Variabilité génétique et virus
Identifieur interne : 001768 ( Istex/Corpus ); précédent : 001767; suivant : 001769Variabilité génétique et virus
Auteurs : L. Fritsch ; V. SchneiderSource :
- Revue Française des Laboratoires [ 0338-9898 ] ; 1996.
English descriptors
- KwdEn :
Abstract
Résumé: Les virus présentent une diversité génétique supérieure aux autres organismes. L'absence d'activité de correction associée aux polymérases virales ARN dépendantes engendre de nombreuses mutations. L'organisation génomique de certaines familles virales permet de plus le phénomène de réassortiment génétique et/ou de recombinaison.La variabilité génétique est reliée d'une part au type d'infection induite par le virus (aiguë ou persistante) et d'autre part aux pressions de sélections exercées par le système immunitaire de l'hôte infecté. Les mécanismes mutationnels concernent aussi bien les régions codantes (protéines d'adhésion du virus grippal, du VIH1…), que des régions impliquées dans la régulation de l'expression des gènes viraux (région amorce de la traduction du poliovirus…). L'exemple de l'HTLV montre au contraire que certains virus possèdent une extraordinaire stabilité provenant de l'absence de multiplication virale au sein de la cellule ayant intégré le génome viral.Cette grande capacité d'adaptation et d'évolution des virus a des répercussions importantes en terme de pathogénicité, de thérapie et de prévention.
Summary: Virus are characterized by a high genetic flexibility rarely found in other microorganism. The high error rate of polymerases (RNA polymerase and reverse transcriptase) is known to generate a great number of mutations, and in some viral families, genetic variability could arise from exchange of genetic markers (recombination, reassortment).Other factors may contribute to viral diversity in individual infection. In acute infection, mutation rate is low, due to the rapid clearance of the virus and the viral divergence appears over time after transmission between individuals or between patient to animal (i.e Influenza). In persistent infection with a high rate of replication (i.e HIV) virus remaining in patient for life, the divergence of viral strains is shaped by a combination of mutations and selection forces. In persistent infection with absence of viral replication (i.e HTLV) virus harbor a high genetic stability.Mutation events occur in coding region (i.e hemagglutinin of Influenza virus) or non coding region (i.e Poliovirus internal ribosome entry site).Genetic variability occurring during viral infection will have consequential effects on viral disease progression, on therapeutic strategy and on viral disease control.
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DOI: 10.1016/S0338-9898(96)80182-X
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ISTEX:23571DE4D41D975EBBE0B51A9BB409A3AA8C1E45Le document en format XML
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L'absence d'activité de correction associée aux polymérases virales ARN dépendantes engendre de nombreuses mutations. L'organisation génomique de certaines familles virales permet de plus le phénomène de réassortiment génétique et/ou de recombinaison.La variabilité génétique est reliée d'une part au type d'infection induite par le virus (aiguë ou persistante) et d'autre part aux pressions de sélections exercées par le système immunitaire de l'hôte infecté. Les mécanismes mutationnels concernent aussi bien les régions codantes (protéines d'adhésion du virus grippal, du VIH1…), que des régions impliquées dans la régulation de l'expression des gènes viraux (région amorce de la traduction du poliovirus…). L'exemple de l'HTLV montre au contraire que certains virus possèdent une extraordinaire stabilité provenant de l'absence de multiplication virale au sein de la cellule ayant intégré le génome viral.Cette grande capacité d'adaptation et d'évolution des virus a des répercussions importantes en terme de pathogénicité, de thérapie et de prévention.</div><div type="abstract" xml:lang="en">Summary: Virus are characterized by a high genetic flexibility rarely found in other microorganism. The high error rate of polymerases (RNA polymerase and reverse transcriptase) is known to generate a great number of mutations, and in some viral families, genetic variability could arise from exchange of genetic markers (recombination, reassortment).Other factors may contribute to viral diversity in individual infection. In acute infection, mutation rate is low, due to the rapid clearance of the virus and the viral divergence appears over time after transmission between individuals or between patient to animal (i.e Influenza). In persistent infection with a high rate of replication (i.e HIV) virus remaining in patient for life, the divergence of viral strains is shaped by a combination of mutations and selection forces. In persistent infection with absence of viral replication (i.e HTLV) virus harbor a high genetic stability.Mutation events occur in coding region (i.e hemagglutinin of Influenza virus) or non coding region (i.e Poliovirus internal ribosome entry site).Genetic variability occurring during viral infection will have consequential effects on viral disease progression, on therapeutic strategy and on viral disease control.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>L. 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L'exemple de l'HTLV montre au contraire que certains virus possèdent une extraordinaire stabilité provenant de l'absence de multiplication virale au sein de la cellule ayant intégré le génome viral.Cette grande capacité d'adaptation et d'évolution des virus a des répercussions importantes en terme de pathogénicité, de thérapie et de prévention.</abstract><qualityIndicators><score>8.884</score><pdfWordCount>7436</pdfWordCount><pdfCharCount>40939</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>612 x 864 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>157</abstractWordCount><abstractCharCount>1144</abstractCharCount><keywordCount>6</keywordCount></qualityIndicators><title>Variabilité génétique et virus</title><pii><json:string>S0338-9898(96)80182-X</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Virology</title><language><json:string>unknown</json:string></language><volume>52</volume><pages><first>1501</first><last>1527</last></pages><editor><json:item><name>B.N. 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FRITSCH</affiliation><affiliation>Laboratoire de microbiologie Hôpital Rothschild 33, bd de Picpus 75571 PARIS CEDEX 12, France</affiliation></author><author xml:id="author-0001"><persName><forename type="first">V.</forename><surname>Schneider</surname></persName><affiliation>Laboratoire de microbiologie Hôpital Rothschild 33, bd de Picpus 75571 PARIS CEDEX 12, France</affiliation></author><idno type="istex">23571DE4D41D975EBBE0B51A9BB409A3AA8C1E45</idno><idno type="ark">ark:/67375/6H6-D07PD08X-Q</idno><idno type="DOI">10.1016/S0338-9898(96)80182-X</idno><idno type="PII">S0338-9898(96)80182-X</idno><idno type="article-id">9680182X</idno></analytic><monogr><title level="j">Revue Française des Laboratoires</title><title level="j" type="abbrev">REVFRA</title><idno type="pISSN">0338-9898</idno><idno type="PII">S0338-9898(00)X0067-4</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996"></date><biblScope unit="volume">1996</biblScope><biblScope unit="issue">283</biblScope><biblScope unit="page" from="41">41</biblScope><biblScope unit="page" to="48">48</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="fr">fr</language></langUsage><abstract xml:lang="fr"><p>Résumé: Les virus présentent une diversité génétique supérieure aux autres organismes. L'absence d'activité de correction associée aux polymérases virales ARN dépendantes engendre de nombreuses mutations. L'organisation génomique de certaines familles virales permet de plus le phénomène de réassortiment génétique et/ou de recombinaison.La variabilité génétique est reliée d'une part au type d'infection induite par le virus (aiguë ou persistante) et d'autre part aux pressions de sélections exercées par le système immunitaire de l'hôte infecté. Les mécanismes mutationnels concernent aussi bien les régions codantes (protéines d'adhésion du virus grippal, du VIH1…), que des régions impliquées dans la régulation de l'expression des gènes viraux (région amorce de la traduction du poliovirus…). L'exemple de l'HTLV montre au contraire que certains virus possèdent une extraordinaire stabilité provenant de l'absence de multiplication virale au sein de la cellule ayant intégré le génome viral.Cette grande capacité d'adaptation et d'évolution des virus a des répercussions importantes en terme de pathogénicité, de thérapie et de prévention.</p></abstract><abstract xml:lang="en"><p>Summary: Virus are characterized by a high genetic flexibility rarely found in other microorganism. The high error rate of polymerases (RNA polymerase and reverse transcriptase) is known to generate a great number of mutations, and in some viral families, genetic variability could arise from exchange of genetic markers (recombination, reassortment).Other factors may contribute to viral diversity in individual infection. In acute infection, mutation rate is low, due to the rapid clearance of the virus and the viral divergence appears over time after transmission between individuals or between patient to animal (i.e Influenza). In persistent infection with a high rate of replication (i.e HIV) virus remaining in patient for life, the divergence of viral strains is shaped by a combination of mutations and selection forces. In persistent infection with absence of viral replication (i.e HTLV) virus harbor a high genetic stability.Mutation events occur in coding region (i.e hemagglutinin of Influenza virus) or non coding region (i.e Poliovirus internal ribosome entry site).Genetic variability occurring during viral infection will have consequential effects on viral disease progression, on therapeutic strategy and on viral disease control.</p></abstract><textClass xml:lang="fr"><keywords scheme="keyword"><list><item><term>virus</term></item><item><term>variabilitégénétique</term></item><item><term>épidémiologie</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key-words</head><item><term>virus</term></item><item><term>genetic variability</term></item><item><term>epidemiology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-D07PD08X-Q/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="fr" docsubtype="fla"><item-info><jid>REVFRA</jid><aid>9680182X</aid><ce:pii>S0338-9898(96)80182-X</ce:pii><ce:doi>10.1016/S0338-9898(96)80182-X</ce:doi><ce:copyright type="unknown" year="1996">Marque et modélé dèposès</ce:copyright></item-info><head><ce:title>Variabilité génétique et virus</ce:title><ce:author-group><ce:author><ce:given-name>L.</ce:given-name><ce:surname>Fritsch</ce:surname><ce:cross-ref refid="fn1"><ce:sup>**</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>V.</ce:given-name><ce:surname>Schneider</ce:surname><ce:cross-ref refid="aff1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>*</ce:label><ce:textfn>Laboratoire de microbiologie Hôpital Rothschild 33, bd de Picpus 75571 PARIS CEDEX 12, France</ce:textfn></ce:affiliation><ce:footnote id="fn1"><ce:label>**</ce:label><ce:note-para>TIRÉS A PART: M. L. FRITSCH</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="7" month="2" year="1996"></ce:date-received><ce:date-accepted day="14" month="2" year="1996"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="fr"><ce:section-title>Résumé</ce:section-title><ce:abstract-sec><ce:simple-para>Les virus présentent une diversité génétique supérieure aux autres organismes. L'absence d'activité de correction associée aux polymérases virales ARN dépendantes engendre de nombreuses mutations. L'organisation génomique de certaines familles virales permet de plus le phénomène de réassortiment génétique et/ou de recombinaison.</ce:simple-para><ce:simple-para>La variabilité génétique est reliée d'une part au type d'infection induite par le virus (aiguë ou persistante) et d'autre part aux pressions de sélections exercées par le système immunitaire de l'hôte infecté. Les mécanismes mutationnels concernent aussi bien les régions codantes (protéines d'adhésion du virus grippal, du VIH1…), que des régions impliquées dans la régulation de l'expression des gènes viraux (région amorce de la traduction du poliovirus…). L'exemple de l'HTLV montre au contraire que certains virus possèdent une extraordinaire stabilité provenant de l'absence de multiplication virale au sein de la cellule ayant intégré le génome viral.</ce:simple-para><ce:simple-para>Cette grande capacité d'adaptation et d'évolution des virus a des répercussions importantes en terme de pathogénicité, de thérapie et de prévention.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:abstract id="ab2" class="author" xml:lang="en"><ce:section-title>Summary</ce:section-title><ce:abstract-sec><ce:simple-para>Virus are characterized by a high genetic flexibility rarely found in other microorganism. The high error rate of polymerases (RNA polymerase and reverse transcriptase) is known to generate a great number of mutations, and in some viral families, genetic variability could arise from exchange of genetic markers (recombination, reassortment).</ce:simple-para><ce:simple-para>Other factors may contribute to viral diversity in individual infection. In acute infection, mutation rate is low, due to the rapid clearance of the virus and the viral divergence appears over time after transmission between individuals or between patient to animal (i.e Influenza). In persistent infection with a high rate of replication (i.e HIV) virus remaining in patient for life, the divergence of viral strains is shaped by a combination of mutations and selection forces. In persistent infection with absence of viral replication (i.e HTLV) virus harbor a high genetic stability.</ce:simple-para><ce:simple-para>Mutation events occur in coding region (i.e hemagglutinin of Influenza virus) or non coding region (i.e Poliovirus internal ribosome entry site).</ce:simple-para><ce:simple-para>Genetic variability occurring during viral infection will have consequential effects on viral disease progression, on therapeutic strategy and on viral disease control.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="fr"><ce:keyword><ce:text>virus</ce:text></ce:keyword><ce:keyword><ce:text>variabilitégénétique</ce:text></ce:keyword><ce:keyword><ce:text>épidémiologie</ce:text></ce:keyword></ce:keywords><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Key-words</ce:section-title><ce:keyword><ce:text>virus</ce:text></ce:keyword><ce:keyword><ce:text>genetic variability</ce:text></ce:keyword><ce:keyword><ce:text>epidemiology</ce:text></ce:keyword></ce:keywords></head><tail><ce:bibliography><ce:section-title>Bibliographie</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Almond</ce:surname><ce:given-name>J.W.</ce:given-name></sb:author><sb:author><ce:surname>Westrop</ce:surname><ce:given-name>G.D.</ce:given-name></sb:author><sb:author><ce:surname>Cann</ce:surname><ce:given-name>A.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Attenuation and reversion to neurovirulence of the Sabin poliovirus type 3 vaccine</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Lerner</ce:surname><ce:given-name>R.H.</ce:given-name></sb:editor><sb:editor><ce:surname>Chanock</ce:surname><ce:given-name>R.M.</ce:given-name></sb:editor><sb:editor><ce:surname>Brown</ce:surname><ce:given-name>F.</ce:given-name></sb:editor></sb:editors><sb:title><sb:maintitle>Vaccine 85: molecular and chemical basis of resistance to parasitic, bacterial and viral diseases</sb:maintitle></sb:title><sb:date>1985</sb:date><sb:publisher><sb:name>Cold Spring Harbor Laboratory</sb:name><sb:location>Paris</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>271</sb:first-page><sb:last-page>279</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib2"><ce:label>2.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bonhoeffer</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Holmes</ce:surname><ce:given-name>E.C.</ce:given-name></sb:author><sb:author><ce:surname>Nowak</ce:surname><ce:given-name>M.A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Causes of HIV diversity</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Nature</sb:maintitle></sb:title><sb:volume-nr>376</sb:volume-nr></sb:series><sb:date>1995</sb:date></sb:issue><sb:pages><sb:first-page>125</sb:first-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib3"><ce:label>3.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bou-Habib</ce:surname><ce:given-name>D.C.</ce:given-name></sb:author><sb:author><ce:surname>Roderiquez</ce:surname><ce:given-name>G.</ce:given-name></sb:author><sb:author><ce:surname>Oravecz</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Berman</ce:surname><ce:given-name>P.W.</ce:given-name></sb:author><sb:author><ce:surname>Lusso</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Norcross</ce:surname><ce:given-name>M.A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Cryptic nature of envelope V3 region epitopes protects primary monocytotropic human immunodeficiency virus type 1 from antibody neutralization</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>68</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>6006</sb:first-page><sb:last-page>6013</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib4"><ce:label>4.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Cann</ce:surname><ce:given-name>A.J.</ce:given-name></sb:author><sb:author><ce:surname>Chen</ce:surname><ce:given-name>I.S.Y.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Human T-cell leukemia virus type I and II</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Fields</ce:surname><ce:given-name>B.N.</ce:given-name></sb:editor><sb:editor><ce:surname>Knipe</ce:surname><ce:given-name>D.M.</ce:given-name></sb:editor><sb:et-al></sb:et-al></sb:editors><sb:edition>2nd ed.</sb:edition><sb:book-series><sb:series><sb:title><sb:maintitle>Virology</sb:maintitle></sb:title><sb:volume-nr>52</sb:volume-nr></sb:series></sb:book-series><sb:date>1990</sb:date><sb:publisher><sb:name>Raven Press</sb:name><sb:location>Cold Spring Harbor, New York</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>1501</sb:first-page><sb:last-page>1527</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib5"><ce:label>5.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Chesebro</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Wehrly</ce:surname><ce:given-name>K.</ce:given-name></sb:author><sb:author><ce:surname>Nishio</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Perryman</ce:surname><ce:given-name>S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Macrophage-tropic human immunodeficiency virus isolates from different patients exhibit unusual V3 envelope sequence homogeneity in comparison with T-cell-tropic isolates: definition of critical amino acids involved in cell tropism</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>66</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>6547</sb:first-page><sb:last-page>6554</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib6"><ce:label>6.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Cooper</ce:surname><ce:given-name>P.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Genetics of poliovirus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Compr. Virol.</sb:maintitle></sb:title><sb:volume-nr>9</sb:volume-nr></sb:series><sb:date>1977</sb:date></sb:issue><sb:pages><sb:first-page>133</sb:first-page><sb:last-page>207</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib7"><ce:label>7.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Coulson</ce:surname><ce:given-name>B.S.</ce:given-name></sb:author><sb:author><ce:surname>Fowler</ce:surname><ce:given-name>K.J.</ce:given-name></sb:author><sb:author><ce:surname>Bishop</ce:surname><ce:given-name>R.F.</ce:given-name></sb:author><sb:author><ce:surname>Cotton</ce:surname><ce:given-name>R.G.H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Neutralizing monoclonal antibodies to human rotavirus and indications of antigenic drift among strains from neonates</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>54</sb:volume-nr></sb:series><sb:date>1985</sb:date></sb:issue><sb:pages><sb:first-page>14</sb:first-page><sb:last-page>20</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib8"><ce:label>8.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Crainic</ce:surname><ce:given-name>R.</ce:given-name></sb:author><sb:author><ce:surname>Kew</ce:surname><ce:given-name>O.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Evolution and polymorphism of poliovirus genomes</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Biologicals</sb:maintitle></sb:title><sb:volume-nr>21</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>379</sb:first-page><sb:last-page>384</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib9"><ce:label>9.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>De Jong</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The V3 domain of HIV-1: role in sycytium, replication and antigenicity</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:book-series><sb:series><sb:title><sb:maintitle>Thèse de doctorat</sb:maintitle></sb:title></sb:series></sb:book-series><sb:date>1994</sb:date><sb:publisher><sb:name>Université d'Amsterdam</sb:name><sb:location>New York</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>7</sb:first-page><sb:last-page>150</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib10"><ce:label>10.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>De Jong</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Boucher</ce:surname><ce:given-name>C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Syncytia formation and HIV load</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Feature, Transcript</sb:maintitle></sb:title></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>9</sb:first-page><sb:last-page>12</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib11"><ce:label>11.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Delassus</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Wain-Hobson</ce:surname><ce:given-name>S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Molecular genetics of the AIDS retroviruses</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Bull. Inst. Pasteur.</sb:maintitle></sb:title><sb:volume-nr>86</sb:volume-nr></sb:series><sb:date>1988</sb:date></sb:issue><sb:pages><sb:first-page>243</sb:first-page><sb:last-page>261</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib12"><ce:label>12.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Eigen</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Les quasi-espèces virales</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pour la Science</sb:maintitle></sb:title><sb:volume-nr>191</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>36</sb:first-page><sb:last-page>45</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib13"><ce:label>13.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Evans</ce:surname><ce:given-name>D.M.A.</ce:given-name></sb:author><sb:author><ce:surname>Dunn</ce:surname><ce:given-name>G.</ce:given-name></sb:author><sb:author><ce:surname>Minor</ce:surname><ce:given-name>P.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Increased neurovirulence associated with a single nucleotide change in a non coding region of the Sabin type 3 poliovaccine genome</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Nature</sb:maintitle></sb:title><sb:volume-nr>314</sb:volume-nr></sb:series><sb:date>1985</sb:date></sb:issue><sb:pages><sb:first-page>548</sb:first-page><sb:last-page>550</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib14"><ce:label>14.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Foucher</ce:surname><ce:given-name>R.A.M.</ce:given-name></sb:author><sb:author><ce:surname>Brouwer</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Broersen</ce:surname><ce:given-name>S.M.</ce:given-name></sb:author><sb:author><ce:surname>Schuitemaker</ce:surname><ce:given-name>H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Simple determination of human immunodeficiency virus type 1 syncytium-inducing V3 genotype by PCR</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Clin. Microbiol.</sb:maintitle></sb:title><sb:volume-nr>33</sb:volume-nr></sb:series><sb:date>1995</sb:date></sb:issue><sb:pages><sb:first-page>906</sb:first-page><sb:last-page>911</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib15"><ce:label>15.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Fouchier</ce:surname><ce:given-name>R.A.M.</ce:given-name></sb:author><sb:author><ce:surname>Groenink</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Koostra</ce:surname><ce:given-name>N.A.</ce:given-name></sb:author><sb:author><ce:surname>Tersmette</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Huisman</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Miedema</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Schuitemaker</ce:surname><ce:given-name>H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type 1 gp120 molecule</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>66</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>3183</sb:first-page><sb:last-page>3187</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib16"><ce:label>16.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Gessain</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Gallo</ce:surname><ce:given-name>R.C.</ce:given-name></sb:author><sb:author><ce:surname>Franchini</ce:surname><ce:given-name>G.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Low degree of HTLV-I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human population</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>66</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>2285</sb:first-page><sb:last-page>2295</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib17"><ce:label>17.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Gombold</ce:surname><ce:given-name>J.L.</ce:given-name></sb:author><sb:author><ce:surname>Ramig</ce:surname><ce:given-name>R.F.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Analysis of reassortment of genome segments in mice mixedly infected with roraviruses SA11 and RRV</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>57</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>110</sb:first-page><sb:last-page>116</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib18"><ce:label>18.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Gorman</ce:surname><ce:given-name>O.T.</ce:given-name></sb:author><sb:author><ce:surname>Bean</ce:surname><ce:given-name>W.J.</ce:given-name></sb:author><sb:author><ce:surname>Kawaoka</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Webster</ce:surname><ce:given-name>R.G.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Evolution of the nucleoprotein gene of influenza A virus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>64</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>1487</sb:first-page><sb:last-page>1497</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib19"><ce:label>19.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Groenink</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Fouchier</ce:surname><ce:given-name>R.A.M.</ce:given-name></sb:author><sb:author><ce:surname>De Goede</ce:surname><ce:given-name>R.E.Y.</ce:given-name></sb:author><sb:author><ce:surname>De Wolf</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Gruters</ce:surname><ce:given-name>R.A.</ce:given-name></sb:author><sb:author><ce:surname>Cuypers</ce:surname><ce:given-name>H.T.M.</ce:given-name></sb:author><sb:author><ce:surname>Huisman</ce:surname><ce:given-name>H.G.</ce:given-name></sb:author><sb:author><ce:surname>Tersmette</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Phenotypic heterogeneity in a panel of infectious molecular human immunodeficiency virus type 1 clones derived from a single individu</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>65</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>1968</sb:first-page><sb:last-page>1975</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib20"><ce:label>20.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Ho</ce:surname><ce:given-name>D.D.</ce:given-name></sb:author><sb:author><ce:surname>Neumann</ce:surname><ce:given-name>A.U.</ce:given-name></sb:author><sb:author><ce:surname>Perelson</ce:surname><ce:given-name>A.S.</ce:given-name></sb:author><sb:author><ce:surname>Chen</ce:surname><ce:given-name>W.</ce:given-name></sb:author><sb:author><ce:surname>Leonard</ce:surname><ce:given-name>J.M.</ce:given-name></sb:author><sb:author><ce:surname>Markowitz</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Nature</sb:maintitle></sb:title><sb:volume-nr>373</sb:volume-nr></sb:series><sb:date>1995</sb:date></sb:issue><sb:pages><sb:first-page>123</sb:first-page><sb:last-page>126</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib21"><ce:label>21.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Holmes</ce:surname><ce:given-name>E.C.</ce:given-name></sb:author><sb:author><ce:surname>Zhang</ce:surname><ce:given-name>L.Q.</ce:given-name></sb:author><sb:author><ce:surname>Simmonds</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Ludlam</ce:surname><ce:given-name>C.A.</ce:given-name></sb:author><sb:author><ce:surname>Leigh Brown</ce:surname><ce:given-name>A.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Convergent and divergent sequence evolution in the surface envelope glycoprotein of human immunodeficiency virus type 1 within a single infected patient</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:book-series><sb:series><sb:title><sb:maintitle>Proc. Natl. Acad. Sci. USA</sb:maintitle></sb:title><sb:volume-nr>89</sb:volume-nr></sb:series></sb:book-series><sb:date>1992</sb:date></sb:edited-book><sb:pages><sb:first-page>4835</sb:first-page><sb:last-page>4839</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib22"><ce:label>22.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Hoshino</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Sereno</ce:surname><ce:given-name>M.M.</ce:given-name></sb:author><sb:author><ce:surname>Midthun</ce:surname><ce:given-name>K.</ce:given-name></sb:author><sb:author><ce:surname>Flores</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Chanock</ce:surname><ce:given-name>R.M.</ce:given-name></sb:author><sb:author><ce:surname>Kapikian</ce:surname><ce:given-name>A.Z.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Analysis by plaque reduction neutralization assay of intertypic rotaviruses suggests that gene reassortment occurs in vivo</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Clin. Microbiol.</sb:maintitle></sb:title><sb:volume-nr>25</sb:volume-nr></sb:series><sb:date>1987</sb:date></sb:issue><sb:pages><sb:first-page>290</sb:first-page><sb:last-page>294</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib23"><ce:label>23.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Hoshino</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Sereno</ce:surname><ce:given-name>M.M.</ce:given-name></sb:author><sb:author><ce:surname>Midthun</ce:surname><ce:given-name>K.</ce:given-name></sb:author><sb:author><ce:surname>Flores</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Kapikian</ce:surname><ce:given-name>A.Z.</ce:given-name></sb:author><sb:author><ce:surname>Chanock</ce:surname><ce:given-name>R.M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Independant segregation of two antigenic specificities (VP3 and VP7) involved in neutralization of rotavirus infectivity</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:book-series><sb:series><sb:title><sb:maintitle>Proc. Natl. Acad. Sci. USA</sb:maintitle></sb:title><sb:volume-nr>82</sb:volume-nr></sb:series></sb:book-series><sb:date>1985</sb:date></sb:edited-book><sb:pages><sb:first-page>8701</sb:first-page><sb:last-page>8704</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib24"><ce:label>24.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Hundley</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Biryahwaho</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Gow</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Desselberger</ce:surname><ce:given-name>U.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Genome rearrangements of bovine rotavirus after serial passage at high multiplicity of infection</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Virology</sb:maintitle></sb:title><sb:volume-nr>143</sb:volume-nr></sb:series><sb:date>1985</sb:date></sb:issue><sb:pages><sb:first-page>88</sb:first-page><sb:last-page>103</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib25"><ce:label>25.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Hundley</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>McIntyre</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Clark</ce:surname><ce:given-name>B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Heterogeneity of genome rearrangements in rotaviruses isolated from a chronically infected immunodeficient child</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>61</sb:volume-nr></sb:series><sb:date>1987</sb:date></sb:issue><sb:pages><sb:first-page>3365</sb:first-page><sb:last-page>3372</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib26"><ce:label>26.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Kapikian</ce:surname><ce:given-name>A.Z.</ce:given-name></sb:author><sb:author><ce:surname>Chanock</ce:surname><ce:given-name>R.M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Rotaviruses</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Fields</ce:surname><ce:given-name>B.N.</ce:given-name></sb:editor><sb:editor><ce:surname>Knipe</ce:surname><ce:given-name>D.M.</ce:given-name></sb:editor><sb:et-al></sb:et-al></sb:editors><sb:edition>2nd ed.</sb:edition><sb:book-series><sb:series><sb:title><sb:maintitle>Virology</sb:maintitle></sb:title><sb:volume-nr>49</sb:volume-nr></sb:series></sb:book-series><sb:date>1990</sb:date><sb:publisher><sb:name>Raven Press</sb:name></sb:publisher></sb:edited-book><sb:pages><sb:first-page>1353</sb:first-page><sb:last-page>1404</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib27"><ce:label>27.</ce:label><sb:reference><sb:comment>Boca Raton, FL</sb:comment><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>King</ce:surname><ce:given-name>A.M.Q.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Genetic recombination in positive strand RNA viruses</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Domingo</ce:surname><ce:given-name>E.</ce:given-name></sb:editor><sb:editor><ce:surname>Holland</ce:surname><ce:given-name>J.J.</ce:given-name></sb:editor><sb:editor><ce:surname>Ahlquist</ce:surname><ce:given-name>P.</ce:given-name></sb:editor></sb:editors><sb:book-series><sb:series><sb:title><sb:maintitle>RNA genetics, vol II. Retroviruses, viroids and RNA recombination</sb:maintitle></sb:title></sb:series></sb:book-series><sb:date>1988</sb:date></sb:edited-book><sb:pages><sb:first-page>149</sb:first-page><sb:last-page>165</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib28"><ce:label>28.</ce:label><sb:reference><sb:contribution langtype="iso" xml:lang="fr"><sb:authors><sb:author><ce:surname>Koralnik</ce:surname><ce:given-name>I.J.</ce:given-name></sb:author><sb:author><ce:surname>Gessain</ce:surname><ce:given-name>A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Virus HTLV-I: structure et fonction des protéines de la région pX</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Médecine-Sciences</sb:maintitle></sb:title><sb:volume-nr>10</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>296</sb:first-page><sb:last-page>305</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib29"><ce:label>29.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Li</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Hui</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Burgess</ce:surname><ce:given-name>C.J.</ce:given-name></sb:author><sb:author><ce:surname>Price</ce:surname><ce:given-name>R.W.</ce:given-name></sb:author><sb:author><ce:surname>Sharp</ce:surname><ce:given-name>P.M.</ce:given-name></sb:author><sb:author><ce:surname>Hahn</ce:surname><ce:given-name>B.H.</ce:given-name></sb:author><sb:author><ce:surname>Shaw</ce:surname><ce:given-name>G.M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Complete nucleotide sequence, genome organization, and biological properties of human immunodeficiency virus type 1 in vivo: evidence for limited defectiveness and complementation</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>66</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>6587</sb:first-page><sb:last-page>6600</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib30"><ce:label>30.</ce:label><sb:reference><sb:comment>Los Alamos, New Mexico</sb:comment><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Los Alamos National Laboratory</ce:surname></sb:author></sb:authors><sb:title><sb:maintitle>HIV sequence database</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:title><sb:maintitle>human retroviruses and AIDS</sb:maintitle></sb:title><sb:date>1993</sb:date></sb:edited-book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib31"><ce:label>31.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Macadam</ce:surname><ce:given-name>A.J.</ce:given-name></sb:author><sb:author><ce:surname>Stone</ce:surname><ce:given-name>D.M.</ce:given-name></sb:author><sb:author><ce:surname>Almond</ce:surname><ce:given-name>J.W.</ce:given-name></sb:author><sb:author><ce:surname>Minor</ce:surname><ce:given-name>P.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The 5′ noncoding region and virulence of poliovirus vaccine strains</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Trends Microbiol.</sb:maintitle></sb:title><sb:volume-nr>vol 2</sb:volume-nr></sb:series><sb:issue-nr>11</sb:issue-nr><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>449</sb:first-page><sb:last-page>454</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib32"><ce:label>32.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Mc Nearney</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Hornickova</ce:surname><ce:given-name>Z.</ce:given-name></sb:author><sb:author><ce:surname>Markham</ce:surname><ce:given-name>R.</ce:given-name></sb:author><sb:author><ce:surname>Birdwell</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Arens</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Saah</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Ratner</ce:surname><ce:given-name>L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Relationship of human immunodeficiency virus type 1 sequence heterogeneity to stage of disease</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:book-series><sb:series><sb:title><sb:maintitle>Proc. Natl. Acad. Sci. USA</sb:maintitle></sb:title><sb:volume-nr>89</sb:volume-nr></sb:series></sb:book-series><sb:date>1992</sb:date></sb:edited-book><sb:pages><sb:first-page>10247</sb:first-page><sb:last-page>10251</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib33"><ce:label>33.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>McKnight</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Weiss</ce:surname><ce:given-name>R.B.</ce:given-name></sb:author><sb:author><ce:surname>Shotton</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Takeuchi</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Hoshino</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Clapham</ce:surname><ce:given-name>P.R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Change in tropism upon immune escape by human immunodeficiency virus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>69</sb:volume-nr></sb:series><sb:date>1995</sb:date></sb:issue><sb:pages><sb:first-page>3167</sb:first-page><sb:last-page>3170</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib34"><ce:label>34.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Mcnicholl</ce:surname><ce:given-name>J.M.</ce:given-name></sb:author><sb:author><ce:surname>Mcdougal</ce:surname><ce:given-name>J.S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Immunologic escape as a mechanism of viral persistence in HIV-1 infection</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Sem. Virol.</sb:maintitle></sb:title><sb:volume-nr>5</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>307</sb:first-page><sb:last-page>317</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib35"><ce:label>35.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Milich</ce:surname><ce:given-name>L.</ce:given-name></sb:author><sb:author><ce:surname>Margolin</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Swanstrom</ce:surname><ce:given-name>R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>V3 loop of the human immunodeficiency virus type 1 env protein: interpreting sequence variability</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>67</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>5623</sb:first-page><sb:last-page>5634</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib36"><ce:label>36.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Minor</ce:surname><ce:given-name>P.D.</ce:given-name></sb:author><sb:author><ce:surname>Dunn</ce:surname><ce:given-name>G.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The effect of sequences in the 5′ non-coding region on the replication of poliovirus in the human gut</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Gen. Virol.</sb:maintitle></sb:title><sb:volume-nr>69</sb:volume-nr></sb:series><sb:date>1988</sb:date></sb:issue><sb:pages><sb:first-page>1091</sb:first-page><sb:last-page>1096</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib37"><ce:label>37.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Murphy</ce:surname><ce:given-name>B.R.</ce:given-name></sb:author><sb:author><ce:surname>Webster</ce:surname><ce:given-name>R.G.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Orthomyxoviruses</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Fields</ce:surname><ce:given-name>B.N.</ce:given-name></sb:editor><sb:editor><ce:surname>Knipe</ce:surname><ce:given-name>D.M.</ce:given-name></sb:editor><sb:et-al></sb:et-al></sb:editors><sb:edition>2nd ed.</sb:edition><sb:book-series><sb:series><sb:title><sb:maintitle>Virology</sb:maintitle></sb:title><sb:volume-nr>40</sb:volume-nr></sb:series></sb:book-series><sb:date>1990</sb:date><sb:publisher><sb:name>Raven Press</sb:name><sb:location>New York</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>1091</sb:first-page><sb:last-page>1152</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib38"><ce:label>38.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Nakano</ce:surname><ce:given-name>J.H.</ce:given-name></sb:author><sb:author><ce:surname>Hatch</ce:surname><ce:given-name>M.H.</ce:given-name></sb:author><sb:author><ce:surname>Thieme</ce:surname><ce:given-name>M.L.</ce:given-name></sb:author><sb:author><ce:surname>Nottay</ce:surname><ce:given-name>B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Parameters for differenciating vaccine-derived and wild poliovirus strains</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Prog. Med. Virol.</sb:maintitle></sb:title><sb:volume-nr>24</sb:volume-nr></sb:series><sb:date>1978</sb:date></sb:issue><sb:pages><sb:first-page>178</sb:first-page><sb:last-page>206</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib39"><ce:label>39.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Nomoto</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Omata</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Toyoda</ce:surname><ce:given-name>H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:book-series><sb:series><sb:title><sb:maintitle>Proc. Natl. Acad. Sci. USA</sb:maintitle></sb:title><sb:volume-nr>79</sb:volume-nr></sb:series></sb:book-series><sb:date>1982</sb:date></sb:edited-book><sb:pages><sb:first-page>5793</sb:first-page><sb:last-page>5797</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib40"><ce:label>40.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Nowak</ce:surname><ce:given-name>M.A.</ce:given-name></sb:author><sb:author><ce:surname>Anderson</ce:surname><ce:given-name>R.M.</ce:given-name></sb:author><sb:author><ce:surname>Mc Lean</ce:surname><ce:given-name>A.R.</ce:given-name></sb:author><sb:author><ce:surname>Wolfs</ce:surname><ce:given-name>T.F.W.</ce:given-name></sb:author><sb:author><ce:surname>Goudsmit</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>May</ce:surname><ce:given-name>R.M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Antigenic diversity thresholds and the development of AIDS</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Science</sb:maintitle></sb:title><sb:volume-nr>254</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>963</sb:first-page><sb:last-page>969</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib41"><ce:label>41.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Omata</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Kohara</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Kuge</ce:surname><ce:given-name>S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Genetic analysis of the attenuation phenotype of poliovirus type 1</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>58</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>348</sb:first-page><sb:last-page>358</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib42"><ce:label>42.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Paine</ce:surname><ce:given-name>E.</ce:given-name></sb:author><sb:author><ce:surname>Garcia</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Philpott</ce:surname><ce:given-name>T.C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Limited sequence variation in human T-lymphotropic virus type 1 isolated from North America and African patients</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Virology</sb:maintitle></sb:title><sb:volume-nr>182</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>111</sb:first-page><sb:last-page>123</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib43"><ce:label>43.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Pedley</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Hundley</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Chrystie</ce:surname><ce:given-name>I.</ce:given-name></sb:author><sb:author><ce:surname>McCrae</ce:surname><ce:given-name>M.A.</ce:given-name></sb:author><sb:author><ce:surname>Desselberger</ce:surname><ce:given-name>U.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The genomes of rotaviruses isolated from chronically infected immunodeficient children</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Gen. Virol.</sb:maintitle></sb:title><sb:volume-nr>65</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>1141</sb:first-page><sb:last-page>1150</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib44"><ce:label>44.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Racaniello</ce:surname><ce:given-name>V.R.</ce:given-name></sb:author><sb:author><ce:surname>Baltimore</ce:surname><ce:given-name>D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:book-series><sb:series><sb:title><sb:maintitle>Proc. Natl. Acad. Sci. USA</sb:maintitle></sb:title><sb:volume-nr>214</sb:volume-nr></sb:series></sb:book-series><sb:date>1981</sb:date></sb:edited-book><sb:pages><sb:first-page>4887</sb:first-page><sb:last-page>4891</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib45"><ce:label>45.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Richman</ce:surname><ce:given-name>D.D.</ce:given-name></sb:author><sb:author><ce:surname>Bozzette</ce:surname><ce:given-name>S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The impact of the syncytium-inducing phenotype of human immunodeficiency virus on disease progression</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Infect. Dis.</sb:maintitle></sb:title><sb:volume-nr>69</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>968</sb:first-page><sb:last-page>974</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib46"><ce:label>46.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Rueckert</ce:surname><ce:given-name>R.R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Picornaviridae and their replication</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Fields</ce:surname><ce:given-name>B.N.</ce:given-name></sb:editor><sb:editor><ce:surname>Knipe</ce:surname><ce:given-name>D.M.</ce:given-name></sb:editor><sb:et-al></sb:et-al></sb:editors><sb:edition>2nd ed.</sb:edition><sb:book-series><sb:series><sb:title><sb:maintitle>Virology</sb:maintitle></sb:title><sb:volume-nr>20</sb:volume-nr></sb:series></sb:book-series><sb:date>1990</sb:date><sb:publisher><sb:name>Raven Press</sb:name><sb:location>New York</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>507</sb:first-page><sb:last-page>548</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib47"><ce:label>47.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Scholtissek</ce:surname><ce:given-name>C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Source for influenza pandemics</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Eur. J. Epidemiol.</sb:maintitle></sb:title><sb:volume-nr>10</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>455</sb:first-page><sb:last-page>458</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib48"><ce:label>48.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Scholtissek</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Burger</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Bachmann</ce:surname><ce:given-name>P.A.</ce:given-name></sb:author><sb:author><ce:surname>Hannoun</ce:surname><ce:given-name>C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Genetic relatedness of hemagglutinins of the H1 subtype of influenza A viruses isolated from swine and birds</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Virology</sb:maintitle></sb:title><sb:volume-nr>129</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>521</sb:first-page><sb:last-page>523</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib49"><ce:label>49.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Schultz</ce:surname><ce:given-name>U.</ce:given-name></sb:author><sb:author><ce:surname>Fitch</ce:surname><ce:given-name>W.M.</ce:given-name></sb:author><sb:author><ce:surname>Ludwig</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Mandler</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Scholtissek</ce:surname><ce:given-name>C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Evolution of pig influenza viruses</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Virology</sb:maintitle></sb:title><sb:volume-nr>182</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>61</sb:first-page><sb:last-page>73</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib50"><ce:label>50.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Seillier-Moiseiwitsch</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Margolin</ce:surname><ce:given-name>B.H.</ce:given-name></sb:author><sb:author><ce:surname>Swanstrom</ce:surname><ce:given-name>R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Genetic variability of the human immunodeficiency virus: statistical and biological issues</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Ann. Rev. Genet.</sb:maintitle></sb:title><sb:volume-nr>28</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>559</sb:first-page><sb:last-page>596</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib51"><ce:label>51.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Stamatatos</ce:surname><ce:given-name>L.</ce:given-name></sb:author><sb:author><ce:surname>Cheng-Mayer</ce:surname><ce:given-name>C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Evidence that the structural conformation of envelope gp120 affects human immunodeficiency virus type 1 infectivity, host range, and syncytium-forming ability</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Virol.</sb:maintitle></sb:title><sb:volume-nr>67</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>5635</sb:first-page><sb:last-page>5639</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib52"><ce:label>52.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Stanway</ce:surname><ce:given-name>G.</ce:given-name></sb:author><sb:author><ce:surname>Hughes</ce:surname><ce:given-name>P.J.</ce:given-name></sb:author><sb:author><ce:surname>Mountford</ce:surname><ce:given-name>R.C.</ce:given-name></sb:author><sb:author><ce:surname>Minor</ce:surname><ce:given-name>P.D.</ce:given-name></sb:author><sb:author><ce:surname>Almond</ce:surname><ce:given-name>J.W.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The complete nucleotide sequence of a common cold virus: human rhinovirus 14</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Nucleic. Acids. Res.</sb:maintitle></sb:title><sb:volume-nr>12</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>7859</sb:first-page><sb:last-page>7875</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib53"><ce:label>53.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Wain-Hobson</ce:surname><ce:given-name>S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Human immunodeficiency virus type 1 quasi-species in vivo and ex vivo</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Curr. Top. Microbiol. Immunol.</sb:maintitle></sb:title><sb:volume-nr>176</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>181</sb:first-page><sb:last-page>193</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib54"><ce:label>54.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Webster</ce:surname><ce:given-name>R.G.</ce:given-name></sb:author><sb:author><ce:surname>Bean</ce:surname><ce:given-name>W.J.</ce:given-name></sb:author><sb:author><ce:surname>Gorman</ce:surname><ce:given-name>O.T.</ce:given-name></sb:author><sb:author><ce:surname>Chambers</ce:surname><ce:given-name>T.M.</ce:given-name></sb:author><sb:author><ce:surname>Kawaoka</ce:surname><ce:given-name>Y.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Evolution and ecology of influenza A viruses</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Microbiol. Rev.</sb:maintitle></sb:title><sb:volume-nr>56</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>152</sb:first-page><sb:last-page>179</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib55"><ce:label>55.</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Wei</ce:surname><ce:given-name>X.</ce:given-name></sb:author><sb:author><ce:surname>Ghosh</ce:surname><ce:given-name>S.J.</ce:given-name></sb:author><sb:author><ce:surname>Taylor</ce:surname><ce:given-name>M.E.</ce:given-name></sb:author><sb:author><ce:surname>Johnson</ce:surname><ce:given-name>V.A.</ce:given-name></sb:author><sb:author><ce:surname>Emini</ce:surname><ce:given-name>E.A.</ce:given-name></sb:author><sb:author><ce:surname>Deutsch</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Lifson</ce:surname><ce:given-name>J.D.</ce:given-name></sb:author><sb:author><ce:surname>Bonhoeffer</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Nowak</ce:surname><ce:given-name>M.A.</ce:given-name></sb:author><sb:author><ce:surname>Hahn</ce:surname><ce:given-name>B.H.</ce:given-name></sb:author><sb:author><ce:surname>Saag</ce:surname><ce:given-name>M.S.</ce:given-name></sb:author><sb:author><ce:surname>Shaw</ce:surname><ce:given-name>G.M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Viral dynamics in human immunodeficiency virus type 1 infection</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Nature</sb:maintitle></sb:title><sb:volume-nr>373</sb:volume-nr></sb:series><sb:date>1995</sb:date></sb:issue><sb:pages><sb:first-page>117</sb:first-page><sb:last-page>122</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib56"><ce:label>56.</ce:label><sb:reference><sb:comment>Chapitre 4</sb:comment><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>White</ce:surname><ce:given-name>D.O.</ce:given-name></sb:author><sb:author><ce:surname>Fenner</ce:surname><ce:given-name>F.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Viral genetics and evolution</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:title><sb:maintitle>Medical virology</sb:maintitle></sb:title><sb:edition>Fourth Edition</sb:edition><sb:date>1994</sb:date><sb:publisher><sb:name>Academic Press</sb:name><sb:location>New York</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>54</sb:first-page><sb:last-page>73</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="fr"><title>Variabilité génétique et virus</title></titleInfo><titleInfo type="alternative" lang="fr" contentType="CDATA"><title>Variabilité génétique et virus</title></titleInfo><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Fritsch</namePart><affiliation>Laboratoire de microbiologie Hôpital Rothschild 33, bd de Picpus 75571 PARIS CEDEX 12, France</affiliation><description>TIRÉS A PART: M. L. FRITSCH</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Schneider</namePart><affiliation>Laboratoire de microbiologie Hôpital Rothschild 33, bd de Picpus 75571 PARIS CEDEX 12, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">fre</languageTerm><languageTerm type="code" authority="rfc3066">fr</languageTerm></language><abstract lang="fr">Résumé: Les virus présentent une diversité génétique supérieure aux autres organismes. L'absence d'activité de correction associée aux polymérases virales ARN dépendantes engendre de nombreuses mutations. L'organisation génomique de certaines familles virales permet de plus le phénomène de réassortiment génétique et/ou de recombinaison.La variabilité génétique est reliée d'une part au type d'infection induite par le virus (aiguë ou persistante) et d'autre part aux pressions de sélections exercées par le système immunitaire de l'hôte infecté. Les mécanismes mutationnels concernent aussi bien les régions codantes (protéines d'adhésion du virus grippal, du VIH1…), que des régions impliquées dans la régulation de l'expression des gènes viraux (région amorce de la traduction du poliovirus…). L'exemple de l'HTLV montre au contraire que certains virus possèdent une extraordinaire stabilité provenant de l'absence de multiplication virale au sein de la cellule ayant intégré le génome viral.Cette grande capacité d'adaptation et d'évolution des virus a des répercussions importantes en terme de pathogénicité, de thérapie et de prévention.</abstract><abstract lang="en">Summary: Virus are characterized by a high genetic flexibility rarely found in other microorganism. The high error rate of polymerases (RNA polymerase and reverse transcriptase) is known to generate a great number of mutations, and in some viral families, genetic variability could arise from exchange of genetic markers (recombination, reassortment).Other factors may contribute to viral diversity in individual infection. In acute infection, mutation rate is low, due to the rapid clearance of the virus and the viral divergence appears over time after transmission between individuals or between patient to animal (i.e Influenza). In persistent infection with a high rate of replication (i.e HIV) virus remaining in patient for life, the divergence of viral strains is shaped by a combination of mutations and selection forces. In persistent infection with absence of viral replication (i.e HTLV) virus harbor a high genetic stability.Mutation events occur in coding region (i.e hemagglutinin of Influenza virus) or non coding region (i.e Poliovirus internal ribosome entry site).Genetic variability occurring during viral infection will have consequential effects on viral disease progression, on therapeutic strategy and on viral disease control.</abstract><subject lang="fr"><topic>virus</topic><topic>variabilitégénétique</topic><topic>épidémiologie</topic></subject><subject lang="en"><genre>Key-words</genre><topic>virus</topic><topic>genetic variability</topic><topic>epidemiology</topic></subject><relatedItem type="host"><titleInfo><title>Revue Française des Laboratoires</title></titleInfo><titleInfo type="abbreviated"><title>REVFRA</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued></originInfo><identifier type="ISSN">0338-9898</identifier><identifier type="PII">S0338-9898(00)X0067-4</identifier><part><date>1996</date><detail type="volume"><number>1996</number><caption>vol.</caption></detail><detail type="issue"><number>283</number><caption>no.</caption></detail><extent unit="issue-pages"><start>7</start><end>115</end></extent><extent unit="pages"><start>41</start><end>48</end></extent></part></relatedItem><identifier type="istex">23571DE4D41D975EBBE0B51A9BB409A3AA8C1E45</identifier><identifier type="ark">ark:/67375/6H6-D07PD08X-Q</identifier><identifier type="DOI">10.1016/S0338-9898(96)80182-X</identifier><identifier type="PII">S0338-9898(96)80182-X</identifier><identifier type="ArticleID">9680182X</identifier><accessCondition type="use and reproduction" contentType="copyright">©1996 Marque et modélé dèposès</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource><recordOrigin>Marque et modélé dèposès, ©1996</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-D07PD08X-Q/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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|area= H2N2V1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:23571DE4D41D975EBBE0B51A9BB409A3AA8C1E45
|texte= Variabilité génétique et virus
}}
| This area was generated with Dilib version V0.6.33. |  |