Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine
Identifieur interne : 001398 ( Istex/Corpus ); précédent : 001397; suivant : 001399Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine
Auteurs : Fenghua Zhang ; Fang Fang ; Haiyan Chang ; Bo Peng ; Jian Wu ; Jianjun Chen ; Hanzhong Wang ; Ze ChenSource :
- Archives of Virology [ 0304-8608 ] ; 2013-06-01.
Abstract
Abstract: H5N1 influenza virus is one of the viruses that can potentially cause an influenza pandemic. Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. In this study, female mice were immunized with H5N1 HA DNA vaccine or inactivated whole-virion vaccine, and the protection provided by maternal antibodies in their offspring against a lethal homologous influenza virus challenge was compared. The results showed that maternal antibodies, whether induced by a DNA vaccine or an inactivated vaccine, could completely protect offspring aged 1-4 weeks from a lethal influenza virus challenge. Breast-feeding was the major route of transfer for maternal antibodies. Milk-derived antibodies were able to effectively protect the offspring aged 1-4 weeks from lethal influenza virus infection, whereas maternal antibodies transferred through the placenta only partially protected the offspring 1-2 weeks of age. The milk- and placenta-transferred IgG2a antibody levels in offspring from their mothers, whether vaccinated with DNA vaccine or inactivated vaccine, were higher than the IgG1 levels. Our results indicated that maternal vaccination with HA DNA, as well as with whole-virion inactivated vaccine, could offer effective protection to offspring against H5N1 influenza virus infection.
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DOI: 10.1007/s00705-013-1621-y
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sort="Fang, Fang" uniqKey="Fang F" first="Fang" last="Fang">Fang Fang</name><affiliation><mods:affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: fangfangc@263.net</mods:affiliation></affiliation></author><author><name sortKey="Chang, Haiyan" sort="Chang, Haiyan" uniqKey="Chang H" first="Haiyan" last="Chang">Haiyan Chang</name><affiliation><mods:affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</mods:affiliation></affiliation></author><author><name sortKey="Peng, Bo" sort="Peng, Bo" uniqKey="Peng B" first="Bo" last="Peng">Bo Peng</name><affiliation><mods:affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</mods:affiliation></affiliation></author><author><name sortKey="Wu, Jian" sort="Wu, Jian" uniqKey="Wu J" first="Jian" last="Wu">Jian Wu</name><affiliation><mods:affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</mods:affiliation></affiliation></author><author><name sortKey="Chen, Jianjun" sort="Chen, Jianjun" uniqKey="Chen J" first="Jianjun" last="Chen">Jianjun Chen</name><affiliation><mods:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China</mods:affiliation></affiliation></author><author><name sortKey="Wang, Hanzhong" sort="Wang, Hanzhong" uniqKey="Wang H" first="Hanzhong" last="Wang">Hanzhong Wang</name><affiliation><mods:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China</mods:affiliation></affiliation></author><author><name sortKey="Chen, Ze" sort="Chen, Ze" uniqKey="Chen Z" first="Ze" last="Chen">Ze Chen</name><affiliation><mods:affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</mods:affiliation></affiliation><affiliation><mods:affiliation>Shanghai Institute of Biological Products, 200052, Shanghai, China</mods:affiliation></affiliation><affiliation><mods:affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: chenze2005@hotmail.com</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="sub">Official Journal of the Virology Division of the International Union of Microbiological Societies</title><title level="j" type="abbrev">Arch Virol</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer Vienna</publisher><pubPlace>Vienna</pubPlace><date type="published" when="2013-06-01">2013-06-01</date><biblScope unit="volume">158</biblScope><biblScope unit="issue">6</biblScope><biblScope 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Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. In this study, female mice were immunized with H5N1 HA DNA vaccine or inactivated whole-virion vaccine, and the protection provided by maternal antibodies in their offspring against a lethal homologous influenza virus challenge was compared. The results showed that maternal antibodies, whether induced by a DNA vaccine or an inactivated vaccine, could completely protect offspring aged 1-4 weeks from a lethal influenza virus challenge. Breast-feeding was the major route of transfer for maternal antibodies. Milk-derived antibodies were able to effectively protect the offspring aged 1-4 weeks from lethal influenza virus infection, whereas maternal antibodies transferred through the placenta only partially protected the offspring 1-2 weeks of age. The milk- and placenta-transferred IgG2a antibody levels in offspring from their mothers, whether vaccinated with DNA vaccine or inactivated vaccine, were higher than the IgG1 levels. Our results indicated that maternal vaccination with HA DNA, as well as with whole-virion inactivated vaccine, could offer effective protection to offspring against H5N1 influenza virus infection.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Fenghua Zhang</name><affiliations><json:string>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</json:string></affiliations></json:item><json:item><name>Fang Fang</name><affiliations><json:string>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</json:string><json:string>E-mail: fangfangc@263.net</json:string></affiliations></json:item><json:item><name>Haiyan Chang</name><affiliations><json:string>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</json:string></affiliations></json:item><json:item><name>Bo Peng</name><affiliations><json:string>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</json:string></affiliations></json:item><json:item><name>Jian Wu</name><affiliations><json:string>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</json:string></affiliations></json:item><json:item><name>Jianjun Chen</name><affiliations><json:string>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China</json:string></affiliations></json:item><json:item><name>Hanzhong Wang</name><affiliations><json:string>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China</json:string></affiliations></json:item><json:item><name>Ze Chen</name><affiliations><json:string>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</json:string><json:string>Shanghai Institute of Biological Products, 200052, Shanghai, China</json:string><json:string>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China</json:string><json:string>E-mail: chenze2005@hotmail.com</json:string></affiliations></json:item></author><articleId><json:string>1621</json:string><json:string>s00705-013-1621-y</json:string></articleId><arkIstex>ark:/67375/VQC-0R92K25X-H</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: H5N1 influenza virus is one of the viruses that can potentially cause an influenza pandemic. Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. In this study, female mice were immunized with H5N1 HA DNA vaccine or inactivated whole-virion vaccine, and the protection provided by maternal antibodies in their offspring against a lethal homologous influenza virus challenge was compared. The results showed that maternal antibodies, whether induced by a DNA vaccine or an inactivated vaccine, could completely protect offspring aged 1-4 weeks from a lethal influenza virus challenge. Breast-feeding was the major route of transfer for maternal antibodies. Milk-derived antibodies were able to effectively protect the offspring aged 1-4 weeks from lethal influenza virus infection, whereas maternal antibodies transferred through the placenta only partially protected the offspring 1-2 weeks of age. The milk- and placenta-transferred IgG2a antibody levels in offspring from their mothers, whether vaccinated with DNA vaccine or inactivated vaccine, were higher than the IgG1 levels. Our results indicated that maternal vaccination with HA DNA, as well as with whole-virion inactivated vaccine, could offer effective protection to offspring against H5N1 influenza virus infection.</abstract><qualityIndicators><score>9.244</score><pdfWordCount>7778</pdfWordCount><pdfCharCount>47563</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>13</pdfPageCount><pdfPageSize>595.276 x 790.866 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>187</abstractWordCount><abstractCharCount>1349</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine</title><genre><json:string>research-article</json:string></genre><host><title>Archives of 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Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. In this study, female mice were immunized with H5N1 HA DNA vaccine or inactivated whole-virion vaccine, and the protection provided by maternal antibodies in their offspring against a lethal homologous influenza virus challenge was compared. The results showed that maternal antibodies, whether induced by a DNA vaccine or an inactivated vaccine, could completely protect offspring aged 1-4 weeks from a lethal influenza virus challenge. Breast-feeding was the major route of transfer for maternal antibodies. Milk-derived antibodies were able to effectively protect the offspring aged 1-4 weeks from lethal influenza virus infection, whereas maternal antibodies transferred through the placenta only partially protected the offspring 1-2 weeks of age. The milk- and placenta-transferred IgG2a antibody levels in offspring from their mothers, whether vaccinated with DNA vaccine or inactivated vaccine, were higher than the IgG1 levels. Our results indicated that maternal vaccination with HA DNA, as well as with whole-virion inactivated vaccine, could offer effective protection to offspring against H5N1 influenza virus infection.</p></abstract><textClass><keywords scheme="Journal-Subject-Collection"><list><label>SC3</label><item><term>Biomedical and Life Sciences</term></item></list></keywords></textClass><textClass><keywords scheme="Journal-Subject-Group"><list><label>SCB</label><item><term>Biomedicine</term></item><label>SCB22003</label><item><term>Virology</term></item><label>SCB16003</label><item><term>Medical Microbiology</term></item><label>SCH33096</label><item><term>Infectious Diseases</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2012-08-06">Created</change><change 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TocLevels="0"><ArticleID>1621</ArticleID><ArticleDOI>10.1007/s00705-013-1621-y</ArticleDOI><ArticleSequenceNumber>14</ArticleSequenceNumber><ArticleTitle Language="En" OutputMedium="All">Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine</ArticleTitle><ArticleCategory>Original Article</ArticleCategory><ArticleFirstPage>1253</ArticleFirstPage><ArticleLastPage>1265</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2013</Year><Month>1</Month><Day>22</Day></RegistrationDate><Received><Year>2012</Year><Month>8</Month><Day>6</Day></Received><Accepted><Year>2012</Year><Month>12</Month><Day>17</Day></Accepted><OnlineDate><Year>2013</Year><Month>2</Month><Day>6</Day></OnlineDate></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag Wien</CopyrightHolderName><CopyrightYear>2013</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Fenghua</GivenName><FamilyName>Zhang</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Fang</GivenName><FamilyName>Fang</FamilyName></AuthorName><Contact><Email>fangfangc@263.net</Email></Contact></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Haiyan</GivenName><FamilyName>Chang</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Bo</GivenName><FamilyName>Peng</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Jian</GivenName><FamilyName>Wu</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Jianjun</GivenName><FamilyName>Chen</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>Hanzhong</GivenName><FamilyName>Wang</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1 Aff2 Aff3" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Ze</GivenName><FamilyName>Chen</FamilyName></AuthorName><Contact><Phone>+86-731-88872781</Phone><Email>chenze2005@hotmail.com</Email></Contact></Author><Affiliation ID="Aff1"><OrgDivision>College of Life Sciences</OrgDivision><OrgName>Hunan Normal University</OrgName><OrgAddress><City>Changsha</City><Postcode>410081</Postcode><State>Hunan</State><Country Code="CN">China</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Shanghai Institute of Biological Products</OrgName><OrgAddress><City>Shanghai</City><Postcode>200052</Postcode><Country Code="CN">China</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>State Key Laboratory of Virology, Wuhan Institute of Virology</OrgDivision><OrgName>Chinese Academy of Sciences</OrgName><OrgAddress><City>Wuhan</City><Postcode>430071</Postcode><Country Code="CN">China</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para>H5N1 influenza virus is one of the viruses that can potentially cause an influenza pandemic. Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. In this study, female mice were immunized with H5N1 HA DNA vaccine or inactivated whole-virion vaccine, and the protection provided by maternal antibodies in their offspring against a lethal homologous influenza virus challenge was compared. The results showed that maternal antibodies, whether induced by a DNA vaccine or an inactivated vaccine, could completely protect offspring aged 1-4 weeks from a lethal influenza virus challenge. Breast-feeding was the major route of transfer for maternal antibodies. Milk-derived antibodies were able to effectively protect the offspring aged 1-4 weeks from lethal influenza virus infection, whereas maternal antibodies transferred through the placenta only partially protected the offspring 1-2 weeks of age. The milk- and placenta-transferred IgG2a antibody levels in offspring from their mothers, whether vaccinated with DNA vaccine or inactivated vaccine, were higher than the IgG1 levels. Our results indicated that maternal vaccination with HA DNA, as well as with whole-virion inactivated vaccine, could offer effective protection to offspring against H5N1 influenza virus infection.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine</title></titleInfo><name type="personal"><namePart type="given">Fenghua</namePart><namePart type="family">Zhang</namePart><affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Fang</namePart><namePart type="family">Fang</namePart><affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</affiliation><affiliation>E-mail: fangfangc@263.net</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Haiyan</namePart><namePart type="family">Chang</namePart><affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bo</namePart><namePart type="family">Peng</namePart><affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jian</namePart><namePart type="family">Wu</namePart><affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jianjun</namePart><namePart type="family">Chen</namePart><affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hanzhong</namePart><namePart type="family">Wang</namePart><affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Ze</namePart><namePart type="family">Chen</namePart><affiliation>College of Life Sciences, Hunan Normal University, 410081, Changsha, Hunan, China</affiliation><affiliation>Shanghai Institute of Biological Products, 200052, Shanghai, China</affiliation><affiliation>State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, China</affiliation><affiliation>E-mail: chenze2005@hotmail.com</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer Vienna</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateCreated encoding="w3cdtf">2012-08-06</dateCreated><dateIssued encoding="w3cdtf">2013-06-01</dateIssued><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: H5N1 influenza virus is one of the viruses that can potentially cause an influenza pandemic. Protection of newborns against influenza virus infection could be effectively provided by maternal immunization. In this study, female mice were immunized with H5N1 HA DNA vaccine or inactivated whole-virion vaccine, and the protection provided by maternal antibodies in their offspring against a lethal homologous influenza virus challenge was compared. The results showed that maternal antibodies, whether induced by a DNA vaccine or an inactivated vaccine, could completely protect offspring aged 1-4 weeks from a lethal influenza virus challenge. Breast-feeding was the major route of transfer for maternal antibodies. Milk-derived antibodies were able to effectively protect the offspring aged 1-4 weeks from lethal influenza virus infection, whereas maternal antibodies transferred through the placenta only partially protected the offspring 1-2 weeks of age. The milk- and placenta-transferred IgG2a antibody levels in offspring from their mothers, whether vaccinated with DNA vaccine or inactivated vaccine, were higher than the IgG1 levels. Our results indicated that maternal vaccination with HA DNA, as well as with whole-virion inactivated vaccine, could offer effective protection to offspring against H5N1 influenza virus infection.</abstract><note>Original Article</note><relatedItem type="host"><titleInfo><title>Archives of Virology</title><subTitle>Official Journal of the Virology Division of the International Union of Microbiological Societies</subTitle></titleInfo><titleInfo type="abbreviated"><title>Arch Virol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2013-05-31</dateIssued><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><subject><genre>Journal-Subject-Collection</genre><topic authority="SpringerSubjectCodes" authorityURI="SC3">Biomedical and Life Sciences</topic></subject><subject><genre>Journal-Subject-Group</genre><topic authority="SpringerSubjectCodes" authorityURI="SCB">Biomedicine</topic><topic authority="SpringerSubjectCodes" authorityURI="SCB22003">Virology</topic><topic authority="SpringerSubjectCodes" authorityURI="SCB16003">Medical Microbiology</topic><topic authority="SpringerSubjectCodes" authorityURI="SCH33096">Infectious Diseases</topic></subject><identifier type="ISSN">0304-8608</identifier><identifier type="eISSN">1432-8798</identifier><identifier type="JournalID">705</identifier><identifier type="IssueArticleCount">35</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2013</date><detail type="volume"><number>158</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="pages"><start>1253</start><end>1265</end></extent></part><recordInfo><recordOrigin>Springer-Verlag Wien, 2013</recordOrigin></recordInfo></relatedItem><identifier type="istex">2F3DF92E4A5F85D5B330FFAB26E5A7EC0DEC660B</identifier><identifier type="ark">ark:/67375/VQC-0R92K25X-H</identifier><identifier type="DOI">10.1007/s00705-013-1621-y</identifier><identifier type="ArticleID">1621</identifier><identifier type="ArticleID">s00705-013-1621-y</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag Wien, 2013</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag Wien, 2013</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-0R92K25X-H/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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