The fight against new types of influenza virus
Identifieur interne : 001034 ( Istex/Corpus ); précédent : 001033; suivant : 001035The fight against new types of influenza virus
Auteurs : Julia RomanovaSource :
- Biotechnology Journal [ 1860-6768 ] ; 2006-12.
Abstract
In 1997, during an outbreak in chickens in Hong Kong the avian H5N1 influenza virus crossed the species barrier and infected 18 people, of which 6 cases were fatal. The virus also infected wild birds and continued to circulate and mutate in geese and ducks in southeastern China. Since this occurrence, new antigenic variants that are highly pathogenic for humans as well as wild, domestic, and exotic waterfowl continue to appear in Hong Kong. This virus is spreading across Asia, and is encroaching upon Europe and other continents. Wild birds are now considered as the main reservoir of H5N1 virus. Humans become infected with this H5N1 virus usually via close contact with infected birds or a highly contaminated environment. The very low transmissibility of this virus prevented further person‐to‐person dissemination in spite of the complete absence of immunity in the human population to H5N1 viruses. Viruses of the H5N1 subtype are characterized by an exceptionally high pathogenicity for humans. The cause of the viral virulence is not known so far; however, several virulence factors are considered. The unprecedented capability of H5N1 viruses to kill humans intensifies the concern about its pandemic potential with catastrophic consequences. The effectiveness of existing antivirals as well as vaccines for humans and birds are reviewed.
Url:
DOI: 10.1002/biot.200600159
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ISTEX:B4A8E48218CD4B34AE34880FE501D70A4D51F430Le document en format XML
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The virus also infected wild birds and continued to circulate and mutate in geese and ducks in southeastern China. Since this occurrence, new antigenic variants that are highly pathogenic for humans as well as wild, domestic, and exotic waterfowl continue to appear in Hong Kong. This virus is spreading across Asia, and is encroaching upon Europe and other continents. Wild birds are now considered as the main reservoir of H5N1 virus. Humans become infected with this H5N1 virus usually via close contact with infected birds or a highly contaminated environment. The very low transmissibility of this virus prevented further person‐to‐person dissemination in spite of the complete absence of immunity in the human population to H5N1 viruses. Viruses of the H5N1 subtype are characterized by an exceptionally high pathogenicity for humans. The cause of the viral virulence is not known so far; however, several virulence factors are considered. 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>In 1997, during an outbreak in chickens in Hong Kong the avian H5N1 influenza virus crossed the species barrier and infected 18 people, of which 6 cases were fatal. The virus also infected wild birds and continued to circulate and mutate in geese and ducks in southeastern China. Since this occurrence, new antigenic variants that are highly pathogenic for humans as well as wild, domestic, and exotic waterfowl continue to appear in Hong Kong. This virus is spreading across Asia, and is encroaching upon Europe and other continents. Wild birds are now considered as the main reservoir of H5N1 virus. Humans become infected with this H5N1 virus usually via close contact with infected birds or a highly contaminated environment. The very low transmissibility of this virus prevented further person‐to‐person dissemination in spite of the complete absence of immunity in the human population to H5N1 viruses. Viruses of the H5N1 subtype are characterized by an exceptionally high pathogenicity for humans. The cause of the viral virulence is not known so far; however, several virulence factors are considered. The unprecedented capability of H5N1 viruses to kill humans intensifies the concern about its pandemic potential with catastrophic consequences. The effectiveness of existing antivirals as well as vaccines for humans and birds are reviewed.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">Virus</term><term xml:id="kwd2">Influenza</term><term xml:id="kwd3">Avian</term><term xml:id="kwd4">Vaccine</term></keywords><keywords rend="articleCategory"><term>Review</term></keywords><keywords rend="tocHeading1"><term>Reviews</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-P74MW01C-9/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>WILEY‐VCH Verlag</publisherName><publisherLoc>Weinheim</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1860-7314</doi><issn type="print">1860-6768</issn><issn type="electronic">1860-7314</issn><idGroup><id type="product" value="BIOT"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="BIOTECHNOLOGY JOURNAL">Biotechnology Journal</title><title type="subtitle">Healthcare Nutrition Technology</title><title type="short">Biotechnology Journal</title></titleGroup></publicationMeta><publicationMeta level="part" position="120"><doi origin="wiley" registered="yes">10.1002/biot.v1:12</doi><titleGroup><title type="specialIssueTitle">Caring for a Better World</title></titleGroup><numberingGroup><numbering type="journalVolume" number="1">1</numbering><numbering type="journalIssue">12</numbering></numberingGroup><coverDate startDate="2006-12">December 2006</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="11" status="forIssue"><doi origin="wiley" registered="yes">10.1002/biot.200600159</doi><idGroup><id type="unit" value="BIOT200600159"></id></idGroup><countGroup><count type="pageTotal" number="12"></count></countGroup><titleGroup><title type="articleCategory">Review</title><title type="tocHeading1">Reviews</title></titleGroup><copyright ownership="publisher">Copyright © 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</copyright><eventGroup><event type="manuscriptReceived" date="2006-08-17"></event><event type="manuscriptRevised" date="2006-10-04"></event><event type="manuscriptAccepted" date="2006-10-06"></event><event type="firstOnline" date="2006-11-24"></event><event type="publishedOnlineFinalForm" date="2006-12-07"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-09"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-07"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-15"></event></eventGroup><numberingGroup><numbering type="pageFirst">1381</numbering><numbering type="pageLast">1392</numbering></numberingGroup><correspondenceTo>Julia Romanova, Green Hills Biotechnology GmbH, Gersthofer Str. 29‐31, 1180, Vienna, Austria, <b>Fax:</b> +43‐1‐319‐6099</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:BIOT.BIOT1381.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="3"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="76"></count></countGroup><titleGroup><title type="main" xml:lang="en">The fight against new types of influenza virus</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Julia</givenNames><familyName>Romanova</familyName><degrees>Dr.</degrees></personName><contactDetails><email>j.romanova@greenhillsbiotech.com</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="AT" type="organization"><unparsedAffiliation>Green Hills Biotechnology GmbH, Vienna, Austria</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Virus</keyword><keyword xml:id="kwd2">Influenza</keyword><keyword xml:id="kwd3">Avian</keyword><keyword xml:id="kwd4">Vaccine</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>In 1997, during an outbreak in chickens in Hong Kong the avian H5N1 influenza virus crossed the species barrier and infected 18 people, of which 6 cases were fatal. The virus also infected wild birds and continued to circulate and mutate in geese and ducks in southeastern China. Since this occurrence, new antigenic variants that are highly pathogenic for humans as well as wild, domestic, and exotic waterfowl continue to appear in Hong Kong. This virus is spreading across Asia, and is encroaching upon Europe and other continents. Wild birds are now considered as the main reservoir of H5N1 virus. Humans become infected with this H5N1 virus usually via close contact with infected birds or a highly contaminated environment. The very low transmissibility of this virus prevented further person‐to‐person dissemination in spite of the complete absence of immunity in the human population to H5N1 viruses. Viruses of the H5N1 subtype are characterized by an exceptionally high pathogenicity for humans. The cause of the viral virulence is not known so far; however, several virulence factors are considered. The unprecedented capability of H5N1 viruses to kill humans intensifies the concern about its pandemic potential with catastrophic consequences. The effectiveness of existing antivirals as well as vaccines for humans and birds are reviewed.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The fight against new types of influenza virus</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>The fight against new types of influenza virus</title></titleInfo><name type="personal"><namePart type="given">Julia</namePart><namePart type="family">Romanova</namePart><namePart type="termsOfAddress">Dr.</namePart><affiliation>Green Hills Biotechnology GmbH, Vienna, Austria</affiliation><affiliation>E-mail: j.romanova@greenhillsbiotech.com</affiliation><affiliation>Correspondence address: Julia Romanova, Green Hills Biotechnology GmbH, Gersthofer Str. 29‐31, 1180, Vienna, Austria, +43‐1‐319‐6099</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2006-12</dateIssued><dateCaptured encoding="w3cdtf">2006-08-17</dateCaptured><dateValid encoding="w3cdtf">2006-10-06</dateValid><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">3</extent><extent unit="tables">2</extent><extent unit="references">76</extent></physicalDescription><abstract lang="en">In 1997, during an outbreak in chickens in Hong Kong the avian H5N1 influenza virus crossed the species barrier and infected 18 people, of which 6 cases were fatal. The virus also infected wild birds and continued to circulate and mutate in geese and ducks in southeastern China. Since this occurrence, new antigenic variants that are highly pathogenic for humans as well as wild, domestic, and exotic waterfowl continue to appear in Hong Kong. This virus is spreading across Asia, and is encroaching upon Europe and other continents. Wild birds are now considered as the main reservoir of H5N1 virus. Humans become infected with this H5N1 virus usually via close contact with infected birds or a highly contaminated environment. The very low transmissibility of this virus prevented further person‐to‐person dissemination in spite of the complete absence of immunity in the human population to H5N1 viruses. Viruses of the H5N1 subtype are characterized by an exceptionally high pathogenicity for humans. The cause of the viral virulence is not known so far; however, several virulence factors are considered. The unprecedented capability of H5N1 viruses to kill humans intensifies the concern about its pandemic potential with catastrophic consequences. The effectiveness of existing antivirals as well as vaccines for humans and birds are reviewed.</abstract><subject lang="en"><genre>keywords</genre><topic>Virus</topic><topic>Influenza</topic><topic>Avian</topic><topic>Vaccine</topic></subject><relatedItem type="host"><titleInfo><title>Biotechnology Journal</title><subTitle>Healthcare Nutrition Technology</subTitle></titleInfo><titleInfo type="abbreviated"><title>Biotechnology Journal</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Review</topic><topic>Reviews</topic></subject><identifier type="ISSN">1860-6768</identifier><identifier type="eISSN">1860-7314</identifier><identifier type="DOI">10.1002/(ISSN)1860-7314</identifier><identifier type="PublisherID">BIOT</identifier><part><date>2006</date><detail type="title"><title>Caring for a Better World</title></detail><detail type="volume"><caption>vol.</caption><number>1</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1381</start><end>1392</end><total>12</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus.</title></titleInfo><name type="personal"><namePart type="given">A. H.</namePart><namePart type="family">Reid</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. K.</namePart><namePart type="family">Taubenberger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. G.</namePart><namePart type="family">Fanning</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Reid, A. H., Taubenberger, J. K., Fanning, T. G., Evidence of an absence: the genetic origins of the 1918 pandemic influenza virus. Nat. Rev. Microbiol. 2004, 2, 909–914.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>909</start><end>914</end></extent></part><relatedItem type="host"><titleInfo><title>Nat. Rev. Microbiol.</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>2</number></detail><extent unit="pages"><start>909</start><end>914</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit2"><titleInfo><title>The predicted antigenicity of the haemagglutinin of the 1918 Spanish influenza pandemic suggests an avian origin.</title></titleInfo><name type="personal"><namePart type="given">G. G.</namePart><namePart type="family">Brownlee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Fodor</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Brownlee, G. G., Fodor, E., The predicted antigenicity of the haemagglutinin of the 1918 Spanish influenza pandemic suggests an avian origin. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2001, 356, 1871–1876.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>356</number></detail><extent unit="pages"><start>1871</start><end>1876</end></extent></part><relatedItem type="host"><titleInfo><title>Philos. Trans. R. Soc. Lond. B Biol. Sci.</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>356</number></detail><extent unit="pages"><start>1871</start><end>1876</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit3"><titleInfo><title>Receptor specificity of influenza viruses from birds and mammals: new data on involvement of the inner fragments of the carbohydrate chain.</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Gambaryan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Yamnikova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Lvov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Tuzikov</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gambaryan, A., Yamnikova, S., Lvov, D., Tuzikov, A. et al., Receptor specificity of influenza viruses from birds and mammals: new data on involvement of the inner fragments of the carbohydrate chain. Virology 2005, 334, 276–283.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>334</number></detail><extent unit="pages"><start>276</start><end>283</end></extent></part><relatedItem type="host"><titleInfo><title>Virology</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>334</number></detail><extent unit="pages"><start>276</start><end>283</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit4"><titleInfo><title>Differences between influenza virus receptors on target cells of duck and chicken and receptor specificity of the 1997 H5N1 chicken and human influenza viruses from Hong Kong.</title></titleInfo><name type="personal"><namePart type="given">A. S.</namePart><namePart type="family">Gambaryan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. B.</namePart><namePart type="family">Tuzikov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. V.</namePart><namePart type="family">Bovin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. S.</namePart><namePart type="family">Yamnikova</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gambaryan, A. S., Tuzikov, A. B., Bovin, N. V., Yamnikova, S. S. et al., Differences between influenza virus receptors on target cells of duck and chicken and receptor specificity of the 1997 H5N1 chicken and human influenza viruses from Hong Kong. Avian Dis. 2003, 47, 1154–1160.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>1154</start><end>1160</end></extent></part><relatedItem type="host"><titleInfo><title>Avian Dis.</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>47</number></detail><extent unit="pages"><start>1154</start><end>1160</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit5"><titleInfo><title>Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness.</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Subbarao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Klimov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Katz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Regnery</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Subbarao, K., Klimov, A., Katz, J., Regnery, H. et al., Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 1998, 279, 393–396.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>279</number></detail><extent unit="pages"><start>393</start><end>396</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>279</number></detail><extent unit="pages"><start>393</start><end>396</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit6"><titleInfo><title>The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties.</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Matrosovich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Zhou</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Kawaoka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Webster</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Matrosovich, M., Zhou, N., Kawaoka, Y., Webster, R., The surface glycoproteins of H5 influenza viruses isolated from humans, chickens, and wild aquatic birds have distinguishable properties. J. Virol. 1999, 73, 1146–1155.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>1146</start><end>1155</end></extent></part><relatedItem type="host"><titleInfo><title>J. Virol.</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>1146</start><end>1155</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit7"><titleInfo><title>Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti‐H5 antibody among household and social contacts.</title></titleInfo><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Katz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Lim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. B.</namePart><namePart type="family">Bridges</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Rowe</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Katz, J. M., Lim, W., Bridges, C. B., Rowe, T. et al., Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti‐H5 antibody among household and social contacts. J. Infect. Dis. 1999, 180, 1763–1770.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>180</number></detail><extent unit="pages"><start>1763</start><end>1770</end></extent></part><relatedItem type="host"><titleInfo><title>J. Infect. Dis.</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>180</number></detail><extent unit="pages"><start>1763</start><end>1770</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit8"><titleInfo><title>Continued circulation in China of highly pathogenic avian influenza viruses encoding the hemagglutinin gene associated with the 1997 H5N1 outbreak in poultry and humans.</title></titleInfo><name type="personal"><namePart type="given">A. N.</namePart><namePart type="family">Cauthen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. E.</namePart><namePart type="family">Swayne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Schultz‐Cherry</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Perdue</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cauthen, A. N., Swayne, D. E., Schultz‐Cherry, S., Perdue, M. L. et al., Continued circulation in China of highly pathogenic avian influenza viruses encoding the hemagglutinin gene associated with the 1997 H5N1 outbreak in poultry and humans. J. Virol. 2000, 74, 6592–6599.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>6592</start><end>6599</end></extent></part><relatedItem type="host"><titleInfo><title>J. Virol.</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>6592</start><end>6599</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit9"><titleInfo><title>Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR.</title></titleInfo><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. S.</namePart><namePart type="family">Peiris</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. S.</namePart><namePart type="family">Lipatov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Ellis</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Guan, Y., Peiris, J. S., Lipatov, A. S., Ellis, T. M. et al., Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR. Proc. Natl. Acad. Sci. USA 2002, 99, 8950–8955.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>99</number></detail><extent unit="pages"><start>8950</start><end>8955</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl. Acad. Sci. USA</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>99</number></detail><extent unit="pages"><start>8950</start><end>8955</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit10"><titleInfo><title>Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China.</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Z.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Shi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen, H., Li, Y., Li, Z., Shi, J. et al., Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. J. Virol. 2006, 80, 5976–5983.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>5976</start><end>5983</end></extent></part><relatedItem type="host"><titleInfo><title>J. Virol.</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>5976</start><end>5983</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit11"><titleInfo><title>Global patterns of influenza a virus in wild birds.</title></titleInfo><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Olsen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V. J.</namePart><namePart type="family">Munster</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Wallensten</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Waldenstrom</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Olsen, B., Munster, V. J., Wallensten, A., Waldenstrom, J. et al., Global patterns of influenza a virus in wild birds. Science 2006, 312, 384–388.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>312</number></detail><extent unit="pages"><start>384</start><end>388</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>312</number></detail><extent unit="pages"><start>384</start><end>388</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit12"><titleInfo><title>Avian H5N1 influenza in cats.</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Kuiken</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Rimmelzwaan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">van Riel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">van Amerongen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kuiken, T., Rimmelzwaan, G., van Riel, D., van Amerongen, G. et al., Avian H5N1 influenza in cats. Science 2004, 306, 241.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>306</number></detail><extent unit="pages"><start>241</start></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>306</number></detail><extent unit="pages"><start>241</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit13"><titleInfo><title>Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam.</title></titleInfo><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. S.</namePart><namePart type="family">Naipospos</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. D.</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. D.</namePart><namePart type="family">de Jong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Smith, G. J., Naipospos, T. S., Nguyen, T. D., de Jong, M. D. et al., Evolution and adaptation of H5N1 influenza virus in avian and human hosts in Indonesia and Vietnam. Virology 2006, 350, 258–268.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>350</number></detail><extent unit="pages"><start>258</start><end>268</end></extent></part><relatedItem type="host"><titleInfo><title>Virology</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>350</number></detail><extent unit="pages"><start>258</start><end>268</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit14"><titleInfo><title>Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control.</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. S.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Chen, H., Smith, G. J., Li, K. S., Wang, J. et al., Establishment of multiple sublineages of H5N1 influenza virus in Asia: implications for pandemic control. Proc. Natl. Acad. Sci. USA 2006, 103, 2845–2850.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><extent unit="pages"><start>2845</start><end>2850</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl. Acad. Sci. USA</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><extent unit="pages"><start>2845</start><end>2850</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit15"><titleInfo><title>Avian influenza A (H5N1) in 10 patients in Vietnam.</title></titleInfo><name type="personal"><namePart type="given">T. H.</namePart><namePart type="family">Tran</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. L.</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. D.</namePart><namePart type="family">Nguyen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. S.</namePart><namePart type="family">Luong</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tran, T. H., Nguyen, T. L., Nguyen, T. D., Luong, T. S. et al., Avian influenza A (H5N1) in 10 patients in Vietnam. N. Engl. J. Med. 2004, 350, 1179–1188.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>350</number></detail><extent unit="pages"><start>1179</start><end>1188</end></extent></part><relatedItem type="host"><titleInfo><title>N. Engl. J. Med.</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>350</number></detail><extent unit="pages"><start>1179</start><end>1188</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit16"><titleInfo><title>Probable person‐to‐person transmission of avian influenza A (H5N1).</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Ungchusak</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Auewarakul</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. F.</namePart><namePart type="family">Dowell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Kitphati</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ungchusak, K., Auewarakul, P., Dowell, S. F., Kitphati, R. et al., Probable person‐to‐person transmission of avian influenza A (H5N1). N. Engl. J. Med. 2005, 352, 333–340.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>352</number></detail><extent unit="pages"><start>333</start><end>340</end></extent></part><relatedItem type="host"><titleInfo><title>N. Engl. J. Med.</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>352</number></detail><extent unit="pages"><start>333</start><end>340</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit17"><titleInfo><title>Pathology of fatal human infection associated with avian influenza A H5N1 virus.</title></titleInfo><name type="personal"><namePart type="given">K. F.</namePart><namePart type="family">To</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. K.</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. F.</namePart><namePart type="family">Chan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. K.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">To, K. F., Chan, P. K., Chan, K. F., Lee, W. K. et al., Pathology of fatal human infection associated with avian influenza A H5N1 virus. J. Med. Virol. 2001, 63, 242–246.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>242</start><end>246</end></extent></part><relatedItem type="host"><titleInfo><title>J. Med. Virol.</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>63</number></detail><extent unit="pages"><start>242</start><end>246</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit18"><titleInfo><title>Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses.</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hatta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Gao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Halfmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Kawaoka</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hatta, M., Gao, P., Halfmann, P., Kawaoka, Y., Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses. Science 2001, 293, 1840–1842.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>293</number></detail><extent unit="pages"><start>1840</start><end>1842</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>293</number></detail><extent unit="pages"><start>1840</start><end>1842</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit19"><titleInfo><title>Characterization of the reconstructed 1918 Spanish influenza pandemic virus.</title></titleInfo><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Tumpey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. F.</namePart><namePart type="family">Basler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. V.</namePart><namePart type="family">Aguilar</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Zeng</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Tumpey, T. M., Basler, C. F., Aguilar, P. V., Zeng, H. et al., Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 2005, 310, 77–80.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>310</number></detail><extent unit="pages"><start>77</start><end>80</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>310</number></detail><extent unit="pages"><start>77</start><end>80</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit20"><titleInfo><title>Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?</title></titleInfo><name type="personal"><namePart type="given">C. Y.</namePart><namePart type="family">Cheung</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L. L.</namePart><namePart type="family">Poon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. S.</namePart><namePart type="family">Lau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Luk</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Cheung, C. Y., Poon, L. L., Lau, A. S., Luk, W. et al., Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease? Lancet 2002, 360, 1831–1837.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>360</number></detail><extent unit="pages"><start>1831</start><end>1837</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>360</number></detail><extent unit="pages"><start>1831</start><end>1837</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit21"><titleInfo><title>Large‐scale sequence analysis of avian influenza isolates.</title></titleInfo><name type="personal"><namePart type="given">J. C.</namePart><namePart type="family">Obenauer</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Denson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. K.</namePart><namePart type="family">Mehta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Su</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Obenauer, J. C., Denson, J., Mehta, P. K., Su, X. et al., Large‐scale sequence analysis of avian influenza isolates. Science 2006, 311, 1576–1580.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>311</number></detail><extent unit="pages"><start>1576</start><end>1580</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>311</number></detail><extent unit="pages"><start>1576</start><end>1580</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit22"><titleInfo><title>PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice.</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Shinya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Hamm</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hatta</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Ito</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Shinya, K., Hamm, S., Hatta, M., Ito, H. et al., PB2 amino acid at position 627 affects replicative efficiency, but not cell tropism, of Hong Kong H5N1 influenza A viruses in mice. Virology 2004, 320, 258–266.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>320</number></detail><extent unit="pages"><start>258</start><end>266</end></extent></part><relatedItem type="host"><titleInfo><title>Virology</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>320</number></detail><extent unit="pages"><start>258</start><end>266</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit23"><titleInfo><title>Antivirals for influenza in healthy adults: systematic review.</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Jefferson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Demicheli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Rivetti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Jones</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jefferson, T., Demicheli, V., Rivetti, D., Jones, M. et al., Antivirals for influenza in healthy adults: systematic review. Lancet 2006, 367, 303–313.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>367</number></detail><extent unit="pages"><start>303</start><end>313</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>367</number></detail><extent unit="pages"><start>303</start><end>313</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit24"><titleInfo><title>Perspectives on antiviral use during pandemic influenza.</title></titleInfo><name type="personal"><namePart type="given">F. G.</namePart><namePart type="family">Hayden</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hayden, F. G., Perspectives on antiviral use during pandemic influenza. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2001, 356, 1877–1884.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>356</number></detail><extent unit="pages"><start>1877</start><end>1884</end></extent></part><relatedItem type="host"><titleInfo><title>Philos. Trans. R. Soc. Lond. B Biol. Sci.</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>356</number></detail><extent unit="pages"><start>1877</start><end>1884</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit25"><titleInfo><title>Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP).</title></titleInfo><name type="personal"><namePart type="given">S. A.</namePart><namePart type="family">Harper</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Fukuda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Uyeki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. J.</namePart><namePart type="family">Cox</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Harper, S. A., Fukuda, K., Uyeki, T. M., Cox, N. J. et al., Prevention and control of influenza. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm. Rep. 2005, 54, 1–40.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><extent unit="pages"><start>1</start><end>40</end></extent></part><relatedItem type="host"><titleInfo><title>MMWR Recomm. Rep.</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><extent unit="pages"><start>1</start><end>40</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit26"><titleInfo><title>Low incidence of rimantadine resistance in field isolates of influenza A viruses.</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Ziegler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Hemphill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Ziegler</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Perez‐Oronoz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ziegler, T., Hemphill, M. L., Ziegler, M. L., Perez‐Oronoz, G. et al., Low incidence of rimantadine resistance in field isolates of influenza A viruses. J. Infect. Dis. 1999, 180, 935–939.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>180</number></detail><extent unit="pages"><start>935</start><end>939</end></extent></part><relatedItem type="host"><titleInfo><title>J. Infect. Dis.</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>180</number></detail><extent unit="pages"><start>935</start><end>939</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit27"><titleInfo><title>Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern.</title></titleInfo><name type="personal"><namePart type="given">R. A.</namePart><namePart type="family">Bright</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. J.</namePart><namePart type="family">Medina</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Xu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Perez‐Oronoz</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bright, R. A., Medina, M. J., Xu, X., Perez‐Oronoz, G. et al., Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern. Lancet 2005, 366, 1175–1181.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>366</number></detail><extent unit="pages"><start>1175</start><end>1181</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>366</number></detail><extent unit="pages"><start>1175</start><end>1181</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit28"><titleInfo><title>Emergence of drug‐resistant influenza virus: population dynamical considerations.</title></titleInfo><name type="personal"><namePart type="given">R. R.</namePart><namePart type="family">Regoes</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Bonhoeffer</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Regoes, R. R., Bonhoeffer, S., Emergence of drug‐resistant influenza virus: population dynamical considerations. Science 2006, 312, 389–391.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>312</number></detail><extent unit="pages"><start>389</start><end>391</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>312</number></detail><extent unit="pages"><start>389</start><end>391</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit29"><titleInfo><title>Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia.</title></titleInfo><name type="personal"><namePart type="given">K. S.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Guan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. J.</namePart><namePart type="family">Smith</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Li, K. S., Guan, Y., Wang, J., Smith, G. J. et al., Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia. Nature 2004, 430, 209–213.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>430</number></detail><extent unit="pages"><start>209</start><end>213</end></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>430</number></detail><extent unit="pages"><start>209</start><end>213</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit30"><titleInfo><title>Rapid antiviral effect of inhaled zanamivir in the treatment of naturally occurring influenza in otherwise healthy adults.</title></titleInfo><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Boivin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Goyette</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Hardy</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Aoki</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Boivin, G., Goyette, N., Hardy, I., Aoki, F. et al., Rapid antiviral effect of inhaled zanamivir in the treatment of naturally occurring influenza in otherwise healthy adults. J. Infect. Dis. 2000, 181, 1471–1474.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>181</number></detail><extent unit="pages"><start>1471</start><end>1474</end></extent></part><relatedItem type="host"><titleInfo><title>J. Infect. Dis.</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>181</number></detail><extent unit="pages"><start>1471</start><end>1474</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit31"><titleInfo><title>[Efficacy and safety of the selective oral neuraminidase inhibitor oseltamivir for prophylaxis against influenza‐placebo‐controlled double‐blind multicenter phase III trial].</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kashiwagi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kudoh</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Yoshimura</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kashiwagi, S., Kudoh, S., Watanabe, A., Yoshimura, I., [Efficacy and safety of the selective oral neuraminidase inhibitor oseltamivir for prophylaxis against influenza‐placebo‐controlled double‐blind multicenter phase III trial]. Kansenshogaku Zasshi 2000, 74, 1062–1076.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>1062</start><end>1076</end></extent></part><relatedItem type="host"><titleInfo><title>Kansenshogaku Zasshi</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>74</number></detail><extent unit="pages"><start>1062</start><end>1076</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit32"><titleInfo><title>Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group.</title></titleInfo><name type="personal"><namePart type="given">K. G.</namePart><namePart type="family">Nicholson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F. Y.</namePart><namePart type="family">Aoki</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. D.</namePart><namePart type="family">Osterhaus</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Trottier</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nicholson, K. G., Aoki, F. Y., Osterhaus, A. D., Trottier, S. et al., Efficacy and safety of oseltamivir in treatment of acute influenza: a randomised controlled trial. Neuraminidase Inhibitor Flu Treatment Investigator Group. Lancet 2000, 355, 1845–1850.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>355</number></detail><extent unit="pages"><start>1845</start><end>1850</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>355</number></detail><extent unit="pages"><start>1845</start><end>1850</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit33"><titleInfo><title>Influenza.</title></titleInfo><name type="personal"><namePart type="given">K. G.</namePart><namePart type="family">Nicholson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Wood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Zambon</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nicholson, K. G., Wood, J. M., Zambon, M., Influenza. Lancet 2003, 362, 1733–1745.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>362</number></detail><extent unit="pages"><start>1733</start><end>1745</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>362</number></detail><extent unit="pages"><start>1733</start><end>1745</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit34"><titleInfo><title>Zanamivir: a significant reduction in viral load during treatment in military conscripts with influenza.</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Puhakka</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Lehti</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Vainionpaa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">V.</namePart><namePart type="family">Jormanainen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Puhakka, T., Lehti, H., Vainionpaa, R., Jormanainen, V. et al., Zanamivir: a significant reduction in viral load during treatment in military conscripts with influenza. Scand. J. Infect. Dis. 2003, 35, 52–58.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>52</start><end>58</end></extent></part><relatedItem type="host"><titleInfo><title>Scand. J. Infect. Dis.</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>35</number></detail><extent unit="pages"><start>52</start><end>58</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit35"><titleInfo><title>Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus.</title></titleInfo><name type="personal"><namePart type="given">L. V.</namePart><namePart type="family">Gubareva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. N.</namePart><namePart type="family">Matrosovich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. K.</namePart><namePart type="family">Brenner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. C.</namePart><namePart type="family">Bethell</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gubareva, L. V., Matrosovich, M. N., Brenner, M. K., Bethell, R. C. et al., Evidence for zanamivir resistance in an immunocompromised child infected with influenza B virus. J. Infect. Dis. 1998, 178, 1257–1262.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>178</number></detail><extent unit="pages"><start>1257</start><end>1262</end></extent></part><relatedItem type="host"><titleInfo><title>J. Infect. Dis.</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>178</number></detail><extent unit="pages"><start>1257</start><end>1262</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit36"><titleInfo><title>Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir.</title></titleInfo><name type="personal"><namePart type="given">L. V.</namePart><namePart type="family">Gubareva</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Kaiser</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. N.</namePart><namePart type="family">Matrosovich</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Soo‐Hoo</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Gubareva, L. V., Kaiser, L., Matrosovich, M. N., Soo‐Hoo, Y. et al., Selection of influenza virus mutants in experimentally infected volunteers treated with oseltamivir. J. Infect. Dis. 2001, 183, 523–531.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>183</number></detail><extent unit="pages"><start>523</start><end>531</end></extent></part><relatedItem type="host"><titleInfo><title>J. Infect. Dis.</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>183</number></detail><extent unit="pages"><start>523</start><end>531</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit37"><titleInfo><title>Resistant influenza A viruses in children treated with oseltamivir: descriptive study.</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kiso</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Mitamura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Sakai‐Tagawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Shiraishi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kiso, M., Mitamura, K., Sakai‐Tagawa, Y., Shiraishi, K. et al., Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet 2004, 364, 759–765.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>364</number></detail><extent unit="pages"><start>759</start><end>765</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>364</number></detail><extent unit="pages"><start>759</start><end>765</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit38"><titleInfo><title>Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferrets.</title></titleInfo><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Herlocher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Carr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Ives</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Elias</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Herlocher, M. L., Carr, J., Ives, J., Elias, S. et al., Influenza virus carrying an R292K mutation in the neuraminidase gene is not transmitted in ferrets. Antiviral Res. 2002, 54, 99–111.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><extent unit="pages"><start>99</start><end>111</end></extent></part><relatedItem type="host"><titleInfo><title>Antiviral Res.</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><extent unit="pages"><start>99</start><end>111</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit39"><titleInfo><title>Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferrets.</title></titleInfo><name type="personal"><namePart type="given">M. L.</namePart><namePart type="family">Herlocher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Truscon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Elias</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. L.</namePart><namePart type="family">Yen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Herlocher, M. L., Truscon, R., Elias, S., Yen, H. L. et al., Influenza viruses resistant to the antiviral drug oseltamivir: transmission studies in ferrets. J. Infect. Dis. 2004, 190, 1627–1630.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>190</number></detail><extent unit="pages"><start>1627</start><end>1630</end></extent></part><relatedItem type="host"><titleInfo><title>J. Infect. Dis.</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>190</number></detail><extent unit="pages"><start>1627</start><end>1630</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit40"><titleInfo><title>Flu virus invasion: halfway there.</title></titleInfo><name type="personal"><namePart type="given">C. M.</namePart><namePart type="family">Carr</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. S.</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Carr, C. M., Kim, P. S., Flu virus invasion: halfway there. Science 1994, 266, 234–236.</note><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>266</number></detail><extent unit="pages"><start>234</start><end>236</end></extent></part><relatedItem type="host"><titleInfo><title>Science</title></titleInfo><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>266</number></detail><extent unit="pages"><start>234</start><end>236</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit41"><titleInfo><title>Avian influenza and oseltamivir; a retrospective view.</title></titleInfo><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Galama</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Galama, J. M., Avian influenza and oseltamivir; a retrospective view. Ned. Tijdschr. Geneeskd. 2003, 147, 1100–1102.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>147</number></detail><extent unit="pages"><start>1100</start><end>1102</end></extent></part><relatedItem type="host"><titleInfo><title>Ned. Tijdschr. Geneeskd.</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>147</number></detail><extent unit="pages"><start>1100</start><end>1102</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit42"><titleInfo><title>Avian flu: isolation of drug‐resistant H5N1 virus.</title></titleInfo><name type="personal"><namePart type="given">Q. M.</namePart><namePart type="family">Le</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Kiso</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Someya</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y. T.</namePart><namePart type="family">Sakai</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Le, Q. M., Kiso, M., Someya, K., Sakai, Y. T. et al., Avian flu: isolation of drug‐resistant H5N1 virus. Nature 2005, 437, 1108.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>437</number></detail><extent unit="pages"><start>1108</start></extent></part><relatedItem type="host"><titleInfo><title>Nature</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>437</number></detail><extent unit="pages"><start>1108</start></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit43"><titleInfo><title>Antiviral drugs in influenza: an adjunct to vaccination in some situations.</title></titleInfo><genre>journal-article</genre><note type="citation/reference">Antiviral drugs in influenza: an adjunct to vaccination in some situations. Prescrire Int. 2006, 15, 21–30.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>21</start><end>30</end></extent></part><relatedItem type="host"><titleInfo><title>Prescrire Int.</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>15</number></detail><extent unit="pages"><start>21</start><end>30</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit44"><titleInfo><title>Influenza A vaccine decreases the incidence of otitis media in 6‐ to 30‐month‐old children in day care.</title></titleInfo><name type="personal"><namePart type="given">D. A.</namePart><namePart type="family">Clements</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Langdon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Bland</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Walter</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Clements, D. A., Langdon, L., Bland, C., Walter, E., Influenza A vaccine decreases the incidence of otitis media in 6‐ to 30‐month‐old children in day care. Arch. Pediatr. Adolesc. Med. 1995, 149, 1113–1117.</note><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>149</number></detail><extent unit="pages"><start>1113</start><end>1117</end></extent></part><relatedItem type="host"><titleInfo><title>Arch. Pediatr. Adolesc. Med.</title></titleInfo><part><date>1995</date><detail type="volume"><caption>vol.</caption><number>149</number></detail><extent unit="pages"><start>1113</start><end>1117</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit45"><titleInfo><title>Safety and antigenicity of non‐adjuvanted and MF59‐adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza.</title></titleInfo><name type="personal"><namePart type="given">K. G.</namePart><namePart type="family">Nicholson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. E.</namePart><namePart type="family">Colegate</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Podda</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Stephenson</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Nicholson, K. G., Colegate, A. E., Podda, A., Stephenson, I. et al., Safety and antigenicity of non‐adjuvanted and MF59‐adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a randomised trial of two potential vaccines against H5N1 influenza. Lancet 2001, 357, 1937–1943.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>357</number></detail><extent unit="pages"><start>1937</start><end>1943</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>357</number></detail><extent unit="pages"><start>1937</start><end>1943</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit46"><titleInfo><title>Crossreactivity to highly pathogenic avian influenza H5N1 viruses after vaccination with nonadjuvanted and MF59‐adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a potential priming strategy.</title></titleInfo><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Stephenson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Bugarini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. G.</namePart><namePart type="family">Nicholson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Podda</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Stephenson, I., Bugarini, R., Nicholson, K. G., Podda, A. et al., Crossreactivity to highly pathogenic avian influenza H5N1 viruses after vaccination with nonadjuvanted and MF59‐adjuvanted influenza A/Duck/Singapore/97 (H5N3) vaccine: a potential priming strategy. J. Infect. Dis. 2005, 191, 1210–1215.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>191</number></detail><extent unit="pages"><start>1210</start><end>1215</end></extent></part><relatedItem type="host"><titleInfo><title>J. Infect. Dis.</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>191</number></detail><extent unit="pages"><start>1210</start><end>1215</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit47"><titleInfo><title>Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid‐based reverse genetics.</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Subbarao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Chen</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Swayne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Mingay</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Subbarao, K., Chen, H., Swayne, D., Mingay, L. et al., Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid‐based reverse genetics. Virology 2003, 305, 192–200.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>305</number></detail><extent unit="pages"><start>192</start><end>200</end></extent></part><relatedItem type="host"><titleInfo><title>Virology</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>305</number></detail><extent unit="pages"><start>192</start><end>200</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit48"><titleInfo><title>The development and characterization of H5 influenza virus vaccines derived from a 2003 human isolate.</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Horimoto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Takada</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Fujii</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Goto</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Horimoto, T., Takada, A., Fujii, K., Goto, H. et al., The development and characterization of H5 influenza virus vaccines derived from a 2003 human isolate. Vaccine 2006, 24, 3669–3676.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>3669</start><end>3676</end></extent></part><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>3669</start><end>3676</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit49"><titleInfo><title>Preparation of vaccines against H5N1 influenza.</title></titleInfo><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Wood</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Major</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. W.</namePart><namePart type="family">Newman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Dunleavy</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wood, J. M., Major, D., Newman, R. W., Dunleavy, U. et al., Preparation of vaccines against H5N1 influenza. Vaccine 2002, 20, Suppl 2, S 84–87.</note><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>84</start><end>87</end></extent></part><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>20</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>84</start><end>87</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit50"><titleInfo><title>Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine.</title></titleInfo><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Treanor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. D.</namePart><namePart type="family">Campbell</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. M.</namePart><namePart type="family">Zangwill</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Rowe</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Treanor, J. J., Campbell, J. D., Zangwill, K. M., Rowe, T. et al., Safety and immunogenicity of an inactivated subvirion influenza A (H5N1) vaccine. N. Engl. J. Med. 2006, 354, 1343–1351.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>354</number></detail><extent unit="pages"><start>1343</start><end>1351</end></extent></part><relatedItem type="host"><titleInfo><title>N. Engl. J. Med.</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>354</number></detail><extent unit="pages"><start>1343</start><end>1351</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit51"><titleInfo><title>Safety and immunogenicity of an inactivated split‐virion influenza A/Vietnam/1194/2004 (H5N1) vaccine: phase I randomised trial.</title></titleInfo><name type="personal"><namePart type="given">J. L.</namePart><namePart type="family">Bresson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Perronne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Launay</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Gerdil</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bresson, J. L., Perronne, C., Launay, O., Gerdil, C. et al., Safety and immunogenicity of an inactivated split‐virion influenza A/Vietnam/1194/2004 (H5N1) vaccine: phase I randomised trial. Lancet 2006, 367, 1657–1664.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>367</number></detail><extent unit="pages"><start>1657</start><end>1664</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>367</number></detail><extent unit="pages"><start>1657</start><end>1664</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit52"><titleInfo><title>Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers.</title></titleInfo><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Stephenson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. C.</namePart><namePart type="family">Zambon</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Rudin</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Colegate</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Stephenson, I., Zambon, M. C., Rudin, A., Colegate, A. et al., Phase I evaluation of intranasal trivalent inactivated influenza vaccine with nontoxigenic Escherichia coli enterotoxin and novel biovector as mucosal adjuvants, using adult volunteers. J. Virol. 2006, 80, 4962–4970.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>4962</start><end>4970</end></extent></part><relatedItem type="host"><titleInfo><title>J. Virol.</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>80</number></detail><extent unit="pages"><start>4962</start><end>4970</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit53"><titleInfo><title>Immunogenicity and protective efficacy in mice of influenza B virus vaccines grown in mammalian cells or embryonated chicken eggs.</title></titleInfo><name type="personal"><namePart type="given">I. V.</namePart><namePart type="family">Alymova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kodihalli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E. A.</namePart><namePart type="family">Govorkova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Fanget</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Alymova, I. V., Kodihalli, S., Govorkova, E. A., Fanget, B. et al., Immunogenicity and protective efficacy in mice of influenza B virus vaccines grown in mammalian cells or embryonated chicken eggs. J. Virol. 1998, 72, 4472–4477.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>4472</start><end>4477</end></extent></part><relatedItem type="host"><titleInfo><title>J. Virol.</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>4472</start><end>4477</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit54"><titleInfo><title>The human cell line PER. C6 provides a new manufacturing system for the production of influenza vaccines.</title></titleInfo><name type="personal"><namePart type="given">M. G.</namePart><namePart type="family">Pau</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Ophorst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. H.</namePart><namePart type="family">Koldijk</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Schouten</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Pau, M. G., Ophorst, C., Koldijk, M. H., Schouten, G. et al., The human cell line PER. C6 provides a new manufacturing system for the production of influenza vaccines. Vaccine 2001, 19, 2716–2721.</note><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>2716</start><end>2721</end></extent></part><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><part><date>2001</date><detail type="volume"><caption>vol.</caption><number>19</number></detail><extent unit="pages"><start>2716</start><end>2721</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit55"><titleInfo><title>Dose‐related safety and immunogenicity of a trivalent baculovirus‐expressed influenza‐virus hemagglutinin vaccine in elderly adults.</title></titleInfo><name type="personal"><namePart type="given">J. J.</namePart><namePart type="family">Treanor</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. M.</namePart><namePart type="family">Schiff</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. B.</namePart><namePart type="family">Couch</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. R.</namePart><namePart type="family">Cate</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Treanor, J. J., Schiff, G. M., Couch, R. B., Cate, T. R. et al., Dose‐related safety and immunogenicity of a trivalent baculovirus‐expressed influenza‐virus hemagglutinin vaccine in elderly adults. J. Infect. Dis. 2006, 193, 1223–1228.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>193</number></detail><extent unit="pages"><start>1223</start><end>1228</end></extent></part><relatedItem type="host"><titleInfo><title>J. Infect. Dis.</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>193</number></detail><extent unit="pages"><start>1223</start><end>1228</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit56"><titleInfo><title>Expression and purification of an influenza hemagglutinin‐one step closer to a recombinant protein‐based influenza vaccine.</title></titleInfo><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Wang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. M.</namePart><namePart type="family">Holtz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Anderson</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Chubet</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Wang, K., Holtz, K. M., Anderson, K., Chubet, R. et al., Expression and purification of an influenza hemagglutinin‐one step closer to a recombinant protein‐based influenza vaccine. Vaccine 2006, 24, 2176–2185.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>2176</start><end>2185</end></extent></part><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>2176</start><end>2185</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit57"><titleInfo><title>DNA vaccine encoding hemagglutinin provides protective immunity against H5N1 influenza virus infection in mice.</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Kodihalli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Goto</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. L.</namePart><namePart type="family">Kobasa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Krauss</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kodihalli, S., Goto, H., Kobasa, D. L., Krauss, S. et al., DNA vaccine encoding hemagglutinin provides protective immunity against H5N1 influenza virus infection in mice. J. Virol. 1999, 73, 2094–2098.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>2094</start><end>2098</end></extent></part><relatedItem type="host"><titleInfo><title>J. Virol.</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>73</number></detail><extent unit="pages"><start>2094</start><end>2098</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit58"><titleInfo><title>Development of adenoviral‐vector‐based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice.</title></titleInfo><name type="personal"><namePart type="given">M. A.</namePart><namePart type="family">Hoelscher</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Garg</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. S.</namePart><namePart type="family">Bangari</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. A.</namePart><namePart type="family">Belser</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Hoelscher, M. A., Garg, S., Bangari, D. S., Belser, J. A. et al., Development of adenoviral‐vector‐based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice. Lancet 2006, 367, 475–481.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>367</number></detail><extent unit="pages"><start>475</start><end>481</end></extent></part><relatedItem type="host"><titleInfo><title>Lancet</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>367</number></detail><extent unit="pages"><start>475</start><end>481</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit59"><titleInfo><title>The universal influenza vaccine M2e‐HBc administered intranasally in combination with the adjuvant CTA1‐DD provides complete protection.</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">De Filette</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Ramne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Birkett</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Lycke</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">De Filette, M., Ramne, A., Birkett, A., Lycke, N. et al., The universal influenza vaccine M2e‐HBc administered intranasally in combination with the adjuvant CTA1‐DD provides complete protection. Vaccine 2006, 24, 544–551.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>544</start><end>551</end></extent></part><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>544</start><end>551</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit60"><titleInfo><title>Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody‐dependent NK cell activity.</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Jegerlehner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Schmitz</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Storni</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. F.</namePart><namePart type="family">Bachmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Jegerlehner, A., Schmitz, N., Storni, T., Bachmann, M. F., Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody‐dependent NK cell activity. J. Immunol. 2004, 172, 5598–5605.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>5598</start><end>5605</end></extent></part><relatedItem type="host"><titleInfo><title>J. Immunol.</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>172</number></detail><extent unit="pages"><start>5598</start><end>5605</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit61"><titleInfo><title>Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys.</title></titleInfo><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Fan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">X.</namePart><namePart type="family">Liang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M. S.</namePart><namePart type="family">Horton</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. C.</namePart><namePart type="family">Perry</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Fan, J., Liang, X., Horton, M. S., Perry, H. C. et al., Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys. Vaccine 2004, 22, 2993–3003.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>2993</start><end>3003</end></extent></part><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><extent unit="pages"><start>2993</start><end>3003</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit62"><titleInfo><title>Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines.</title></titleInfo><name type="personal"><namePart type="given">W. A.</namePart><namePart type="family">Ernst</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. J.</namePart><namePart type="family">Kim</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. M.</namePart><namePart type="family">Tumpey</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. D.</namePart><namePart type="family">Jansen</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ernst, W. A., Kim, H. J., Tumpey, T. M., Jansen, A. D. et al., Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines. Vaccine 2006, 24, 5158–5168.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>5158</start><end>5168</end></extent></part><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><extent unit="pages"><start>5158</start><end>5168</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit63"><titleInfo><title>Cold‐adapted live attenuated influenza vaccines developed in Russia: can they contribute to meeting the needs for influenza control in other countries?</title></titleInfo><name type="personal"><namePart type="given">A. P.</namePart><namePart type="family">Kendal</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Kendal, A. P., Cold‐adapted live attenuated influenza vaccines developed in Russia: can they contribute to meeting the needs for influenza control in other countries? Eur. J. Epidemiol. 1997, 13, 591–609.</note><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>591</start><end>609</end></extent></part><relatedItem type="host"><titleInfo><title>Eur. J. Epidemiol.</title></titleInfo><part><date>1997</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><extent unit="pages"><start>591</start><end>609</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit64"><titleInfo><title>Efficacy of vaccination with live attenuated, cold‐adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine.</title></titleInfo><name type="personal"><namePart type="given">R. B.</namePart><namePart type="family">Belshe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. C.</namePart><namePart type="family">Gruber</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P. M.</namePart><namePart type="family">Mendelman</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Cho</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Belshe, R. B., Gruber, W. C., Mendelman, P. M., Cho, I. et al., Efficacy of vaccination with live attenuated, cold‐adapted, trivalent, intranasal influenza virus vaccine against a variant (A/Sydney) not contained in the vaccine. J. Pediatr. 2000, 136, 168–175.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>136</number></detail><extent unit="pages"><start>168</start><end>175</end></extent></part><relatedItem type="host"><titleInfo><title>J. Pediatr.</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>136</number></detail><extent unit="pages"><start>168</start><end>175</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit65"><titleInfo><title>Recombinant influenza A virus vaccines for the pathogenic human A/Hong Kong/97 (H5N1) viruses.</title></titleInfo><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Li</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Liu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Klimov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Subbarao</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Li, S., Liu, C., Klimov, A., Subbarao, K. et al., Recombinant influenza A virus vaccines for the pathogenic human A/Hong Kong/97 (H5N1) viruses. J. Infect. Dis. 1999, 179, 1132–1138.</note><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>1132</start><end>1138</end></extent></part><relatedItem type="host"><titleInfo><title>J. Infect. Dis.</title></titleInfo><part><date>1999</date><detail type="volume"><caption>vol.</caption><number>179</number></detail><extent unit="pages"><start>1132</start><end>1138</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit66"><titleInfo><title>Live, attenuated influenza A H5N1 candidate vaccines provide broad cross‐protection in mice and ferrets.</title></titleInfo><name type="personal"><namePart type="given">A. L.</namePart><namePart type="family">Suguitan</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">McAuliffe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. L.</namePart><namePart type="family">Mills</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Jin</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Suguitan, A. L., McAuliffe, J., Mills, K. L., Jin, H. et al., Live, attenuated influenza A H5N1 candidate vaccines provide broad cross‐protection in mice and ferrets. PLoS Med. 2006, 3.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>3</number></detail></part><relatedItem type="host"><titleInfo><title>PLoS Med.</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>3</number></detail></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit67"><titleInfo><title>Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells.</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Egorov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Brandt</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Sereinig</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Romanova</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Egorov, A., Brandt, S., Sereinig, S., Romanova, J. et al., Transfectant influenza A viruses with long deletions in the NS1 protein grow efficiently in Vero cells. J. Virol. 1998, 72, 6437–6441.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>6437</start><end>6441</end></extent></part><relatedItem type="host"><titleInfo><title>J. Virol.</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>72</number></detail><extent unit="pages"><start>6437</start><end>6441</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit68"><titleInfo><title>Influenza A virus lacking the NS1 gene replicates in interferon‐deficient systems.</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Garcia‐Sastre</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Egorov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Matassov</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Brandt</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Garcia‐Sastre, A., Egorov, A., Matassov, D., Brandt, S. et al., Influenza A virus lacking the NS1 gene replicates in interferon‐deficient systems. Virology 1998, 252, 324–330.</note><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>252</number></detail><extent unit="pages"><start>324</start><end>330</end></extent></part><relatedItem type="host"><titleInfo><title>Virology</title></titleInfo><part><date>1998</date><detail type="volume"><caption>vol.</caption><number>252</number></detail><extent unit="pages"><start>324</start><end>330</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit69"><titleInfo><title>Immunogenicity and protection efficacy of replication‐deficient influenza A viruses with altered NS1 genes.</title></titleInfo><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Ferko</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Stasakova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Romanova</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Kittel</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Ferko, B., Stasakova, J., Romanova, J., Kittel, C. et al., Immunogenicity and protection efficacy of replication‐deficient influenza A viruses with altered NS1 genes. J. Virol. 2004, 78, 13037–13045.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>13037</start><end>13045</end></extent></part><relatedItem type="host"><titleInfo><title>J. Virol.</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>13037</start><end>13045</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit70"><titleInfo><title>Type I IFN is a powerful mucosal adjuvant for a selective intranasal vaccination against influenza virus in mice and affects antigen capture at mucosal level.</title></titleInfo><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Bracci</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Canini</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Puzelli</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Sestili</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Bracci, L., Canini, I., Puzelli, S., Sestili, P. et al., Type I IFN is a powerful mucosal adjuvant for a selective intranasal vaccination against influenza virus in mice and affects antigen capture at mucosal level. Vaccine 2005, 23, 2994–3004.</note><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>2994</start><end>3004</end></extent></part><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><part><date>2005</date><detail type="volume"><caption>vol.</caption><number>23</number></detail><extent unit="pages"><start>2994</start><end>3004</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit71"><titleInfo><title>Failure of a recombinant fowl poxvirus vaccine containing an avian influenza hemagglutinin gene to provide consistent protection against influenza in chickens preimmunized with a fowl pox vaccine.</title></titleInfo><name type="personal"><namePart type="given">D. E.</namePart><namePart type="family">Swayne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. R.</namePart><namePart type="family">Beck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Kinney</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Swayne, D. E., Beck, J. R., Kinney, N., Failure of a recombinant fowl poxvirus vaccine containing an avian influenza hemagglutinin gene to provide consistent protection against influenza in chickens preimmunized with a fowl pox vaccine. Avian Dis. 2000, 44, 132–137.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>132</start><end>137</end></extent></part><relatedItem type="host"><titleInfo><title>Avian Dis.</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>44</number></detail><extent unit="pages"><start>132</start><end>137</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit72"><titleInfo><title>Protection against diverse highly pathogenic H5 avian influenza viruses in chickens immunized with a recombinant fowlpox vaccine containing an H5 avian influenza hemagglutinin gene insert.</title></titleInfo><name type="personal"><namePart type="given">D. E.</namePart><namePart type="family">Swayne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Garcia</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. R.</namePart><namePart type="family">Beck</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Kinney</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Swayne, D. E., Garcia, M., Beck, J. R., Kinney, N. et al., Protection against diverse highly pathogenic H5 avian influenza viruses in chickens immunized with a recombinant fowlpox vaccine containing an H5 avian influenza hemagglutinin gene insert. Vaccine 2000, 18, 1088–1095.</note><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>1088</start><end>1095</end></extent></part><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><part><date>2000</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><extent unit="pages"><start>1088</start><end>1095</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit73"><titleInfo><title>Effect of vaccine use in the evolution of Mexican lineage H5N2 avian influenza virus.</title></titleInfo><name type="personal"><namePart type="given">C. W.</namePart><namePart type="family">Lee</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. A.</namePart><namePart type="family">Senne</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. L.</namePart><namePart type="family">Suarez</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Lee, C. W., Senne, D. A., Suarez, D. L., Effect of vaccine use in the evolution of Mexican lineage H5N2 avian influenza virus. J. Virol. 2004, 78, 8372–8381.</note><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>8372</start><end>8381</end></extent></part><relatedItem type="host"><titleInfo><title>J. Virol.</title></titleInfo><part><date>2004</date><detail type="volume"><caption>vol.</caption><number>78</number></detail><extent unit="pages"><start>8372</start><end>8381</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit74"><titleInfo><title>Protection of chickens against highly lethal H5N1 and H7N1 avian influenza viruses with a recombinant fowlpox virus co‐expressing H5 haemagglutinin and N1 neuraminidase genes.</title></titleInfo><name type="personal"><namePart type="given">C. L.</namePart><namePart type="family">Qiao</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K. Z.</namePart><namePart type="family">Yu</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y. P.</namePart><namePart type="family">Jiang</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y. Q.</namePart><namePart type="family">Jia</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Qiao, C. L., Yu, K. Z., Jiang, Y. P., Jia, Y. Q. et al., Protection of chickens against highly lethal H5N1 and H7N1 avian influenza viruses with a recombinant fowlpox virus co‐expressing H5 haemagglutinin and N1 neuraminidase genes. Avian Pathol. 2003, 32, 25–32.</note><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>25</start><end>32</end></extent></part><relatedItem type="host"><titleInfo><title>Avian Pathol.</title></titleInfo><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><extent unit="pages"><start>25</start><end>32</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit75"><titleInfo><title>From the Cover: Engineered viral vaccine constructs with dual specificity: Avian influenza and Newcastle disease.</title></titleInfo><name type="personal"><namePart type="given">M. S.</namePart><namePart type="family">Park</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Steel</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Garcia‐Sastre</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Swayne</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Park, M. S., Steel, J., Garcia‐Sastre, A., Swayne, D. et al., From the Cover: Engineered viral vaccine constructs with dual specificity: Avian influenza and Newcastle disease. Proc. Natl. Acad. Sci. USA 2006, 103, 8203–8208.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><extent unit="pages"><start>8203</start><end>8208</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl. Acad. Sci. USA</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><extent unit="pages"><start>8203</start><end>8208</end></extent></part></relatedItem></relatedItem><relatedItem type="references" displayLabel="cit76"><titleInfo><title>Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza.</title></titleInfo><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Veits</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Wiesner</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Fuchs</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">B.</namePart><namePart type="family">Hoffmann</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Veits, J., Wiesner, D., Fuchs, W., Hoffmann, B. et al., Newcastle disease virus expressing H5 hemagglutinin gene protects chickens against Newcastle disease and avian influenza. Proc. Natl. Acad. Sci. USA 2006, 103, 8197–8202.</note><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><extent unit="pages"><start>8197</start><end>8202</end></extent></part><relatedItem type="host"><titleInfo><title>Proc. Natl. Acad. Sci. USA</title></titleInfo><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>103</number></detail><extent unit="pages"><start>8197</start><end>8202</end></extent></part></relatedItem></relatedItem><identifier type="istex">B4A8E48218CD4B34AE34880FE501D70A4D51F430</identifier><identifier type="ark">ark:/67375/WNG-P74MW01C-9</identifier><identifier type="DOI">10.1002/biot.200600159</identifier><identifier type="ArticleID">BIOT200600159</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 WILEY‐VCH Verlag GmbH & Co. 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