Immunity to influenza
Identifieur interne : 001093 ( Istex/Corpus ); précédent : 001092; suivant : 001094Immunity to influenza
Auteurs : Jacqueline M. Katz ; Julie Plowden ; Mary Renshaw-Hoelscher ; Xiuhua Lu ; Terrence M. Tumpey ; Suryaprakash SambharaSource :
- Immunologic Research [ 0257-277X ] ; 2004-06-01.
English descriptors
- KwdEn :
Abstract
Abstract: Influenz a viruses cause annual epidemics and occasional pandemics of acute respiratory disease. Improved vaccines that can overcome the decline in immune function with aging and/or can induce broader immunity to novel pandemic strains are a high priority. To design improved vaccines for the elderly, we need to better understand the effects of age on both innate and adaptive immunity. In a murine model, we have determined that defects in antigen-presenting cell (APC) expression of pattern-recognition molecules, costimulatory molecules, and cytokine production may play an important role in the reduced clonal expansion of T cells in aging. The use of immunomodulators such as adjuvants may overcome some of the defects of aging immunity and may also be, useful in the development of improved vaccines for avian influenza A subtypes that pose a pandemic threat. Several novel strategies including the use of ISCOM-formulated vaccines, mucosal delivery, or DNA vaccination provided cross-subtype protection that could provide an important component of immunity in the event of a pandemic.
Url:
DOI: 10.1385/IR:29:1-3:113
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ISTEX:AB1AFA18822426F14179BE049382CAAD4AD2319FLe document en format XML
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Improved vaccines that can overcome the decline in immune function with aging and/or can induce broader immunity to novel pandemic strains are a high priority. To design improved vaccines for the elderly, we need to better understand the effects of age on both innate and adaptive immunity. In a murine model, we have determined that defects in antigen-presenting cell (APC) expression of pattern-recognition molecules, costimulatory molecules, and cytokine production may play an important role in the reduced clonal expansion of T cells in aging. The use of immunomodulators such as adjuvants may overcome some of the defects of aging immunity and may also be, useful in the development of improved vaccines for avian influenza A subtypes that pose a pandemic threat. Several novel strategies including the use of ISCOM-formulated vaccines, mucosal delivery, or DNA vaccination provided cross-subtype protection that could provide an important component of immunity in the event of a pandemic.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Jacqueline M. 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Language="En"><Heading>Abstract</Heading><Para>Influenz a viruses cause annual epidemics and occasional pandemics of acute respiratory disease. Improved vaccines that can overcome the decline in immune function with aging and/or can induce broader immunity to novel pandemic strains are a high priority. To design improved vaccines for the elderly, we need to better understand the effects of age on both innate and adaptive immunity. In a murine model, we have determined that defects in antigen-presenting cell (APC) expression of pattern-recognition molecules, costimulatory molecules, and cytokine production may play an important role in the reduced clonal expansion of T cells in aging. The use of immunomodulators such as adjuvants may overcome some of the defects of aging immunity and may also be, useful in the development of improved vaccines for avian influenza A subtypes that pose a pandemic threat. Several novel strategies including the use of ISCOM-formulated vaccines, mucosal delivery, or DNA vaccination provided cross-subtype protection that could provide an important component of immunity in the event of a pandemic.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Influenza virus</Keyword><Keyword>Immune response</Keyword><Keyword>Aging</Keyword><Keyword>Pandemics</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Immunity to influenza</title><subTitle>The challenges of protecting an aging population</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Immunity to influenza</title></titleInfo><name type="personal"><namePart type="given">Jacqueline</namePart><namePart type="given">M.</namePart><namePart type="family">Katz</namePart><affiliation>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clilton Road, Mailstop G-16, 30333, Atlanta, GA</affiliation><affiliation>E-mail: JKatz@cdc.gov</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Julie</namePart><namePart type="family">Plowden</namePart><affiliation>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clilton Road, Mailstop G-16, 30333, Atlanta, GA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mary</namePart><namePart type="family">Renshaw-Hoelscher</namePart><affiliation>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clilton Road, Mailstop G-16, 30333, Atlanta, GA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Xiuhua</namePart><namePart type="family">Lu</namePart><affiliation>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clilton Road, Mailstop G-16, 30333, Atlanta, GA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Terrence</namePart><namePart type="given">M.</namePart><namePart type="family">Tumpey</namePart><affiliation>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clilton Road, Mailstop G-16, 30333, Atlanta, GA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Suryaprakash</namePart><namePart type="family">Sambhara</namePart><affiliation>Influenza Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clilton Road, Mailstop G-16, 30333, Atlanta, GA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Humana Press</publisher><place><placeTerm type="text">Totowa</placeTerm></place><dateIssued encoding="w3cdtf">2004-06-01</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Influenz a viruses cause annual epidemics and occasional pandemics of acute respiratory disease. Improved vaccines that can overcome the decline in immune function with aging and/or can induce broader immunity to novel pandemic strains are a high priority. To design improved vaccines for the elderly, we need to better understand the effects of age on both innate and adaptive immunity. In a murine model, we have determined that defects in antigen-presenting cell (APC) expression of pattern-recognition molecules, costimulatory molecules, and cytokine production may play an important role in the reduced clonal expansion of T cells in aging. The use of immunomodulators such as adjuvants may overcome some of the defects of aging immunity and may also be, useful in the development of improved vaccines for avian influenza A subtypes that pose a pandemic threat. Several novel strategies including the use of ISCOM-formulated vaccines, mucosal delivery, or DNA vaccination provided cross-subtype protection that could provide an important component of immunity in the event of a pandemic.</abstract><note>Immunology at Emory University</note><subject lang="en"><genre>Key words</genre><topic>Influenza virus</topic><topic>Immune response</topic><topic>Aging</topic><topic>Pandemics</topic></subject><relatedItem type="host"><titleInfo><title>Immunologic Research</title></titleInfo><titleInfo type="abbreviated"><title>Immunol Res</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2004-06-01</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Allergology</topic><topic>Immunology</topic><topic>Medicine/Public Health, general</topic><topic>Internal Medicine</topic></subject><identifier type="ISSN">0257-277X</identifier><identifier type="eISSN">1559-0755</identifier><identifier type="JournalID">12026</identifier><identifier type="IssueArticleCount">26</identifier><identifier type="VolumeIssueCount">3</identifier><part><date>2004</date><detail type="volume"><number>29</number><caption>vol.</caption></detail><detail type="issue"><number>1-3</number><caption>no.</caption></detail><extent unit="pages"><start>113</start><end>124</end></extent></part><recordInfo><recordOrigin>Humana Press Inc., 2004</recordOrigin></recordInfo></relatedItem><identifier type="istex">AB1AFA18822426F14179BE049382CAAD4AD2319F</identifier><identifier type="ark">ark:/67375/VQC-ZKR19J1D-G</identifier><identifier type="DOI">10.1385/IR:29:1-3:113</identifier><identifier type="ArticleID">291103113</identifier><identifier type="ArticleID">Art291103113</identifier><accessCondition type="use and reproduction" contentType="copyright">Humana Press Inc, 2004</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Humana Press Inc, 2004</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-ZKR19J1D-G/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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