Translational research on influenza virus infection using a nonhuman primate model
Identifieur interne : 001449 ( Istex/Corpus ); précédent : 001448; suivant : 001450Translational research on influenza virus infection using a nonhuman primate model
Auteurs : Yasushi ItohSource :
- Pathology International [ 1320-5463 ] ; 2016-03.
Abstract
Influenza virus infection is a seasonal infectious disease for humans, whereas it is also a zoonosis that is originally transmitted from animals to humans. Therefore, several animal models are used in research on influenza virus infection. We have used a nonhuman primate (NHP) model to extrapolate pathogenicity of various influenza viruses and efficacy of vaccines and antiviral drugs against the influenza viruses in humans. NHPs have genes, anatomical structure, and immune responses similar to those of humans as compared to other animal models. Using an NHP model, we revealed that the pandemic 2009 influenza A virus caused viral pneumonia as reported in human patients. Thus, it is thought that NHP models can be used to predict replication of emerging viruses in humans. We also examined the pathogenicity of highly pathogenic avian influenza viruses and evaluated a new therapeutic antibody in macaques under an immunocompromised condition. NHP models have provided promising results in research on other infectious diseases including Ebola virus and human/simian immunodeficiency virus infections. Thus, NHPs are important in biomedical research for determining the pathogenesis and for development of treatments, especially when clinical trials are difficult. We summarize the characteristics and advantages of research using NHP models in this review.
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DOI: 10.1111/pin.12385
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Translational research on influenza virus infection using a nonhuman primate model</title><author><name sortKey="Itoh, Yasushi" sort="Itoh, Yasushi" uniqKey="Itoh Y" first="Yasushi" last="Itoh">Yasushi Itoh</name><affiliation><mods:affiliation>Department of Pathology, Shiga University of Medical Science, Shiga, Otsu, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: yasushii@belle.shiga-med.ac.jp</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CCBCA2A9D0C5D56061DEA4B703212E94C072AC0D</idno><date when="2016" year="2016">2016</date><idno type="doi">10.1111/pin.12385</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-LXGCBHKS-F/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001449</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001449</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Translational research on influenza virus infection using a nonhuman primate model</title><author><name sortKey="Itoh, Yasushi" sort="Itoh, Yasushi" uniqKey="Itoh Y" first="Yasushi" last="Itoh">Yasushi Itoh</name><affiliation><mods:affiliation>Department of Pathology, Shiga University of Medical Science, Shiga, Otsu, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: yasushii@belle.shiga-med.ac.jp</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pathology International</title><title level="j" type="alt">PATHOLOGY INTERNATIONAL</title><idno type="ISSN">1320-5463</idno><idno type="eISSN">1440-1827</idno><imprint><biblScope unit="vol">66</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="132">132</biblScope><biblScope unit="page" to="141">141</biblScope><biblScope unit="page-count">10</biblScope><date type="published" when="2016-03">2016-03</date></imprint><idno type="ISSN">1320-5463</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1320-5463</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Influenza virus infection is a seasonal infectious disease for humans, whereas it is also a zoonosis that is originally transmitted from animals to humans. 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Email: <email>yasushii@belle.shiga-med.ac.jp</email></correspondenceTo><selfCitationGroup><citation type="self" xml:id="pin12385-cit-0000"><author><familyName>Itoh</familyName>, <givenNames>Y.</givenNames></author> (<pubYear year="2016">2016</pubYear>) <articleTitle>Translational research on influenza virus infection using a nonhuman primate model</articleTitle>. <journalTitle>Pathology International</journalTitle>, <vol>66</vol>: <pageFirst>132</pageFirst>–<pageLast>141</pageLast>. doi: <accessionId ref="info:doi/10.1111/pin.12385">10.1111/pin.12385</accessionId>.</citation></selfCitationGroup><linkGroup><link type="toTypesetVersion" href="file:PIN.PIN12385.pdf"></link></linkGroup></publicationMeta><contentMeta><titleGroup><title type="short">Influenza research in nonhuman primates</title><title type="shortAuthors">Y. <fc>I</fc>toh</title><title type="main">Translational research on influenza virus infection using a nonhuman primate model</title></titleGroup><creators><creator affiliationRef="#pin12385-aff-0001" corresponding="yes" creatorRole="author" xml:id="pin12385-cr-0001"><personName><givenNames>Yasushi</givenNames><familyName>Itoh</familyName></personName></creator></creators><affiliationGroup><affiliation countryCode="JP" xml:id="pin12385-aff-0001"><orgDiv>Department of Pathology</orgDiv><orgName>Shiga University of Medical Science</orgName><address><city>Otsu</city><countryPart>Shiga</countryPart><country>Japan</country></address></affiliation></affiliationGroup><keywordGroup type="author"><keyword xml:id="pin12385-kwd-0001">influenza virus</keyword><keyword xml:id="pin12385-kwd-0002"><fc>NA</fc> inhibitor</keyword><keyword xml:id="pin12385-kwd-0003">nonhuman primate</keyword><keyword xml:id="pin12385-kwd-0004">translational research</keyword><keyword xml:id="pin12385-kwd-0005">vaccine</keyword></keywordGroup><fundingInfo><fundingAgency>Grants‐in‐Aid for Scientific Research (B) JSPS KAKENHI</fundingAgency><fundingNumber>22390076</fundingNumber><fundingNumber>15H04720</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Regional Research and Development Resources Utilization Program</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Japan Science and Technology Agency</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Ministry of Education, Culture, Sports, Science and Technology, Japan</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Japan Initiative for Global Research Network on Infectious Diseases (J‐GRID) in Japan Agency for Medical Research and Development (AMED)</fundingAgency></fundingInfo><abstractGroup><abstract type="main"><p>Influenza virus infection is a seasonal infectious disease for humans, whereas it is also a zoonosis that is originally transmitted from animals to humans. Therefore, several animal models are used in research on influenza virus infection. We have used a nonhuman primate (<fc>NHP</fc>) model to extrapolate pathogenicity of various influenza viruses and efficacy of vaccines and antiviral drugs against the influenza viruses in humans. <fc>NHP</fc>s have genes, anatomical structure, and immune responses similar to those of humans as compared to other animal models. Using an <fc>NHP</fc> model, we revealed that the pandemic 2009 influenza <fc>A</fc> virus caused viral pneumonia as reported in human patients. Thus, it is thought that <fc>NHP</fc> models can be used to predict replication of emerging viruses in humans. We also examined the pathogenicity of highly pathogenic avian influenza viruses and evaluated a new therapeutic antibody in macaques under an immunocompromised condition. <fc>NHP</fc> models have provided promising results in research on other infectious diseases including <fc>E</fc>bola virus and human/simian immunodeficiency virus infections. Thus, <fc>NHP</fc>s are important in biomedical research for determining the pathogenesis and for development of treatments, especially when clinical trials are difficult. We summarize the characteristics and advantages of research using <fc>NHP</fc> models in this review.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Translational research on influenza virus infection using a nonhuman primate model</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Influenza research in nonhuman primates</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Translational research on influenza virus infection using a nonhuman primate model</title></titleInfo><name type="personal"><namePart type="given">Yasushi</namePart><namePart type="family">Itoh</namePart><affiliation>Department of Pathology, Shiga University of Medical Science, Shiga, Otsu, Japan</affiliation><affiliation>E-mail: yasushii@belle.shiga-med.ac.jp</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><dateIssued encoding="w3cdtf">2016-03</dateIssued><dateCreated encoding="w3cdtf">2016-01-19</dateCreated><dateValid encoding="w3cdtf">2016-01-06</dateValid><edition>Itoh, Y. (2016) Translational research on influenza virus infection using a nonhuman primate model. Pathology International, 66: 132–141. doi: 10.1111/pin.12385.</edition><copyrightDate encoding="w3cdtf">2016</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract>Influenza virus infection is a seasonal infectious disease for humans, whereas it is also a zoonosis that is originally transmitted from animals to humans. Therefore, several animal models are used in research on influenza virus infection. We have used a nonhuman primate (NHP) model to extrapolate pathogenicity of various influenza viruses and efficacy of vaccines and antiviral drugs against the influenza viruses in humans. NHPs have genes, anatomical structure, and immune responses similar to those of humans as compared to other animal models. Using an NHP model, we revealed that the pandemic 2009 influenza A virus caused viral pneumonia as reported in human patients. Thus, it is thought that NHP models can be used to predict replication of emerging viruses in humans. We also examined the pathogenicity of highly pathogenic avian influenza viruses and evaluated a new therapeutic antibody in macaques under an immunocompromised condition. NHP models have provided promising results in research on other infectious diseases including Ebola virus and human/simian immunodeficiency virus infections. Thus, NHPs are important in biomedical research for determining the pathogenesis and for development of treatments, especially when clinical trials are difficult. We summarize the characteristics and advantages of research using NHP models in this review.</abstract><note type="funding">Grants‐in‐Aid for Scientific Research (B) JSPS KAKENHI - No. 22390076; No. 15H04720; </note><note type="funding">Regional Research and Development Resources Utilization Program</note><note type="funding">Japan Science and Technology Agency</note><note type="funding">Ministry of Education, Culture, Sports, Science and Technology, Japan</note><note type="funding">Japan Initiative for Global Research Network on Infectious Diseases (J‐GRID) in Japan Agency for Medical Research and Development (AMED)</note><subject><genre>keywords</genre><topic>influenza virus</topic><topic>NA inhibitor</topic><topic>nonhuman primate</topic><topic>translational research</topic><topic>vaccine</topic></subject><relatedItem type="host"><titleInfo><title>Pathology International</title></titleInfo><titleInfo type="abbreviated"><title>Pathology International</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Review Articles</topic><topic>Review Article</topic></subject><identifier type="ISSN">1320-5463</identifier><identifier type="eISSN">1440-1827</identifier><identifier type="DOI">10.1111/(ISSN)1440-1827</identifier><identifier type="PublisherID">PIN</identifier><part><date>2016</date><detail type="volume"><caption>vol.</caption><number>66</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>132</start><end>141</end><total>10</total></extent></part></relatedItem><relatedItem type="references" displayLabel="pin12385-cit-0001"><titleInfo><title>Expected and unexpected features of the newly discovered bat influenza A‐like viruses</title></titleInfo><name type="personal"><namePart type="given">W</namePart><namePart type="family">Ma</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Garcia‐Sastre</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Schwemmle</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ma W, Garcia‐Sastre A, Schwemmle M. Expected and unexpected features of the newly discovered bat influenza A‐like viruses. 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