Heterologous immunity between viruses
Identifieur interne : 001326 ( Istex/Corpus ); précédent : 001325; suivant : 001327Heterologous immunity between viruses
Auteurs : Raymond M. Welsh ; Jenny W. Che ; Michael A. Brehm ; Liisa K. SelinSource :
- Immunological Reviews [ 0105-2896 ] ; 2010-05.
Url:
DOI: 10.1111/j.0105-2896.2010.00897.x
Links to Exploration step
ISTEX:AB44BAF2DE4D8B7A1A1B354A847ECA6C9A7DE552Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Heterologous immunity between viruses</title><author><name sortKey="Welsh, Raymond M" sort="Welsh, Raymond M" uniqKey="Welsh R" first="Raymond M." last="Welsh">Raymond M. Welsh</name><affiliation><mods:affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</mods:affiliation></affiliation></author><author><name sortKey="Che, Jenny W" sort="Che, Jenny W" uniqKey="Che J" first="Jenny W." last="Che">Jenny W. Che</name><affiliation><mods:affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</mods:affiliation></affiliation></author><author><name sortKey="Brehm, Michael A" sort="Brehm, Michael A" uniqKey="Brehm M" first="Michael A." last="Brehm">Michael A. Brehm</name><affiliation><mods:affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</mods:affiliation></affiliation></author><author><name sortKey="Selin, Liisa K" sort="Selin, Liisa K" uniqKey="Selin L" first="Liisa K." last="Selin">Liisa K. Selin</name><affiliation><mods:affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AB44BAF2DE4D8B7A1A1B354A847ECA6C9A7DE552</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.0105-2896.2010.00897.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-LBC859RT-P/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001326</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001326</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Heterologous immunity between viruses</title><author><name sortKey="Welsh, Raymond M" sort="Welsh, Raymond M" uniqKey="Welsh R" first="Raymond M." last="Welsh">Raymond M. Welsh</name><affiliation><mods:affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</mods:affiliation></affiliation></author><author><name sortKey="Che, Jenny W" sort="Che, Jenny W" uniqKey="Che J" first="Jenny W." last="Che">Jenny W. Che</name><affiliation><mods:affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</mods:affiliation></affiliation></author><author><name sortKey="Brehm, Michael A" sort="Brehm, Michael A" uniqKey="Brehm M" first="Michael A." last="Brehm">Michael A. Brehm</name><affiliation><mods:affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</mods:affiliation></affiliation></author><author><name sortKey="Selin, Liisa K" sort="Selin, Liisa K" uniqKey="Selin L" first="Liisa K." last="Selin">Liisa K. Selin</name><affiliation><mods:affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Immunological Reviews</title><title level="j" type="sub">Cytotoxic Cells</title><title level="j" type="alt">IMMUNOLOGICAL REVIEWS</title><idno type="ISSN">0105-2896</idno><idno type="eISSN">1600-065X</idno><imprint><biblScope unit="vol">235</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="244">244</biblScope><biblScope unit="page" to="266">266</biblScope><biblScope unit="page-count">23</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-05">2010-05</date></imprint><idno type="ISSN">0105-2896</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0105-2896</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>heterologous</json:string><json:string>epitope</json:string><json:string>heterologous immunity</json:string><json:string>lcmv</json:string><json:string>viral</json:string><json:string>immunol</json:string><json:string>immune</json:string><json:string>pathogen</json:string><json:string>dengue</json:string><json:string>ifnc</json:string><json:string>cytokine</json:string><json:string>immunological</json:string><json:string>selin</json:string><json:string>peptide</json:string><json:string>viral infection</json:string><json:string>private specificity</json:string><json:string>cytotoxic</json:string><json:string>protective immunity</json:string><json:string>allospecific</json:string><json:string>mcmv</json:string><json:string>receptor</json:string><json:string>clone</json:string><json:string>memory cell</json:string><json:string>virol</json:string><json:string>lymphocyte</json:string><json:string>immunodominance</json:string><json:string>immunopathology</json:string><json:string>pmhc</json:string><json:string>amino acid</json:string><json:string>allogeneic</json:string><json:string>amino</json:string><json:string>repertoire</json:string><json:string>immunity</json:string><json:string>lymphocytic</json:string><json:string>vaccinia</json:string><json:string>memory pool</json:string><json:string>john wiley son immunological review welsh</json:string><json:string>brehm</json:string><json:string>naive mouse</json:string><json:string>infection</json:string><json:string>immunodominant</json:string><json:string>choriomeningitis</json:string><json:string>immune response</json:string><json:string>apoptosis</json:string><json:string>autoimmunity</json:string><json:string>immunologically</json:string><json:string>antiviral</json:string><json:string>encode</json:string><json:string>splenocytes</json:string><json:string>subset</json:string><json:string>virus infection</json:string><json:string>cdr3</json:string><json:string>clin</json:string><json:string>john wiley son immunological review</json:string><json:string>crossreactive</json:string><json:string>oligoclonal</json:string><json:string>mouse</json:string><json:string>welsh</json:string><json:string>vaccine</json:string><json:string>autoimmune</json:string><json:string>cornberg</json:string><json:string>lymphocytic choriomeningitis virus</json:string><json:string>balb</json:string><json:string>interferon</json:string><json:string>cfse</json:string><json:string>allograft</json:string><json:string>transplantation</json:string><json:string>macrophage</json:string><json:string>virus</json:string><json:string>heterologous virus</json:string><json:string>unpublished datum</json:string><json:string>cell specific</json:string><json:string>lcmv infection</json:string><json:string>immune mouse</json:string><json:string>bystander</json:string><json:string>datum</json:string><json:string>immunologically naive mouse</json:string><json:string>ifnc production</json:string><json:string>mouse model</json:string><json:string>pmhc complex</json:string><json:string>high level</json:string><json:string>vaccinia virus</json:string><json:string>heterologous viral infection</json:string><json:string>high frequency</json:string><json:string>immunodominant epitope</json:string><json:string>immunization</json:string><json:string>assay</json:string><json:string>persistent viral infection</json:string><json:string>viral epitope</json:string><json:string>dramatic variation</json:string><json:string>viral variant</json:string><json:string>memory population</json:string><json:string>lcmv mcmv</json:string><json:string>second virus</json:string><json:string>cell population</json:string><json:string>cell response</json:string><json:string>bystander activation</json:string><json:string>immune pathology</json:string><json:string>cell repertoire</json:string><json:string>molecular mimicry</json:string><json:string>cognate ligand</json:string><json:string>influenza</json:string><json:string>ligand</json:string><json:string>matrix</json:string><json:string>more difficult</json:string><json:string>less dependent</json:string><json:string>lcmv epitope</json:string><json:string>peritoneal cavity</json:string><json:string>bacterial infection</json:string><json:string>other virus</json:string><json:string>world arenavirus</json:string><json:string>epidemiological study</json:string><json:string>young adult</json:string><json:string>dengue virus</json:string><json:string>identical individual</json:string><json:string>original antigenic</json:string><json:string>lcmv lcmv</json:string><json:string>virus table</json:string><json:string>unrelated virus</json:string><json:string>recipient mouse</json:string><json:string>naive cell</json:string><json:string>tolerization process</json:string><json:string>higher affinity</json:string><json:string>negative selection</json:string><json:string>immune system</json:string><json:string>high affinity</json:string><json:string>different virus</json:string><json:string>immunol today</json:string><json:string>viral disease</json:string><json:string>cell memory</json:string><json:string>lymphocyte response</json:string><json:string>proc natl acad</json:string><json:string>naive</json:string><json:string>cell</json:string></teeft></keywords><author><json:item><name>Raymond M. Welsh</name><affiliations><json:string>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</json:string></affiliations></json:item><json:item><name>Jenny W. Che</name><affiliations><json:string>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</json:string></affiliations></json:item><json:item><name>Michael A. Brehm</name><affiliations><json:string>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</json:string></affiliations></json:item><json:item><name>Liisa K. Selin</name><affiliations><json:string>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>heterologous immunity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cross‐reactive T cell</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>private specificity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>viral pathogenesis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>T‐cell memory</value></json:item></subject><articleId><json:string>IMR897</json:string></articleId><arkIstex>ark:/67375/WNG-LBC859RT-P</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>reviewArticle</json:string></originalGenre><qualityIndicators><score>7.012</score><pdfWordCount>16534</pdfWordCount><pdfCharCount>105620</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>23</pdfPageCount><pdfPageSize>595.276 x 782.362 pts</pdfPageSize><pdfWordsPerPage>719</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>true</refBibsNative><abstractWordCount>1</abstractWordCount><abstractCharCount>0</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Heterologous immunity between viruses</title><pmid><json:string>20536568</json:string></pmid><genre><json:string>review-article</json:string></genre><host><title>Immunological Reviews</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-065X</json:string></doi><issn><json:string>0105-2896</json:string></issn><eissn><json:string>1600-065X</json:string></eissn><publisherId><json:string>IMR</json:string></publisherId><volume>235</volume><issue>1</issue><pages><first>244</first><last>266</last><total>23</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2958</json:string><json:string>1015</json:string><json:string>1960s</json:string><json:string>1444</json:string><json:string>7000</json:string><json:string>2010</json:string></date><geogName></geogName><orgName><json:string>Welsh Department of Pathology University of Massachusetts Medical School</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>K.A. Daniels</json:string><json:string>K.K. Selin</json:string><json:string>Michael A. Brehm</json:string><json:string>Myriam Wlodarczyk</json:string><json:string>M. Wlodarczik</json:string><json:string>M. Wlodarczyk</json:string><json:string>John Wiley</json:string><json:string>Keith Daniels</json:string><json:string>S. Nie</json:string><json:string>Shalyn Clute</json:string><json:string>Levi Watkin</json:string><json:string>Jenny W. Che</json:string><json:string>L.K. Selin</json:string><json:string>A. Kraft</json:string><json:string>Of</json:string><json:string>K. Selin</json:string><json:string>Selin</json:string><json:string>K. A. Daniels</json:string><json:string>R.M. Welsh</json:string><json:string>M. A. Brehm</json:string><json:string>Markus Cornberg</json:string><json:string>R. M. Welsh</json:string><json:string>Selin Wlodarczyk</json:string><json:string>Raymond M. Welsh</json:string><json:string>Alex Chen</json:string><json:string>A. Chen</json:string><json:string>M.A. Brehm</json:string></persName><placeName><json:string>Seoul</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Welsh et al</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-LBC859RT-P</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - immunology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus></categories><publicationDate>2010</publicationDate><copyrightDate>2010</copyrightDate><doi><json:string>10.1111/j.0105-2896.2010.00897.x</json:string></doi><id>AB44BAF2DE4D8B7A1A1B354A847ECA6C9A7DE552</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LBC859RT-P/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LBC859RT-P/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-LBC859RT-P/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Heterologous immunity between viruses</title><title level="a" type="short">Heterologous immunity between viruses</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><licence>© 2010 John Wiley & Sons A/S</licence></availability><date type="published" when="2010-05"></date></publicationStmt><notesStmt><note type="content-type" subtype="review-article" source="reviewArticle" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="review-article"><analytic><title level="a" type="main">Heterologous immunity between viruses</title><title level="a" type="short">Heterologous immunity between viruses</title><author xml:id="author-0000"><persName><forename type="first">Raymond M.</forename><surname>Welsh</surname></persName><affiliation><orgName type="department">Department of Pathology</orgName><orgName type="institution">University of Massachusetts Medical School</orgName><address><addrLine>Worcester</addrLine><addrLine>MA, USA.</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Jenny W.</forename><surname>Che</surname></persName><affiliation><orgName type="department">Department of Pathology</orgName><orgName type="institution">University of Massachusetts Medical School</orgName><address><addrLine>Worcester</addrLine><addrLine>MA, USA.</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Michael A.</forename><surname>Brehm</surname></persName><affiliation><orgName type="department">Department of Pathology</orgName><orgName type="institution">University of Massachusetts Medical School</orgName><address><addrLine>Worcester</addrLine><addrLine>MA, USA.</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Liisa K.</forename><surname>Selin</surname></persName><affiliation><orgName type="department">Department of Pathology</orgName><orgName type="institution">University of Massachusetts Medical School</orgName><address><addrLine>Worcester</addrLine><addrLine>MA, USA.</addrLine><country key="US" xml:lang="en">UNITED STATES</country></address></affiliation></author><idno type="istex">AB44BAF2DE4D8B7A1A1B354A847ECA6C9A7DE552</idno><idno type="ark">ark:/67375/WNG-LBC859RT-P</idno><idno type="DOI">10.1111/j.0105-2896.2010.00897.x</idno><idno type="unit">IMR897</idno><idno type="toTypesetVersion">file:IMR.IMR897.pdf</idno></analytic><monogr><title level="j" type="main">Immunological Reviews</title><title level="j" type="sub">Cytotoxic Cells</title><title level="j" type="alt">IMMUNOLOGICAL REVIEWS</title><idno type="pISSN">0105-2896</idno><idno type="eISSN">1600-065X</idno><idno type="book-DOI">10.1111/(ISSN)1600-065X</idno><idno type="book-part-DOI">10.1111/imr.2010.235.issue-1</idno><idno type="product">IMR</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">235</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="244">244</biblScope><biblScope unit="page" to="266">266</biblScope><biblScope unit="page-count">23</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-05"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="bold">Summary: </hi> Immune memory responses to previously encountered pathogens can sometimes alter the immune response to and the course of infection of an unrelated pathogen by a process known as heterologous immunity. This response can lead to enhanced or diminished protective immunity and altered immunopathology. Here, we discuss the nature of T‐cell cross‐reactivity and describe matrices of epitopes from different viruses eliciting cross‐reactive CD8<hi rend="superscript">+</hi> T‐cell responses. We examine the parameters of heterologous immunity mediated by these cross‐reactive T cells during viral infections in mice and humans. We show that heterologous immunity can disrupt T‐cell memory pools, alter the complexity of the T‐cell repertoire, change patterns of T‐cell immunodominance, lead to the selection of viral epitope‐escape variants, alter the pathogenesis of viral infections, and, by virtue of the private specificity of T‐cell repertoires within individuals, contribute to dramatic variations in viral disease. We propose that heterologous immunity is an important factor in resistance to and variations of human viral infections and that issues of heterologous immunity should be considered in the design of vaccines.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1"><hi rend="italic">heterologous immunity</hi></term><term xml:id="k2"><hi rend="italic">cross‐reactive T cell</hi></term><term xml:id="k3"><hi rend="italic">private specificity</hi></term><term xml:id="k4"><hi rend="italic">viral pathogenesis</hi></term><term xml:id="k5"><hi rend="italic">T‐cell memory</hi></term></keywords><keywords rend="tocHeading1"><term>Review Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LBC859RT-P/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-065X</doi><issn type="print">0105-2896</issn><issn type="electronic">1600-065X</issn><idGroup><id type="product" value="IMR"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="IMMUNOLOGICAL REVIEWS">Immunological Reviews</title></titleGroup></publicationMeta><publicationMeta level="part" position="05001"><doi origin="wiley">10.1111/imr.2010.235.issue-1</doi><titleGroup><title type="specialIssueTitle">Cytotoxic Cells</title></titleGroup><numberingGroup><numbering type="journalVolume" number="235">235</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2010-05">May 2010</coverDate></publicationMeta><publicationMeta level="unit" type="reviewArticle" position="18" status="forIssue"><doi origin="wiley">10.1111/j.0105-2896.2010.00897.x</doi><idGroup><id type="unit" value="IMR897"></id></idGroup><countGroup><count type="pageTotal" number="23"></count></countGroup><titleGroup><title type="tocHeading1">Review Articles</title></titleGroup><copyright>© 2010 John Wiley & Sons A/S</copyright><eventGroup><event type="firstOnline" date="2010-04-28"></event><event type="publishedOnlineFinalForm" date="2010-04-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-04-29"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-13"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-24"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="244">244</numbering><numbering type="pageLast" number="266">266</numbering></numberingGroup><correspondenceTo><i>Raymond M. Welsh</i>
Department of Pathology
University of Massachusetts Medical School
55 Lake Ave North
Worcester, MA 01655, USA
Tel.: +1 508 856 5819
Fax: +1 508 856 0019
e‐mail: <email>raymond.welsh@umassmed.edu</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:IMR.IMR897.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="2"></count></countGroup><titleGroup><title type="main">Heterologous immunity between viruses</title><title type="shortAuthors">Welsh et al</title><title type="short">Heterologous immunity between viruses</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Raymond M.</givenNames><familyName>Welsh</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Jenny W.</givenNames><familyName>Che</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1" noteRef="#fn1"><personName><givenNames>Michael A.</givenNames><familyName>Brehm</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Liisa K.</givenNames><familyName>Selin</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="US"><unparsedAffiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1"><i>heterologous immunity</i></keyword><keyword xml:id="k2"><i>cross‐reactive T cell</i></keyword><keyword xml:id="k3"><i>private specificity</i></keyword><keyword xml:id="k4"><i>viral pathogenesis</i></keyword><keyword xml:id="k5"><i>T‐cell memory</i></keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Summary: </b> Immune memory responses to previously encountered pathogens can sometimes alter the immune response to and the course of infection of an unrelated pathogen by a process known as heterologous immunity. This response can lead to enhanced or diminished protective immunity and altered immunopathology. Here, we discuss the nature of T‐cell cross‐reactivity and describe matrices of epitopes from different viruses eliciting cross‐reactive CD8<sup>+</sup> T‐cell responses. We examine the parameters of heterologous immunity mediated by these cross‐reactive T cells during viral infections in mice and humans. We show that heterologous immunity can disrupt T‐cell memory pools, alter the complexity of the T‐cell repertoire, change patterns of T‐cell immunodominance, lead to the selection of viral epitope‐escape variants, alter the pathogenesis of viral infections, and, by virtue of the private specificity of T‐cell repertoires within individuals, contribute to dramatic variations in viral disease. We propose that heterologous immunity is an important factor in resistance to and variations of human viral infections and that issues of heterologous immunity should be considered in the design of vaccines.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><label>*</label><p>
Present address: Department of Medicine, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA, USA.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Heterologous immunity between viruses</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Heterologous immunity between viruses</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Heterologous immunity between viruses</title></titleInfo><name type="personal"><namePart type="given">Raymond M.</namePart><namePart type="family">Welsh</namePart><affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jenny W.</namePart><namePart type="family">Che</namePart><affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael A.</namePart><namePart type="family">Brehm</namePart><affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</affiliation><description>Present address: Department of Medicine, Immunology and Virology Program, University of Massachusetts Medical School, Worcester, MA, USA.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Liisa K.</namePart><namePart type="family">Selin</namePart><affiliation>Department of Pathology, University of Massachusetts Medical School, Worcester, MA, USA.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-05</dateIssued><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">5</extent><extent unit="tables">2</extent></physicalDescription>Summary: Immune memory responses to previously encountered pathogens can sometimes alter the immune response to and the course of infection of an unrelated pathogen by a process known as heterologous immunity. This response can lead to enhanced or diminished protective immunity and altered immunopathology. Here, we discuss the nature of T‐cell cross‐reactivity and describe matrices of epitopes from different viruses eliciting cross‐reactive CD8+ T‐cell responses. We examine the parameters of heterologous immunity mediated by these cross‐reactive T cells during viral infections in mice and humans. We show that heterologous immunity can disrupt T‐cell memory pools, alter the complexity of the T‐cell repertoire, change patterns of T‐cell immunodominance, lead to the selection of viral epitope‐escape variants, alter the pathogenesis of viral infections, and, by virtue of the private specificity of T‐cell repertoires within individuals, contribute to dramatic variations in viral disease. We propose that heterologous immunity is an important factor in resistance to and variations of human viral infections and that issues of heterologous immunity should be considered in the design of vaccines.<subject lang="en"><genre>keywords</genre><topic>heterologous immunity</topic><topic>cross‐reactive T cell</topic><topic>private specificity</topic><topic>viral pathogenesis</topic><topic>T‐cell memory</topic></subject><relatedItem type="host"><titleInfo><title>Immunological Reviews</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0105-2896</identifier><identifier type="eISSN">1600-065X</identifier><identifier type="DOI">10.1111/(ISSN)1600-065X</identifier><identifier type="PublisherID">IMR</identifier><part><date>2010</date><detail type="title"><title>Cytotoxic Cells</title></detail><detail type="volume"><caption>vol.</caption><number>235</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>244</start><end>266</end><total>23</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Heterologous immunity revisited</title></titleInfo><name type="personal"><namePart type="given">IA</namePart><namePart type="family">Clark</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Clark IA. Heterologous immunity revisited. Parasitology 2001;122(Suppl):S51–S59.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><detail type="issue"><caption>no.</caption><number>Suppl</number></detail><extent unit="pages"><start>S51</start><end>S59</end></extent></part><relatedItem type="host"><titleInfo><title>Parasitology</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>122</number></detail><detail type="issue"><caption>no.</caption><number>Suppl</number></detail><extent unit="pages"><start>S51</start><end>S59</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations</title></titleInfo><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Varga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IC</namePart><namePart type="family">Wong</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Selin LK, Varga SM, Wong IC, Welsh RM. Protective heterologous antiviral immunity and enhanced immunopathogenesis mediated by memory T cell populations. J Exp Med 1998;188:1705–1715.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>188</number></detail><extent unit="pages"><start>1705</start><end>1715</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>188</number></detail><extent unit="pages"><start>1705</start><end>1715</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>No one is naive: the significance of heterologous T‐cell immunity</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Welsh RM, Selin LK. No one is naive: the significance of heterologous T‐cell immunity. Nat Rev Immunol 2002;2:417–426.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>417</start><end>426</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Rev Immunol</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>417</start><end>426</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>CD4 T‐cell‐mediated heterologous immunity between mycobacteria and poxviruses</title></titleInfo><name type="personal"><namePart type="given">KS</namePart><namePart type="family">Mathurin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GW</namePart><namePart type="family">Martens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Kornfeld</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mathurin KS, Martens GW, Kornfeld H, Welsh RM. CD4 T‐cell‐mediated heterologous immunity between mycobacteria and poxviruses. J Virol 2009;83:3528–3539.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>3528</start><end>3539</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>3528</start><end>3539</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>The immunological basis of acquired cellular resistance</title></titleInfo><name type="personal"><namePart type="given">GB</namePart><namePart type="family">Mackaness</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mackaness GB. The immunological basis of acquired cellular resistance. J Exp Med 1964;120:105–120.</note><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>120</number></detail><extent unit="pages"><start>105</start><end>120</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1964</date><detail type="volume"><caption>vol.</caption><number>120</number></detail><extent unit="pages"><start>105</start><end>120</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>Specific history of heterologous virus infections determines antiviral immunity and immunopathology in the lung</title></titleInfo><name type="personal"><namePart type="given">HD</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AE</namePart><namePart type="family">Fraire</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Joris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen HD, Fraire AE, Joris I, Welsh RM, Selin LK. Specific history of heterologous virus infections determines antiviral immunity and immunopathology in the lung. Am J Pathol 2003;163:1341–1355.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>163</number></detail><extent unit="pages"><start>1341</start><end>1355</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Pathol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>163</number></detail><extent unit="pages"><start>1341</start><end>1355</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Influenza virus lung infection protects from respiratory syncitial virus‐induced immunopathology</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Walzl</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Tafuro</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Moss</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PJ</namePart><namePart type="family">Openshaw</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Hussell</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Walzl G, Tafuro S, Moss P, Openshaw PJ, Hussell T. Influenza virus lung infection protects from respiratory syncitial virus‐induced immunopathology. J Exp Med 2000;192:1317–1326.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>192</number></detail><extent unit="pages"><start>1317</start><end>1326</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>192</number></detail><extent unit="pages"><start>1317</start><end>1326</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Non‐specific beneficial effect of measles immunisation:analysis of mortality studies from developing countries</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Aaby</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Samb</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Simondon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Seck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Knudsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Whittle</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Aaby P, Samb B, Simondon F, Seck AM, Knudsen K, Whittle H. Non‐specific beneficial effect of measles immunisation:analysis of mortality studies from developing countries. Brit Med J 1995;311:481–485.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>311</number></detail><extent unit="pages"><start>481</start><end>485</end></extent></part><relatedItem type="host"><titleInfo><title>Brit Med J</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>311</number></detail><extent unit="pages"><start>481</start><end>485</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Routine vaccinations and child survival: follow up study in Guinea‐Bissau, West Africa</title></titleInfo><name type="personal"><namePart type="given">I</namePart><namePart type="family">Kristensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Aaby</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kristensen I, Aaby P, Jensen H. Routine vaccinations and child survival: follow up study in Guinea‐Bissau, West Africa. Brit Med J 2000;321:1435–1438.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>321</number></detail><extent unit="pages"><start>1435</start><end>1438</end></extent></part><relatedItem type="host"><titleInfo><title>Brit Med J</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>321</number></detail><extent unit="pages"><start>1435</start><end>1438</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>BCG vaccination scar associated with better childhood survival in Guinea‐Bissau</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Roth</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Roth A, et al. BCG vaccination scar associated with better childhood survival in Guinea‐Bissau. Int J Epidemiol 2005;34:540–547.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>540</start><end>547</end></extent></part><relatedItem type="host"><titleInfo><title>Int J Epidemiol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>34</number></detail><extent unit="pages"><start>540</start><end>547</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Beneficial non‐targeted effects of BCG – ethical implications for the coming introduction of new TB vaccines</title></titleInfo><name type="personal"><namePart type="given">AE</namePart><namePart type="family">Roth</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LG</namePart><namePart type="family">Stensballe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">Garly</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Aaby</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Roth AE, Stensballe LG, Garly ML, Aaby P. Beneficial non‐targeted effects of BCG – ethical implications for the coming introduction of new TB vaccines. Tuberculosis 2006;86:397–403.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>86</number></detail><extent unit="pages"><start>397</start><end>403</end></extent></part><relatedItem type="host"><titleInfo><title>Tuberculosis</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>86</number></detail><extent unit="pages"><start>397</start><end>403</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Private specificities of CD8 T cell responses control patterns of heterologous immunity</title></titleInfo><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Cornberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">XZ</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HD</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kim SK, Cornberg M, Wang XZ, Chen HD, Selin LK, Welsh RM. Private specificities of CD8 T cell responses control patterns of heterologous immunity. J Exp Med 2005;201:523–533.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>201</number></detail><extent unit="pages"><start>523</start><end>533</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>201</number></detail><extent unit="pages"><start>523</start><end>533</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Herpesvirus latency confers symbiotic protection from bacterial infection</title></titleInfo><name type="personal"><namePart type="given">ES</namePart><namePart type="family">Barton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Barton ES, et al. Herpesvirus latency confers symbiotic protection from bacterial infection. Nature 2007;447:326–329.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>447</number></detail><extent unit="pages"><start>326</start><end>329</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>447</number></detail><extent unit="pages"><start>326</start><end>329</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Elevated natural killer cell‐mediated cytotoxicity, plasma interferon, and tumor cell rejection in mice persistently infected with lymphocytic choriomeningitis virus</title></titleInfo><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Bukowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CA</namePart><namePart type="family">Biron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bukowski JF, Biron CA, Welsh RM. Elevated natural killer cell‐mediated cytotoxicity, plasma interferon, and tumor cell rejection in mice persistently infected with lymphocytic choriomeningitis virus. J Immunol 1983;131:991–996.</note><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>131</number></detail><extent unit="pages"><start>991</start><end>996</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>131</number></detail><extent unit="pages"><start>991</start><end>996</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Bystander activation of CD8+ T lymphocytes during experimental mycobacterial infection</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Gilbertson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Germano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Steele</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Turner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GB</namePart><namePart type="family">Fazekas de St</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Cheers</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gilbertson B, Germano S, Steele P, Turner S, Fazekas de St GB, Cheers C. Bystander activation of CD8+ T lymphocytes during experimental mycobacterial infection. Infect Immun 2004;72:6884–6891.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>6884</start><end>6891</end></extent></part><relatedItem type="host"><titleInfo><title>Infect Immun</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>6884</start><end>6891</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Activation of virus‐specific CD8+ T cells by lipopolysaccharide‐induced IL‐12 and IL‐18</title></titleInfo><name type="personal"><namePart type="given">HP</namePart><namePart type="family">Raue</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Brien</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Hammarlund</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MK</namePart><namePart type="family">Slifka</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Raue HP, Brien JD, Hammarlund E, Slifka MK. Activation of virus‐specific CD8+ T cells by lipopolysaccharide‐induced IL‐12 and IL‐18. J Immunol 2004;173:6873–6881.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>173</number></detail><extent unit="pages"><start>6873</start><end>6881</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>173</number></detail><extent unit="pages"><start>6873</start><end>6881</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Enhanced susceptibility to cytotoxic T lymphocytes of target cells isolated from virus‐infected or interferon‐treated mice</title></titleInfo><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Bukowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bukowski JF, Welsh RM. Enhanced susceptibility to cytotoxic T lymphocytes of target cells isolated from virus‐infected or interferon‐treated mice. J Virol 1986;59:735–739.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><extent unit="pages"><start>735</start><end>739</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>59</number></detail><extent unit="pages"><start>735</start><end>739</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Specificity and degeneracy of T cells</title></titleInfo><name type="personal"><namePart type="given">DB</namePart><namePart type="family">Wilson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wilson DB, et al. Specificity and degeneracy of T cells. Mol Immunol 2004;40:1047–1055.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>1047</start><end>1055</end></extent></part><relatedItem type="host"><titleInfo><title>Mol Immunol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>40</number></detail><extent unit="pages"><start>1047</start><end>1055</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Polyspecificity of T cell and B cell receptor recognition</title></titleInfo><name type="personal"><namePart type="given">KW</namePart><namePart type="family">Wucherpfennig</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wucherpfennig KW, et al. Polyspecificity of T cell and B cell receptor recognition. Semin Immunol 2007;19:216–224.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>216</start><end>224</end></extent></part><relatedItem type="host"><titleInfo><title>Semin Immunol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>216</start><end>224</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>A very high level of crossreactivity is an essential feature of the T cell repertoire</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Mason</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mason D. A very high level of crossreactivity is an essential feature of the T cell repertoire. Immunol Today 1998;19:395–404.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>395</start><end>404</end></extent></part><relatedItem type="host"><titleInfo><title>Immunol Today</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>395</start><end>404</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Casrouge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Beaudoing</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Dalle</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Pannetier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Kanellopoulos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Kourilsky</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Casrouge A, Beaudoing E, Dalle S, Pannetier C, Kanellopoulos J, Kourilsky P. Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes. J Immunol 2000;164:5782–5787.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>164</number></detail><extent unit="pages"><start>5782</start><end>5787</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>164</number></detail><extent unit="pages"><start>5782</start><end>5787</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>The many important facets of T‐cell repertoire diversity</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Nikolich‐Zugich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MK</namePart><namePart type="family">Slifka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Messaoudi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nikolich‐Zugich J, Slifka MK, Messaoudi I. The many important facets of T‐cell repertoire diversity. Nat Rev Immunol 2004;4:123–132.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>123</start><end>132</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Rev Immunol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>123</start><end>132</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>A direct estimate of the human alphabeta T cell receptor diversity</title></titleInfo><name type="personal"><namePart type="given">TP</namePart><namePart type="family">Arstila</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Casrouge</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V</namePart><namePart type="family">Baron</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Even</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Kanellopoulos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Kourilsky</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Arstila TP, Casrouge A, Baron V, Even J, Kanellopoulos J, Kourilsky P. A direct estimate of the human alphabeta T cell receptor diversity. Science 1999;286:958–961.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>286</number></detail><extent unit="pages"><start>958</start><end>961</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>286</number></detail><extent unit="pages"><start>958</start><end>961</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Crossreactivity of the T‐cell receptor</title></titleInfo><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Borghans</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RJ</namePart><namePart type="family">De Boer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Borghans JA, De Boer RJ. Crossreactivity of the T‐cell receptor. Immunol Today 1998;19:428–429.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>428</start><end>429</end></extent></part><relatedItem type="host"><titleInfo><title>Immunol Today</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>428</start><end>429</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>The repertoire of T cells shaped by a single MHC/peptide ligand</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Ignatowicz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Kappler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Marrack</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ignatowicz L, Kappler J, Marrack P. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell 1996;84:521–529.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>521</start><end>529</end></extent></part><relatedItem type="host"><titleInfo><title>Cell</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>84</number></detail><extent unit="pages"><start>521</start><end>529</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Virus‐specific CD8+ T‐cell responses in mice transgenic for a T‐cell receptor beta chain selected at random</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Ewing</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ewing C, et al. Virus‐specific CD8+ T‐cell responses in mice transgenic for a T‐cell receptor beta chain selected at random. J Virol 1994;68:3065–3070.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>3065</start><end>3070</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>68</number></detail><extent unit="pages"><start>3065</start><end>3070</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Minimal bystander activation of CD8 T cells during the virus‐induced polyclonal T cell response</title></titleInfo><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Zarozinski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Zarozinski CC, Welsh RM. Minimal bystander activation of CD8 T cells during the virus‐induced polyclonal T cell response. J Exp Med 1997;185:1629–1639.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>185</number></detail><extent unit="pages"><start>1629</start><end>1639</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>185</number></detail><extent unit="pages"><start>1629</start><end>1639</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>Probing degeneracy in T‐cell recognition using peptide combinatorial libraries</title></titleInfo><name type="personal"><namePart type="given">B</namePart><namePart type="family">Hemmer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Vergelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Pinilla</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Houghten</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Martin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hemmer B, Vergelli M, Pinilla C, Houghten R, Martin R. Probing degeneracy in T‐cell recognition using peptide combinatorial libraries. Immunol Today 1998;19:163–168.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>163</start><end>168</end></extent></part><relatedItem type="host"><titleInfo><title>Immunol Today</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>163</start><end>168</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit29"><titleInfo><title>Amino acid similarity accounts for T cell cross‐reactivity and for “holes” in the T cell repertoire</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Frankild</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RJ</namePart><namePart type="family">De Boer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O</namePart><namePart type="family">Lund</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Nielsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Kesmir</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Frankild S, De Boer RJ, Lund O, Nielsen M, Kesmir C. Amino acid similarity accounts for T cell cross‐reactivity and for “holes” in the T cell repertoire. PLoS ONE 2008;3:e1831.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>e1831</start></extent></part><relatedItem type="host"><titleInfo><title>PLoS ONE</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>e1831</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit30"><titleInfo><title>T cell cross‐reactivity and conformational changes during TCR engagement</title></titleInfo><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lee JK, et al. T cell cross‐reactivity and conformational changes during TCR engagement. J Exp Med 2004;200:1455–1466.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>200</number></detail><extent unit="pages"><start>1455</start><end>1466</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>200</number></detail><extent unit="pages"><start>1455</start><end>1466</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit31"><titleInfo><title>A consensus epitope prediction approach identifies the breadth of murine T(CD8+)‐cell responses to vaccinia virus</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Moutaftsi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Moutaftsi M, et al. A consensus epitope prediction approach identifies the breadth of murine T(CD8+)‐cell responses to vaccinia virus. Nat Biotechnol 2006;24:817–819.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>817</start><end>819</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Biotechnol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>817</start><end>819</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit32"><titleInfo><title>Vaccinia virus‐specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Moutaftsi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Moutaftsi M, et al. Vaccinia virus‐specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses. J Immunol 2007;178:6814–6820.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>178</number></detail><extent unit="pages"><start>6814</start><end>6820</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>178</number></detail><extent unit="pages"><start>6814</start><end>6820</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit33"><titleInfo><title>Very diverse CD8 T cell clonotypic responses after virus infections</title></titleInfo><name type="personal"><namePart type="given">LL</namePart><namePart type="family">Pewe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Netland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SB</namePart><namePart type="family">Heard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Perlman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pewe LL, Netland JM, Heard SB, Perlman S. Very diverse CD8 T cell clonotypic responses after virus infections. J Immunol 2004;172:3151–3156.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>3151</start><end>3156</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>3151</start><end>3156</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit34"><titleInfo><title>Resting memory CD8+ T cells are hyperactive to antigenic challenge in vitro</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Pihlgren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Dubois</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Tomkowiak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Sjogren</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Marvel</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pihlgren M, Dubois PM, Tomkowiak M, Sjogren T, Marvel J. Resting memory CD8+ T cells are hyperactive to antigenic challenge in vitro. J Exp Med 1996;184:2141–2151.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>184</number></detail><extent unit="pages"><start>2141</start><end>2151</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>184</number></detail><extent unit="pages"><start>2141</start><end>2151</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit35"><titleInfo><title>Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR</title></titleInfo><name type="personal"><namePart type="given">MK</namePart><namePart type="family">Slifka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Whitton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Slifka MK, Whitton JL. Functional avidity maturation of CD8(+) T cells without selection of higher affinity TCR. Nat Immunol 2001;2:711–717.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>711</start><end>717</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Immunol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>711</start><end>717</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit36"><titleInfo><title>CD8+ memory T cells (CD44high, Ly‐6C+) are more sensitive than naive cells (CD44low,Ly6C‐) to TCR/CD8 signaling in response to antigen</title></titleInfo><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Curtsinger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Lins</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MF</namePart><namePart type="family">Mescher</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Curtsinger JM, Lins DC, Mescher MF. CD8+ memory T cells (CD44high, Ly‐6C+) are more sensitive than naive cells (CD44low,Ly6C‐) to TCR/CD8 signaling in response to antigen. J Immunol 1998;160:3236–3243.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>160</number></detail><extent unit="pages"><start>3236</start><end>3243</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>160</number></detail><extent unit="pages"><start>3236</start><end>3243</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit37"><titleInfo><title>Two‐step binding mechanism for T‐cell receptor recognition of peptide MHC</title></titleInfo><name type="personal"><namePart type="given">LC</namePart><namePart type="family">Wu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DS</namePart><namePart type="family">Tuot</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DS</namePart><namePart type="family">Lyons</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KC</namePart><namePart type="family">Garcia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MM</namePart><namePart type="family">Davis</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wu LC, Tuot DS, Lyons DS, Garcia KC, Davis MM. Two‐step binding mechanism for T‐cell receptor recognition of peptide MHC. Nature 2002;418:552–556.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>418</number></detail><extent unit="pages"><start>552</start><end>556</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>418</number></detail><extent unit="pages"><start>552</start><end>556</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit38"><titleInfo><title>Multiple glycines in TCR alpha‐chains determine clonally diverse nature of human T cell memory to influenza A virus</title></titleInfo><name type="personal"><namePart type="given">YN</namePart><namePart type="family">Naumov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EN</namePart><namePart type="family">Naumova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MB</namePart><namePart type="family">Yassai</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kota</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Naumov YN, Naumova EN, Yassai MB, Kota K, Welsh RM, Selin LK. Multiple glycines in TCR alpha‐chains determine clonally diverse nature of human T cell memory to influenza A virus. J Immunol 2008;181:7407–7419.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>181</number></detail><extent unit="pages"><start>7407</start><end>7419</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>181</number></detail><extent unit="pages"><start>7407</start><end>7419</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit39"><titleInfo><title>Lack of prominent peptide‐major histocompatibility complex features limits repertoire diversity in virus‐specific CD8+ T cell populations</title></titleInfo><name type="personal"><namePart type="given">SJ</namePart><namePart type="family">Turner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Turner SJ, et al. Lack of prominent peptide‐major histocompatibility complex features limits repertoire diversity in virus‐specific CD8+ T cell populations. Nat Immunol 2005;6:382–389.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>382</start><end>389</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Immunol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>382</start><end>389</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit40"><titleInfo><title>Influenza basic polymerase 2 peptides are recognized by influenza nucleoprotein‐specific cytotoxic T lymphocytes</title></titleInfo><name type="personal"><namePart type="given">RW</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Bennick</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JW</namePart><namePart type="family">Yewdell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WL</namePart><namePart type="family">Maloy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Coligan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Anderson RW, Bennick JR, Yewdell JW, Maloy WL, Coligan JE. Influenza basic polymerase 2 peptides are recognized by influenza nucleoprotein‐specific cytotoxic T lymphocytes. Mol Immunol 1992;29:1089–1096.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>1089</start><end>1096</end></extent></part><relatedItem type="host"><titleInfo><title>Mol Immunol</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>29</number></detail><extent unit="pages"><start>1089</start><end>1096</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit41"><titleInfo><title>Immunological memory to viral infections</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Szomolanyi‐Tsuda</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Welsh RM, Selin LK, Szomolanyi‐Tsuda E. Immunological memory to viral infections. Annu Rev Immunol 2004;22:711–743.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>711</start><end>743</end></extent></part><relatedItem type="host"><titleInfo><title>Annu Rev Immunol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>711</start><end>743</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit42"><titleInfo><title>High frequencies of virus‐specific CD8+ T cell precursors</title></titleInfo><name type="personal"><namePart type="given">MO</namePart><namePart type="family">Seedhom</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ER</namePart><namePart type="family">Jellison</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Daniels</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Seedhom MO, Jellison ER, Daniels KA, Welsh RM. High frequencies of virus‐specific CD8+ T cell precursors. J Virol 2009;83:12907–12916.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>12907</start><end>12916</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>83</number></detail><extent unit="pages"><start>12907</start><end>12916</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit43"><titleInfo><title>The CD8+ T‐cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus</title></titleInfo><name type="personal"><namePart type="given">MF</namePart><namePart type="family">Kotturi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kotturi MF, et al. The CD8+ T‐cell response to lymphocytic choriomeningitis virus involves the L antigen: uncovering new tricks for an old virus. J Virol 2007;81:4928–4940.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>4928</start><end>4940</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>4928</start><end>4940</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit44"><titleInfo><title>Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance</title></titleInfo><name type="personal"><namePart type="given">MF</namePart><namePart type="family">Kotturi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kotturi MF, et al. Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance. J Immunol 2008;181:2124–2133.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>181</number></detail><extent unit="pages"><start>2124</start><end>2133</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>181</number></detail><extent unit="pages"><start>2124</start><end>2133</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit45"><titleInfo><title>Immunodominance in major histocompatibility complex class I‐restricted T lymphocyte responses</title></titleInfo><name type="personal"><namePart type="given">JW</namePart><namePart type="family">Yewdell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Bennink</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yewdell JW, Bennink JR. Immunodominance in major histocompatibility complex class I‐restricted T lymphocyte responses. Annu Rev Immunol 1999;17:51–88.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>51</start><end>88</end></extent></part><relatedItem type="host"><titleInfo><title>Annu Rev Immunol</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>51</start><end>88</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit46"><titleInfo><title>Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Klenerman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Zinkernagel</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Klenerman P, Zinkernagel RM. Original antigenic sin impairs cytotoxic T lymphocyte responses to viruses bearing variant epitopes. Nature 1998;394:421–422.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>394</number></detail><extent unit="pages"><start>421</start><end>422</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>394</number></detail><extent unit="pages"><start>421</start><end>422</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit47"><titleInfo><title>Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Mongkolsapaya</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mongkolsapaya J, et al. Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever. Nat Med 2003;9:921–927.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>921</start><end>927</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Med</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><extent unit="pages"><start>921</start><end>927</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit48"><titleInfo><title>T cell immunodominance and maintenance of memory regulated by unexpectedly cross‐reactive pathogens</title></titleInfo><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Brehm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AK</namePart><namePart type="family">Pinto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Daniels</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JP</namePart><namePart type="family">Schneck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brehm MA, Pinto AK, Daniels KA, Schneck JP, Welsh RM, Selin LK. T cell immunodominance and maintenance of memory regulated by unexpectedly cross‐reactive pathogens. Nat Immunol 2002;3:627–634.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>627</start><end>634</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Immunol</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>627</start><end>634</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit49"><titleInfo><title>Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Cornberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cornberg M, et al. Narrowed TCR repertoire and viral escape as a consequence of heterologous immunity. J Clin Invest 2006;116:1443–1456.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>116</number></detail><extent unit="pages"><start>1443</start><end>1456</end></extent></part><relatedItem type="host"><titleInfo><title>J Clin Invest</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>116</number></detail><extent unit="pages"><start>1443</start><end>1456</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit50"><titleInfo><title>Antiviral pressure exerted by HIV‐1‐specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus</title></titleInfo><name type="personal"><namePart type="given">P</namePart><namePart type="family">Borrow</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Borrow P, et al. Antiviral pressure exerted by HIV‐1‐specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nat Med 1997;3:205–211.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>205</start><end>211</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Med</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>3</number></detail><extent unit="pages"><start>205</start><end>211</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit51"><titleInfo><title>Limited T cell receptor diversity of HCV‐specific T cell responses is associated with CTL escape</title></titleInfo><name type="personal"><namePart type="given">D</namePart><namePart type="family">Meyer‐Olson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Meyer‐Olson D, et al. Limited T cell receptor diversity of HCV‐specific T cell responses is associated with CTL escape. J Exp Med 2004;200:307–319.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>200</number></detail><extent unit="pages"><start>307</start><end>319</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>200</number></detail><extent unit="pages"><start>307</start><end>319</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit52"><titleInfo><title>Clonotypic structure of the human CD4+ memory T cell response to cytomegalovirus</title></titleInfo><name type="personal"><namePart type="given">AD</namePart><namePart type="family">Bitmansour</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bitmansour AD, et al. Clonotypic structure of the human CD4+ memory T cell response to cytomegalovirus. J Immunol 2001;167:1151–1163.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>167</number></detail><extent unit="pages"><start>1151</start><end>1163</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>167</number></detail><extent unit="pages"><start>1151</start><end>1163</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit53"><titleInfo><title>Selective expansion of cross‐reactive CD8(+) memory T cells by viral variants</title></titleInfo><name type="personal"><namePart type="given">JB</namePart><namePart type="family">Haanan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MC</namePart><namePart type="family">Wolkers</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Kruisbeek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TN</namePart><namePart type="family">Schumacher</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Haanan JB, Wolkers MC, Kruisbeek AM, Schumacher TN. Selective expansion of cross‐reactive CD8(+) memory T cells by viral variants. J Exp Med 1999;190:1319–1328.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>190</number></detail><extent unit="pages"><start>1319</start><end>1328</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>190</number></detail><extent unit="pages"><start>1319</start><end>1328</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit54"><titleInfo><title>Oligoclonal CD8+ T‐cell expansion in patients with chronic hepatitis C is associated with liver pathology and poor response to interferon‐alpha therapy</title></titleInfo><name type="personal"><namePart type="given">BJ</namePart><namePart type="family">Manfras</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Manfras BJ, et al. Oligoclonal CD8+ T‐cell expansion in patients with chronic hepatitis C is associated with liver pathology and poor response to interferon‐alpha therapy. J Clin Immunol 2004;24:258–271.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>258</start><end>271</end></extent></part><relatedItem type="host"><titleInfo><title>J Clin Immunol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>258</start><end>271</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit55"><titleInfo><title>T cell receptor recognition motifs govern immune escape patterns in acute SIV infection</title></titleInfo><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Price</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Price DA, et al. T cell receptor recognition motifs govern immune escape patterns in acute SIV infection. Immunity 2004;21:793–803.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>793</start><end>803</end></extent></part><relatedItem type="host"><titleInfo><title>Immunity</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>21</number></detail><extent unit="pages"><start>793</start><end>803</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit56"><titleInfo><title>Cross‐reactive influenza virus‐specific CD8+ T cells contribute to lymphoproliferation in Epstein‐Barr virus‐associated infectious mononucleosis</title></titleInfo><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Clute</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Clute SC, et al. Cross‐reactive influenza virus‐specific CD8+ T cells contribute to lymphoproliferation in Epstein‐Barr virus‐associated infectious mononucleosis. J Clin Invest 2005;115:3602–3612.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>115</number></detail><extent unit="pages"><start>3602</start><end>3612</end></extent></part><relatedItem type="host"><titleInfo><title>J Clin Invest</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>115</number></detail><extent unit="pages"><start>3602</start><end>3612</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit57"><titleInfo><title>Single‐cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is composed of very few clones</title></titleInfo><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Maryanski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CV</namePart><namePart type="family">Jongeneel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Bucher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Casanova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PR</namePart><namePart type="family">Walker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Maryanski JL, Jongeneel CV, Bucher P, Casanova JL, Walker PR. Single‐cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is composed of very few clones. Immunity 1996;4:47–55.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>47</start><end>55</end></extent></part><relatedItem type="host"><titleInfo><title>Immunity</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>47</start><end>55</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit58"><titleInfo><title>Individuality of Ag‐selected and preimmune TCR repertoires</title></titleInfo><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Maryanski</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Maryanski JL, et al. Individuality of Ag‐selected and preimmune TCR repertoires. Immunol Res 2001;23:75–84.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>75</start><end>84</end></extent></part><relatedItem type="host"><titleInfo><title>Immunol Res</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>75</start><end>84</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit59"><titleInfo><title>Stability and diversity of T cell receptor (TCR) repertoire usage during lymphocytic choriomeningitis virus infection of mice</title></titleInfo><name type="personal"><namePart type="given">MY</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lin MY, Welsh RM. Stability and diversity of T cell receptor (TCR) repertoire usage during lymphocytic choriomeningitis virus infection of mice. J Exp Med 1998;188:1993–2005.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>188</number></detail><extent unit="pages"><start>1993</start><end>2005</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>188</number></detail><extent unit="pages"><start>1993</start><end>2005</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit60"><titleInfo><title>The privacy of T cell memory to viruses</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Cornberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Clute</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YN</namePart><namePart type="family">Naumov</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Welsh RM, Kim SK, Cornberg M, Clute SC, Selin LK, Naumov YN. The privacy of T cell memory to viruses. Curr Top Microbiol Immunol 2006;311:117–153.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>311</number></detail><extent unit="pages"><start>117</start><end>153</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Top Microbiol Immunol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>311</number></detail><extent unit="pages"><start>117</start><end>153</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit61"><titleInfo><title>Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection</title></titleInfo><name type="personal"><namePart type="given">JN</namePart><namePart type="family">Blattman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Sourdive</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Murali‐Krishna</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Ahmed</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Altman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Blattman JN, Sourdive DJ, Murali‐Krishna K, Ahmed R, Altman JD. Evolution of the T cell repertoire during primary, memory, and recall responses to viral infection. J Immunol 2000;165:6081–6090.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>165</number></detail><extent unit="pages"><start>6081</start><end>6090</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>165</number></detail><extent unit="pages"><start>6081</start><end>6090</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit62"><titleInfo><title>A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses</title></titleInfo><name type="personal"><namePart type="given">YN</namePart><namePart type="family">Naumov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EN</namePart><namePart type="family">Naumova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KT</namePart><namePart type="family">Hogan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Gorski</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Naumov YN, Naumova EN, Hogan KT, Selin LK, Gorski J. A fractal clonotype distribution in the CD8+ memory T cell repertoire could optimize potential for immune responses. J Immunol 2003;170:3994–4001.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>170</number></detail><extent unit="pages"><start>3994</start><end>4001</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>170</number></detail><extent unit="pages"><start>3994</start><end>4001</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit63"><titleInfo><title>MHC‐restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T‐cell restriction‐specificity, function, and responsiveness</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Zinkernagel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PC</namePart><namePart type="family">Doherty</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Zinkernagel RM, Doherty PC. MHC‐restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T‐cell restriction‐specificity, function, and responsiveness. Adv Immunol 1979;27:51–177.</note><part><date>1979</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>51</start><end>177</end></extent></part><relatedItem type="host"><titleInfo><title>Adv Immunol</title></titleInfo><part><date>1979</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>51</start><end>177</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit64"><titleInfo><title>Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Baenziger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Hengartner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Zinkernagel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GA</namePart><namePart type="family">Cole</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Baenziger J, Hengartner H, Zinkernagel RM, Cole GA. Induction or prevention of immunopathological disease by cloned cytotoxic T cell lines specific for lymphocytic choriomeningitis virus. Eur J Immunol 1986;16:387–393.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>387</start><end>393</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Immunol</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>16</number></detail><extent unit="pages"><start>387</start><end>393</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit65"><titleInfo><title>Private specificities of heterologous immunity</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Welsh RM. Private specificities of heterologous immunity. Curr Opin Immunol 2006;18:331–337.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>331</start><end>337</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Opin Immunol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>331</start><end>337</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit66"><titleInfo><title>Heterologous T cell immunity in severe hepatitis C virus infection</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Urbani</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Urbani S, et al. Heterologous T cell immunity in severe hepatitis C virus infection. J Exp Med 2005;201:675–680.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>201</number></detail><extent unit="pages"><start>675</start><end>680</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>201</number></detail><extent unit="pages"><start>675</start><end>680</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit67"><titleInfo><title>Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells</title></titleInfo><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Kaech</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Ahmed</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kaech SM, Ahmed R. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat Immunol 2001;2:415–422.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>415</start><end>422</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Immunol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>415</start><end>422</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit68"><titleInfo><title>Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation</title></titleInfo><name type="personal"><namePart type="given">MJ</namePart><namePart type="family">Van Stipdonk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EE</namePart><namePart type="family">Lemmens</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SP</namePart><namePart type="family">Schoenberger</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Van Stipdonk MJ, Lemmens EE, Schoenberger SP. Naive CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation. Nat Immunol 2001;2:423–429.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>423</start><end>429</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Immunol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>423</start><end>429</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit69"><titleInfo><title>Early programming of T cell populations responding to bacterial infection</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Mercado</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Vijh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SE</namePart><namePart type="family">Allen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kerksiek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IM</namePart><namePart type="family">Pilip</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EG</namePart><namePart type="family">Pamer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mercado R, Vijh S, Allen SE, Kerksiek K, Pilip IM, Pamer EG. Early programming of T cell populations responding to bacterial infection. J Immunol 2000;165:6833–6839.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>165</number></detail><extent unit="pages"><start>6833</start><end>6839</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>165</number></detail><extent unit="pages"><start>6833</start><end>6839</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit70"><titleInfo><title>Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses</title></titleInfo><name type="personal"><namePart type="given">KE</namePart><namePart type="family">Foulds</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Zenewicz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Shedlock</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Jiang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AE</namePart><namePart type="family">Troy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Shen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Foulds KE, Zenewicz LA, Shedlock DJ, Jiang J, Troy AE, Shen H. Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J Immunol 2002;168:1528–1532.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>168</number></detail><extent unit="pages"><start>1528</start><end>1532</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>168</number></detail><extent unit="pages"><start>1528</start><end>1532</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit71"><titleInfo><title>Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr and Bcl‐2‐transgenic mice</title></titleInfo><name type="personal"><namePart type="given">ES</namePart><namePart type="family">Razvi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Jiang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BA</namePart><namePart type="family">Woda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Razvi ES, Jiang Z, Woda BA, Welsh RM. Lymphocyte apoptosis during the silencing of the immune response to acute viral infections in normal, lpr and Bcl‐2‐transgenic mice. Am J Pathol 1995;147:79–91.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>147</number></detail><extent unit="pages"><start>79</start><end>91</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Pathol</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>147</number></detail><extent unit="pages"><start>79</start><end>91</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit72"><titleInfo><title>Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction</title></titleInfo><name type="personal"><namePart type="given">AE</namePart><namePart type="family">Weant</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RD</namePart><namePart type="family">Michalek</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">IU</namePart><namePart type="family">Khan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BC</namePart><namePart type="family">Holbrook</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MC</namePart><namePart type="family">Willingham</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Grayson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Weant AE, Michalek RD, Khan IU, Holbrook BC, Willingham MC, Grayson JM. Apoptosis regulators Bim and Fas function concurrently to control autoimmunity and CD8+ T cell contraction. Immunity 2008;28:218–230.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>218</start><end>230</end></extent></part><relatedItem type="host"><titleInfo><title>Immunity</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>218</start><end>230</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit73"><titleInfo><title>Cytolytically active memory CTL present in lymphocytic choriomeningitis virus (LCMV)‐immune mice after clearance of virus infection</title></titleInfo><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Selin LK, Welsh RM. Cytolytically active memory CTL present in lymphocytic choriomeningitis virus (LCMV)‐immune mice after clearance of virus infection. J Immunol 1997;158:5366–5373.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>158</number></detail><extent unit="pages"><start>5366</start><end>5373</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>158</number></detail><extent unit="pages"><start>5366</start><end>5373</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit74"><titleInfo><title>In vivo state of antiviral CTL precursors: characterization of a cycling population containing CTL precursors in immune mice</title></titleInfo><name type="personal"><namePart type="given">ES</namePart><namePart type="family">Razvi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HI</namePart><namePart type="family">McFarland</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Razvi ES, Welsh RM, McFarland HI. In vivo state of antiviral CTL precursors: characterization of a cycling population containing CTL precursors in immune mice. J Immunol 1995;154:620–632.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>154</number></detail><extent unit="pages"><start>620</start><end>632</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>154</number></detail><extent unit="pages"><start>620</start><end>632</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit75"><titleInfo><title>Turnover of naive‐ and memory‐phenotype T cells</title></titleInfo><name type="personal"><namePart type="given">DF</namePart><namePart type="family">Tough</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Sprent</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tough DF, Sprent J. Turnover of naive‐ and memory‐phenotype T cells. J Exp Med 1994;179:1127–1135.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>1127</start><end>1135</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>1127</start><end>1135</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit76"><titleInfo><title>Visualization, characterization, and turnover of CD8+ memory T cells in virus‐infected hosts</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Zimmermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Brduscha‐Riem</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C</namePart><namePart type="family">Blaser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Zinkernagel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Pircher</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Zimmermann C, Brduscha‐Riem K, Blaser C, Zinkernagel RM, Pircher H. Visualization, characterization, and turnover of CD8+ memory T cells in virus‐infected hosts. J Exp Med 1996;183:1367–1375.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>183</number></detail><extent unit="pages"><start>1367</start><end>1375</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>183</number></detail><extent unit="pages"><start>1367</start><end>1375</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit77"><titleInfo><title>Reduction of otherwise remarkably stable virus‐specific cytotoxic T lymphocyte memory by heterologous viral infections</title></titleInfo><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Vergilis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Nahill</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Selin LK, Vergilis K, Welsh RM, Nahill SR. Reduction of otherwise remarkably stable virus‐specific cytotoxic T lymphocyte memory by heterologous viral infections. J Exp Med 1996;183:2489–2499.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>183</number></detail><extent unit="pages"><start>2489</start><end>2499</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>183</number></detail><extent unit="pages"><start>2489</start><end>2499</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit78"><titleInfo><title>Attrition of T cell memory:selective loss of lymphocytic choriomeningitis virus (LCMV) epitope‐specific memory CD8 T cells following infections with heterologous viruses</title></titleInfo><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Selin LK, et al. Attrition of T cell memory:selective loss of lymphocytic choriomeningitis virus (LCMV) epitope‐specific memory CD8 T cells following infections with heterologous viruses. Immunity 1999;11:733–742.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>733</start><end>742</end></extent></part><relatedItem type="host"><titleInfo><title>Immunity</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>733</start><end>742</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit79"><titleInfo><title>Attrition of bystander CD8 T cells during virus‐induced T cell and interferon responses</title></titleInfo><name type="personal"><namePart type="given">JM</namePart><namePart type="family">McNally</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CC</namePart><namePart type="family">Zarozinski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MY</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Brehm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HD</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">McNally JM, Zarozinski CC, Lin MY, Brehm MA, Chen HD, Welsh RM. Attrition of bystander CD8 T cells during virus‐induced T cell and interferon responses. J Virol 2001;75:5965–5976.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>5965</start><end>5976</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>5965</start><end>5976</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit80"><titleInfo><title>Comprehensive early and lasting loss of memory CD8 T cells and functional memory during acute and persistent viral infections</title></titleInfo><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kim SK, Welsh RM. Comprehensive early and lasting loss of memory CD8 T cells and functional memory during acute and persistent viral infections. J Immunol 2004;172:3139–3150.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>3139</start><end>3150</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>3139</start><end>3150</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit81"><titleInfo><title>Interferon‐induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Bahl</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bahl K, et al. Interferon‐induced attrition of CD8 T cells in the presence or absence of cognate antigen during the early stages of viral infections. J Immunol 2006;176:4284–4295.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>176</number></detail><extent unit="pages"><start>4284</start><end>4295</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>176</number></detail><extent unit="pages"><start>4284</start><end>4295</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit82"><titleInfo><title>Depletion of T cells by type I interferon: differences between young and aged mice</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Jiang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Gross</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Nogusa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Elbaum</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Murasko</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jiang J, Gross D, Nogusa S, Elbaum P, Murasko DM. Depletion of T cells by type I interferon: differences between young and aged mice. J Immunol 2005;175:1820–1826.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>175</number></detail><extent unit="pages"><start>1820</start><end>1826</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>175</number></detail><extent unit="pages"><start>1820</start><end>1826</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit83"><titleInfo><title>Attrition of virus‐specific memory CD8(+) T cells during reconstitution of lymphopenic environments</title></titleInfo><name type="personal"><namePart type="given">CD</namePart><namePart type="family">Peacock</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S‐K</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Peacock CD, Kim S‐K, Welsh RM. Attrition of virus‐specific memory CD8(+) T cells during reconstitution of lymphopenic environments. J Immunol 2003;171:655–663.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>171</number></detail><extent unit="pages"><start>655</start><end>663</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>171</number></detail><extent unit="pages"><start>655</start><end>663</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit84"><titleInfo><title>Cross‐reactive antigen is required to prevent erosion of established T cell memory and tumor immunity: a heterologous bacterial model of attrition</title></titleInfo><name type="personal"><namePart type="given">DK</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Dudani</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Pedras‐Vasconcelos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y</namePart><namePart type="family">Chapdelaine</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Van Faassen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Sad</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Smith DK, Dudani R, Pedras‐Vasconcelos JA, Chapdelaine Y, Van Faassen H, Sad S. Cross‐reactive antigen is required to prevent erosion of established T cell memory and tumor immunity: a heterologous bacterial model of attrition. J Immunol 2002;169:1197–1206.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>169</number></detail><extent unit="pages"><start>1197</start><end>1206</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>169</number></detail><extent unit="pages"><start>1197</start><end>1206</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit85"><titleInfo><title>Memory CD8 T‐cell compartment grows in size with immunological experience</title></titleInfo><name type="personal"><namePart type="given">V</namePart><namePart type="family">Vezys</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Vezys V, et al. Memory CD8 T‐cell compartment grows in size with immunological experience. Nature 2009;457:196–199.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>457</number></detail><extent unit="pages"><start>196</start><end>199</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>457</number></detail><extent unit="pages"><start>196</start><end>199</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit86"><titleInfo><title>Attrition of memory CD8 T cells</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Welsh RM, Selin LK. Attrition of memory CD8 T cells. Nature 2009;459:E3–E4.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>459</number></detail><extent unit="pages"><start>E3</start><end>E4</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>459</number></detail><extent unit="pages"><start>E3</start><end>E4</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit87"><titleInfo><title>The role of T cells in anti‐herpes simplex virus immunity. I. Induction of antigen‐specific cytotoxic T lymphocytes</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Pfizenmaier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Jung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Starzinski‐Powitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Rollinghoff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Wagner</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pfizenmaier K, Jung H, Starzinski‐Powitz A, Rollinghoff M, Wagner H. The role of T cells in anti‐herpes simplex virus immunity. I. Induction of antigen‐specific cytotoxic T lymphocytes. J Immunol 1977;119:939–944.</note><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>939</start><end>944</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>119</number></detail><extent unit="pages"><start>939</start><end>944</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit88"><titleInfo><title>T cell homeostatic proliferation elicits effective antitumor autoimmunity</title></titleInfo><name type="personal"><namePart type="given">W</namePart><namePart type="family">Dummer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Dummer W, et al. T cell homeostatic proliferation elicits effective antitumor autoimmunity. J Clin Invest 2002;110:185–192.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>110</number></detail><extent unit="pages"><start>185</start><end>192</end></extent></part><relatedItem type="host"><titleInfo><title>J Clin Invest</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>110</number></detail><extent unit="pages"><start>185</start><end>192</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit89"><titleInfo><title>Cuttine edge: T cells from aged mice are resistant to depletion early during virus infection</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Jiang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Anaraki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KJ</namePart><namePart type="family">Blank</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Murasko</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jiang J, Anaraki F, Blank KJ, Murasko DM. Cuttine edge: T cells from aged mice are resistant to depletion early during virus infection. J Immunol 2003;171:3353–3357.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>171</number></detail><extent unit="pages"><start>3353</start><end>3357</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>171</number></detail><extent unit="pages"><start>3353</start><end>3357</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit90"><titleInfo><title>Defective generation but normal maintenance of memory T cells in old mice</title></titleInfo><name type="personal"><namePart type="given">ZF</namePart><namePart type="family">Kapasi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Murali‐Krishna</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ML</namePart><namePart type="family">McRae</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Ahmed</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kapasi ZF, Murali‐Krishna K, McRae ML, Ahmed R. Defective generation but normal maintenance of memory T cells in old mice. Eur J Immunol 2002;32:1567–1573.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>1567</start><end>1573</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Immunol</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>1567</start><end>1573</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit91"><titleInfo><title>Necrosis of adipose tissue induced by sequential infections with unrelated viruses</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Joris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G</namePart><namePart type="family">Majno</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yang H, Joris I, Majno G, Welsh RM. Necrosis of adipose tissue induced by sequential infections with unrelated viruses. Am J Pathol 1985;120:173–177.</note><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>120</number></detail><extent unit="pages"><start>173</start><end>177</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Pathol</title></titleInfo><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>120</number></detail><extent unit="pages"><start>173</start><end>177</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit92"><titleInfo><title>Virus‐induced polyclonal cytotoxic T lymphocyte stimulation</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PL</namePart><namePart type="family">Dundon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Nahill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yang H, Dundon PL, Nahill SR, Welsh RM. Virus‐induced polyclonal cytotoxic T lymphocyte stimulation. J Immunol 1989;142:1710–1718.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>142</number></detail><extent unit="pages"><start>1710</start><end>1718</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>142</number></detail><extent unit="pages"><start>1710</start><end>1718</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit93"><titleInfo><title>Cross‐reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses</title></titleInfo><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Nahill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Selin LK, Nahill SR, Welsh RM. Cross‐reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses. J Exp Med 1994;179:1933–1943.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>1933</start><end>1943</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>1933</start><end>1943</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit94"><titleInfo><title>Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung</title></titleInfo><name type="personal"><namePart type="given">HD</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AE</namePart><namePart type="family">Fraire</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Joris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Brehm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen HD, Fraire AE, Joris I, Brehm MA, Welsh RM, Selin LK. Memory CD8+ T cells in heterologous antiviral immunity and immunopathology in the lung. Nat Immunol 2001;2:1067–1076.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>1067</start><end>1076</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Immunol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>1067</start><end>1076</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit95"><titleInfo><title>Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Cornberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BS</namePart><namePart type="family">Sheridan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FM</namePart><namePart type="family">Saccoccio</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Brehm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cornberg M, Sheridan BS, Saccoccio FM, Brehm MA, Selin LK. Protection against vaccinia virus challenge by CD8 memory T cells resolved by molecular mimicry. J Virol 2007;81:934–944.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>934</start><end>944</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>81</number></detail><extent unit="pages"><start>934</start><end>944</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit96"><titleInfo><title>Pathological features of heterologous immunity are regulated by the private specificities of the immune repertoire</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Nie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S‐J</namePart><namePart type="family">Lin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S‐K</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nie S, Lin S‐J, Kim S‐K, Welsh RM, Selin LK. Pathological features of heterologous immunity are regulated by the private specificities of the immune repertoire. Am J Pathol 2010; in press.</note><part><date>2010</date></part><relatedItem type="host"><titleInfo><title>Am J Pathol</title></titleInfo><part><date>2010</date></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit97"><titleInfo><title>Resistance to vaccinia virus is less dependent on TNF under conditions of heterologous immunity</title></titleInfo><name type="personal"><namePart type="given">S</namePart><namePart type="family">Nie</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Cornberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nie S, Cornberg M, Selin LK. Resistance to vaccinia virus is less dependent on TNF under conditions of heterologous immunity. J Immunol 2009;183:6554–6560.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>183</number></detail><extent unit="pages"><start>6554</start><end>6560</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>183</number></detail><extent unit="pages"><start>6554</start><end>6560</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit98"><titleInfo><title>Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation</title></titleInfo><name type="personal"><namePart type="given">SK</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Brehm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kim SK, Brehm MA, Welsh RM, Selin LK. Dynamics of memory T cell proliferation under conditions of heterologous immunity and bystander stimulation. J Immunol 2002;169:90–98.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>169</number></detail><extent unit="pages"><start>90</start><end>98</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>169</number></detail><extent unit="pages"><start>90</start><end>98</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit99"><titleInfo><title>Viral strategies of immune evasion</title></titleInfo><name type="personal"><namePart type="given">HL</namePart><namePart type="family">Ploegh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ploegh HL. Viral strategies of immune evasion. Science 1998;280:248–253.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>280</number></detail><extent unit="pages"><start>248</start><end>253</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>280</number></detail><extent unit="pages"><start>248</start><end>253</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit100"><titleInfo><title>Programming for CD8 T cell memory development requires IL‐12 or type I IFN</title></titleInfo><name type="personal"><namePart type="given">Z</namePart><namePart type="family">Xiao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Casey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Jameson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JM</namePart><namePart type="family">Curtsinger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MF</namePart><namePart type="family">Mescher</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Xiao Z, Casey KA, Jameson SC, Curtsinger JM, Mescher MF. Programming for CD8 T cell memory development requires IL‐12 or type I IFN. J Immunol 2009;182:2786–2794.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>182</number></detail><extent unit="pages"><start>2786</start><end>2794</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>182</number></detail><extent unit="pages"><start>2786</start><end>2794</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit101"><titleInfo><title>Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection</title></titleInfo><name type="personal"><namePart type="given">GA</namePart><namePart type="family">Kolumam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Thomas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LJ</namePart><namePart type="family">Thompson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Sprent</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Murali‐Krishna</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kolumam GA, Thomas S, Thompson LJ, Sprent J, Murali‐Krishna K. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J Exp Med 2005;202:637–650.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>202</number></detail><extent unit="pages"><start>637</start><end>650</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>202</number></detail><extent unit="pages"><start>637</start><end>650</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit102"><titleInfo><title>Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen</title></titleInfo><name type="personal"><namePart type="given">RE</namePart><namePart type="family">Berg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Crossley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Murray</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Forman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Berg RE, Crossley E, Murray S, Forman J. Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen. J Exp Med 2003;198:1583–1593.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>198</number></detail><extent unit="pages"><start>1583</start><end>1593</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>198</number></detail><extent unit="pages"><start>1583</start><end>1593</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit103"><titleInfo><title>Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis</title></titleInfo><name type="personal"><namePart type="given">SC</namePart><namePart type="family">Bangs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D</namePart><namePart type="family">Baban</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HJ</namePart><namePart type="family">Cattan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CK</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AJ</namePart><namePart type="family">McMichael</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">XN</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bangs SC, Baban D, Cattan HJ, Li CK, McMichael AJ, Xu XN. Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis. J Immunol 2009;182:1962–1971.</note><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>182</number></detail><extent unit="pages"><start>1962</start><end>1971</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>182</number></detail><extent unit="pages"><start>1962</start><end>1971</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit104"><titleInfo><title>Chronic Leishmania donovani infection promotes bystander CD8+‐T‐cell expansion and heterologous immunity</title></titleInfo><name type="personal"><namePart type="given">R</namePart><namePart type="family">Polley</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Sanos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Prickett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Haque</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Kaye</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Polley R, Sanos SL, Prickett S, Haque A, Kaye PM. Chronic Leishmania donovani infection promotes bystander CD8+‐T‐cell expansion and heterologous immunity. Infect Immun 2005;73:7996–8001.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>7996</start><end>8001</end></extent></part><relatedItem type="host"><titleInfo><title>Infect Immun</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>7996</start><end>8001</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit105"><titleInfo><title>Interferon enhances the susceptibility of virus‐infected fibroblasts to cytotoxic T cells</title></titleInfo><name type="personal"><namePart type="given">JF</namePart><namePart type="family">Bukowski</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bukowski JF, Welsh RM. Interferon enhances the susceptibility of virus‐infected fibroblasts to cytotoxic T cells. J Exp Med 1985;161:257–262.</note><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>161</number></detail><extent unit="pages"><start>257</start><end>262</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>161</number></detail><extent unit="pages"><start>257</start><end>262</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit106"><titleInfo><title>Cutting edge: re‐evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections</title></titleInfo><name type="personal"><namePart type="given">F</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Whitton</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Liu F, Whitton JL. Cutting edge: re‐evaluating the in vivo cytokine responses of CD8+ T cells during primary and secondary viral infections. J Immunol 2005;174:5936–5940.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>174</number></detail><extent unit="pages"><start>5936</start><end>5940</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>174</number></detail><extent unit="pages"><start>5936</start><end>5940</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit107"><titleInfo><title>Development of the Mycobacterium bovis BCG vaccine: review of the historical and biochemical evidence for a genealogical tree</title></titleInfo><name type="personal"><namePart type="given">T</namePart><namePart type="family">Oettinger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Jorgensen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Ladefoged</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Haslov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P</namePart><namePart type="family">Andersen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Oettinger T, Jorgensen M, Ladefoged A, Haslov K, Andersen P. Development of the Mycobacterium bovis BCG vaccine: review of the historical and biochemical evidence for a genealogical tree. Tuber Lung Dis 1999;79:243–250.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>243</start><end>250</end></extent></part><relatedItem type="host"><titleInfo><title>Tuber Lung Dis</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>79</number></detail><extent unit="pages"><start>243</start><end>250</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit108"><titleInfo><title>Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Alcami</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GL</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Alcami A, Smith GL. Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity. J Virol 1995;69:4633–4639.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><extent unit="pages"><start>4633</start><end>4639</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>69</number></detail><extent unit="pages"><start>4633</start><end>4639</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit109"><titleInfo><title>An epidemiological study of altered clinical reactivity to respiratory syncitial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine</title></titleInfo><name type="personal"><namePart type="given">AZ</namePart><namePart type="family">Kapikian</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RH</namePart><namePart type="family">Mitchell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Chanock</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RA</namePart><namePart type="family">Shvedoff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CE</namePart><namePart type="family">Stewart</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kapikian AZ, Mitchell RH, Chanock RM, Shvedoff RA, Stewart CE. An epidemiological study of altered clinical reactivity to respiratory syncitial (RS) virus infection in children previously vaccinated with an inactivated RS virus vaccine. Am J Epidemiol 1969;89:405–421.</note><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>89</number></detail><extent unit="pages"><start>405</start><end>421</end></extent></part><relatedItem type="host"><titleInfo><title>Am J Epidemiol</title></titleInfo><part><date>1969</date><detail type="volume"><caption>vol.</caption><number>89</number></detail><extent unit="pages"><start>405</start><end>421</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit110"><titleInfo><title>Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen‐specific CD4+ T cells</title></titleInfo><name type="personal"><namePart type="given">SM</namePart><namePart type="family">Varga</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TJ</namePart><namePart type="family">Braciale</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Varga SM, Wang X, Welsh RM, Braciale TJ. Immunopathology in RSV infection is mediated by a discrete oligoclonal subset of antigen‐specific CD4+ T cells. Immunity 2001;15:637–646.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>637</start><end>646</end></extent></part><relatedItem type="host"><titleInfo><title>Immunity</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>637</start><end>646</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit111"><titleInfo><title>Secreted respiratory syncytial virus G glcoprotein induces interleukin‐5 (IL‐5), IL‐13, and eosinophilia by an IL‐4‐dependent mechanism</title></titleInfo><name type="personal"><namePart type="given">TR</namePart><namePart type="family">Johnson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BS</namePart><namePart type="family">Graham</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Johnson TR, Graham BS. Secreted respiratory syncytial virus G glcoprotein induces interleukin‐5 (IL‐5), IL‐13, and eosinophilia by an IL‐4‐dependent mechanism. J Virol 1999;73:8485–8495.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>8485</start><end>8495</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>8485</start><end>8495</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit112"><titleInfo><title>Generation of both cross‐reactive and virus‐specific T‐cell populations after immunization with serologically distinct influenza A viruses</title></titleInfo><name type="personal"><namePart type="given">RB</namePart><namePart type="family">Effros</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PC</namePart><namePart type="family">Doherty</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W</namePart><namePart type="family">Gerhard</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J</namePart><namePart type="family">Bennink</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Effros RB, Doherty PC, Gerhard W, Bennink J. Generation of both cross‐reactive and virus‐specific T‐cell populations after immunization with serologically distinct influenza A viruses. J Exp Med 1977;145:557–568.</note><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>145</number></detail><extent unit="pages"><start>557</start><end>568</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1977</date><detail type="volume"><caption>vol.</caption><number>145</number></detail><extent unit="pages"><start>557</start><end>568</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit113"><titleInfo><title>Memory T cells established by seasonal human influenza A infection cross‐react with avian influenza A (H5N1) in healthy individuals</title></titleInfo><name type="personal"><namePart type="given">LY</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lee LY, et al. Memory T cells established by seasonal human influenza A infection cross‐react with avian influenza A (H5N1) in healthy individuals. J Clin Invest 2008;118:3478–3490.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>118</number></detail><extent unit="pages"><start>3478</start><end>3490</end></extent></part><relatedItem type="host"><titleInfo><title>J Clin Invest</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>118</number></detail><extent unit="pages"><start>3478</start><end>3490</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit114"><titleInfo><title>Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature</title></titleInfo><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Epstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Epstein SL. Prior H1N1 influenza infection and susceptibility of Cleveland Family Study participants during the H2N2 pandemic of 1957: an experiment of nature. J Infect Dis 2006;193:49–53.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>193</number></detail><extent unit="pages"><start>49</start><end>53</end></extent></part><relatedItem type="host"><titleInfo><title>J Infect Dis</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>193</number></detail><extent unit="pages"><start>49</start><end>53</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit115"><titleInfo><title>The effect of a previous attack of A1 influenza on susceptibility to A2 virus during the 1957 outbreak</title></titleInfo><name type="personal"><namePart type="given">AN</namePart><namePart type="family">Slepushkin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Slepushkin AN. The effect of a previous attack of A1 influenza on susceptibility to A2 virus during the 1957 outbreak. Bull World Health Organ 1959;20:297–301.</note><part><date>1959</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>297</start><end>301</end></extent></part><relatedItem type="host"><titleInfo><title>Bull World Health Organ</title></titleInfo><part><date>1959</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>297</start><end>301</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit116"><titleInfo><title>Extensive conservation of a and b chains of the human T‐cell antigen receptor recognizing HLA‐A2 and influenza A matrix peptide</title></titleInfo><name type="personal"><namePart type="given">PAH</namePart><namePart type="family">Moss</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Moss PAH, et al. Extensive conservation of a and b chains of the human T‐cell antigen receptor recognizing HLA‐A2 and influenza A matrix peptide. Proc Natl Acad Sci 1991;88:8987–8990.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>8987</start><end>8990</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>88</number></detail><extent unit="pages"><start>8987</start><end>8990</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit117"><titleInfo><title>Cross‐reactivity between hepatitis C virus and influenza A virus determinant‐specific cytotoxic T cells</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Wedemeyer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Mizukoshi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AR</namePart><namePart type="family">Davis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Bennink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B</namePart><namePart type="family">Rehermann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wedemeyer H, Mizukoshi E, Davis AR, Bennink JR, Rehermann B. Cross‐reactivity between hepatitis C virus and influenza A virus determinant‐specific cytotoxic T cells. J Virol 2001;75:11392–11400.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>11392</start><end>11400</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>75</number></detail><extent unit="pages"><start>11392</start><end>11400</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit118"><titleInfo><title>Respiratory manifestations of chickenpox</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">Weinstein</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RH</namePart><namePart type="family">Meade</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Weinstein L, Meade RH. Respiratory manifestations of chickenpox. Arch Intern Med 1956;98:91–99.</note><part><date>1956</date><detail type="volume"><caption>vol.</caption><number>98</number></detail><extent unit="pages"><start>91</start><end>99</end></extent></part><relatedItem type="host"><titleInfo><title>Arch Intern Med</title></titleInfo><part><date>1956</date><detail type="volume"><caption>vol.</caption><number>98</number></detail><extent unit="pages"><start>91</start><end>99</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit119"><titleInfo><title>Epstein‐Barr virus</title></titleInfo><name type="personal"><namePart type="given">AB</namePart><namePart type="family">Rickinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E</namePart><namePart type="family">Kieff</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Rickinson AB, Kieff E. Epstein‐Barr virus. In: Fields BN, et al. eds. Virology Volume 2. Philadelphia: Lippincott‐Raven Publishers, 1996:2397–2446.</note><originInfo><publisher>Lippincott‐Raven Publishers</publisher></originInfo><part><date>1996</date><extent unit="pages"><start>2397</start><end>2446</end></extent></part><relatedItem type="host"><titleInfo><title>Virology Volume 2</title></titleInfo><originInfo><publisher>Lippincott‐Raven Publishers</publisher></originInfo><part><date>1996</date><extent unit="pages"><start>2397</start><end>2446</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit120"><titleInfo><title>Asymptomatic primary Epstein‐Barr virus infection occurs in the absence of blood T‐cell repertoire perturbations despite high levels of systemic viral load</title></titleInfo><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Silins</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Silins SL, et al. Asymptomatic primary Epstein‐Barr virus infection occurs in the absence of blood T‐cell repertoire perturbations despite high levels of systemic viral load. Blood 2001;98:3739–3744.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>98</number></detail><extent unit="pages"><start>3739</start><end>3744</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>98</number></detail><extent unit="pages"><start>3739</start><end>3744</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit121"><titleInfo><title>Antibody‐dependent enhancement of infection and the pathogenesis of viral disease</title></titleInfo><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Morens</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Morens DM. Antibody‐dependent enhancement of infection and the pathogenesis of viral disease. Clin Infect Dis 1994;19:500–512.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>500</start><end>512</end></extent></part><relatedItem type="host"><titleInfo><title>Clin Infect Dis</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>500</start><end>512</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit122"><titleInfo><title>Antibody, macrophages, dengue virus infection, shock and hemorrhage: a pathogenetic cascade</title></titleInfo><name type="personal"><namePart type="given">SB</namePart><namePart type="family">Halstead</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Halstead SB. Antibody, macrophages, dengue virus infection, shock and hemorrhage: a pathogenetic cascade. Rev Infect Dis 1989;11:S830–S839.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>S830</start><end>S839</end></extent></part><relatedItem type="host"><titleInfo><title>Rev Infect Dis</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>11</number></detail><extent unit="pages"><start>S830</start><end>S839</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit123"><titleInfo><title>Predominance of HLA‐restricted cytotoxic T‐lymphocyte responses to serotype‐cross‐reactive epitopes on nonstructural proteins following natural secondary dengue virus infection</title></titleInfo><name type="personal"><namePart type="given">A</namePart><namePart type="family">Matthew</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Matthew A, et al. Predominance of HLA‐restricted cytotoxic T‐lymphocyte responses to serotype‐cross‐reactive epitopes on nonstructural proteins following natural secondary dengue virus infection. J Virol 1998;72:3999–4004.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>3999</start><end>4004</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>3999</start><end>4004</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit124"><titleInfo><title>Essential flexibility in the T‐cell recognition of antigen</title></titleInfo><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Allen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">GJ</namePart><namePart type="family">Kersh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Allen PM, Kersh GJ. Essential flexibility in the T‐cell recognition of antigen. Nature 1996;380:495–498.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>380</number></detail><extent unit="pages"><start>495</start><end>498</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>380</number></detail><extent unit="pages"><start>495</start><end>498</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit125"><titleInfo><title>A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Daniel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Horvath</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Allen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Daniel C, Horvath S, Allen PM. A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR. Immunity 1998;8:543–552.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>543</start><end>552</end></extent></part><relatedItem type="host"><titleInfo><title>Immunity</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>543</start><end>552</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit126"><titleInfo><title>Rapid production of TNF‐alpha following TCR engagement of naive CD8 T cells</title></titleInfo><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Brehm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Daniels</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brehm MA, Daniels KA, Welsh RM. Rapid production of TNF‐alpha following TCR engagement of naive CD8 T cells. J Immunol 2005;175:5043–5049.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>175</number></detail><extent unit="pages"><start>5043</start><end>5049</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>175</number></detail><extent unit="pages"><start>5043</start><end>5049</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit127"><titleInfo><title>Rapid quantification of naive alloreactive T cells by TNF‐alpha production and correlation with allograft rejection in mice</title></titleInfo><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Brehm</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brehm MA, et al. Rapid quantification of naive alloreactive T cells by TNF‐alpha production and correlation with allograft rejection in mice. Blood 2007;109:819–826.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>109</number></detail><extent unit="pages"><start>819</start><end>826</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>109</number></detail><extent unit="pages"><start>819</start><end>826</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit128"><titleInfo><title>Induction of alloreactive cytotoxic T cells by acute virus infection of mice</title></titleInfo><name type="personal"><namePart type="given">H</namePart><namePart type="family">Yang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yang H, Welsh RM. Induction of alloreactive cytotoxic T cells by acute virus infection of mice. J Immunol 1986;136:1186–1193.</note><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>136</number></detail><extent unit="pages"><start>1186</start><end>1193</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1986</date><detail type="volume"><caption>vol.</caption><number>136</number></detail><extent unit="pages"><start>1186</start><end>1193</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit129"><titleInfo><title>High frequency of cross‐reactive cytotoxic T lymphocytes elicited during the virus‐induced polyclonal cytotoxic T lymphocyte response</title></titleInfo><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Nahill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nahill SR, Welsh RM. High frequency of cross‐reactive cytotoxic T lymphocytes elicited during the virus‐induced polyclonal cytotoxic T lymphocyte response. J Exp Med 1993;177:317–327.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>177</number></detail><extent unit="pages"><start>317</start><end>327</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>177</number></detail><extent unit="pages"><start>317</start><end>327</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit130"><titleInfo><title>Direct visualization of cross‐reactive effector and memory allo‐specific CD8 T cells generated in response to viral infections</title></titleInfo><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Brehm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">TG</namePart><namePart type="family">Markees</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">KA</namePart><namePart type="family">Daniels</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DL</namePart><namePart type="family">Greiner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AA</namePart><namePart type="family">Rossini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brehm MA, Markees TG, Daniels KA, Greiner DL, Rossini AA, Welsh RM. Direct visualization of cross‐reactive effector and memory allo‐specific CD8 T cells generated in response to viral infections. J Immunol 2003;170:4077–4086.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>170</number></detail><extent unit="pages"><start>4077</start><end>4086</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>170</number></detail><extent unit="pages"><start>4077</start><end>4086</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit131"><titleInfo><title>Characterization of the T cell‐mediated cellular cytotoxicity during infectious mononucleosis</title></titleInfo><name type="personal"><namePart type="given">BE</namePart><namePart type="family">Tomkinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Maziarz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Sullivan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tomkinson BE, Maziarz R, Sullivan JL. Characterization of the T cell‐mediated cellular cytotoxicity during infectious mononucleosis. J Immunol 1989;143:660–670.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>143</number></detail><extent unit="pages"><start>660</start><end>670</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>143</number></detail><extent unit="pages"><start>660</start><end>670</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit132"><titleInfo><title>Multiple HLA class I‐dependent cytotoxicities constitute the “non‐HLA‐restricted” response in infectious mononucleosis</title></titleInfo><name type="personal"><namePart type="given">G</namePart><namePart type="family">Strang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AB</namePart><namePart type="family">Rickinson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Strang G, Rickinson AB. Multiple HLA class I‐dependent cytotoxicities constitute the “non‐HLA‐restricted” response in infectious mononucleosis. Eur J Immunol 1987;17:1007–1013.</note><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>1007</start><end>1013</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Immunol</title></titleInfo><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><extent unit="pages"><start>1007</start><end>1013</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit133"><titleInfo><title>Cross‐reactive memory T cells for Epstein‐Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex‐bound peptide by T cells and its role in alloreactivity</title></titleInfo><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Burrows</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Burrows SR, et al. Cross‐reactive memory T cells for Epstein‐Barr virus augment the alloresponse to common human leukocyte antigens: degenerate recognition of major histocompatibility complex‐bound peptide by T cells and its role in alloreactivity. Eur J Immunol 1997;27:1726–1736.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>1726</start><end>1736</end></extent></part><relatedItem type="host"><titleInfo><title>Eur J Immunol</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>27</number></detail><extent unit="pages"><start>1726</start><end>1736</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit134"><titleInfo><title>Structural basis of 2C TCR allorecognition of H‐2Ld peptide complexes</title></titleInfo><name type="personal"><namePart type="given">JA</namePart><namePart type="family">Speir</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Speir JA, et al. Structural basis of 2C TCR allorecognition of H‐2Ld peptide complexes. Immunity 1998;8:553–562.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>553</start><end>562</end></extent></part><relatedItem type="host"><titleInfo><title>Immunity</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>8</number></detail><extent unit="pages"><start>553</start><end>562</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit135"><titleInfo><title>The influence of antiviral T‐cell responses on the alloreactive repertoire</title></titleInfo><name type="personal"><namePart type="given">SR</namePart><namePart type="family">Burrows</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Khanna</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SL</namePart><namePart type="family">Silins</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Moss</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Burrows SR, Khanna R, Silins SL, Moss DJ. The influence of antiviral T‐cell responses on the alloreactive repertoire. Immunol Today 1999;20:203–207.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>203</start><end>207</end></extent></part><relatedItem type="host"><titleInfo><title>Immunol Today</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><extent unit="pages"><start>203</start><end>207</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit136"><titleInfo><title>Viral infection and renal transplant rejection</title></titleInfo><name type="personal"><namePart type="given">JD</namePart><namePart type="family">Briggs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MC</namePart><namePart type="family">Timbury</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AM</namePart><namePart type="family">Paton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">PR</namePart><namePart type="family">Bell</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Briggs JD, Timbury MC, Paton AM, Bell PR. Viral infection and renal transplant rejection. Br Med J 1972;4:520–522.</note><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>520</start><end>522</end></extent></part><relatedItem type="host"><titleInfo><title>Br Med J</title></titleInfo><part><date>1972</date><detail type="volume"><caption>vol.</caption><number>4</number></detail><extent unit="pages"><start>520</start><end>522</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit137"><titleInfo><title>Epstein‐Barr virus and bone marrow transplantation</title></titleInfo><name type="personal"><namePart type="given">C</namePart><namePart type="family">Caldas</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R</namePart><namePart type="family">Ambinder</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Caldas C, Ambinder R. Epstein‐Barr virus and bone marrow transplantation. Curr Opin Oncol 1995;7:626–629.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>626</start><end>629</end></extent></part><relatedItem type="host"><titleInfo><title>Curr Opin Oncol</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>626</start><end>629</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit138"><titleInfo><title>Human herpes virus 6:infection and disease following autologous and allogeneic bone marrow transplantation</title></titleInfo><name type="personal"><namePart type="given">MP</namePart><namePart type="family">Kadakia</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kadakia MP, et al. Human herpes virus 6:infection and disease following autologous and allogeneic bone marrow transplantation. Blood 1996;87:5341–5354.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>5341</start><end>5354</end></extent></part><relatedItem type="host"><titleInfo><title>Blood</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>87</number></detail><extent unit="pages"><start>5341</start><end>5354</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit139"><titleInfo><title>An analysis of cytomegalovirus infection and HLA antigen matching on the outcome of renal transplantation</title></titleInfo><name type="personal"><namePart type="given">AG</namePart><namePart type="family">May</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RF</namePart><namePart type="family">Betts</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RB</namePart><namePart type="family">Freeman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CH</namePart><namePart type="family">Andrus</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">May AG, Betts RF, Freeman RB, Andrus CH. An analysis of cytomegalovirus infection and HLA antigen matching on the outcome of renal transplantation. Ann Surg 1978;187:110–117.</note><part><date>1978</date><detail type="volume"><caption>vol.</caption><number>187</number></detail><extent unit="pages"><start>110</start><end>117</end></extent></part><relatedItem type="host"><titleInfo><title>Ann Surg</title></titleInfo><part><date>1978</date><detail type="volume"><caption>vol.</caption><number>187</number></detail><extent unit="pages"><start>110</start><end>117</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit140"><titleInfo><title>Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand</title></titleInfo><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Parker</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Parker DC, et al. Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand. Proc Natl Acad Sci USA 1995;92:9560–9564.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>92</number></detail><extent unit="pages"><start>9560</start><end>9564</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>92</number></detail><extent unit="pages"><start>9560</start><end>9564</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit141"><titleInfo><title>Heterologous immunity provides a potent barrier to transplantation tolerance</title></titleInfo><name type="personal"><namePart type="given">AB</namePart><namePart type="family">Adams</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Adams AB, et al. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest 2003;111:1887–1895.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>111</number></detail><extent unit="pages"><start>1887</start><end>1895</end></extent></part><relatedItem type="host"><titleInfo><title>J Clin Invest</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>111</number></detail><extent unit="pages"><start>1887</start><end>1895</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit142"><titleInfo><title>Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade‐based regimen</title></titleInfo><name type="personal"><namePart type="given">MA</namePart><namePart type="family">Williams</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Williams MA, et al. Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade‐based regimen. J Immunol 2002;169:5387–5391.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>169</number></detail><extent unit="pages"><start>5387</start><end>5391</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>169</number></detail><extent unit="pages"><start>5387</start><end>5391</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit143"><titleInfo><title>Virus‐induced abrogation of transplantation tolerance induced by donor‐specific transfusion and anti‐CD154 antibody</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Welsh RM, et al. Virus‐induced abrogation of transplantation tolerance induced by donor‐specific transfusion and anti‐CD154 antibody. J Virol 2000;74:2210–2218.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>2210</start><end>2218</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>2210</start><end>2218</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit144"><titleInfo><title>Type 1 IFN mediates cross‐talk between innate and adaptive immunity that abrogates transplantation tolerance</title></titleInfo><name type="personal"><namePart type="given">TB</namePart><namePart type="family">Thornley</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Thornley TB, et al. Type 1 IFN mediates cross‐talk between innate and adaptive immunity that abrogates transplantation tolerance. J Immunol 2007;179:6620–6629.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>6620</start><end>6629</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>6620</start><end>6629</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit145"><titleInfo><title>Pathogenic epitopes, heterologous immunity and vaccine design</title></titleInfo><name type="personal"><namePart type="given">RM</namePart><namePart type="family">Welsh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RS</namePart><namePart type="family">Fujinami</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Welsh RM, Fujinami RS. Pathogenic epitopes, heterologous immunity and vaccine design. Nat Rev Microbiol 2007;5:555–563.</note><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>555</start><end>563</end></extent></part><relatedItem type="host"><titleInfo><title>Nat Rev Microbiol</title></titleInfo><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>5</number></detail><extent unit="pages"><start>555</start><end>563</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit146"><titleInfo><title>Molecular mimicry: a mechanism for autoimmune injury</title></titleInfo><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Barnett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RS</namePart><namePart type="family">Fujinami</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Barnett LA, Fujinami RS. Molecular mimicry: a mechanism for autoimmune injury. FASEB J 1992;6:840–844.</note><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>840</start><end>844</end></extent></part><relatedItem type="host"><titleInfo><title>FASEB J</title></titleInfo><part><date>1992</date><detail type="volume"><caption>vol.</caption><number>6</number></detail><extent unit="pages"><start>840</start><end>844</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit147"><titleInfo><title>Multiple sclerosis and virus induced immune responses: autoimmunity can be primed by molecular mimicry and augmented by bystander activation</title></titleInfo><name type="personal"><namePart type="given">L</namePart><namePart type="family">McCoy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Tsunoda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RS</namePart><namePart type="family">Fujinami</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">McCoy L, Tsunoda I, Fujinami RS. Multiple sclerosis and virus induced immune responses: autoimmunity can be primed by molecular mimicry and augmented by bystander activation. Autoimmunity 2006;39:9–19.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>9</start><end>19</end></extent></part><relatedItem type="host"><titleInfo><title>Autoimmunity</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>39</number></detail><extent unit="pages"><start>9</start><end>19</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit148"><titleInfo><title>Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Sospedra</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Sospedra M, et al. Recognition of conserved amino acid motifs of common viruses and its role in autoimmunity. PLoS Pathog 2005;1:e41.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>e41</start></extent></part><relatedItem type="host"><titleInfo><title>PLoS Pathog</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>e41</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit149"><titleInfo><title>Viruses can silently prime for and trigger central nervous system autoimmune disease</title></titleInfo><name type="personal"><namePart type="given">DJ</namePart><namePart type="family">Theil</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Tsunoda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F</namePart><namePart type="family">Rodriguez</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JL</namePart><namePart type="family">Whitton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RS</namePart><namePart type="family">Fujinami</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Theil DJ, Tsunoda I, Rodriguez F, Whitton JL, Fujinami RS. Viruses can silently prime for and trigger central nervous system autoimmune disease. J Neurovirol 2001;7:220–227.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>220</start><end>227</end></extent></part><relatedItem type="host"><titleInfo><title>J Neurovirol</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><extent unit="pages"><start>220</start><end>227</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit150"><titleInfo><title>Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease</title></titleInfo><name type="personal"><namePart type="given">CF</namePart><namePart type="family">Evans</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MS</namePart><namePart type="family">Horwitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MV</namePart><namePart type="family">Hobbs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">MBA</namePart><namePart type="family">Oldstone</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Evans CF, Horwitz MS, Hobbs MV, Oldstone MBA. Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease. J Exp Med 1996;184:2371–2384.</note><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>184</number></detail><extent unit="pages"><start>2371</start><end>2384</end></extent></part><relatedItem type="host"><titleInfo><title>J Exp Med</title></titleInfo><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>184</number></detail><extent unit="pages"><start>2371</start><end>2384</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit151"><titleInfo><title>A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes</title></titleInfo><name type="personal"><namePart type="given">U</namePart><namePart type="family">Christen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Christen U, et al. A viral epitope that mimics a self antigen can accelerate but not initiate autoimmune diabetes. J Clin Invest 2004;114:1290–1298.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>114</number></detail><extent unit="pages"><start>1290</start><end>1298</end></extent></part><relatedItem type="host"><titleInfo><title>J Clin Invest</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>114</number></detail><extent unit="pages"><start>1290</start><end>1298</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit152"><titleInfo><title>Quantitative analysis of hepatitis C virus‐specific CD8+ T cells in peripheral blood and liver using peptide‐MHC tetramers</title></titleInfo><name type="personal"><namePart type="given">X‐S</namePart><namePart type="family">He</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">He X‐S, et al. Quantitative analysis of hepatitis C virus‐specific CD8+ T cells in peripheral blood and liver using peptide‐MHC tetramers. Proc Natl Acad Sci USA 1999;96:5692–5697.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>96</number></detail><extent unit="pages"><start>5692</start><end>5697</end></extent></part><relatedItem type="host"><titleInfo><title>Proc Natl Acad Sci USA</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>96</number></detail><extent unit="pages"><start>5692</start><end>5697</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit153"><titleInfo><title>Memory of mice and men: CD8+ T‐cell cross‐reactivity and heterologous immunity</title></titleInfo><name type="personal"><namePart type="given">LK</namePart><namePart type="family">Selin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Selin LK, et al. Memory of mice and men: CD8+ T‐cell cross‐reactivity and heterologous immunity. Immunol Rev 2006;211:164–181.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>211</number></detail><extent unit="pages"><start>164</start><end>181</end></extent></part><relatedItem type="host"><titleInfo><title>Immunol Rev</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>211</number></detail><extent unit="pages"><start>164</start><end>181</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit154"><titleInfo><title>Immunization of mice with vaccinia virus‐M2 recombinant induces epitope‐specific and cross‐reactive Kd‐restricted CD8+ cytotoxic T cells</title></titleInfo><name type="personal"><namePart type="given">AB</namePart><namePart type="family">Kulkarni</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HC</namePart><namePart type="family">Morse III</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JR</namePart><namePart type="family">Bennink</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JW</namePart><namePart type="family">Yewdell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">BR</namePart><namePart type="family">Murphy</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kulkarni AB, Morse HC III, Bennink JR, Yewdell JW, Murphy BR. Immunization of mice with vaccinia virus‐M2 recombinant induces epitope‐specific and cross‐reactive Kd‐restricted CD8+ cytotoxic T cells. J Virol 1993;67:4086–4092.</note><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>67</number></detail><extent unit="pages"><start>4086</start><end>4092</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>1993</date><detail type="volume"><caption>vol.</caption><number>67</number></detail><extent unit="pages"><start>4086</start><end>4092</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit155"><titleInfo><title>Recognition of disparate HA and NS1 peptides by an H‐2kd‐restricted, influenza specific CTL clone</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Kuwano</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RE</namePart><namePart type="family">Reyes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RE</namePart><namePart type="family">Humphreys</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FA</namePart><namePart type="family">Ennis</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kuwano K, Reyes RE, Humphreys RE, Ennis FA. Recognition of disparate HA and NS1 peptides by an H‐2kd‐restricted, influenza specific CTL clone. Mol Immunol 1991;28:1–7.</note><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>1</start><end>7</end></extent></part><relatedItem type="host"><titleInfo><title>Mol Immunol</title></titleInfo><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>28</number></detail><extent unit="pages"><start>1</start><end>7</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit156"><titleInfo><title>Analysis of murine CD8(+) T‐cell clones specific for the Dengue virus NS3 protein: flavivirus cross‐reactivity and influence of infecting serotype</title></titleInfo><name type="personal"><namePart type="given">AC</namePart><namePart type="family">Spaulding</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I</namePart><namePart type="family">Kurane</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FA</namePart><namePart type="family">Ennis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Rothman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Spaulding AC, Kurane I, Ennis FA, Rothman AL. Analysis of murine CD8(+) T‐cell clones specific for the Dengue virus NS3 protein: flavivirus cross‐reactivity and influence of infecting serotype. J Virol 1999;73:398–403.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>398</start><end>403</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>398</start><end>403</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit157"><titleInfo><title>Cross‐reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence‐specific manner</title></titleInfo><name type="personal"><namePart type="given">CM</namePart><namePart type="family">Beaumier</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Mathew</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">HS</namePart><namePart type="family">Bashyam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Rothman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Beaumier CM, Mathew A, Bashyam HS, Rothman AL. Cross‐reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence‐specific manner. J Infect Dis 2008;197:608–617.</note><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>197</number></detail><extent unit="pages"><start>608</start><end>617</end></extent></part><relatedItem type="host"><titleInfo><title>J Infect Dis</title></titleInfo><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>197</number></detail><extent unit="pages"><start>608</start><end>617</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit158"><titleInfo><title>Identification and analysis for cross‐reactivity among hantaviruses of H‐2b‐restricted cytotoxic T‐lymphocyte epitopes in Sin Nombre virus nucleocapsid protein</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Maeda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">West</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Toyosaki‐Maeda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Rothman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FA</namePart><namePart type="family">Ennis</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Terajima</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Maeda K, West K, Toyosaki‐Maeda T, Rothman AL, Ennis FA, Terajima M. Identification and analysis for cross‐reactivity among hantaviruses of H‐2b‐restricted cytotoxic T‐lymphocyte epitopes in Sin Nombre virus nucleocapsid protein. J Gen Virol 2004;85:1909–1919.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>85</number></detail><extent unit="pages"><start>1909</start><end>1919</end></extent></part><relatedItem type="host"><titleInfo><title>J Gen Virol</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>85</number></detail><extent unit="pages"><start>1909</start><end>1919</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit159"><titleInfo><title>Poxvirus CD8+ T‐cell determinants and cross‐reactivity in BALB/c mice</title></titleInfo><name type="personal"><namePart type="given">DC</namePart><namePart type="family">Tscharke</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tscharke DC, et al. Poxvirus CD8+ T‐cell determinants and cross‐reactivity in BALB/c mice. J Virol 2006;80:6318–6323.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>6318</start><end>6323</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>6318</start><end>6323</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit160"><titleInfo><title>Cross‐reactivity between HLA‐A2‐restricted FLU‐M1:58‐66 and HIV p17 GAG:77‐85 epitopes in HIV‐infected and uninfected individuals</title></titleInfo><name type="personal"><namePart type="given">PM</namePart><namePart type="family">Acierno</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DA</namePart><namePart type="family">Newton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">EA</namePart><namePart type="family">Brown</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">LA</namePart><namePart type="family">Maes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Baatz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Gattoni‐Celli</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Acierno PM, Newton DA, Brown EA, Maes LA, Baatz JE, Gattoni‐Celli S. Cross‐reactivity between HLA‐A2‐restricted FLU‐M1:58‐66 and HIV p17 GAG:77‐85 epitopes in HIV‐infected and uninfected individuals. J Transl Med 2003;1:3.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>3</start></extent></part><relatedItem type="host"><titleInfo><title>J Transl Med</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>1</number></detail><extent unit="pages"><start>3</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit161"><titleInfo><title>CD8 T Cell Cross‐Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Cornberg</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cornberg M, et al. CD8 T Cell Cross‐Reactivity Networks Mediate Heterologous Immunity in Human EBV and Murine Vaccinia Virus Infections. J Immunol 2010;184:2825–2838.</note><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>184</number></detail><extent unit="pages"><start>2825</start><end>2838</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>184</number></detail><extent unit="pages"><start>2825</start><end>2838</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit162"><titleInfo><title>Human papillomavirus type 16 E7 peptide‐directed CD8+ T cells from patients with cervical cancer are cross‐reactive with the coronavirus NS2 protein</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Nilges</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nilges K, et al. Human papillomavirus type 16 E7 peptide‐directed CD8+ T cells from patients with cervical cancer are cross‐reactive with the coronavirus NS2 protein. J Virol 2003;77:5464–5474.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>5464</start><end>5474</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>77</number></detail><extent unit="pages"><start>5464</start><end>5474</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit163"><titleInfo><title>Specificity of peptide binding by the HLA‐A2.1 molecule</title></titleInfo><name type="personal"><namePart type="given">N</namePart><namePart type="family">Shimojo</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WL</namePart><namePart type="family">Maloy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">RW</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">WE</namePart><namePart type="family">Biddison</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JE</namePart><namePart type="family">Coligan</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shimojo N, Maloy WL, Anderson RW, Biddison WE, Coligan JE. Specificity of peptide binding by the HLA‐A2.1 molecule. J Immunol 1989;143:2939–2947.</note><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>143</number></detail><extent unit="pages"><start>2939</start><end>2947</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>143</number></detail><extent unit="pages"><start>2939</start><end>2947</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit164"><titleInfo><title>Partial agonist effect influences the CTL response to a heterologous dengue virus serotype</title></titleInfo><name type="personal"><namePart type="given">J</namePart><namePart type="family">Zivny</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Zivny J, et al. Partial agonist effect influences the CTL response to a heterologous dengue virus serotype. J Immunol 1999;163:2754–2760.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>163</number></detail><extent unit="pages"><start>2754</start><end>2760</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>163</number></detail><extent unit="pages"><start>2754</start><end>2760</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit165"><titleInfo><title>Dengue virus‐reactive CD8+ T cells display quantitative and qualitative differences in their response to variant epitopes of heterologous viral serotypes</title></titleInfo><name type="personal"><namePart type="given">HS</namePart><namePart type="family">Bashyam</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S</namePart><namePart type="family">Green</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AL</namePart><namePart type="family">Rothman</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bashyam HS, Green S, Rothman AL. Dengue virus‐reactive CD8+ T cells display quantitative and qualitative differences in their response to variant epitopes of heterologous viral serotypes. J Immunol 2006;176:2817–2824.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>176</number></detail><extent unit="pages"><start>2817</start><end>2824</end></extent></part><relatedItem type="host"><titleInfo><title>J Immunol</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>176</number></detail><extent unit="pages"><start>2817</start><end>2824</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit166"><titleInfo><title>Human memory cytotoxic T‐lymphocyte (CTL) responses to Hantaan virus infection: identification of virus‐specific and cross‐reactive CD8(+) CTL epitopes on nucleocapsid protein</title></titleInfo><name type="personal"><namePart type="given">HL</namePart><namePart type="family">Van Epps</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">CS</namePart><namePart type="family">Schmaljohn</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">FA</namePart><namePart type="family">Ennis</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Van Epps HL, Schmaljohn CS, Ennis FA. Human memory cytotoxic T‐lymphocyte (CTL) responses to Hantaan virus infection: identification of virus‐specific and cross‐reactive CD8(+) CTL epitopes on nucleocapsid protein. J Virol 1999;73:5301–5308.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>5301</start><end>5308</end></extent></part><relatedItem type="host"><titleInfo><title>J Virol</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>5301</start><end>5308</end></extent></part></relatedItem></relatedItem><identifier type="istex">AB44BAF2DE4D8B7A1A1B354A847ECA6C9A7DE552</identifier><identifier type="ark">ark:/67375/WNG-LBC859RT-P</identifier><identifier type="DOI">10.1111/j.0105-2896.2010.00897.x</identifier><identifier type="ArticleID">IMR897</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2010 John Wiley & Sons A/S</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-11-15</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-LBC859RT-P/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001326 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001326 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:AB44BAF2DE4D8B7A1A1B354A847ECA6C9A7DE552
|texte= Heterologous immunity between viruses
}}
| This area was generated with Dilib version V0.6.33. |  |