H2N2V1, Istex, Corpus, bibRecord, 001665

Effective Immunization with Live Attenuated Influenza A Virus Can Be Achieved in Early Infancy

Identifieur interne : 001665 ( Istex/Corpus ); précédent : 001664; suivant : 001666

Effective Immunization with Live Attenuated Influenza A Virus Can Be Achieved in Early Infancy

Auteurs : Mary Lou Clements ; Mamodikoe K. Makhene ; Ruth A. Karron ; Brian R. Murphy ; Mark C. Steinhoff ; Kanta Subbarao ; Modena H. Wilson ; Pediatric Care Center ; Peter F. Wright

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1996.

RBID : ISTEX:B66CC0796028ADDED903FE61DBA7543AAEAB74BF

Abstract

The immunogenicity of vaccines can be modified in infancy by maternal antibodies and other immunizations. Hence, the safety and immunogenicity of two doses of 107 TCID50 of live, attenuated cold-adapted (ca) influenza A/Kawasaki/86 (H1N1) reassortant virus vaccine given with or apart from childhood immunizations were evaluated in infants, starting at 2, 4, or >6 months of age, in randomized, double-blind trials. The ca vaccine was safe and did not significantly reduce the immunogenicity of the childhood vaccines in these infants. Infectivity of ca virus (virus shedding, ⩾4-fold rise in serum hemagglutination inhibition antibody titer, or both) was affected by age, quantity of ca virus given, and prior ca virus infection. Two doses of 107 TCID50 of ca influenza virus infected all infants, indicating that both doses are probably needed to achieve immunity against influenza in infants <6 months of age.

Url:

https://api.istex.fr/ark:/67375/HXZ-60R53QLR-2/fulltext.pdf

DOI: 10.1093/infdis/173.1.44

Links to Exploration step

ISTEX:B66CC0796028ADDED903FE61DBA7543AAEAB74BF

Le document en format XML

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<profileDesc><abstract><p>The immunogenicity of vaccines can be modified in infancy by maternal antibodies and other immunizations. Hence, the safety and immunogenicity of two doses of 10<hi rend="superscript">7</hi>
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<surname>Clements</surname>

<given-names>Mary Lou</given-names>

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<given-names>Mark C.</given-names>

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<given-names>Kanta</given-names>

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<contrib contrib-type="author">

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<given-names>Modena H.</given-names>

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<aff><institution>Department of Pediatrics, Vanderbilt University Medical Center</institution>
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<corresp id="cor1">Reprints or correspondence: Dr. Mary Lou Clements, Johns Hopkins University Center for Immunization Research, Hampton House 125, 624 N. Broadway, Baltimore, MD 21205.</corresp>

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<abstract>

<p>The immunogenicity of vaccines can be modified in infancy by maternal antibodies and other immunizations. Hence, the safety and immunogenicity of two doses of 10<sup>7</sup>
 TCID<sub>50</sub>
 of live, attenuated cold-adapted <italic>(ca)</italic>
 influenza A/Kawasaki/86 (H1N1) reassortant virus vaccine given with or apart from childhood immunizations were evaluated in infants, starting at 2, 4, or >6 months of age, in randomized, double-blind trials. The <italic>ca</italic>
 vaccine was safe and did not significantly reduce the immunogenicity of the childhood vaccines in these infants. Infectivity of <italic>ca</italic>
 virus (virus shedding, ⩾4-fold rise in serum hemagglutination inhibition antibody titer, or both) was affected by age, quantity of <italic>ca</italic>
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 virus infection. Two doses of 10<sup>7</sup>
 TCID<sub>50</sub>
 of <italic>ca</italic>
 influenza virus infected all infants, indicating that both doses are probably needed to achieve immunity against influenza in infants <6 months of age.</p>

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<abstract>The immunogenicity of vaccines can be modified in infancy by maternal antibodies and other immunizations. Hence, the safety and immunogenicity of two doses of 107 TCID50 of live, attenuated cold-adapted (ca) influenza A/Kawasaki/86 (H1N1) reassortant virus vaccine given with or apart from childhood immunizations were evaluated in infants, starting at 2, 4, or >6 months of age, in randomized, double-blind trials. The ca vaccine was safe and did not significantly reduce the immunogenicity of the childhood vaccines in these infants. Infectivity of ca virus (virus shedding, ⩾4-fold rise in serum hemagglutination inhibition antibody titer, or both) was affected by age, quantity of ca virus given, and prior ca virus infection. Two doses of 107 TCID50 of ca influenza virus infected all infants, indicating that both doses are probably needed to achieve immunity against influenza in infants <6 months of age.</abstract>
<note type="author-notes">Reprints or correspondence: Dr. Mary Lou Clements, Johns Hopkins University Center for Immunization Research, Hampton House 125, 624 N. Broadway, Baltimore, MD 21205.</note>
<relatedItem type="host"><titleInfo><title>Journal of Infectious Diseases</title>
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<titleInfo type="abbreviated"><title>J Infect Dis.</title>
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<identifier type="ISSN">0022-1899</identifier>
<identifier type="eISSN">1537-6613</identifier>
<identifier type="PublisherID">jid</identifier>
<identifier type="PublisherID-hwp">jinfdis</identifier>
<part><date>1996</date>
<detail type="volume"><caption>vol.</caption>
<number>173</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>1</number>
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<extent unit="pages"><start>44</start>
<end>51</end>
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<identifier type="DOI">10.1093/infdis/173.1.44</identifier>
<accessCondition type="use and reproduction" contentType="copyright">© 1996 by The University of Chicago</accessCondition>
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Effective Immunization with Live Attenuated Influenza A Virus Can Be Achieved in Early Infancy

Effective Immunization with Live Attenuated Influenza A Virus Can Be Achieved in Early Infancy

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