H2N2V1, Istex, Corpus, bibRecord, 001247

Comparison of Live Attenuated Cold-Adapted and Avian-Human Influenza A/Bethesda/85 (H3N2) Reassortant Virus Vaccines in Infants and Children

Identifieur interne : 001247 ( Istex/Corpus ); précédent : 001246; suivant : 001248

Comparison of Live Attenuated Cold-Adapted and Avian-Human Influenza A/Bethesda/85 (H3N2) Reassortant Virus Vaccines in Infants and Children

Auteurs : Mark C. Steinhoff ; Neal A. Halsey ; Modena H. Wilson ; Barbara A. Burns ; Roberta K. Samorodin ; Louis F. Fries ; Brian R. Murphy ; Mary Lou Clements

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1990.

RBID : ISTEX:FB0DFE97F372E8B587AAC6FECF8BD413D0D0701B

Abstract

Randomized, placebo-controlled studies with 103–10' 50% tissue-culture infectious dose (TCID50) of avian-human (ah) and cold-adapted (ca) influenza A/Bethesda/85 (H3N2) reassortant viruses were completed in 106 seronegative young children 6–48 months of age. Although the reassortants differed in six of eight RNA segments, they exhibited similar properties in level of attenuation, infectivity, immunogenicity, and efficacy. The 50% human infectious dose was 104.6 TCID50 for ah and 104.4 for ca vaccines. Both reassortants were satisfactorily attenuated with restricted replication and were no more reactogenic than placebo. The mean peak titer of virus shed was 101.5 (ah) to 102.0 (ca) TCID50/ml, and each of 37 isolates tested retained their characteristic vaccine phenotypes. Infection with ah or ca virus conferred immunity to experimental challenge with homologous virus. These findings indicate that both ah and ca influenza A/Bethesda/85 (H3N2) reassortants should be suitable vaccine candidates for use in healthy infants and young children.

Url:

https://api.istex.fr/ark:/67375/HXZ-QRM182FH-J/fulltext.pdf

DOI: 10.1093/infdis/162.2.394

Links to Exploration step

ISTEX:FB0DFE97F372E8B587AAC6FECF8BD413D0D0701B

Le document en format XML

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<profileDesc><abstract><p>Randomized, placebo-controlled studies with 103–10' 50% tissue-culture infectious dose (TCID<hi rend="subscript">50</hi>
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<article-title>Comparison of Live Attenuated Cold-Adapted and Avian-Human Influenza A/Bethesda/85 (H3N2) Reassortant Virus Vaccines in Infants and Children</article-title>

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<surname>Steinhoff</surname>
<given-names>Mark C.</given-names>

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<contrib contrib-type="author">

<name>

<surname>Halsey</surname>
<given-names>Neal A.</given-names>

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<contrib contrib-type="author">

<name>

<surname>Wilson</surname>
<given-names>Modena H.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Burns</surname>
<given-names>Barbara A.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Samorodin</surname>
<given-names>Roberta K.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Fries</surname>
<given-names>Louis F.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Murphy</surname>
<given-names>Brian R.</given-names>

</name>

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<contrib contrib-type="author">

<name>

<surname>Clements</surname>
<given-names>Mary Lou</given-names>

</name>

</contrib>

<aff><institution>From the Department of International Health (Center for Immunization Research), School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, School of Medicine, Johns Hopkins University, Baltimore, and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</institution>
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</aff>

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<corresp id="COR1">Reprints and correspondence: Dr. Mark C. Steinhoff, Johns Hopkins University Center for Immunization Research, 624 N. Broadway, Baltimore, MD 21205.</corresp>

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<month>8</month>

<year>1990</year>

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<issue>2</issue>

<fpage>394</fpage>

<lpage>401</lpage>

<history>

<date date-type="received">

<day>16</day>

<month>10</month>

<year>1989</year>

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<month>2</month>

<year>1990</year>

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<copyright-statement>© 1990 by The University of Chicago</copyright-statement>

<copyright-year>1990</copyright-year>

<abstract>

<p>Randomized, placebo-controlled studies with 103–10' 50% tissue-culture infectious dose (TCID<sub>50</sub>
) of avian-human (ah) and cold-adapted (ca) influenza A/Bethesda/85 (H3N2) reassortant viruses were completed in 106 seronegative young children 6–48 months of age. Although the reassortants differed in six of eight RNA segments, they exhibited similar properties in level of attenuation, infectivity, immunogenicity, and efficacy. The 50% human infectious dose was 10<sup>4.6</sup>
 TCID<sub>50</sub>
 for ah and 10<sup>4.4</sup>
 for ca vaccines. Both reassortants were satisfactorily attenuated with restricted replication and were no more reactogenic than placebo. The mean peak titer of virus shed was 10<sup>1.5</sup>
 (ah) to 10<sup>2.0</sup>
 (ca) TCID<sub>50</sub>
/ml, and each of 37 isolates tested retained their characteristic vaccine phenotypes. Infection with <italic>ah</italic>
 or <italic>ca</italic>
 virus conferred immunity to experimental challenge with homologous virus. These findings indicate that both <italic>ah</italic>
 and <italic>ca</italic>
 influenza A/Bethesda/85 (H3N2) reassortants should be suitable vaccine candidates for use in healthy infants and young children.</p>

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<note type="author-notes">Reprints and correspondence: Dr. Mark C. Steinhoff, Johns Hopkins University Center for Immunization Research, 624 N. Broadway, Baltimore, MD 21205.</note>
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Comparison of Live Attenuated Cold-Adapted and Avian-Human Influenza A/Bethesda/85 (H3N2) Reassortant Virus Vaccines in Infants and Children

Comparison of Live Attenuated Cold-Adapted and Avian-Human Influenza A/Bethesda/85 (H3N2) Reassortant Virus Vaccines in Infants and Children

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