassortant that derived two genes encoding the hemagglutinin and neuraminidase from influenza B/Ann Arbor/1/86 wild-type virus and six internal RNA segments from ca influenza B/Ann Arbor/l/66 virus was evaluated in 66 adult volunteers having a serum hemagglutination inhibition antibody titer ≤1:8. The ca reassortant was attenuated and elicited the production of systemic and local antibodies; the 50% human infectious dose was 106,4 TCID50. Six weeks after vaccination, 12 unvaccinated volunteers and 13 recipients of ca virus (107,5 TCID50) were challenged experimentally with homologous wild-type influenza B virus. The ca vaccine completely protected against illness. and the magnitude of shedding was 50-fold less in vaccinees than in unimmunized controls, fiveof whom became ill. These findings indicate that the six internal RNA segments of the ca influenza B/Ann Arbor/66 donor virus confer desirable properties of a live virus vaccine to a reassortant derived from a virulent virus. Such reassortants may be suitable vaccines for healthy adults.
Url:
DOI: 10.1093/infdis/161.5.869
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ISTEX:8857D86C0253D7D0A162C64BEC576C0AACB20648Le document en format XML
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Murphy</name><affiliation><mods:affiliation>From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, Bethesda, Maryland, Ann Arbor</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1990-05">1990</date><biblScope unit="vol">161</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="869">869</biblScope><biblScope unit="page" to="877">877</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">A cold-adapted (ca) influenza B reassortant that derived two genes encoding the hemagglutinin and neuraminidase from influenza B/Ann Arbor/1/86 wild-type virus and six internal RNA segments from ca influenza B/Ann Arbor/l/66 virus was evaluated in 66 adult volunteers having a serum hemagglutination inhibition antibody titer ≤1:8. The ca reassortant was attenuated and elicited the production of systemic and local antibodies; the 50% human infectious dose was 106,4 TCID50. Six weeks after vaccination, 12 unvaccinated volunteers and 13 recipients of ca virus (107,5 TCID50) were challenged experimentally with homologous wild-type influenza B virus. The ca vaccine completely protected against illness. and the magnitude of shedding was 50-fold less in vaccinees than in unimmunized controls, fiveof whom became ill. These findings indicate that the six internal RNA segments of the ca influenza B/Ann Arbor/66 donor virus confer desirable properties of a live virus vaccine to a reassortant derived from a virulent virus. 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Six weeks after vaccination, 12 unvaccinated volunteers and 13 recipients of ca virus (107,5 TCID50) were challenged experimentally with homologous wild-type influenza B virus. The ca vaccine completely protected against illness. and the magnitude of shedding was 50-fold less in vaccinees than in unimmunized controls, fiveof whom became ill. These findings indicate that the six internal RNA segments of the ca influenza B/Ann Arbor/66 donor virus confer desirable properties of a live virus vaccine to a reassortant derived from a virulent virus. Such reassortants may be suitable vaccines for healthy adults.</abstract><qualityIndicators><score>7.575</score><pdfWordCount>6920</pdfWordCount><pdfCharCount>44003</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>619.2 x 806.4 pts</pdfPageSize><pdfWordsPerPage>769</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>false</refBibsNative><abstractWordCount>159</abstractWordCount><abstractCharCount>1088</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Evaluation of the Infectivity, Immunogenicity, and Efficacy of Live Cold-Adapted Influenza B/Ann Arbor/1/86 Reassortant Virus Vaccine in Adult Volunteers</title><pmid><json:string>2324538</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Journal of Infectious Diseases</title><language><json:string>unknown</json:string></language><issn><json:string>0022-1899</json:string></issn><eissn><json:string>1537-6591</json:string></eissn><publisherId><json:string>jid</json:string></publisherId><volume>161</volume><issue>5</issue><pages><first>869</first><last>877</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Major Articles</value></json:item></subject></host><namedEntities><unitex><date><json:string>1990</json:string><json:string>1075</json:string></date><geogName></geogName><orgName><json:string>Francis Scott Key Medical Center</json:string><json:string>University of Michigan</json:string><json:string>The Johns Hopkins University</json:string><json:string>Dowell Student Health Center</json:string><json:string>US Department of Human Services, the Clinical Research Subpanel of the National Institute of Allergy and Infectious Diseases</json:string><json:string>Johns Hopkins Center for Immunization Research</json:string><json:string>and Department of Epidemiology, School of Public Health</json:string><json:string>Influenza Research Center, Baylor College of Medicine, Houston</json:string><json:string>National Institute of Allergy and Infectious Diseases</json:string><json:string>National Institutes of Health</json:string><json:string>Towson State University</json:string><json:string>University of Chicago</json:string><json:string>Laboratory of Infectious Diseases</json:string><json:string>Flow Laboratories</json:string><json:string>Joint Committee on Clinical Investigation of the Johns Hopkins University School of Medicine, and the Institutional Review Board of Francis Scott Key Medical Center</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Karen Christina</json:string><json:string>Mark H. Snyder</json:string><json:string>Hong Kong</json:string><json:string>Janice Marll</json:string><json:string>Helen Lester</json:string><json:string>Sharon Kanellopulos</json:string><json:string>Frank Wood</json:string><json:string>F. Maassab</json:string><json:string>Of</json:string><json:string>Barbara Baxter</json:string><json:string>Clarence Banks</json:string><json:string>Stephen D. Sears</json:string><json:string>Ann Arbor</json:string><json:string>Mary Lou</json:string><json:string>Brian R. Murphy</json:string><json:string>Wendy Keitel</json:string><json:string>Jane Halpern</json:string><json:string>Louis Potash</json:string><json:string>Bruce Campbell</json:string><json:string>Paul Kilmon</json:string></persName><placeName><json:string>Ann Arbor</json:string><json:string>Houston</json:string><json:string>Palo Alto</json:string><json:string>Norwich</json:string><json:string>Baltimore</json:string><json:string>CT</json:string><json:string>MD</json:string><json:string>CA</json:string><json:string>MI</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[25, 26]</json:string><json:string>[34]</json:string><json:string>[34, 39, 41]</json:string><json:string>[38, 40, 42]</json:string><json:string>[21-24]</json:string><json:string>[32, 33]</json:string><json:string>[28]</json:string><json:string>[11, 30, 37]</json:string><json:string>[32]</json:string><json:string>[26, 31]</json:string><json:string>[38]</json:string><json:string>Anderson et al.</json:string><json:string>[32-34]</json:string><json:string>[28-30]</json:string><json:string>[44, 45]</json:string><json:string>Clements et al.</json:string><json:string>[25]</json:string><json:string>[1-3]</json:string><json:string>[25-27]</json:string><json:string>[29, 30]</json:string><json:string>[46]</json:string><json:string>Snyder et al. [42]</json:string><json:string>[14-20]</json:string><json:string>[4-11]</json:string><json:string>[34, 43]</json:string><json:string>[9, 12]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/HXZ-7R8VKZXD-D</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - microbiology</json:string><json:string>2 - infectious diseases</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - microbiology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - pathologie infectieuse</json:string></inist></categories><publicationDate>1990</publicationDate><copyrightDate>1990</copyrightDate><doi><json:string>10.1093/infdis/161.5.869</json:string></doi><id>8857D86C0253D7D0A162C64BEC576C0AACB20648</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-7R8VKZXD-D/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-7R8VKZXD-D/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/HXZ-7R8VKZXD-D/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Evaluation of the Infectivity, Immunogenicity, and Efficacy of Live Cold-Adapted Influenza B/Ann Arbor/1/86 Reassortant Virus Vaccine in Adult Volunteers</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>The University of Chicago Press</publisher><availability><licence>© 1990 by The University of Chicago</licence></availability><date type="Copyright" when="1990">1990</date><date when="1990-05">1990</date></publicationStmt><notesStmt><note type="content-type" source="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="publication-type" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Evaluation of the Infectivity, Immunogenicity, and Efficacy of Live Cold-Adapted Influenza B/Ann Arbor/1/86 Reassortant Virus Vaccine in Adult Volunteers</title><author xml:id="author-0000" role="corresp"><persName><surname>Clements</surname><forename type="first">Mary Lou</forename></persName><affiliation><orgName type="institution">From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health</orgName><address><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation><orgName type="institution">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases</orgName><address><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation><orgName type="institution">Department of Epidemiology, School of Public Health, University of Michigan</orgName><address><addrLine>Ann Arbor</addrLine></address></affiliation><affiliation><orgName type="institution">From the Center for Immunization Research</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><address><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><address><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation><orgName type="department">Department of Epidemiology</orgName><orgName type="department">School of Public Health</orgName><orgName type="institution">University of Michigan</orgName><address><addrLine>Ann Arbor</addrLine></address></affiliation><affiliation role="corresp">Reprints and correspondence: Dr. Mary Lou Clements. The Johns Hopkins University Center for Immunization Research, 624 N. Broadway,Hampton House Room 125, Baltimore, MD 21205.</affiliation></author><author xml:id="author-0001"><persName><surname>Snyder</surname><forename type="first">Mark H.</forename></persName><affiliation><orgName type="institution">From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health</orgName><address><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation><orgName type="institution">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases</orgName><address><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation><orgName type="institution">Department of Epidemiology, School of Public Health, University of Michigan</orgName><address><addrLine>Ann Arbor</addrLine></address></affiliation><affiliation><orgName type="institution">From the Center for Immunization Research</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><address><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><address><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation><orgName type="department">Department of Epidemiology</orgName><orgName type="department">School of Public Health</orgName><orgName type="institution">University of Michigan</orgName><address><addrLine>Ann Arbor</addrLine></address></affiliation><affiliation role="corresp">Reprints and correspondence: Dr. Mary Lou Clements. The Johns Hopkins University Center for Immunization Research, 624 N. Broadway,Hampton House Room 125, Baltimore, MD 21205.</affiliation></author><author xml:id="author-0002"><persName><surname>Sears</surname><forename type="first">Stephen D.</forename></persName><affiliation><orgName type="institution">From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health</orgName><address><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation><orgName type="institution">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases</orgName><address><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation><orgName type="institution">Department of Epidemiology, School of Public Health, University of Michigan</orgName><address><addrLine>Ann Arbor</addrLine></address></affiliation><affiliation><orgName type="institution">From the Center for Immunization Research</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><address><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><address><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation><orgName type="department">Department of Epidemiology</orgName><orgName type="department">School of Public Health</orgName><orgName type="institution">University of Michigan</orgName><address><addrLine>Ann Arbor</addrLine></address></affiliation><affiliation role="corresp">Reprints and correspondence: Dr. Mary Lou Clements. The Johns Hopkins University Center for Immunization Research, 624 N. Broadway,Hampton House Room 125, Baltimore, MD 21205.</affiliation></author><author xml:id="author-0003"><persName><surname>Maassab</surname><forename type="first">Hunein F.</forename></persName><affiliation><orgName type="institution">From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health</orgName><address><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation><orgName type="institution">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases</orgName><address><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation><orgName type="institution">Department of Epidemiology, School of Public Health, University of Michigan</orgName><address><addrLine>Ann Arbor</addrLine></address></affiliation><affiliation><orgName type="institution">From the Center for Immunization Research</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><address><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><address><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation><orgName type="department">Department of Epidemiology</orgName><orgName type="department">School of Public Health</orgName><orgName type="institution">University of Michigan</orgName><address><addrLine>Ann Arbor</addrLine></address></affiliation><affiliation role="corresp">Reprints and correspondence: Dr. Mary Lou Clements. The Johns Hopkins University Center for Immunization Research, 624 N. Broadway,Hampton House Room 125, Baltimore, MD 21205.</affiliation></author><author xml:id="author-0004"><persName><surname>Murphy</surname><forename type="first">Brian R.</forename></persName><affiliation><orgName type="institution">From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health</orgName><address><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation><orgName type="institution">Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases</orgName><address><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation><orgName type="institution">Department of Epidemiology, School of Public Health, University of Michigan</orgName><address><addrLine>Ann Arbor</addrLine></address></affiliation><affiliation><orgName type="institution">From the Center for Immunization Research</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><address><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><address><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation><orgName type="department">Department of Epidemiology</orgName><orgName type="department">School of Public Health</orgName><orgName type="institution">University of Michigan</orgName><address><addrLine>Ann Arbor</addrLine></address></affiliation><affiliation role="corresp">Reprints and correspondence: Dr. Mary Lou Clements. The Johns Hopkins University Center for Immunization Research, 624 N. Broadway,Hampton House Room 125, Baltimore, MD 21205.</affiliation></author><idno type="istex">8857D86C0253D7D0A162C64BEC576C0AACB20648</idno><idno type="ark">ark:/67375/HXZ-7R8VKZXD-D</idno><idno type="DOI">10.1093/infdis/161.5.869</idno></analytic><monogr><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="hwp">jinfdis</idno><idno type="publisher-id">jid</idno><idno type="pISSN">0022-1899</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1990-05">1990</date><biblScope unit="vol">161</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="869">869</biblScope><biblScope unit="page" to="877">877</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-09"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract><p>A cold-adapted (<hi rend="italic">ca</hi>) influenza B reassortant that derived two genes encoding the hemagglutinin and neuraminidase from influenza B/Ann Arbor/1/86 wild-type virus and six internal RNA segments from <hi rend="italic">ca</hi> influenza B/Ann Arbor/l/66 virus was evaluated in 66 adult volunteers having a serum hemagglutination inhibition antibody titer ≤1:8. The <hi rend="italic">ca</hi> reassortant was attenuated and elicited the production of systemic and local antibodies; the 50% human infectious dose was 10<hi rend="superscript">6,4</hi> TCID<hi rend="subscript">50</hi>. Six weeks after vaccination, 12 unvaccinated volunteers and 13 recipients of <hi rend="italic">ca</hi> virus (10<hi rend="superscript">7,5</hi> TCID<hi rend="subscript">50</hi>) were challenged experimentally with homologous wild-type influenza B virus. The <hi rend="italic">ca</hi> vaccine completely protected against illness. and the magnitude of shedding was 50-fold less in vaccinees than in unimmunized controls, fiveof whom became ill. These findings indicate that the six internal RNA segments of the <hi rend="italic">ca</hi> influenza B/Ann Arbor/66 donor virus confer desirable properties of a live virus vaccine to a reassortant derived from a virulent virus. Such reassortants may be suitable vaccines for healthy adults.</p></abstract><textClass ana="subject"><keywords scheme="subject"><term>Major Articles</term></keywords></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-09" who="#istex" xml:id="pub2tei">formatting</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2019-12-11">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-7R8VKZXD-D/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article">
<front>
<journal-meta>
<journal-id journal-id-type="hwp">jinfdis</journal-id>
<journal-id journal-id-type="publisher-id">jid</journal-id>
<journal-title>Journal of Infectious Diseases</journal-title>
<abbrev-journal-title>J Infect Dis.</abbrev-journal-title>
<issn pub-type="ppub">0022-1899</issn>
<issn pub-type="epub">1537-6591</issn>
<publisher>
<publisher-name>The University of Chicago Press</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.1093/infdis/161.5.869</article-id>
<article-categories>
<subj-group>
<subject>Major Articles</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Evaluation of the Infectivity, Immunogenicity, and Efficacy of Live Cold-Adapted Influenza B/Ann Arbor/1/86 Reassortant Virus Vaccine in Adult Volunteers</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Clements</surname><given-names>Mary Lou</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Snyder</surname><given-names>Mark H.</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Sears</surname><given-names>Stephen D.</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Maassab</surname><given-names>Hunein F.</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Murphy</surname><given-names>Brian R.</given-names></name>
</contrib>
<aff>
<institution>From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health</institution>, <addr-line>Baltimore, Maryland</addr-line>
</aff>
<aff>
<institution>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases</institution>, <addr-line>Bethesda, Maryland</addr-line>
</aff>
<aff>
<institution>Department of Epidemiology, School of Public Health, University of Michigan</institution>, <addr-line>Ann Arbor</addr-line>
</aff>
</contrib-group>
<author-notes>
<corresp>Reprints and correspondence: Dr. Mary Lou Clements. The Johns Hopkins University Center for Immunization Research, 624 N. Broadway,Hampton House Room 125, Baltimore, MD 21205.</corresp>
<fn fn-type="other"><p>Written informed consent was obtained from each volunteer. Guidelines for human experimentation of the US Department of Human Services, the Clinical Research Subpanel of the National Institute of Allergy and Infectious Diseases, the Joint Committee on Clinical Investigation of the Johns Hopkins University School of Medicine, and the Institutional Review Board of Francis Scott Key Medical Center were followedin the conduct of this study.</p></fn>
</author-notes>
<pub-date pub-type="ppub">
<month>5</month>
<year>1990</year>
</pub-date>
<volume>161</volume>
<issue>5</issue>
<fpage>869</fpage>
<lpage>877</lpage>
<history>
<date date-type="received">
<day>30</day><month>3</month><year>1989</year>
</date>
<date date-type="rev-recd">
<day>6</day><month>12</month><year>1989</year>
</date>
</history>
<copyright-statement>© 1990 by The University of Chicago</copyright-statement>
<copyright-year>1990</copyright-year>
<abstract>
<p>A cold-adapted (<italic>ca</italic>) influenza B reassortant that derived two genes encoding the hemagglutinin and neuraminidase from influenza B/Ann Arbor/1/86 wild-type virus and six internal RNA segments from <italic>ca</italic> influenza B/Ann Arbor/l/66 virus was evaluated in 66 adult volunteers having a serum hemagglutination inhibition antibody titer ≤1:8. The <italic>ca</italic> reassortant was attenuated and elicited the production of systemic and local antibodies; the 50% human infectious dose was 10<sup>6,4</sup> TCID<sub>50</sub>. Six weeks after vaccination, 12 unvaccinated volunteers and 13 recipients of <italic>ca</italic> virus (10<sup>7,5</sup> TCID<sub>50</sub>) were challenged experimentally with homologous wild-type influenza B virus. The <italic>ca</italic> vaccine completely protected against illness. and the magnitude of shedding was 50-fold less in vaccinees than in unimmunized controls, fiveof whom became ill. These findings indicate that the six internal RNA segments of the <italic>ca</italic> influenza B/Ann Arbor/66 donor virus confer desirable properties of a live virus vaccine to a reassortant derived from a virulent virus. Such reassortants may be suitable vaccines for healthy adults.</p>
</abstract>
</article-meta>
</front>
</article>
</istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Evaluation of the Infectivity, Immunogenicity, and Efficacy of Live Cold-Adapted Influenza B/Ann Arbor/1/86 Reassortant Virus Vaccine in Adult Volunteers</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Evaluation of the Infectivity, Immunogenicity, and Efficacy of Live Cold-Adapted Influenza B/Ann Arbor/1/86 Reassortant Virus Vaccine in Adult Volunteers</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Mary Lou</namePart><namePart type="family">Clements</namePart><affiliation>From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, Bethesda, Maryland, Ann Arbor</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mark H.</namePart><namePart type="family">Snyder</namePart><affiliation>From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, Bethesda, Maryland, Ann Arbor</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stephen D.</namePart><namePart type="family">Sears</namePart><affiliation>From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, Bethesda, Maryland, Ann Arbor</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hunein F.</namePart><namePart type="family">Maassab</namePart><affiliation>From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, Bethesda, Maryland, Ann Arbor</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brian R.</namePart><namePart type="family">Murphy</namePart><affiliation>From the Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland, Bethesda, Maryland, Ann Arbor</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>The University of Chicago Press</publisher><dateIssued encoding="w3cdtf">1990-05</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><abstract>A cold-adapted (ca) influenza B reassortant that derived two genes encoding the hemagglutinin and neuraminidase from influenza B/Ann Arbor/1/86 wild-type virus and six internal RNA segments from ca influenza B/Ann Arbor/l/66 virus was evaluated in 66 adult volunteers having a serum hemagglutination inhibition antibody titer ≤1:8. The ca reassortant was attenuated and elicited the production of systemic and local antibodies; the 50% human infectious dose was 106,4 TCID50. Six weeks after vaccination, 12 unvaccinated volunteers and 13 recipients of ca virus (107,5 TCID50) were challenged experimentally with homologous wild-type influenza B virus. The ca vaccine completely protected against illness. and the magnitude of shedding was 50-fold less in vaccinees than in unimmunized controls, fiveof whom became ill. These findings indicate that the six internal RNA segments of the ca influenza B/Ann Arbor/66 donor virus confer desirable properties of a live virus vaccine to a reassortant derived from a virulent virus. Such reassortants may be suitable vaccines for healthy adults.</abstract><note type="footnotes">Written informed consent was obtained from each volunteer. Guidelines for human experimentation of the US Department of Human Services, the Clinical Research Subpanel of the National Institute of Allergy and Infectious Diseases, the Joint Committee on Clinical Investigation of the Johns Hopkins University School of Medicine, and the Institutional Review Board of Francis Scott Key Medical Center were followedin the conduct of this study.</note><note type="author-notes">Reprints and correspondence: Dr. Mary Lou Clements. The Johns Hopkins University Center for Immunization Research, 624 N. 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