Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children
Identifieur interne : 001524 ( Istex/Corpus ); précédent : 001523; suivant : 001525Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children
Auteurs : Peter F. Wright ; Nobuhiko Okabe ; Kelly T. Mckee ; H. F. Maassab ; David T. KarzonSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1982.
Abstract
Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.
Url:
DOI: 10.1093/infdis/146.1.71
Links to Exploration step
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<front><div type="abstract">Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.</div>
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<profileDesc><abstract><p>Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.</p>
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<xref ref-type="author-notes" rid="FN2">†</xref>
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<contrib contrib-type="author">
<name><surname>Maassab</surname>
<given-names>H. F.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name><surname>Karzon</surname>
<given-names>David T.</given-names>
</name>
</contrib>
<aff><institution>Vanderbilt University School of Medicine</institution>
, <addr-line>Nashville, Tennessee</addr-line>
; and the <institution>University of Michigan</institution>
, <addr-line>Ann Arbor, Michigan</addr-line>
</aff>
</contrib-group>
<author-notes>
<corresp id="COR1">Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.</corresp>
<fn fn-type="present-address" id="FN1">
<label>*</label>
<p>Present address: Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.</p>
</fn>
<fn fn-type="present-address" id="FN2">
<p>Present address: Division of Virology, U.S. Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub">
<month>7</month>
<year>1982</year>
</pub-date>
<volume>146</volume>
<issue>1</issue>
<fpage>71</fpage>
<lpage>79</lpage>
<history>
<date date-type="received">
<day>23</day>
<month>11</month>
<year>1981</year>
</date>
<date date-type="rev-recd">
<day>22</day>
<month>2</month>
<year>1982</year>
</date>
</history>
<copyright-statement>© 1982 by The University of Chicago</copyright-statement>
<copyright-year>1982</copyright-year>
<abstract>
<p>Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.</p>
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<name type="personal" displayLabel="corresp"><namePart type="given">Peter F.</namePart>
<namePart type="family">Wright</namePart>
<affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</affiliation>
<affiliation>Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.</affiliation>
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<name type="personal"><namePart type="given">Nobuhiko</namePart>
<namePart type="family">Okabe</namePart>
<affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</affiliation>
<affiliation>,</affiliation>
<description>* Present address: Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.</description>
<role><roleTerm type="text">author</roleTerm>
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<name type="personal"><namePart type="given">Kelly T.</namePart>
<namePart type="family">McKee</namePart>
<namePart type="termsOfAddress">Jr.</namePart>
<affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</affiliation>
<affiliation>,</affiliation>
<description>Present address: Division of Virology, U.S. Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland.</description>
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<name type="personal"><namePart type="given">H. F.</namePart>
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<role><roleTerm type="text">author</roleTerm>
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<name type="personal"><namePart type="given">David T.</namePart>
<namePart type="family">Karzon</namePart>
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<copyrightDate encoding="w3cdtf">1982</copyrightDate>
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<abstract>Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.</abstract>
<note type="footnotes">Present address: Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.</note>
<note type="author-notes">Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.</note>
<relatedItem type="host"><titleInfo><title>Journal of Infectious Diseases</title>
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<part><date>1982</date>
<detail type="volume"><caption>vol.</caption>
<number>146</number>
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<detail type="issue"><caption>no.</caption>
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