Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-ts-l[E] Recombinant Viruses in Human Adults
Identifieur interne : 001211 ( Istex/Corpus ); précédent : 001210; suivant : 001212Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-ts-l[E] Recombinant Viruses in Human Adults
Auteurs : Douglas D. Richman ; Brian R. Murphy ; Robert M. Chanock ; Jack M. Gwaltney ; R. Gordon Douglas ; Douglas Betts ; Neil R. Blacklow ; Frederick B. Rose ; Thomas A. Parrino ; Myron M. Levine ; Ellis S. CaplanSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1976.
Abstract
The presence of the temperature-sensitive (ts) lesions of complementation-recombination groups I and 5 in the Hong Kong/68-ts-I[A] virus was confirmed by genetic analysis of ts recombinants of the Hong Kongj68-ts-1 [A] virus and a Udorn / 72 wildtype virus. Three classes of Udorn/72-ts recombinants were found. One class possessed both ts genes of the Hong Kong/68-ts-I[A] parent, a second class possessed the ts lesion characteristic of group I, and a third class possessed the ts lesion of group 5. The Hong Kongj68-ts-1 [AJ parent and the Udorn/72-ts recombinants exhibited a lO,OOO-fold or greater restriction of replication in the lungs of hamsters than did the homologous wild-type virus. All isolates from the lungs and nasal turbinates of recipients of two of the four Udorn/72-ts-I[AJ recombinants contained only ts virus. These two properties, restricted replication and genetic stability after replication in vivo, suggest that the Udorn/72-ts-I[AJ recombinants should be considered for evaluation as vaccines for use in humans.
Url:
DOI: 10.1093/infdis/134.6.585
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ISTEX:557925DE5FA9FFB3EBDB2EACC976B1F1F41B7B21Le document en format XML
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Murphy</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation><affiliation><mods:affiliation>Please address requests for reprints to Dr. Brian R. Murphy, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 301, Bethesda, Maryland 20014.</mods:affiliation></affiliation></author><author><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Gwaltney, Jack M" sort="Gwaltney, Jack M" uniqKey="Gwaltney J" first="Jack M." last="Gwaltney">Jack M. Gwaltney</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Douglas, R Gordon" sort="Douglas, R Gordon" uniqKey="Douglas R" first="R. Gordon" last="Douglas">R. Gordon Douglas</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Betts, Douglas" sort="Betts, Douglas" uniqKey="Betts D" first="Douglas" last="Betts">Douglas Betts</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Blacklow, Neil R" sort="Blacklow, Neil R" uniqKey="Blacklow N" first="Neil R." last="Blacklow">Neil R. Blacklow</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation><affiliation><mods:affiliation>,</mods:affiliation></affiliation></author><author><name sortKey="Rose, Frederick B" sort="Rose, Frederick B" uniqKey="Rose F" first="Frederick B." last="Rose">Frederick B. Rose</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Parrino, Thomas A" sort="Parrino, Thomas A" uniqKey="Parrino T" first="Thomas A." last="Parrino">Thomas A. Parrino</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Levine, Myron M" sort="Levine, Myron M" uniqKey="Levine M" first="Myron M." last="Levine">Myron M. Levine</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Caplan, Ellis S" sort="Caplan, Ellis S" uniqKey="Caplan E" first="Ellis S." last="Caplan">Ellis S. Caplan</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:557925DE5FA9FFB3EBDB2EACC976B1F1F41B7B21</idno><date when="1976" year="1976">1976</date><idno type="doi">10.1093/infdis/134.6.585</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-BRGTD7QZ-Q/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001211</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001211</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-<hi rend="italic">ts</hi>-l[E] Recombinant Viruses in Human Adults</title><author><name sortKey="Richman, Douglas D" sort="Richman, Douglas D" uniqKey="Richman D" first="Douglas D." last="Richman">Douglas D. Richman</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation><affiliation><mods:affiliation>,</mods:affiliation></affiliation></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation><affiliation><mods:affiliation>Please address requests for reprints to Dr. Brian R. Murphy, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 301, Bethesda, Maryland 20014.</mods:affiliation></affiliation></author><author><name sortKey="Chanock, Robert M" sort="Chanock, Robert M" uniqKey="Chanock R" first="Robert M." last="Chanock">Robert M. Chanock</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Gwaltney, Jack M" sort="Gwaltney, Jack M" uniqKey="Gwaltney J" first="Jack M." last="Gwaltney">Jack M. Gwaltney</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Douglas, R Gordon" sort="Douglas, R Gordon" uniqKey="Douglas R" first="R. Gordon" last="Douglas">R. Gordon Douglas</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Betts, Douglas" sort="Betts, Douglas" uniqKey="Betts D" first="Douglas" last="Betts">Douglas Betts</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Blacklow, Neil R" sort="Blacklow, Neil R" uniqKey="Blacklow N" first="Neil R." last="Blacklow">Neil R. Blacklow</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation><affiliation><mods:affiliation>,</mods:affiliation></affiliation></author><author><name sortKey="Rose, Frederick B" sort="Rose, Frederick B" uniqKey="Rose F" first="Frederick B." last="Rose">Frederick B. Rose</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Parrino, Thomas A" sort="Parrino, Thomas A" uniqKey="Parrino T" first="Thomas A." last="Parrino">Thomas A. Parrino</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Levine, Myron M" sort="Levine, Myron M" uniqKey="Levine M" first="Myron M." last="Levine">Myron M. Levine</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Caplan, Ellis S" sort="Caplan, Ellis S" uniqKey="Caplan E" first="Ellis S." last="Caplan">Ellis S. Caplan</name><affiliation><mods:affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1976-12">1976</date><biblScope unit="vol">134</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="577">577</biblScope><biblScope unit="page" to="554">554</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The presence of the temperature-sensitive (ts) lesions of complementation-recombination groups I and 5 in the Hong Kong/68-ts-I[A] virus was confirmed by genetic analysis of ts recombinants of the Hong Kongj68-ts-1 [A] virus and a Udorn / 72 wildtype virus. Three classes of Udorn/72-ts recombinants were found. One class possessed both ts genes of the Hong Kong/68-ts-I[A] parent, a second class possessed the ts lesion characteristic of group I, and a third class possessed the ts lesion of group 5. The Hong Kongj68-ts-1 [AJ parent and the Udorn/72-ts recombinants exhibited a lO,OOO-fold or greater restriction of replication in the lungs of hamsters than did the homologous wild-type virus. All isolates from the lungs and nasal turbinates of recipients of two of the four Udorn/72-ts-I[AJ recombinants contained only ts virus. These two properties, restricted replication and genetic stability after replication in vivo, suggest that the Udorn/72-ts-I[AJ recombinants should be considered for evaluation as vaccines for use in humans.</div></front></TEI><istex><corpusName>oup</corpusName><keywords><teeft><json:string>recombinant</json:string><json:string>clone</json:string><json:string>shutoff</json:string><json:string>shutoff temperature</json:string><json:string>attenuation</json:string><json:string>seronegative</json:string><json:string>attenuated</json:string><json:string>neuraminidase</json:string><json:string>mutant</json:string><json:string>influenza</json:string><json:string>richman</json:string><json:string>recombinant virus</json:string><json:string>vaccinee</json:string><json:string>chanock</json:string><json:string>influenza virus</json:string><json:string>lesion</json:string><json:string>neutralizing</json:string><json:string>hemagglutinin</json:string><json:string>udorn</json:string><json:string>hamster</json:string><json:string>vaccine</json:string><json:string>antigenic</json:string><json:string>subset</json:string><json:string>tcid</json:string><json:string>influenzal</json:string><json:string>virus</json:string><json:string>seronegative volunteer</json:string><json:string>infectious disease</json:string><json:string>national institute</json:string><json:string>present report</json:string><json:string>genetic stability</json:string><json:string>hong kong</json:string><json:string>udorn clone</json:string><json:string>febrile</json:string><json:string>lesion present</json:string><json:string>plaque formation</json:string><json:string>virus suspension</json:string><json:string>seronegative child</json:string><json:string>average duration</json:string><json:string>wild type</json:string><json:string>parent virus</json:string><json:string>present study</json:string><json:string>titer</json:string><json:string>nasal</json:string></teeft></keywords><author><json:item><name>Douglas D. Richman</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string><json:string>,</json:string></affiliations></json:item><json:item><name>Brian R. Murphy</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string><json:string>Please address requests for reprints to Dr. Brian R. Murphy, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 301, Bethesda, Maryland 20014.</json:string></affiliations></json:item><json:item><name>Robert M. Chanock</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string></affiliations></json:item><json:item><name>Jack M. Gwaltney Jr.</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string></affiliations></json:item><json:item><name>R. Gordon Douglas</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string></affiliations></json:item><json:item><name>Douglas Betts</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string></affiliations></json:item><json:item><name>Neil R. Blacklow</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string><json:string>,</json:string></affiliations></json:item><json:item><name>Frederick B. Rose</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string></affiliations></json:item><json:item><name>Thomas A. Parrino</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string></affiliations></json:item><json:item><name>Myron M. Levine</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string></affiliations></json:item><json:item><name>Ellis S. Caplan</name><affiliations><json:string>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</json:string></affiliations></json:item></author><arkIstex>ark:/67375/HXZ-BRGTD7QZ-Q</arkIstex><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>The presence of the temperature-sensitive (ts) lesions of complementation-recombination groups I and 5 in the Hong Kong/68-ts-I[A] virus was confirmed by genetic analysis of ts recombinants of the Hong Kongj68-ts-1 [A] virus and a Udorn / 72 wildtype virus. Three classes of Udorn/72-ts recombinants were found. One class possessed both ts genes of the Hong Kong/68-ts-I[A] parent, a second class possessed the ts lesion characteristic of group I, and a third class possessed the ts lesion of group 5. The Hong Kongj68-ts-1 [AJ parent and the Udorn/72-ts recombinants exhibited a lO,OOO-fold or greater restriction of replication in the lungs of hamsters than did the homologous wild-type virus. All isolates from the lungs and nasal turbinates of recipients of two of the four Udorn/72-ts-I[AJ recombinants contained only ts virus. These two properties, restricted replication and genetic stability after replication in vivo, suggest that the Udorn/72-ts-I[AJ recombinants should be considered for evaluation as vaccines for use in humans.</abstract><qualityIndicators><score>7.5</score><pdfWordCount>4961</pdfWordCount><pdfCharCount>30868</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>612 x 768.96 pts</pdfPageSize><pdfWordsPerPage>496</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>false</refBibsNative><abstractWordCount>156</abstractWordCount><abstractCharCount>1040</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-ts-l[E] Recombinant Viruses in Human Adults</title><genre><json:string>research-article</json:string></genre><host><title>Journal of Infectious Diseases</title><language><json:string>unknown</json:string></language><issn><json:string>0022-1899</json:string></issn><eissn><json:string>1537-6613</json:string></eissn><publisherId><json:string>jid</json:string></publisherId><volume>134</volume><issue>6</issue><pages><first>577</first><last>554</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1968</json:string><json:string>1947</json:string><json:string>1976</json:string><json:string>1972</json:string></date><geogName></geogName><orgName><json:string>University Hospital, Boston, Massachusetts</json:string><json:string>Veterans Administration Hospital, La Jolla, California</json:string><json:string>University of Rochester School of Medicine</json:string><json:string>Department of Pathology and Medicine</json:string><json:string>Boston City Hospital, Boston, Mass</json:string><json:string>Strong Memorial Hospital, Rochester, New York</json:string><json:string>University of Rochester</json:string><json:string>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases</json:string><json:string>Spafas, Inc.</json:string><json:string>National Institutes of Health, Building</json:string><json:string>University of Maryland School of Medicine</json:string><json:string>University of Virginia</json:string><json:string>Judes Children's Research Hospital, Memphis, Tenn</json:string><json:string>Department of Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts</json:string><json:string>Clinical Research Center for Vaccine Development</json:string><json:string>Division of Infectious Diseases</json:string><json:string>National Institutes of Health, Bethesda, Maryland</json:string><json:string>University of Maryland</json:string><json:string>Walter Reed Army Institute of Research, Washington</json:string><json:string>Division of Adult Infectious Diseases</json:string><json:string>University of California</json:string><json:string>Boston University Clinical Research Center</json:string><json:string>Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia</json:string><json:string>World Health Organization</json:string><json:string>Calbiochem, Los Angeles</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Philip Russell</json:string><json:string>Thomas A. Parrino</json:string><json:string>Hong Kongj</json:string><json:string>Hong KongJ</json:string><json:string>Robert M. Chanock</json:string><json:string>M. Levine</json:string><json:string>Hong Kong</json:string><json:string>Frederick B. Rose</json:string><json:string>Walter Dowdle</json:string><json:string>Neil R. Blacklow</json:string><json:string>Robert F. Betts</json:string><json:string>Gordon Douglas</json:string><json:string>Jack M. Gwaltney</json:string><json:string>Brian R. Murphy</json:string><json:string>Ellis S. Caplan</json:string><json:string>Hong Kongf</json:string><json:string>Any Percentage</json:string><json:string>Robert Webster</json:string></persName><placeName><json:string>San Diego</json:string><json:string>Rochester</json:string><json:string>Port Chalmers</json:string><json:string>Atlanta</json:string><json:string>Baltimore</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[1-5]</json:string><json:string>[4]</json:string><json:string>[10, 15]</json:string><json:string>[22]</json:string><json:string>Richman et al.</json:string><json:string>[10, 11]</json:string><json:string>[19, 20]</json:string><json:string>[21]</json:string><json:string>[16]</json:string><json:string>[3]</json:string><json:string>[10, 17]</json:string><json:string>[5]</json:string><json:string>[15]</json:string><json:string>[4, 9]</json:string><json:string>[14]</json:string><json:string>[9]</json:string><json:string>[15, 18]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/HXZ-BRGTD7QZ-Q</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - microbiology</json:string><json:string>2 - infectious diseases</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - microbiology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>1976</publicationDate><copyrightDate>1976</copyrightDate><doi><json:string>10.1093/infdis/134.6.585</json:string></doi><id>557925DE5FA9FFB3EBDB2EACC976B1F1F41B7B21</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-BRGTD7QZ-Q/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-BRGTD7QZ-Q/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/HXZ-BRGTD7QZ-Q/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-ts-l[E] Recombinant Viruses in Human Adults</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>The University of Chicago Press</publisher><availability><licence>© 1976 by the University of Chicago</licence></availability><date type="Copyright" when="1976">1976</date><date when="1976-12">1976</date></publicationStmt><notesStmt><note type="content-type" source="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="publication-type" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-<hi rend="italic">ts</hi>-l[E] Recombinant Viruses in Human Adults</title><author xml:id="author-0000"><persName><surname>Richman</surname><forename type="first">Douglas D.</forename></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation><note place="foot" n="fn2"><ref>*</ref><p>Present address: Department of Pathology and Medicine, University of California at San Diego and Veterans Administration Hospital, La Jolla, California.</p></note></author><author xml:id="author-0001" role="corresp"><persName><surname>Murphy</surname><forename type="first">Brian R.</forename></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation><affiliation role="corresp">Please address requests for reprints to Dr. Brian R. Murphy, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 301, Bethesda, Maryland 20014.</affiliation></author><author xml:id="author-0002"><persName><surname>Chanock</surname><forename type="first">Robert M.</forename></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation></author><author xml:id="author-0003"><persName><surname>Gwaltney</surname><forename type="first">Jack M.</forename><genName>Jr.</genName></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation></author><author xml:id="author-0004"><persName><surname>Douglas</surname><forename type="first">R. Gordon</forename></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation></author><author xml:id="author-0005"><persName><surname>Betts</surname><forename type="first">Douglas</forename></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation></author><author xml:id="author-0006"><persName><surname>Blacklow</surname><forename type="first">Neil R.</forename></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation><note place="foot" n="fn3"><ref>†</ref><p>Present address: Department of Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts.</p></note></author><author xml:id="author-0007"><persName><surname>Rose</surname><forename type="first">Frederick B.</forename></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation></author><author xml:id="author-0008"><persName><surname>Parrino</surname><forename type="first">Thomas A.</forename></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation></author><author xml:id="author-0009"><persName><surname>Levine</surname><forename type="first">Myron M.</forename></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation></author><author xml:id="author-0010"><persName><surname>Caplan</surname><forename type="first">Ellis S.</forename></persName><affiliation><orgName type="laboratory">From the Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><orgName type="institution">Bethesda</orgName><orgName type="department">Maryland the Department of Preventive Medicine</orgName><orgName type="institution">University of Virginia School of Medicine</orgName><orgName type="laboratory">Infectious Disease Unit</orgName><orgName type="institution">University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</orgName><orgName type="department">Division of Adult Infectious Diseases</orgName><orgName type="institution">University Hospital</orgName><orgName type="institution">Boston</orgName><orgName type="department">Massachusetts and the Division of Infectious Diseases</orgName><orgName type="institution">University of Maryland School of Medicine</orgName><address><addrLine>Charlottesville, Virginia</addrLine><addrLine>Rochester, New York</addrLine><addrLine>Baltimore, Maryland</addrLine></address></affiliation></author><idno type="istex">557925DE5FA9FFB3EBDB2EACC976B1F1F41B7B21</idno><idno type="ark">ark:/67375/HXZ-BRGTD7QZ-Q</idno><idno type="DOI">10.1093/infdis/134.6.585</idno></analytic><monogr><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="hwp">jinfdis</idno><idno type="publisher-id">jid</idno><idno type="pISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1976-12">1976</date><biblScope unit="vol">134</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="577">577</biblScope><biblScope unit="page" to="554">554</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract><p>The presence of the temperature-sensitive (<hi rend="italic">ts</hi>) lesions of complementation-recombination groups I and 5 in the Hong Kong/68-<hi rend="italic">ts</hi>-I[A] virus was confirmed by genetic analysis of <hi rend="italic">ts</hi> recombinants of the Hong Kongj68-<hi rend="italic">ts</hi>-1 [A] virus and a Udorn / 72 wildtype virus. Three classes of Udorn/72-<hi rend="italic">ts</hi> recombinants were found. One class possessed both <hi rend="italic">ts</hi> genes of the Hong Kong/68-<hi rend="italic">ts</hi>-I[A] parent, a second class possessed the <hi rend="italic">ts</hi> lesion characteristic of group I, and a third class possessed the <hi rend="italic">ts</hi> lesion of group 5. The Hong Kongj68-ts-1 [AJ parent and the Udorn/72-<hi rend="italic">ts</hi> recombinants exhibited a lO,OOO-fold or greater restriction of replication in the lungs of hamsters than did the homologous wild-type virus. All isolates from the lungs and nasal turbinates of recipients of two of the four Udorn/72-<hi rend="italic">ts</hi>-I[AJ recombinants contained only <hi rend="italic">ts</hi> virus. These two properties, restricted replication and genetic stability after replication in vivo, suggest that the Udorn/72-<hi rend="italic">ts</hi>-I[AJ recombinants should be considered for evaluation as vaccines for use in humans.</p></abstract><textClass ana="subject"><keywords scheme="heading"><term>Major Articles</term></keywords></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-09" who="#istex" xml:id="pub2tei">formatting</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2019-12-10">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-BRGTD7QZ-Q/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article">
<front>
<journal-meta>
<journal-id journal-id-type="hwp">jinfdis</journal-id>
<journal-id journal-id-type="publisher-id">jid</journal-id>
<journal-title>Journal of Infectious Diseases</journal-title>
<abbrev-journal-title>J Infect Dis.</abbrev-journal-title>
<issn pub-type="ppub">0022-1899</issn>
<issn pub-type="epub">1537-6613</issn>
<publisher>
<publisher-name>The University of Chicago Press</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.1093/infdis/134.6.585</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Major Articles</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-<italic>ts</italic>-l[E] Recombinant Viruses in Human Adults</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name><surname>Richman</surname>
<given-names>Douglas D.</given-names>
</name><xref ref-type="author-notes" rid="fn2">*</xref>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name><surname>Murphy</surname>
<given-names>Brian R.</given-names>
</name><xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Chanock</surname>
<given-names>Robert M.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name><surname>Gwaltney</surname>
<given-names>Jack M.</given-names>
<suffix>Jr.</suffix>
</name>
</contrib>
<contrib contrib-type="author">
<name><surname>Douglas</surname>
<given-names>R. Gordon</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name><surname>Betts</surname>
<given-names>Douglas</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name><surname>Blacklow</surname>
<given-names>Neil R.</given-names>
</name><xref ref-type="author-notes" rid="fn3">†</xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Rose</surname>
<given-names>Frederick B.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name><surname>Parrino</surname>
<given-names>Thomas A.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name><surname>Levine</surname>
<given-names>Myron M.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name><surname>Caplan</surname>
<given-names>Ellis S.</given-names>
</name>
</contrib>
<aff><institution>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine</institution>, <addr-line>Charlottesville, Virginia</addr-line>; the <institution>Infectious Disease Unit, University of Rochester School of Medicine and Dentistry and Strong Memorial Hospital</institution>, <addr-line>Rochester, New York</addr-line>; the <institution>Division of Adult Infectious Diseases, University Hospital, Boston, Massachusetts; and the Division of Infectious Diseases, University of Maryland School of Medicine</institution>, <addr-line>Baltimore, Maryland</addr-line></aff>
</contrib-group>
<author-notes>
<corresp id="cor1">Please address requests for reprints to Dr. Brian R. Murphy, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 301, Bethesda, Maryland 20014.</corresp>
<fn fn-type="present-address" id="fn2">
<label>*</label>
<p>Present address: Department of Pathology and Medicine, University of California at San Diego and Veterans Administration Hospital, La Jolla, California.</p>
</fn>
<fn fn-type="present-address" id="fn3">
<label>†</label>
<p>Present address: Department of Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub">
<month>12</month>
<year>1976</year>
</pub-date>
<volume>134</volume>
<issue>6</issue>
<fpage>577</fpage>
<lpage>554</lpage>
<history>
<date date-type="received">
<day>23</day>
<month>3</month>
<year>1976</year>
</date>
<date date-type="rev-recd">
<day>8</day>
<month>6</month>
<year>1976</year>
</date>
</history>
<copyright-statement>© 1976 by the University of Chicago</copyright-statement>
<copyright-year>1976</copyright-year>
<abstract>
<p>The presence of the temperature-sensitive (<italic>ts</italic>) lesions of complementation-recombination groups I and 5 in the Hong Kong/68-<italic>ts</italic>-I[A] virus was confirmed by genetic analysis of <italic>ts</italic> recombinants of the Hong Kongj68-<italic>ts</italic>-1 [A] virus and a Udorn / 72 wildtype virus. Three classes of Udorn/72-<italic>ts</italic> recombinants were found. One class possessed both <italic>ts</italic> genes of the Hong Kong/68-<italic>ts</italic>-I[A] parent, a second class possessed the <italic>ts</italic> lesion characteristic of group I, and a third class possessed the <italic>ts</italic> lesion of group 5. The Hong Kongj68-ts-1 [AJ parent and the Udorn/72-<italic>ts</italic> recombinants exhibited a lO,OOO-fold or greater restriction of replication in the lungs of hamsters than did the homologous wild-type virus. All isolates from the lungs and nasal turbinates of recipients of two of the four Udorn/72-<italic>ts</italic>-I[AJ recombinants contained only <italic>ts</italic> virus. These two properties, restricted replication and genetic stability after replication in vivo, suggest that the Udorn/72-<italic>ts</italic>-I[AJ recombinants should be considered for evaluation as vaccines for use in humans.</p>
</abstract>
</article-meta>
</front>
</article>
</istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-ts-l[E] Recombinant Viruses in Human Adults</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Temperature-Sensitive Mutants of Influenza A Virus. XII. Safety, Antigenicity, Transmissibility, and Efficacy of Influenza A/Udorn/72-ts-l[E] Recombinant Viruses in Human Adults</title></titleInfo><name type="personal"><namePart type="given">Douglas D.</namePart><namePart type="family">Richman</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><affiliation>,</affiliation><description>* Present address: Department of Pathology and Medicine, University of California at San Diego and Veterans Administration Hospital, La Jolla, California.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Brian R.</namePart><namePart type="family">Murphy</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><affiliation>Please address requests for reprints to Dr. Brian R. Murphy, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 301, Bethesda, Maryland 20014.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert M.</namePart><namePart type="family">Chanock</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jack M.</namePart><namePart type="family">Gwaltney</namePart><namePart type="termsOfAddress">Jr.</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. Gordon</namePart><namePart type="family">Douglas</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Douglas</namePart><namePart type="family">Betts</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Neil R.</namePart><namePart type="family">Blacklow</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><affiliation>,</affiliation><description>Present address: Department of Medicine, University of Massachusetts School of Medicine, Worcester, Massachusetts.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frederick B.</namePart><namePart type="family">Rose</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Thomas A.</namePart><namePart type="family">Parrino</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Myron M.</namePart><namePart type="family">Levine</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ellis S.</namePart><namePart type="family">Caplan</namePart><affiliation>From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; the Department of Preventive Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, Rochester, New York, Baltimore, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>The University of Chicago Press</publisher><dateIssued encoding="w3cdtf">1976-12</dateIssued><copyrightDate encoding="w3cdtf">1976</copyrightDate></originInfo><abstract>The presence of the temperature-sensitive (ts) lesions of complementation-recombination groups I and 5 in the Hong Kong/68-ts-I[A] virus was confirmed by genetic analysis of ts recombinants of the Hong Kongj68-ts-1 [A] virus and a Udorn / 72 wildtype virus. Three classes of Udorn/72-ts recombinants were found. One class possessed both ts genes of the Hong Kong/68-ts-I[A] parent, a second class possessed the ts lesion characteristic of group I, and a third class possessed the ts lesion of group 5. The Hong Kongj68-ts-1 [AJ parent and the Udorn/72-ts recombinants exhibited a lO,OOO-fold or greater restriction of replication in the lungs of hamsters than did the homologous wild-type virus. All isolates from the lungs and nasal turbinates of recipients of two of the four Udorn/72-ts-I[AJ recombinants contained only ts virus. These two properties, restricted replication and genetic stability after replication in vivo, suggest that the Udorn/72-ts-I[AJ recombinants should be considered for evaluation as vaccines for use in humans.</abstract><note type="footnotes">Present address: Department of Pathology and Medicine, University of California at San Diego and Veterans Administration Hospital, La Jolla, California.</note><note type="author-notes">Please address requests for reprints to Dr. Brian R. Murphy, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 301, Bethesda, Maryland 20014.</note><relatedItem type="host"><titleInfo><title>Journal of Infectious Diseases</title></titleInfo><titleInfo type="abbreviated"><title>J Infect Dis.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-1899</identifier><identifier type="eISSN">1537-6613</identifier><identifier type="PublisherID">jid</identifier><identifier type="PublisherID-hwp">jinfdis</identifier><part><date>1976</date><detail type="volume"><caption>vol.</caption><number>134</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>577</start><end>554</end></extent></part></relatedItem><identifier type="istex">557925DE5FA9FFB3EBDB2EACC976B1F1F41B7B21</identifier><identifier type="ark">ark:/67375/HXZ-BRGTD7QZ-Q</identifier><identifier type="DOI">10.1093/infdis/134.6.585</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1976 by the University of Chicago</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-GTWS0RDP-M">oup</recordContentSource><recordOrigin>Converted from (version 1.2.0) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-12-09</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-BRGTD7QZ-Q/record.json</uri></json:item></metadata><covers><json:item><extension>tiff</extension><original>true</original><mimetype>image/tiff</mimetype><uri>https://api.istex.fr/document/557925DE5FA9FFB3EBDB2EACC976B1F1F41B7B21/covers/tiff</uri></json:item></covers><annexes><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-BRGTD7QZ-Q/annexes.pdf</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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