H2N2V1, Istex, Corpus, bibRecord, 001180

Increased Anti-Influenza A Virus Cytotoxic T Cell Activity following Vaccination of the Chronically III Elderly with Live Attenuated or Inactivated Influenza Virus Vaccine

Identifieur interne : 001180 ( Istex/Corpus ); précédent : 001179; suivant : 001181

Increased Anti-Influenza A Virus Cytotoxic T Cell Activity following Vaccination of the Chronically III Elderly with Live Attenuated or Inactivated Influenza Virus Vaccine

Auteurs : Geoffrey J. Gorse ; Mark J. Campbell ; Esther E. Otto ; Douglas C. Powers ; Guy W. Chambers ; Frances K. Newman

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1995.

RBID : ISTEX:FEF84CD4EE1C721599756E83B80634DCAC1277AA

Abstract

The possible enhancement of anti-influenza A virus memory cytotoxic T cell (CTL) responses to inactivated influenza virus vaccine by coadministration of intranasal live attenuated influenza A virus vaccine was investigated. Fifty elderly nursing home residents received inactivated trivalent influenza virus vaccine intramuscularly and simultaneously were randomly assigned to receive either bivalent live attenuated influenza A virus vaccine or saline placebo intranasally in a blinded fashion. A larger proportion of volunteers who received live attenuated virus vaccine than of those who received placebo experienced a postvaccination rise in anti-influenza A virus CTL activity (15 of 23 vs. 8 of 24; P < .05). Anti-influenza A virus cytotoxicity was primarily mediated by CD8+ T cells and was influenza A virus-specific and HLA-restricted. There was a possible advantage of administering live attenuated with inactivated virus vaccine because of enhanced memory anti-influenza A virus CTL activity.

Url:

https://api.istex.fr/ark:/67375/HXZ-17WWGW9T-T/fulltext.pdf

DOI: 10.1093/infdis/172.1.1

Links to Exploration step

ISTEX:FEF84CD4EE1C721599756E83B80634DCAC1277AA

Le document en format XML

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<profileDesc><abstract><p>The possible enhancement of anti-influenza A virus memory cytotoxic T cell (CTL) responses to inactivated influenza virus vaccine by coadministration of intranasal live attenuated influenza A virus vaccine was investigated. Fifty elderly nursing home residents received inactivated trivalent influenza virus vaccine intramuscularly and simultaneously were randomly assigned to receive either bivalent live attenuated influenza A virus vaccine or saline placebo intranasally in a blinded fashion. A larger proportion of volunteers who received live attenuated virus vaccine than of those who received placebo experienced a postvaccination rise in anti-influenza A virus CTL activity (15 of 23 vs. 8 of 24; <hi rend="italic">P</hi>
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<p>The possible enhancement of anti-influenza A virus memory cytotoxic T cell (CTL) responses to inactivated influenza virus vaccine by coadministration of intranasal live attenuated influenza A virus vaccine was investigated. Fifty elderly nursing home residents received inactivated trivalent influenza virus vaccine intramuscularly and simultaneously were randomly assigned to receive either bivalent live attenuated influenza A virus vaccine or saline placebo intranasally in a blinded fashion. A larger proportion of volunteers who received live attenuated virus vaccine than of those who received placebo experienced a postvaccination rise in anti-influenza A virus CTL activity (15 of 23 vs. 8 of 24; <italic>P</italic>
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Increased Anti-Influenza A Virus Cytotoxic T Cell Activity following Vaccination of the Chronically III Elderly with Live Attenuated or Inactivated Influenza Virus Vaccine

Increased Anti-Influenza A Virus Cytotoxic T Cell Activity following Vaccination of the Chronically III Elderly with Live Attenuated or Inactivated Influenza Virus Vaccine

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