Antigenic structure of the hemagglutinin of H9N2 influenza viruses
Identifieur interne : 000E68 ( Istex/Corpus ); précédent : 000E67; suivant : 000E69Antigenic structure of the hemagglutinin of H9N2 influenza viruses
Auteurs : Masatoshi Okamatsu ; Yoshihiro Sakoda ; Noriko Kishida ; Norikazu Isoda ; Hiroshi KidaSource :
- Archives of Virology [ 0304-8608 ] ; 2008-12-01.
Abstract
Abstract: The hemagglutinins (HAs) of H9 influenza viruses isolated from birds and mammals of different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs). Based on the reactivity patterns of these mutants with a panel of MAbs, at least five non-overlapping antigenic sites were defined using eight MAbs which recognized seven distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis.
Url:
DOI: 10.1007/s00705-008-0243-2
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Kishida</name><affiliation><mods:affiliation>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</mods:affiliation></affiliation></author><author><name sortKey="Isoda, Norikazu" sort="Isoda, Norikazu" uniqKey="Isoda N" first="Norikazu" last="Isoda">Norikazu Isoda</name><affiliation><mods:affiliation>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</mods:affiliation></affiliation></author><author><name sortKey="Kida, Hiroshi" sort="Kida, Hiroshi" uniqKey="Kida H" first="Hiroshi" last="Kida">Hiroshi Kida</name><affiliation><mods:affiliation>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>Hokkaido University Research Center for Zoonosis Control, North 21, West 11, Kita-ku, 001-0021, Sapporo, Hokkaido, Japan</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: kida@vetmed.hokudai.ac.jp</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="sub">Official Journal of the Virology Division of the International Union of Microbiological Societies</title><title level="j" type="abbrev">Arch Virol</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer Vienna</publisher><pubPlace>Vienna</pubPlace><date type="published" when="2008-12-01">2008-12-01</date><biblScope unit="volume">153</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2189">2189</biblScope><biblScope unit="page" to="2195">2195</biblScope></imprint><idno 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Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs). Based on the reactivity patterns of these mutants with a panel of MAbs, at least five non-overlapping antigenic sites were defined using eight MAbs which recognized seven distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis.</div></front></TEI><istex><corpusName>springer-journals</corpusName><author><json:item><name>Masatoshi Okamatsu</name><affiliations><json:string>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</json:string></affiliations></json:item><json:item><name>Yoshihiro Sakoda</name><affiliations><json:string>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</json:string></affiliations></json:item><json:item><name>Noriko Kishida</name><affiliations><json:string>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</json:string></affiliations></json:item><json:item><name>Norikazu Isoda</name><affiliations><json:string>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</json:string></affiliations></json:item><json:item><name>Hiroshi Kida</name><affiliations><json:string>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</json:string><json:string>Hokkaido University Research Center for Zoonosis Control, North 21, West 11, Kita-ku, 001-0021, Sapporo, Hokkaido, Japan</json:string><json:string>E-mail: kida@vetmed.hokudai.ac.jp</json:string></affiliations></json:item></author><articleId><json:string>243</json:string><json:string>s00705-008-0243-2</json:string></articleId><arkIstex>ark:/67375/VQC-R5BD3Z9P-K</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: The hemagglutinins (HAs) of H9 influenza viruses isolated from birds and mammals of different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs). Based on the reactivity patterns of these mutants with a panel of MAbs, at least five non-overlapping antigenic sites were defined using eight MAbs which recognized seven distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. 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different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs). Based on the reactivity patterns of these mutants with a panel of MAbs, at least five non-overlapping antigenic sites were defined using eight MAbs which recognized seven distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Infectious Diseases</term></item><item><term>Medical Microbiology</term></item><item><term>Virology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-06-10">Created</change><change when="2008-12-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-R5BD3Z9P-K/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType 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CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Hiroshi</GivenName><FamilyName>Kida</FamilyName></AuthorName><Contact><Phone>+81-11-7065207</Phone><Fax>+81-11-7065273</Fax><Email>kida@vetmed.hokudai.ac.jp</Email></Contact></Author><Affiliation ID="Aff1"><OrgDivision>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine</OrgDivision><OrgName>Hokkaido University</OrgName><OrgAddress><Street>North 18, West 9, Kita-ku</Street><City>Sapporo</City><State>Hokkaido</State><Postcode>060-0818</Postcode><Country Code="JP">Japan</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Hokkaido University Research Center for Zoonosis Control</OrgName><OrgAddress><Street>North 21, West 11, Kita-ku</Street><City>Sapporo</City><State>Hokkaido</State><Postcode>001-0021</Postcode><Country Code="JP">Japan</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En" OutputMedium="All"><Heading>Abstract</Heading><Para TextBreak="No">The hemagglutinins (HAs) of H9 influenza viruses isolated from birds and mammals of different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs). Based on the reactivity patterns of these mutants with a panel of MAbs, at least five non-overlapping antigenic sites were defined using eight MAbs which recognized seven distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Antigenic structure of the hemagglutinin of H9N2 influenza viruses</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Antigenic structure of the hemagglutinin of H9N2 influenza viruses</title></titleInfo><name type="personal"><namePart type="given">Masatoshi</namePart><namePart type="family">Okamatsu</namePart><affiliation>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yoshihiro</namePart><namePart type="family">Sakoda</namePart><affiliation>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Noriko</namePart><namePart type="family">Kishida</namePart><affiliation>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Norikazu</namePart><namePart type="family">Isoda</namePart><affiliation>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">Hiroshi</namePart><namePart type="family">Kida</namePart><affiliation>Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, North 18, West 9, Kita-ku, 060-0818, Sapporo, Hokkaido, Japan</affiliation><affiliation>Hokkaido University Research Center for Zoonosis Control, North 21, West 11, Kita-ku, 001-0021, Sapporo, Hokkaido, Japan</affiliation><affiliation>E-mail: kida@vetmed.hokudai.ac.jp</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer Vienna</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateCreated encoding="w3cdtf">2008-06-10</dateCreated><dateIssued encoding="w3cdtf">2008-12-01</dateIssued><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: The hemagglutinins (HAs) of H9 influenza viruses isolated from birds and mammals of different species were antigenically and genetically analyzed. Antigenic variants were selected from A/swine/Hong Kong/10/98 (H9N2) and A/duck/Hokkaido/13/00 (H9N2) in the presence of monoclonal antibodies (MAbs). Based on the reactivity patterns of these mutants with a panel of MAbs, at least five non-overlapping antigenic sites were defined using eight MAbs which recognized seven distinct epitopes on the H9 HA molecule. Based on the reactivity patterns with the panel of monoclonal antibodies, 21 H9N2 virus strains isolated from birds and mammals were divided into 7 antigenically distinct groups. The present findings indicate that it is important to monitor the antigenic variation in H9 influenza viruses. The panel of MAbs in the present study, thus, should be useful for detailed antigenic analysis of the H9 HAs for epidemiological studies, the selection of vaccine strains, and diagnosis.</abstract><note>Original Article</note><relatedItem type="host"><titleInfo><title>Archives of Virology</title><subTitle>Official Journal of the Virology Division of the International Union of Microbiological Societies</subTitle></titleInfo><titleInfo type="abbreviated"><title>Arch Virol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">2009-01-06</dateIssued><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Infectious Diseases</topic><topic>Medical Microbiology</topic><topic>Virology</topic></subject><identifier type="ISSN">0304-8608</identifier><identifier type="eISSN">1432-8798</identifier><identifier type="JournalID">705</identifier><identifier type="IssueArticleCount">17</identifier><identifier type="VolumeIssueCount">12</identifier><part><date>2008</date><detail type="volume"><number>153</number><caption>vol.</caption></detail><detail type="issue"><number>12</number><caption>no.</caption></detail><extent unit="pages"><start>2189</start><end>2195</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 2008</recordOrigin></recordInfo></relatedItem><identifier type="istex">482969D0884F9821495E489C6E3BF3B1C80B481B</identifier><identifier type="ark">ark:/67375/VQC-R5BD3Z9P-K</identifier><identifier type="DOI">10.1007/s00705-008-0243-2</identifier><identifier type="ArticleID">243</identifier><identifier type="ArticleID">s00705-008-0243-2</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 2008</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 2008</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/VQC-R5BD3Z9P-K/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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