EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING
Identifieur interne : 001549 ( Istex/Corpus ); précédent : 001548; suivant : 001550EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING
Auteurs : Stephen C. Schoenbaum ; Marion T. Coleman ; Walter R. Dowdle ; Stephen R. MostowSource :
- American Journal of Epidemiology [ 0002-9262 ] ; 1976.
Abstract
During the Hong Kong influenza epidemic of 1968–1969 the attack rate among persons born prior to 1890 was about one-third the rate among persons born after 1899. During an Asian influenza epidemic in the same community two years earlier there was no apparent age effect. Most persons born before 1890 had detectable pre-epidemic antibody against A/Hong Kong/68 whereas most persons born after 1899 had no detectable pre-epidemic antibody. The lower attack rate in the older age group is consistent with the hypothesis that influenza A viruses with similar or identical hemagglutinins can reemerge over time and that remote previous experience with the same or a similar strain can be protective. Also, no age group born after 1890 was found to have a high prevalence of antibody against A/England/72 or A/Dunedin/73, the successors to A/Hong Kong/68, indicating that recycling of hemagglutinin antigens is not strictly ordered.
Url:
DOI: 10.1093/oxfordjournals.aje.a112214
Links to Exploration step
ISTEX:A8C058169F58C7DBDC93013148BB978BA5E9EC39Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING</title><author><name sortKey="Schoenbaum, Stephen C" sort="Schoenbaum, Stephen C" uniqKey="Schoenbaum S" first="Stephen C." last="Schoenbaum">Stephen C. Schoenbaum</name><affiliation><mods:affiliation>Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, MA, formerly, Bureau of Epidemiology, Center for Disease Control Atlanta</mods:affiliation></affiliation></author><author><name sortKey="Coleman, Marion T" sort="Coleman, Marion T" uniqKey="Coleman M" first="Marion T" last="Coleman">Marion T. Coleman</name><affiliation><mods:affiliation>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</mods:affiliation></affiliation><affiliation><mods:affiliation>Deceased, January 19, 1975.</mods:affiliation></affiliation></author><author><name sortKey="Dowdle, Walter R" sort="Dowdle, Walter R" uniqKey="Dowdle W" first="Walter R." last="Dowdle">Walter R. Dowdle</name><affiliation><mods:affiliation>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</mods:affiliation></affiliation><affiliation><mods:affiliation>Reprint requests to Dr Dowdle</mods:affiliation></affiliation></author><author><name sortKey="Mostow, Stephen R" sort="Mostow, Stephen R" uniqKey="Mostow S" first="Stephen R." last="Mostow">Stephen R. Mostow</name><affiliation><mods:affiliation>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A8C058169F58C7DBDC93013148BB978BA5E9EC39</idno><date when="1976" year="1976">1976</date><idno type="doi">10.1093/oxfordjournals.aje.a112214</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-RKQN0BZH-S/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001549</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001549</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING</title><author><name sortKey="Schoenbaum, Stephen C" sort="Schoenbaum, Stephen C" uniqKey="Schoenbaum S" first="Stephen C." last="Schoenbaum">Stephen C. Schoenbaum</name><affiliation><mods:affiliation>Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, MA, formerly, Bureau of Epidemiology, Center for Disease Control Atlanta</mods:affiliation></affiliation></author><author><name sortKey="Coleman, Marion T" sort="Coleman, Marion T" uniqKey="Coleman M" first="Marion T" last="Coleman">Marion T. Coleman</name><affiliation><mods:affiliation>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</mods:affiliation></affiliation><affiliation><mods:affiliation>Deceased, January 19, 1975.</mods:affiliation></affiliation></author><author><name sortKey="Dowdle, Walter R" sort="Dowdle, Walter R" uniqKey="Dowdle W" first="Walter R." last="Dowdle">Walter R. Dowdle</name><affiliation><mods:affiliation>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</mods:affiliation></affiliation><affiliation><mods:affiliation>Reprint requests to Dr Dowdle</mods:affiliation></affiliation></author><author><name sortKey="Mostow, Stephen R" sort="Mostow, Stephen R" uniqKey="Mostow S" first="Stephen R." last="Mostow">Stephen R. Mostow</name><affiliation><mods:affiliation>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">American Journal of Epidemiology</title><idno type="eISSN">1476-6256</idno><idno type="ISSN">0002-9262</idno><imprint><publisher>Oxford University Press</publisher><date when="1976-02">1976</date><biblScope unit="vol">103</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="166">166</biblScope><biblScope unit="page" to="173">173</biblScope></imprint><idno type="ISSN">0002-9262</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9262</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">During the Hong Kong influenza epidemic of 1968–1969 the attack rate among persons born prior to 1890 was about one-third the rate among persons born after 1899. During an Asian influenza epidemic in the same community two years earlier there was no apparent age effect. Most persons born before 1890 had detectable pre-epidemic antibody against A/Hong Kong/68 whereas most persons born after 1899 had no detectable pre-epidemic antibody. The lower attack rate in the older age group is consistent with the hypothesis that influenza A viruses with similar or identical hemagglutinins can reemerge over time and that remote previous experience with the same or a similar strain can be protective. Also, no age group born after 1890 was found to have a high prevalence of antibody against A/England/72 or A/Dunedin/73, the successors to A/Hong Kong/68, indicating that recycling of hemagglutinin antigens is not strictly ordered.</div></front></TEI><istex><corpusName>oup</corpusName><keywords><teeft><json:string>influenza</json:string><json:string>vaccine</json:string><json:string>attack rate</json:string><json:string>hemagglutinin</json:string><json:string>epidemiology</json:string><json:string>dowdle</json:string><json:string>neuraminidase</json:string><json:string>serologic</json:string><json:string>recycling</json:string><json:string>detectable antibody</json:string><json:string>retirement community</json:string><json:string>recombinant</json:string><json:string>antigenic</json:string><json:string>morbidity</json:string><json:string>influenza virus</json:string><json:string>hong kong influenza</json:string><json:string>excess mortality</json:string><json:string>asian influenza</json:string><json:string>influenza vaccine</json:string><json:string>similar strain</json:string><json:string>asian influenza vaccine</json:string><json:string>datum</json:string><json:string>recombinant virus</json:string><json:string>field trial</json:string><json:string>excess mortality rate</json:string><json:string>strain similar</json:string><json:string>hong kong vaccine</json:string><json:string>high prevalence</json:string><json:string>asian influenza epidemic</json:string><json:string>hemagglutinin antigen</json:string><json:string>public health</json:string><json:string>neuraminidase antibody</json:string><json:string>original antigenic</json:string><json:string>antibody response</json:string><json:string>california retirement community</json:string><json:string>vaccine group</json:string><json:string>antibody</json:string><json:string>vaccination</json:string><json:string>titer</json:string><json:string>medical clinic</json:string><json:string>antibody prevalence</json:string><json:string>detectable titer</json:string><json:string>influenza antibody pattern</json:string><json:string>antigenic relationship</json:string><json:string>comparative datum</json:string><json:string>test antigen</json:string><json:string>disease control</json:string><json:string>elderly person</json:string><json:string>asian strain</json:string><json:string>antibody titer</json:string><json:string>serologic test</json:string><json:string>hong kong influenza epidemic</json:string><json:string>zonal centrifugation</json:string><json:string>serologic recapitulation</json:string><json:string>identical result</json:string><json:string>epidemic</json:string></teeft></keywords><author><json:item><name>STEPHEN C. SCHOENBAUM</name><affiliations><json:string>Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, MA, formerly, Bureau of Epidemiology, Center for Disease Control Atlanta</json:string></affiliations></json:item><json:item><name>MARION T COLEMAN</name><affiliations><json:string>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</json:string><json:string>Deceased, January 19, 1975.</json:string></affiliations></json:item><json:item><name>WALTER R. DOWDLE</name><affiliations><json:string>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</json:string><json:string>Reprint requests to Dr Dowdle</json:string></affiliations></json:item><json:item><name>STEPHEN R. MOSTOW</name><affiliations><json:string>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</json:string></affiliations></json:item></author><subject><json:item><value>aged</value></json:item><json:item><value>epidemiology</value></json:item><json:item><value>hemagglutinins</value></json:item><json:item><value>viral</value></json:item><json:item><value>influenza A</value></json:item><json:item><value>virus diseases</value></json:item></subject><articleId><json:string>103.2.166</json:string></articleId><arkIstex>ark:/67375/HXZ-RKQN0BZH-S</arkIstex><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>During the Hong Kong influenza epidemic of 1968–1969 the attack rate among persons born prior to 1890 was about one-third the rate among persons born after 1899. During an Asian influenza epidemic in the same community two years earlier there was no apparent age effect. Most persons born before 1890 had detectable pre-epidemic antibody against A/Hong Kong/68 whereas most persons born after 1899 had no detectable pre-epidemic antibody. The lower attack rate in the older age group is consistent with the hypothesis that influenza A viruses with similar or identical hemagglutinins can reemerge over time and that remote previous experience with the same or a similar strain can be protective. Also, no age group born after 1890 was found to have a high prevalence of antibody against A/England/72 or A/Dunedin/73, the successors to A/Hong Kong/68, indicating that recycling of hemagglutinin antigens is not strictly ordered.</abstract><qualityIndicators><score>5.351</score><pdfWordCount>3611</pdfWordCount><pdfCharCount>22469</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>478 x 698 pts</pdfPageSize><pdfWordsPerPage>451</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>false</refBibsNative><abstractWordCount>145</abstractWordCount><abstractCharCount>927</abstractCharCount><keywordCount>6</keywordCount></qualityIndicators><title>EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING</title><pmid><json:string>1251831</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>American Journal of Epidemiology</title><language><json:string>unknown</json:string></language><issn><json:string>0002-9262</json:string></issn><eissn><json:string>1476-6256</json:string></eissn><publisherId><json:string>aje</json:string></publisherId><volume>103</volume><issue>2</issue><pages><first>166</first><last>173</last></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>ORIGINAL CONTRIBUTIONS</value></json:item></subject></host><namedEntities><unitex><date><json:string>1974</json:string><json:string>1923</json:string><json:string>1928</json:string><json:string>1968</json:string><json:string>1957</json:string><json:string>1975</json:string><json:string>1964</json:string><json:string>1899</json:string><json:string>1969</json:string><json:string>1931</json:string><json:string>1890</json:string><json:string>1918</json:string><json:string>1960</json:string><json:string>1936</json:string><json:string>1976</json:string><json:string>1895</json:string><json:string>1965</json:string><json:string>1891</json:string><json:string>1919</json:string><json:string>1878</json:string><json:string>1800</json:string><json:string>1880</json:string><json:string>1950</json:string><json:string>1966</json:string><json:string>1857</json:string><json:string>1900</json:string><json:string>2114</json:string></date><geogName></geogName><orgName><json:string>Bureau of Laboratories</json:string><json:string>General Hospital, Cleveland, OH Compared</json:string><json:string>Department of Medicine, Metro</json:string><json:string>The Johns Hopkins University</json:string><json:string>Bureau of Epidemiology, Center for Disease</json:string><json:string>Department of Medicine, Peter Bent Brigham</json:string><json:string>Childrens Hospital, Memphis, TN</json:string><json:string>Bureau of Laboratories, Center for Disease Control</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Sinai School</json:string><json:string>Hong Kong</json:string><json:string>R. G. Webster</json:string><json:string>W. R. Dowdle</json:string><json:string>In</json:string><json:string>B. Yarbrough</json:string><json:string>Hong Received</json:string><json:string>E. D. Kilbourne</json:string><json:string>W. M. Marine</json:string><json:string>S. R. Mostow</json:string><json:string>Dowdle</json:string></persName><placeName><json:string>NY</json:string><json:string>Dunedin</json:string><json:string>Port Chalmers</json:string><json:string>GA</json:string><json:string>Boston</json:string><json:string>Atlanta</json:string><json:string>York</json:string><json:string>MA</json:string></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/HXZ-RKQN0BZH-S</json:string></ark><categories><wos><json:string>1 - social science</json:string><json:string>2 - public, environmental & occupational health</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - public health & health services</json:string><json:string>3 - epidemiology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Epidemiology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1976</publicationDate><copyrightDate>1976</copyrightDate><doi><json:string>10.1093/oxfordjournals.aje.a112214</json:string></doi><id>A8C058169F58C7DBDC93013148BB978BA5E9EC39</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-RKQN0BZH-S/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-RKQN0BZH-S/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/HXZ-RKQN0BZH-S/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><licence>© 1976 by The Johns Hopkins University School of Hygiene and Public Health</licence></availability><date type="Copyright" when="1976">1976</date><date when="1976-02">1976</date></publicationStmt><notesStmt><note type="content-type" source="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="publication-type" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING</title><author xml:id="author-0000"><persName><surname>SCHOENBAUM</surname><forename type="first">STEPHEN C.</forename></persName><affiliation><orgName type="department">Department of Medicine</orgName><orgName type="institution">Peter Bent Brigham Hospital and Harvard Medical School</orgName><orgName type="institution">Boston</orgName><orgName type="institution">MA</orgName><orgName type="institution">formerly</orgName><orgName type="department">Bureau of Epidemiology</orgName><orgName type="institution">Center for Disease Control</orgName><address><addrLine>Atlanta</addrLine></address></affiliation></author><author xml:id="author-0001"><persName><surname>COLEMAN</surname><forename type="first">MARION T</forename></persName><affiliation><orgName>Respiratory Virology Branch</orgName><orgName type="department">Virology Division</orgName><orgName type="laboratory">Bureau of Laboratories</orgName><orgName type="institution">Center for Disease Control</orgName><address><addrLine>Atlanta, GA 30333</addrLine></address></affiliation><affiliation><orgName type="institution">3Deceased</orgName><address><addrLine>January 19, 1975</addrLine></address></affiliation></author><author xml:id="author-0002"><persName><surname>DOWDLE</surname><forename type="first">WALTER R.</forename></persName><affiliation><orgName>Respiratory Virology Branch</orgName><orgName type="department">Virology Division</orgName><orgName type="laboratory">Bureau of Laboratories</orgName><orgName type="institution">Center for Disease Control</orgName><address><addrLine>Atlanta, GA 30333</addrLine></address></affiliation><affiliation role="corresp">Reprint requests to Dr Dowdle</affiliation></author><author xml:id="author-0003"><persName><surname>MOSTOW</surname><forename type="first">STEPHEN R.</forename></persName><affiliation><orgName>Respiratory Virology Branch</orgName><orgName type="department">Virology Division</orgName><orgName type="laboratory">Bureau of Laboratories</orgName><orgName type="institution">Center for Disease Control</orgName><address><addrLine>Atlanta, GA 30333</addrLine></address></affiliation><note place="foot" n="fn1"><p><hi rend="superscript">4</hi>Present address: Department of Medicine, Metropolitan General Hospital, Cleveland, OH</p></note></author><idno type="istex">A8C058169F58C7DBDC93013148BB978BA5E9EC39</idno><idno type="ark">ark:/67375/HXZ-RKQN0BZH-S</idno><idno type="publisher-id">103.2.166</idno><idno type="DOI">10.1093/oxfordjournals.aje.a112214</idno></analytic><monogr><title level="j" type="main">American Journal of Epidemiology</title><idno type="hwp">amjepid</idno><idno type="publisher-id">aje</idno><idno type="pmc">amjepid</idno><idno type="eISSN">1476-6256</idno><idno type="pISSN">0002-9262</idno><imprint><publisher>Oxford University Press</publisher><date when="1976-02">1976</date><biblScope unit="vol">103</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="166">166</biblScope><biblScope unit="page" to="173">173</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-09"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract><p>During the Hong Kong influenza epidemic of 1968–1969 the attack rate among persons born prior to 1890 was about one-third the rate among persons born after 1899. During an Asian influenza epidemic in the same community two years earlier there was no apparent age effect. Most persons born before 1890 had detectable pre-epidemic antibody against A/Hong Kong/68 whereas most persons born after 1899 had no detectable pre-epidemic antibody. The lower attack rate in the older age group is consistent with the hypothesis that influenza A viruses with similar or identical hemagglutinins can reemerge over time and that remote previous experience with the same or a similar strain can be protective. Also, no age group born after 1890 was found to have a high prevalence of antibody against A/England/72 or A/Dunedin/73, the successors to A/Hong Kong/68, indicating that recycling of hemagglutinin antigens is not strictly ordered.</p></abstract><textClass ana="subject"><keywords scheme="subject"><term>ORIGINAL CONTRIBUTIONS</term></keywords></textClass><textClass ana="keyword"><keywords><term>aged</term><term>epidemiology</term><term>hemagglutinins</term><term>viral</term><term>influenza A</term><term>virus diseases</term></keywords></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-09" who="#istex" xml:id="pub2tei">formatting</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2019-12-12">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-RKQN0BZH-S/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article">
<front>
<journal-meta>
<journal-id journal-id-type="hwp">amjepid</journal-id>
<journal-id journal-id-type="publisher-id">aje</journal-id>
<journal-id journal-id-type="pmc">amjepid</journal-id>
<journal-title>American Journal of Epidemiology</journal-title>
<issn pub-type="epub">1476-6256</issn>
<issn pub-type="ppub">0002-9262</issn>
<publisher>
<publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">103.2.166</article-id>
<article-id pub-id-type="doi">10.1093/oxfordjournals.aje.a112214</article-id>
<article-categories>
<subj-group>
<subject>ORIGINAL CONTRIBUTIONS</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name><surname>SCHOENBAUM</surname><given-names>STEPHEN C.</given-names></name><xref ref-type="aff" rid="au1"><sup>1</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>COLEMAN</surname><given-names>MARION T</given-names></name><xref ref-type="aff" rid="au2"><sup>2</sup></xref><xref ref-type="aff" rid="au3"><sup>3</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>DOWDLE</surname><given-names>WALTER R.</given-names></name><xref ref-type="aff" rid="au2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>MOSTOW</surname><given-names>STEPHEN R.</given-names></name><xref ref-type="aff" rid="au2"><sup>2</sup></xref><xref ref-type="fn" rid="fn1"><sup>4</sup></xref>
</contrib>
<aff id="au1"><sup>1</sup><institution>Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, MA, formerly, Bureau of Epidemiology, Center for Disease Control</institution> <addr-line>Atlanta</addr-line></aff>
<aff id="au2"><sup>2</sup><institution>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control</institution> <addr-line>Atlanta, GA 30333</addr-line></aff>
<aff id="au3"><sup>3</sup>Deceased, January 19, 1975.</aff>
</contrib-group>
<author-notes>
<corresp id="cor1">Reprint requests to Dr Dowdle</corresp>
<fn id="fn1"><p><sup>4</sup>Present address: Department of Medicine, Metropolitan General Hospital, Cleveland, OH</p></fn>
</author-notes>
<pub-date pub-type="ppub">
<month>2</month>
<year>1976</year>
</pub-date>
<volume>103</volume>
<issue>2</issue>
<fpage>166</fpage>
<lpage>173</lpage>
<history>
<date date-type="received">
<day>12</day>
<month>5</month>
<year>1975</year>
</date>
<date date-type="rev-recd">
<day>22</day>
<month>7</month>
<year>1975</year>
</date>
</history>
<copyright-statement>© 1976 by The Johns Hopkins University School of Hygiene and Public Health</copyright-statement>
<copyright-year>1976</copyright-year>
<abstract>
<p>During the Hong Kong influenza epidemic of 1968–1969 the attack rate among persons born prior to 1890 was about one-third the rate among persons born after 1899. During an Asian influenza epidemic in the same community two years earlier there was no apparent age effect. Most persons born before 1890 had detectable pre-epidemic antibody against A/Hong Kong/68 whereas most persons born after 1899 had no detectable pre-epidemic antibody. The lower attack rate in the older age group is consistent with the hypothesis that influenza A viruses with similar or identical hemagglutinins can reemerge over time and that remote previous experience with the same or a similar strain can be protective. Also, no age group born after 1890 was found to have a high prevalence of antibody against A/England/72 or A/Dunedin/73, the successors to A/Hong Kong/68, indicating that recycling of hemagglutinin antigens is not strictly ordered.</p>
</abstract>
<kwd-group>
<kwd>aged</kwd>
<kwd>epidemiology</kwd>
<kwd>hemagglutinins</kwd>
<kwd>viral</kwd>
<kwd>influenza A</kwd>
<kwd>virus diseases</kwd>
</kwd-group>
</article-meta>
</front>
</article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING</title></titleInfo><name type="personal"><namePart type="given">STEPHEN C.</namePart><namePart type="family">SCHOENBAUM</namePart><affiliation>Department of Medicine, Peter Bent Brigham Hospital and Harvard Medical School, Boston, MA, formerly, Bureau of Epidemiology, Center for Disease Control Atlanta</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MARION T</namePart><namePart type="family">COLEMAN</namePart><affiliation>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</affiliation><affiliation>Deceased, January 19, 1975.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WALTER R.</namePart><namePart type="family">DOWDLE</namePart><affiliation>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</affiliation><affiliation>Reprint requests to Dr Dowdle</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">STEPHEN R.</namePart><namePart type="family">MOSTOW</namePart><affiliation>Respiratory Virology Branch, Virology Division, Bureau of Laboratories, Center for Disease Control Atlanta, GA 30333</affiliation><description>4Present address: Department of Medicine, Metropolitan General Hospital, Cleveland, OH</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">1976-02</dateIssued><copyrightDate encoding="w3cdtf">1976</copyrightDate></originInfo><abstract>During the Hong Kong influenza epidemic of 1968–1969 the attack rate among persons born prior to 1890 was about one-third the rate among persons born after 1899. During an Asian influenza epidemic in the same community two years earlier there was no apparent age effect. Most persons born before 1890 had detectable pre-epidemic antibody against A/Hong Kong/68 whereas most persons born after 1899 had no detectable pre-epidemic antibody. The lower attack rate in the older age group is consistent with the hypothesis that influenza A viruses with similar or identical hemagglutinins can reemerge over time and that remote previous experience with the same or a similar strain can be protective. Also, no age group born after 1890 was found to have a high prevalence of antibody against A/England/72 or A/Dunedin/73, the successors to A/Hong Kong/68, indicating that recycling of hemagglutinin antigens is not strictly ordered.</abstract><note type="footnotes">4Present address: Department of Medicine, Metropolitan General Hospital, Cleveland, OH</note><note type="author-notes">Reprint requests to Dr Dowdle</note><subject><genre>keywords</genre><topic>aged</topic><topic>epidemiology</topic><topic>hemagglutinins</topic><topic>viral</topic><topic>influenza A</topic><topic>virus diseases</topic></subject><relatedItem type="host"><titleInfo><title>American Journal of Epidemiology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><topic>ORIGINAL CONTRIBUTIONS</topic></subject><identifier type="ISSN">0002-9262</identifier><identifier type="eISSN">1476-6256</identifier><identifier type="PublisherID">aje</identifier><identifier type="PublisherID-hwp">amjepid</identifier><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>166</start><end>173</end></extent></part></relatedItem><identifier type="istex">A8C058169F58C7DBDC93013148BB978BA5E9EC39</identifier><identifier type="ark">ark:/67375/HXZ-RKQN0BZH-S</identifier><identifier type="DOI">10.1093/oxfordjournals.aje.a112214</identifier><identifier type="ArticleID">103.2.166</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1976 by The Johns Hopkins University School of Hygiene and Public Health</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-GTWS0RDP-M">oup</recordContentSource><recordOrigin>Converted from (version 1.2.0) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-12-09</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-RKQN0BZH-S/record.json</uri></json:item></metadata><annexes><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-RKQN0BZH-S/annexes.pdf</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001549 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001549 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:A8C058169F58C7DBDC93013148BB978BA5E9EC39
|texte= EPIDEMIOLOGY OF INFLUENZA IN THE ELDERLY: EVIDENCE OF VIRUS RECYCLING
}}
| This area was generated with Dilib version V0.6.33. |  |