EFFECT OF NEURAMINIDASE ANTIBODY ON HONG KONG INFLUENZA
Identifieur interne : 000F01 ( Istex/Corpus ); précédent : 000F00; suivant : 000F02EFFECT OF NEURAMINIDASE ANTIBODY ON HONG KONG INFLUENZA
Auteurs : Arnolds. Monto ; Alanp. KendalSource :
- The Lancet [ 0140-6736 ] ; 1973.
English descriptors
- Teeft :
- Antibody, Antibody levels, Antineuraminidase antibody, Chemical test, Clinical expression, Clinical illness, Epidemic influenza, Hong kong, Hong kong influenza, Hong kong variant, Hsemagglutinin antibodies, Illness frequency, Infection, Influenza, Influenza infection, Influenza infections, Influenza virus, Major shifts, National institutes, Neuraminidase, Neuraminidase antibodies, Neuraminidase antibody, Neuraminidase antigens, Outbreak, Present report, Public health, Respiratory illness, Serum samples, Tecumseh, Tecumseh area.
Abstract
Abstract: The relation between antineuraminidase antibody (A.N.) and natural influenza infection in 1968 was investigated in the community of Tecumseh, Michigan. The outbreak was caused by Hong Kong influenza virus, which contained a new hæmagglutinin antigen (H3), while the neuraminidase antigen (N2) was more closely related to that of Asian viruses circulating since 1957. In the study group of two hundred and seventy-four randomly selected adults (aged 20-45), titres of N2 neuraminidase antibody were detected in a hundred and fifteen (42%) serum samples collected before the outbreak. Influenza infection during the course of the outbreak was identified serologically. The frequency of infection decreased significantly at increasing levels of pre-existing A.N. antibody. In those subjects who were not protected from infection, A.N. antibody significantly suppressed the clinical expression of infection. It is concluded that antibody against the neuraminidase of the influenza virus prevented or modified infection in a situation in which hæmagglutinin antibody had no effect.
Url:
DOI: 10.1016/S0140-6736(73)92196-X
Links to Exploration step
ISTEX:FD633812CD9707C94D10F7E3F6F3BBE927768DE1Le document en format XML
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Monto</name><affiliation><mods:affiliation>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, U.S.A..</mods:affiliation></affiliation></author><author><name sortKey="Kendal, Alanp" sort="Kendal, Alanp" uniqKey="Kendal A" first="Alanp." last="Kendal">Alanp. Kendal</name><affiliation><mods:affiliation>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, U.S.A..</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">The Lancet</title><title level="j" type="abbrev">LANCET</title><idno type="ISSN">0140-6736</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1973">1973</date><biblScope unit="volume">301</biblScope><biblScope unit="issue">7804</biblScope><biblScope unit="page" from="623">623</biblScope><biblScope unit="page" to="625">625</biblScope></imprint><idno type="ISSN">0140-6736</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody</term><term>Antibody levels</term><term>Antineuraminidase antibody</term><term>Chemical test</term><term>Clinical expression</term><term>Clinical illness</term><term>Epidemic influenza</term><term>Hong kong</term><term>Hong kong influenza</term><term>Hong kong variant</term><term>Hsemagglutinin antibodies</term><term>Illness frequency</term><term>Infection</term><term>Influenza</term><term>Influenza infection</term><term>Influenza infections</term><term>Influenza virus</term><term>Major shifts</term><term>National institutes</term><term>Neuraminidase</term><term>Neuraminidase antibodies</term><term>Neuraminidase antibody</term><term>Neuraminidase antigens</term><term>Outbreak</term><term>Present report</term><term>Public health</term><term>Respiratory illness</term><term>Serum samples</term><term>Tecumseh</term><term>Tecumseh area</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The relation between antineuraminidase antibody (A.N.) and natural influenza infection in 1968 was investigated in the community of Tecumseh, Michigan. The outbreak was caused by Hong Kong influenza virus, which contained a new hæmagglutinin antigen (H3), while the neuraminidase antigen (N2) was more closely related to that of Asian viruses circulating since 1957. In the study group of two hundred and seventy-four randomly selected adults (aged 20-45), titres of N2 neuraminidase antibody were detected in a hundred and fifteen (42%) serum samples collected before the outbreak. Influenza infection during the course of the outbreak was identified serologically. The frequency of infection decreased significantly at increasing levels of pre-existing A.N. antibody. In those subjects who were not protected from infection, A.N. antibody significantly suppressed the clinical expression of infection. It is concluded that antibody against the neuraminidase of the influenza virus prevented or modified infection in a situation in which hæmagglutinin antibody had no effect.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>neuraminidase</json:string><json:string>influenza</json:string><json:string>tecumseh</json:string><json:string>hong kong influenza</json:string><json:string>influenza infection</json:string><json:string>clinical expression</json:string><json:string>outbreak</json:string><json:string>neuraminidase antibody</json:string><json:string>respiratory illness</json:string><json:string>antibody</json:string><json:string>antineuraminidase antibody</json:string><json:string>hsemagglutinin antibodies</json:string><json:string>influenza virus</json:string><json:string>major shifts</json:string><json:string>neuraminidase antigens</json:string><json:string>national institutes</json:string><json:string>present report</json:string><json:string>neuraminidase antibodies</json:string><json:string>public health</json:string><json:string>serum samples</json:string><json:string>chemical test</json:string><json:string>tecumseh area</json:string><json:string>hong kong</json:string><json:string>antibody levels</json:string><json:string>influenza infections</json:string><json:string>clinical illness</json:string><json:string>illness frequency</json:string><json:string>epidemic influenza</json:string><json:string>hong kong variant</json:string><json:string>infection</json:string></teeft></keywords><author><json:item><name>ArnoldS. Monto</name><affiliations><json:string>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, U.S.A..</json:string></affiliations></json:item><json:item><name>AlanP. Kendal</name><affiliations><json:string>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, U.S.A..</json:string></affiliations></json:item></author><arkIstex>ark:/67375/6H6-CBD1Z6RX-8</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The relation between antineuraminidase antibody (A.N.) and natural influenza infection in 1968 was investigated in the community of Tecumseh, Michigan. The outbreak was caused by Hong Kong influenza virus, which contained a new hæmagglutinin antigen (H3), while the neuraminidase antigen (N2) was more closely related to that of Asian viruses circulating since 1957. In the study group of two hundred and seventy-four randomly selected adults (aged 20-45), titres of N2 neuraminidase antibody were detected in a hundred and fifteen (42%) serum samples collected before the outbreak. Influenza infection during the course of the outbreak was identified serologically. The frequency of infection decreased significantly at increasing levels of pre-existing A.N. antibody. In those subjects who were not protected from infection, A.N. antibody significantly suppressed the clinical expression of infection. 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The outbreak was caused by Hong Kong influenza virus, which contained a new hæmagglutinin antigen (H3), while the neuraminidase antigen (N2) was more closely related to that of Asian viruses circulating since 1957. In the study group of two hundred and seventy-four randomly selected adults (aged 20-45), titres of N2 neuraminidase antibody were detected in a hundred and fifteen (42%) serum samples collected before the outbreak. Influenza infection during the course of the outbreak was identified serologically. The frequency of infection decreased significantly at increasing levels of pre-existing A.N. antibody. In those subjects who were not protected from infection, A.N. antibody significantly suppressed the clinical expression of infection. It is concluded that antibody against the neuraminidase of the influenza virus prevented or modified infection in a situation in which hæmagglutinin antibody had no effect.</p></abstract></profileDesc><revisionDesc><change when="1973">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-CBD1Z6RX-8/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>LANCET</jid><aid>7392196X</aid><ce:pii>S0140-6736(73)92196-X</ce:pii><ce:doi>10.1016/S0140-6736(73)92196-X</ce:doi><ce:copyright type="unknown" year="1973"></ce:copyright></item-info><head><ce:title>EFFECT OF NEURAMINIDASE ANTIBODY ON HONG KONG INFLUENZA</ce:title><ce:author-group><ce:author><ce:given-name>ArnoldS.</ce:given-name><ce:surname>Monto</ce:surname></ce:author><ce:author><ce:given-name>AlanP.</ce:given-name><ce:surname>Kendal</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, U.S.A..</ce:textfn></ce:affiliation></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The relation between antineuraminidase antibody (A.N.) and natural influenza infection in 1968 was investigated in the community of Tecumseh, Michigan. The outbreak was caused by Hong Kong influenza virus, which contained a new hæmagglutinin antigen (H<ce:inf>3</ce:inf>), while the neuraminidase antigen (N<ce:inf>2</ce:inf>) was more closely related to that of Asian viruses circulating since 1957. In the study group of two hundred and seventy-four randomly selected adults (aged 20-45), titres of N<ce:inf>2</ce:inf> neuraminidase antibody were detected in a hundred and fifteen (42%) serum samples collected before the outbreak. Influenza infection during the course of the outbreak was identified serologically. The frequency of infection decreased significantly at increasing levels of pre-existing A.N. antibody. In those subjects who were not protected from infection, A.N. antibody significantly suppressed the clinical expression of infection. It is concluded that antibody against the neuraminidase of the influenza virus prevented or modified infection in a situation in which hæmagglutinin antibody had no effect.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>EFFECT OF NEURAMINIDASE ANTIBODY ON HONG KONG INFLUENZA</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>EFFECT OF NEURAMINIDASE ANTIBODY ON HONG KONG INFLUENZA</title></titleInfo><name type="personal"><namePart type="given">ArnoldS.</namePart><namePart type="family">Monto</namePart><affiliation>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, U.S.A..</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">AlanP.</namePart><namePart type="family">Kendal</namePart><affiliation>Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan 48104, U.S.A..</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1973</dateIssued><copyrightDate encoding="w3cdtf">1973</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The relation between antineuraminidase antibody (A.N.) and natural influenza infection in 1968 was investigated in the community of Tecumseh, Michigan. The outbreak was caused by Hong Kong influenza virus, which contained a new hæmagglutinin antigen (H3), while the neuraminidase antigen (N2) was more closely related to that of Asian viruses circulating since 1957. In the study group of two hundred and seventy-four randomly selected adults (aged 20-45), titres of N2 neuraminidase antibody were detected in a hundred and fifteen (42%) serum samples collected before the outbreak. Influenza infection during the course of the outbreak was identified serologically. The frequency of infection decreased significantly at increasing levels of pre-existing A.N. antibody. In those subjects who were not protected from infection, A.N. antibody significantly suppressed the clinical expression of infection. 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