Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children
Identifieur interne : 001524 ( Istex/Corpus ); précédent : 001523; suivant : 001525Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children
Auteurs : Peter F. Wright ; Nobuhiko Okabe ; Kelly T. Mckee ; H. F. Maassab ; David T. KarzonSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1982.
Abstract
Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.
Url:
DOI: 10.1093/infdis/146.1.71
Links to Exploration step
ISTEX:7D1CFBB6515C842AED8BD3213D684A9011D47E78Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children</title><author><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name><affiliation><mods:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</mods:affiliation></affiliation><affiliation><mods:affiliation>Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.</mods:affiliation></affiliation></author><author><name sortKey="Okabe, Nobuhiko" sort="Okabe, Nobuhiko" uniqKey="Okabe N" first="Nobuhiko" last="Okabe">Nobuhiko Okabe</name><affiliation><mods:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</mods:affiliation></affiliation><affiliation><mods:affiliation>,</mods:affiliation></affiliation></author><author><name sortKey="Mckee, Kelly T" sort="Mckee, Kelly T" uniqKey="Mckee K" first="Kelly T." last="Mckee">Kelly T. Mckee</name><affiliation><mods:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</mods:affiliation></affiliation><affiliation><mods:affiliation>,</mods:affiliation></affiliation></author><author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><affiliation><mods:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</mods:affiliation></affiliation></author><author><name sortKey="Karzon, David T" sort="Karzon, David T" uniqKey="Karzon D" first="David T." last="Karzon">David T. Karzon</name><affiliation><mods:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7D1CFBB6515C842AED8BD3213D684A9011D47E78</idno><date when="1982" year="1982">1982</date><idno type="doi">10.1093/infdis/146.1.71</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-W1JZWSDW-6/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001524</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001524</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children</title><author><name sortKey="Wright, Peter F" sort="Wright, Peter F" uniqKey="Wright P" first="Peter F." last="Wright">Peter F. Wright</name><affiliation><mods:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</mods:affiliation></affiliation><affiliation><mods:affiliation>Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.</mods:affiliation></affiliation></author><author><name sortKey="Okabe, Nobuhiko" sort="Okabe, Nobuhiko" uniqKey="Okabe N" first="Nobuhiko" last="Okabe">Nobuhiko Okabe</name><affiliation><mods:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</mods:affiliation></affiliation><affiliation><mods:affiliation>,</mods:affiliation></affiliation></author><author><name sortKey="Mckee, Kelly T" sort="Mckee, Kelly T" uniqKey="Mckee K" first="Kelly T." last="Mckee">Kelly T. Mckee</name><affiliation><mods:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</mods:affiliation></affiliation><affiliation><mods:affiliation>,</mods:affiliation></affiliation></author><author><name sortKey="Maassab, H F" sort="Maassab, H F" uniqKey="Maassab H" first="H. F." last="Maassab">H. F. Maassab</name><affiliation><mods:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</mods:affiliation></affiliation></author><author><name sortKey="Karzon, David T" sort="Karzon, David T" uniqKey="Karzon D" first="David T." last="Karzon">David T. Karzon</name><affiliation><mods:affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1982-07">1982</date><biblScope unit="vol">146</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="71">71</biblScope><biblScope unit="page" to="79">79</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Peter F. Wright</name><affiliations><json:string>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</json:string><json:string>Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.</json:string></affiliations></json:item><json:item><name>Nobuhiko Okabe</name><affiliations><json:string>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</json:string><json:string>,</json:string></affiliations></json:item><json:item><name>Kelly T. McKee Jr.</name><affiliations><json:string>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</json:string><json:string>,</json:string></affiliations></json:item><json:item><name>H. F. Maassab</name><affiliations><json:string>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</json:string></affiliations></json:item><json:item><name>David T. Karzon</name><affiliations><json:string>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</json:string></affiliations></json:item></author><arkIstex>ark:/67375/HXZ-W1JZWSDW-6</arkIstex><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.</abstract><qualityIndicators><score>6.867</score><pdfWordCount>4772</pdfWordCount><pdfCharCount>31016</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>594 x 774 pts</pdfPageSize><pdfWordsPerPage>530</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>false</refBibsNative><abstractWordCount>119</abstractWordCount><abstractCharCount>939</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children</title><pmid><json:string>7045254</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Journal of Infectious Diseases</title><language><json:string>unknown</json:string></language><issn><json:string>0022-1899</json:string></issn><eissn><json:string>1537-6613</json:string></eissn><publisherId><json:string>jid</json:string></publisherId><volume>146</volume><issue>1</issue><pages><first>71</first><last>79</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1981</json:string><json:string>1982</json:string><json:string>From December 1980 to February 1981</json:string><json:string>1947</json:string><json:string>1977</json:string><json:string>1980</json:string></date><geogName></geogName><orgName><json:string>University of Michigan</json:string><json:string>Department of Health and Human Services</json:string><json:string>Vanderbilt University</json:string><json:string>Vanderbilt Clinical Research Center</json:string><json:string>Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland</json:string><json:string>Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan</json:string><json:string>Division of Virology</json:string><json:string>Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Md</json:string><json:string>Committee for the Protection of Human Subjects of Vanderbilt University</json:string><json:string>National Institute of Allergy and Infectious Diseases</json:string><json:string>Clinical Research Center</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Peter F. Wright</json:string><json:string>Kelly T. McKee</json:string><json:string>Hong Kong</json:string><json:string>Chanock</json:string><json:string>Brian Murphy</json:string><json:string>Ann Arbor</json:string><json:string>H. F. Maassab</json:string><json:string>David T. Karzon</json:string><json:string>Murphy</json:string><json:string>Robert Chanock</json:string><json:string>Janet Paolini</json:string><json:string>Jill Blackmore</json:string></persName><placeName><json:string>Brazil</json:string><json:string>Bangkok</json:string><json:string>Port Chalmers</json:string><json:string>Nashville</json:string><json:string>Atlanta</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[4]</json:string><json:string>[12]</json:string><json:string>Wright et al.</json:string><json:string>[18]</json:string><json:string>Murphy et al. [2]</json:string><json:string>[11]</json:string><json:string>[8]</json:string><json:string>[17]</json:string><json:string>[1]</json:string><json:string>[7, 9]</json:string><json:string>[21]</json:string><json:string>[16]</json:string><json:string>[3]</json:string><json:string>[20]</json:string><json:string>[13, 14]</json:string><json:string>[15]</json:string><json:string>[7,9]</json:string><json:string>[7]</json:string><json:string>[4-6]</json:string><json:string>[2]</json:string><json:string>[19]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/HXZ-W1JZWSDW-6</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - microbiology</json:string><json:string>2 - infectious diseases</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - microbiology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1982</publicationDate><copyrightDate>1982</copyrightDate><doi><json:string>10.1093/infdis/146.1.71</json:string></doi><id>7D1CFBB6515C842AED8BD3213D684A9011D47E78</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-W1JZWSDW-6/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-W1JZWSDW-6/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/HXZ-W1JZWSDW-6/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>The University of Chicago Press</publisher><availability><licence>© 1982 by The University of Chicago</licence></availability><date type="Copyright" when="1982">1982</date><date when="1982-07">1982</date></publicationStmt><notesStmt><note type="content-type" source="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="publication-type" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children</title><author xml:id="author-0000" role="corresp"><persName><surname>Wright</surname><forename type="first">Peter F.</forename></persName><affiliation><orgName type="institution">Vanderbilt University School of Medicine</orgName><orgName type="institution">University of Michigan</orgName><address><addrLine>Nashville, Tennessee</addrLine><addrLine>Ann Arbor, Michigan</addrLine></address></affiliation><affiliation role="corresp">Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.</affiliation></author><author xml:id="author-0001"><persName><surname>Okabe</surname><forename type="first">Nobuhiko</forename></persName><affiliation><orgName type="institution">Vanderbilt University School of Medicine</orgName><orgName type="institution">University of Michigan</orgName><address><addrLine>Nashville, Tennessee</addrLine><addrLine>Ann Arbor, Michigan</addrLine></address></affiliation><note place="foot" n="FN1"><ref>*</ref><p>Present address: Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.</p></note></author><author xml:id="author-0002"><persName><surname>McKee</surname><forename type="first">Kelly T.</forename><genName>Jr.</genName></persName><affiliation><orgName type="institution">Vanderbilt University School of Medicine</orgName><orgName type="institution">University of Michigan</orgName><address><addrLine>Nashville, Tennessee</addrLine><addrLine>Ann Arbor, Michigan</addrLine></address></affiliation><note place="foot" n="FN2"><p>Present address: Division of Virology, U.S. Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland.</p></note></author><author xml:id="author-0003"><persName><surname>Maassab</surname><forename type="first">H. F.</forename></persName><affiliation><orgName type="institution">Vanderbilt University School of Medicine</orgName><orgName type="institution">University of Michigan</orgName><address><addrLine>Nashville, Tennessee</addrLine><addrLine>Ann Arbor, Michigan</addrLine></address></affiliation></author><author xml:id="author-0004"><persName><surname>Karzon</surname><forename type="first">David T.</forename></persName><affiliation><orgName type="institution">Vanderbilt University School of Medicine</orgName><orgName type="institution">University of Michigan</orgName><address><addrLine>Nashville, Tennessee</addrLine><addrLine>Ann Arbor, Michigan</addrLine></address></affiliation></author><idno type="istex">7D1CFBB6515C842AED8BD3213D684A9011D47E78</idno><idno type="ark">ark:/67375/HXZ-W1JZWSDW-6</idno><idno type="DOI">10.1093/infdis/146.1.71</idno></analytic><monogr><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="hwp">jinfdis</idno><idno type="publisher-id">jid</idno><idno type="pISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1982-07">1982</date><biblScope unit="vol">146</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="71">71</biblScope><biblScope unit="page" to="79">79</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-09"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract><p>Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.</p></abstract><textClass ana="subject"><keywords scheme="heading"><term>Original Articles</term></keywords></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-09" who="#istex" xml:id="pub2tei">formatting</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2019-12-13">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-W1JZWSDW-6/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article">
<front>
<journal-meta>
<journal-id journal-id-type="hwp">jinfdis</journal-id>
<journal-id journal-id-type="publisher-id">jid</journal-id>
<journal-title>Journal of Infectious Diseases</journal-title>
<abbrev-journal-title>J Infect Dis.</abbrev-journal-title>
<issn pub-type="ppub">0022-1899</issn>
<issn pub-type="epub">1537-6613</issn>
<publisher>
<publisher-name>The University of Chicago Press</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.1093/infdis/146.1.71</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Original Articles</subject>
<subj-group subj-group-type="heading">
<subject>Immunization and Therapeutics</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Wright</surname><given-names>Peter F.</given-names></name><xref ref-type="corresp" rid="COR1"></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Okabe</surname><given-names>Nobuhiko</given-names></name><xref ref-type="author-notes" rid="FN1">*</xref>
</contrib>
<contrib contrib-type="author">
<name><surname>McKee</surname><given-names>Kelly T.</given-names><suffix>Jr.</suffix></name><xref ref-type="author-notes" rid="FN2">†</xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Maassab</surname><given-names>H. F.</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Karzon</surname><given-names>David T.</given-names></name>
</contrib>
<aff><institution>Vanderbilt University School of Medicine</institution>, <addr-line>Nashville, Tennessee</addr-line>; and the <institution>University of Michigan</institution>, <addr-line>Ann Arbor, Michigan</addr-line></aff>
</contrib-group>
<author-notes>
<corresp id="COR1">Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.</corresp>
<fn fn-type="present-address" id="FN1">
<label>*</label>
<p>Present address: Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.</p>
</fn>
<fn fn-type="present-address" id="FN2">
<p>Present address: Division of Virology, U.S. Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub">
<month>7</month>
<year>1982</year>
</pub-date>
<volume>146</volume>
<issue>1</issue>
<fpage>71</fpage>
<lpage>79</lpage>
<history>
<date date-type="received">
<day>23</day>
<month>11</month>
<year>1981</year>
</date>
<date date-type="rev-recd">
<day>22</day>
<month>2</month>
<year>1982</year>
</date>
</history>
<copyright-statement>© 1982 by The University of Chicago</copyright-statement>
<copyright-year>1982</copyright-year>
<abstract>
<p>Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.</p>
</abstract>
</article-meta>
</front>
</article>
</istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Peter F.</namePart><namePart type="family">Wright</namePart><affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</affiliation><affiliation>Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nobuhiko</namePart><namePart type="family">Okabe</namePart><affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</affiliation><affiliation>,</affiliation><description>* Present address: Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kelly T.</namePart><namePart type="family">McKee</namePart><namePart type="termsOfAddress">Jr.</namePart><affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</affiliation><affiliation>,</affiliation><description>Present address: Division of Virology, U.S. Army Medical Research Institute for Infectious Diseases, Fort Detrick, Frederick, Maryland.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. F.</namePart><namePart type="family">Maassab</namePart><affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">David T.</namePart><namePart type="family">Karzon</namePart><affiliation>Vanderbilt University School of Medicine, Nashville, Tennessee, Ann Arbor, Michigan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>The University of Chicago Press</publisher><dateIssued encoding="w3cdtf">1982-07</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><abstract>Two live, attenuated, intranasally administered influenza virus vaccines were evaluated in 21 seronegative young children at Vanderbilt Children's Hospital (Nashville, Tennessee). The vaccines were derivatives of a cold-adapted master strain, influenza A/Ann Arbor/6/60 virus, containing the hemagglutinin and neuraminidase of one of two contemporary strains, influenza A/Hong Kong/123/77 (H1N1) or A/Alaska/6/77 (H3N2) virus. Both vaccine strains replicated in seronegative young children without evidence of genetic instability. In additon, both vaccine strains caused no identifiable clinical reactions, were not transmitted to other seronegative children, and gave long-lasting immunity. In a subsequent naturally occurring epidemic of influenza A/Bangkok (H3N2) virus, children previously vaccinated with the related strain, influenza A/Alaska (H3N2) virus, were significantly protected as judged by serologic evidence of reinfection.</abstract><note type="footnotes">Present address: Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.</note><note type="author-notes">Please address requests for reprints to Dr. Peter F. Wright, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.</note><relatedItem type="host"><titleInfo><title>Journal of Infectious Diseases</title></titleInfo><titleInfo type="abbreviated"><title>J Infect Dis.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-1899</identifier><identifier type="eISSN">1537-6613</identifier><identifier type="PublisherID">jid</identifier><identifier type="PublisherID-hwp">jinfdis</identifier><part><date>1982</date><detail type="volume"><caption>vol.</caption><number>146</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>71</start><end>79</end></extent></part></relatedItem><identifier type="istex">7D1CFBB6515C842AED8BD3213D684A9011D47E78</identifier><identifier type="ark">ark:/67375/HXZ-W1JZWSDW-6</identifier><identifier type="DOI">10.1093/infdis/146.1.71</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1982 by The University of Chicago</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-GTWS0RDP-M">oup</recordContentSource><recordOrigin>Converted from (version 1.2.0) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-12-09</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-W1JZWSDW-6/record.json</uri></json:item></metadata><covers><json:item><extension>tiff</extension><original>true</original><mimetype>image/tiff</mimetype><uri>https://api.istex.fr/document/7D1CFBB6515C842AED8BD3213D684A9011D47E78/covers/tiff</uri></json:item></covers><annexes><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-W1JZWSDW-6/annexes.pdf</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001524 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001524 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:7D1CFBB6515C842AED8BD3213D684A9011D47E78
|texte= Cold-Adapted Recombinant Influenza A Virus Vaccines in Seronegative Young Children
}}
| This area was generated with Dilib version V0.6.33. |  |