IgM and IgG Antibody Responses after Immunization of Children with Inactivated Monovalent (A/New Jersey/76) and Bivalent (A/New Jersey/76-A/Victoria/75) Influenza Virus Vaccines
Identifieur interne : 000E16 ( Istex/Corpus ); précédent : 000E15; suivant : 000E17IgM and IgG Antibody Responses after Immunization of Children with Inactivated Monovalent (A/New Jersey/76) and Bivalent (A/New Jersey/76-A/Victoria/75) Influenza Virus Vaccines
Auteurs : Kenneth M. Boyer ; James D. Cherry ; Robert C. Welliver ; James P. Dudley ; Jaime Deseda Tous ; John M. Zahradnik ; Peter J. Krause ; Mary J. Spencer ; Yvonne J. Bryson ; Alice J. GarakianSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1977.
Abstract
The character of the immune response to inactivated monovalent influenza A/New Jersey/76 and bivalent influenza A/New Jersey/76-A/Victoria/75 vaccines was studied in children six months to 18 years of age. Titers of hemagglutination-inhibiting antibody in sera taken after vaccination were measured before and after treatment with 2-mercaptoethanol. IgG antibody predominated in responses to the influenza A/Victoria/75 component of bivalent vaccines. In contrast, specific IgM antibody to influenza A/New Jersey/76 virus developed after administration of both monovalent and bivalent vaccines and appeared to characterize the immune response to this antigenic “shift” strain in children. Prevalences of IgM antibody against influenza A/New Jersey /76 virus did not differ significantly by age. This finding implies that type rather than extent of previous experience with influenza determines the IgM antibody response to an antigenic “shift.” Split-product vaccines produced significantly fewer IgM antibody responses to influenza A/New Jersey/76 virus than did whole-virus vaccines, a phenomenon that may correlate with their diminished reactogenicity and immunogenicity in children.
Url:
DOI: 10.1093/infdis/136.Supplement_3.S665
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Boyer</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Cherry, James D" sort="Cherry, James D" uniqKey="Cherry J" first="James D." last="Cherry">James D. Cherry</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</mods:affiliation></affiliation><affiliation><mods:affiliation>Please address requests for reprints to Dr. James D. Cherry, Division of Infectious Diseases, Department of Pediatrics, UCLA Center for the Health Sciences, Los Angeles, California 90024.</mods:affiliation></affiliation></author><author><name sortKey="Welliver, Robert C" sort="Welliver, Robert C" uniqKey="Welliver R" first="Robert C." last="Welliver">Robert C. Welliver</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Dudley, James P" sort="Dudley, James P" uniqKey="Dudley J" first="James P." last="Dudley">James P. Dudley</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Tous, Jaime Deseda" sort="Tous, Jaime Deseda" uniqKey="Tous J" first="Jaime Deseda" last="Tous">Jaime Deseda Tous</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Zahradnik, John M" sort="Zahradnik, John M" uniqKey="Zahradnik J" first="John M." last="Zahradnik">John M. Zahradnik</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Krause, Peter J" sort="Krause, Peter J" uniqKey="Krause P" first="Peter J" last="Krause">Peter J. Krause</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Spencer, Mary J" sort="Spencer, Mary J" uniqKey="Spencer M" first="Mary J." last="Spencer">Mary J. Spencer</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Bryson, Yvonne J" sort="Bryson, Yvonne J" uniqKey="Bryson Y" first="Yvonne J." last="Bryson">Yvonne J. Bryson</name><affiliation><mods:affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</mods:affiliation></affiliation></author><author><name sortKey="Garakian, Alice J" sort="Garakian, Alice J" uniqKey="Garakian A" first="Alice J." last="Garakian">Alice J. 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Boyer</name><affiliations><json:string>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</json:string></affiliations></json:item><json:item><name>James D. Cherry</name><affiliations><json:string>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</json:string><json:string>Please address requests for reprints to Dr. James D. Cherry, Division of Infectious Diseases, Department of Pediatrics, UCLA Center for the Health Sciences, Los Angeles, California 90024.</json:string></affiliations></json:item><json:item><name>Robert C. Welliver</name><affiliations><json:string>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</json:string></affiliations></json:item><json:item><name>James P. Dudley</name><affiliations><json:string>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</json:string></affiliations></json:item><json:item><name>Jaime Deseda Tous</name><affiliations><json:string>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</json:string></affiliations></json:item><json:item><name>John M. Zahradnik</name><affiliations><json:string>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</json:string></affiliations></json:item><json:item><name>Peter J Krause</name><affiliations><json:string>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</json:string></affiliations></json:item><json:item><name>Mary J. Spencer</name><affiliations><json:string>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</json:string></affiliations></json:item><json:item><name>Yvonne J. Bryson</name><affiliations><json:string>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</json:string></affiliations></json:item><json:item><name>Alice J. Garakian</name><affiliations><json:string>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</json:string></affiliations></json:item></author><arkIstex>ark:/67375/HXZ-4XP7D9Q1-Z</arkIstex><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>The character of the immune response to inactivated monovalent influenza A/New Jersey/76 and bivalent influenza A/New Jersey/76-A/Victoria/75 vaccines was studied in children six months to 18 years of age. Titers of hemagglutination-inhibiting antibody in sera taken after vaccination were measured before and after treatment with 2-mercaptoethanol. IgG antibody predominated in responses to the influenza A/Victoria/75 component of bivalent vaccines. In contrast, specific IgM antibody to influenza A/New Jersey/76 virus developed after administration of both monovalent and bivalent vaccines and appeared to characterize the immune response to this antigenic “shift” strain in children. Prevalences of IgM antibody against influenza A/New Jersey /76 virus did not differ significantly by age. This finding implies that type rather than extent of previous experience with influenza determines the IgM antibody response to an antigenic “shift.” Split-product vaccines produced significantly fewer IgM antibody responses to influenza A/New Jersey/76 virus than did whole-virus vaccines, a phenomenon that may correlate with their diminished reactogenicity and immunogenicity in children.</abstract><qualityIndicators><score>6.445</score><pdfWordCount>3858</pdfWordCount><pdfCharCount>24864</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>7</pdfPageCount><pdfPageSize>612 x 768.96 pts</pdfPageSize><pdfWordsPerPage>551</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>false</refBibsNative><abstractWordCount>160</abstractWordCount><abstractCharCount>1186</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>IgM and IgG Antibody Responses after Immunization of Children with Inactivated Monovalent (A/New Jersey/76) and Bivalent (A/New Jersey/76-A/Victoria/75) Influenza Virus Vaccines</title><pmid><json:string>342632</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Journal of Infectious Diseases</title><language><json:string>unknown</json:string></language><issn><json:string>0022-1899</json:string></issn><eissn><json:string>1537-6613</json:string></eissn><publisherId><json:string>jid</json:string></publisherId><volume>136</volume><issue>Supplement-3</issue><pages><first>S665</first><last>S671</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1976</json:string><json:string>1977</json:string></date><geogName></geogName><orgName><json:string>Merrell-National Laboratories</json:string><json:string>Division of Laboratories</json:string><json:string>Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California Kenneth M</json:string><json:string>Wyeth Laboratories</json:string><json:string>Bureau of Biologics</json:string><json:string>National Institute of Allergy and Infectious Diseases</json:string><json:string>Division of Infectious Diseases</json:string><json:string>National Institutes of Health</json:string><json:string>Department of Pediatrics, UCLA Center for the Health Sciences, Los Angeles, California</json:string><json:string>Bureau of Laboratories, Center for Disease Control</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>G. R. Summary</json:string><json:string>J. R. Summary</json:string><json:string>Yvonne J. Bryson</json:string><json:string>J. Exp</json:string><json:string>Gary R. Noble</json:string><json:string>James D. Cherry</json:string><json:string>J. D. Cherry</json:string><json:string>Jaime Deseda-Tous</json:string><json:string>Mary J. Spencer</json:string><json:string>J. Pediatr</json:string><json:string>Robert C. Welliver</json:string><json:string>John M. Zahradnik</json:string><json:string>J. K. Dissociation</json:string><json:string>S. J. Reactivity</json:string><json:string>F. M. Effect</json:string><json:string>J. Infect</json:string><json:string>J. Immunol</json:string><json:string>Carmen Castillo</json:string><json:string>Alice J. Garakian</json:string><json:string>A. J. Garakian</json:string><json:string>James P. Dudley</json:string><json:string>Stephanie Biggs</json:string><json:string>M. J. Spencer</json:string></persName><placeName><json:string>Specificity</json:string><json:string>Cincinnati</json:string><json:string>Atlanta</json:string><json:string>Los Angeles</json:string><json:string>Detroit</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[2-4]</json:string><json:string>[6]</json:string><json:string>Boyer et al, 5666</json:string><json:string>[11]</json:string><json:string>[1]</json:string><json:string>[10]</json:string><json:string>Boyer et al.</json:string><json:string>[3]</json:string><json:string>[8, 9]</json:string><json:string>[5]</json:string><json:string>[2, 3, 5]</json:string><json:string>[7]</json:string><json:string>Boyer et al, 5668</json:string><json:string>[2]</json:string><json:string>Nossal et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/HXZ-4XP7D9Q1-Z</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - microbiology</json:string><json:string>2 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récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>The University of Chicago Press</publisher><availability><licence>© 1977 the University of Chicago</licence></availability><date type="Copyright" when="1977">1977</date><date when="1977-12">1977</date></publicationStmt><notesStmt><note type="content-type" source="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="publication-type" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">IgM and IgG Antibody Responses after Immunization of Children with Inactivated Monovalent (A/New Jersey/76) and Bivalent (A/New Jersey/76-A/Victoria/75) Influenza Virus Vaccines</title><author xml:id="author-0000"><persName><surname>Boyer</surname><forename type="first">Kenneth M.</forename></persName><affiliation><orgName type="department">Division of Infectious Diseases</orgName><orgName type="department">Department Of Pediatrics</orgName><orgName type="department">UCLA School Of Medicine</orgName><address><addrLine>Los Angeles</addrLine><country key="" xml:lang="en"></country></address></affiliation></author><author xml:id="author-0001" role="corresp"><persName><surname>Cherry</surname><forename type="first">James D.</forename></persName><affiliation><orgName type="department">Division of Infectious Diseases</orgName><orgName type="department">Department Of Pediatrics</orgName><orgName type="department">UCLA School Of Medicine</orgName><address><addrLine>Los Angeles</addrLine><country key="" xml:lang="en"></country></address></affiliation><affiliation role="corresp"><address><addrLine>Los Angeles, California 90024</addrLine></address></affiliation></author><author xml:id="author-0002"><persName><surname>Welliver</surname><forename type="first">Robert C.</forename></persName><affiliation><orgName type="department">Division of Infectious Diseases</orgName><orgName type="department">Department Of Pediatrics</orgName><orgName type="department">UCLA School Of Medicine</orgName><address><addrLine>Los Angeles</addrLine><country key="" xml:lang="en"></country></address></affiliation></author><author xml:id="author-0003"><persName><surname>Dudley</surname><forename type="first">James P.</forename></persName><affiliation><orgName type="department">Division of Infectious Diseases</orgName><orgName type="department">Department Of Pediatrics</orgName><orgName type="department">UCLA School Of Medicine</orgName><address><addrLine>Los Angeles</addrLine><country key="" xml:lang="en"></country></address></affiliation></author><author xml:id="author-0004"><persName><surname>Tous</surname><forename type="first">Jaime Deseda</forename></persName><affiliation><orgName type="department">Division of Infectious Diseases</orgName><orgName type="department">Department Of Pediatrics</orgName><orgName type="department">UCLA School Of Medicine</orgName><address><addrLine>Los Angeles</addrLine><country key="" xml:lang="en"></country></address></affiliation></author><author xml:id="author-0005"><persName><surname>Zahradnik</surname><forename type="first">John M.</forename></persName><affiliation><orgName type="department">Division of Infectious Diseases</orgName><orgName type="department">Department Of Pediatrics</orgName><orgName type="department">UCLA School Of Medicine</orgName><address><addrLine>Los Angeles</addrLine><country key="" xml:lang="en"></country></address></affiliation></author><author xml:id="author-0006"><persName><surname>Krause</surname><forename type="first">Peter J</forename></persName><affiliation><orgName type="department">Division of Infectious Diseases</orgName><orgName type="department">Department Of Pediatrics</orgName><orgName type="department">UCLA School Of Medicine</orgName><address><addrLine>Los Angeles</addrLine><country key="" xml:lang="en"></country></address></affiliation></author><author xml:id="author-0007"><persName><surname>Spencer</surname><forename type="first">Mary J.</forename></persName><affiliation><orgName type="department">Division of Infectious Diseases</orgName><orgName type="department">Department Of Pediatrics</orgName><orgName type="department">UCLA School Of Medicine</orgName><address><addrLine>Los Angeles</addrLine><country key="" xml:lang="en"></country></address></affiliation></author><author xml:id="author-0008"><persName><surname>Bryson</surname><forename type="first">Yvonne J.</forename></persName><affiliation><orgName type="department">Division of Infectious Diseases</orgName><orgName type="department">Department Of Pediatrics</orgName><orgName type="department">UCLA School Of Medicine</orgName><address><addrLine>Los Angeles</addrLine><country key="" xml:lang="en"></country></address></affiliation></author><author xml:id="author-0009"><persName><surname>Garakian</surname><forename type="first">Alice J.</forename></persName><affiliation><orgName type="department">Division of Infectious Diseases</orgName><orgName type="department">Department Of Pediatrics</orgName><orgName type="department">UCLA School Of Medicine</orgName><address><addrLine>Los Angeles</addrLine><country key="" xml:lang="en"></country></address></affiliation></author><idno type="istex">FB50F4A7FA8400D93B453C4E5ABEA36CBF875117</idno><idno type="ark">ark:/67375/HXZ-4XP7D9Q1-Z</idno><idno type="DOI">10.1093/infdis/136.Supplement_3.S665</idno></analytic><monogr><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="hwp">jinfdis</idno><idno type="publisher-id">jid</idno><idno type="pISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1977-12">1977</date><biblScope unit="vol">136</biblScope><biblScope unit="issue">Supplemet_3</biblScope><biblScope unit="page" from="S665">S665</biblScope><biblScope unit="page" to="S671">S671</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef><appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-09"><label>pub2TEI-ISTEX</label><desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract><p>The character of the immune response to inactivated monovalent influenza A/New Jersey/76 and bivalent influenza A/New Jersey/76-A/Victoria/75 vaccines was studied in children six months to 18 years of age. Titers of hemagglutination-inhibiting antibody in sera taken after vaccination were measured before and after treatment with 2-mercaptoethanol. IgG antibody predominated in responses to the influenza A/Victoria/75 component of bivalent vaccines. In contrast, specific IgM antibody to influenza A/New Jersey/76 virus developed after administration of both monovalent and bivalent vaccines and appeared to characterize the immune response to this antigenic “shift” strain in children. Prevalences of IgM antibody against influenza A/New Jersey /76 virus did not differ significantly by age. This finding implies that type rather than extent of previous experience with influenza determines the IgM antibody response to an antigenic “shift.” Split-product vaccines produced significantly fewer IgM antibody responses to influenza A/New Jersey/76 virus than did whole-virus vaccines, a phenomenon that may correlate with their diminished reactogenicity and immunogenicity in children.</p></abstract><textClass ana="subject"><keywords scheme="heading"><term>Session III. Vaccine Trials</term></keywords><keywords scheme="heading"><term>E. Bivalent Vaccine in Children: One- and Two-Dose Trials</term></keywords></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-09" who="#istex" xml:id="pub2tei">formatting</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2019-12-12">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-4XP7D9Q1-Z/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article">
<front>
<journal-meta>
<journal-id journal-id-type="hwp">jinfdis</journal-id>
<journal-id journal-id-type="publisher-id">jid</journal-id>
<journal-title>Journal of Infectious Diseases</journal-title>
<abbrev-journal-title>J Infect Dis.</abbrev-journal-title>
<issn pub-type="ppub">0022-1899</issn>
<issn pub-type="epub">1537-6613</issn>
<publisher>
<publisher-name>The University of Chicago Press</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.1093/infdis/136.Supplement_3.S665</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Session III. Vaccine Trials</subject>
</subj-group>
<subj-group subj-group-type="heading">
<subject>E. Bivalent Vaccine in Children: One- and Two-Dose Trials</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>IgM and IgG Antibody Responses after Immunization of Children with Inactivated Monovalent (A/New Jersey/76) and Bivalent (A/New Jersey/76-A/Victoria/75) Influenza Virus Vaccines</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name><surname>Boyer</surname><given-names>Kenneth M.</given-names></name>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name><surname>Cherry</surname><given-names>James D.</given-names></name><xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Welliver</surname><given-names>Robert C.</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Dudley</surname><given-names>James P.</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Tous</surname><given-names>Jaime Deseda</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Zahradnik</surname><given-names>John M.</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Krause</surname><given-names>Peter J</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Spencer</surname><given-names>Mary J.</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Bryson</surname><given-names>Yvonne J.</given-names></name>
</contrib>
<contrib contrib-type="author">
<name><surname>Garakian</surname><given-names>Alice J.</given-names></name>
</contrib>
<aff><institution>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine</institution>, <addr-line>Los Angeles</addr-line>, <country>California</country></aff>
</contrib-group>
<author-notes>
<corresp id="cor1">Please address requests for reprints to Dr. James D. Cherry, <institution>Division of Infectious Diseases, Department of Pediatrics, UCLA Center for the Health Sciences</institution>, <addr-line>Los Angeles, California 90024</addr-line>.</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>12</month>
<year>1977</year>
</pub-date>
<volume>136</volume>
<issue>Supplement_3</issue>
<fpage>S665</fpage>
<lpage>S671</lpage>
<copyright-statement>© 1977 the University of Chicago</copyright-statement>
<copyright-year>1977</copyright-year>
<abstract>
<p>The character of the immune response to inactivated monovalent influenza A/New Jersey/76 and bivalent influenza A/New Jersey/76-A/Victoria/75 vaccines was studied in children six months to 18 years of age. Titers of hemagglutination-inhibiting antibody in sera taken after vaccination were measured before and after treatment with 2-mercaptoethanol. IgG antibody predominated in responses to the influenza A/Victoria/75 component of bivalent vaccines. In contrast, specific IgM antibody to influenza A/New Jersey/76 virus developed after administration of both monovalent and bivalent vaccines and appeared to characterize the immune response to this antigenic “shift” strain in children. Prevalences of IgM antibody against influenza A/New Jersey /76 virus did not differ significantly by age. This finding implies that type rather than extent of previous experience with influenza determines the IgM antibody response to an antigenic “shift.” Split-product vaccines produced significantly fewer IgM antibody responses to influenza A/New Jersey/76 virus than did whole-virus vaccines, a phenomenon that may correlate with their diminished reactogenicity and immunogenicity in children.</p>
</abstract>
</article-meta>
</front>
</article>
</istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>IgM and IgG Antibody Responses after Immunization of Children with Inactivated Monovalent (A/New Jersey/76) and Bivalent (A/New Jersey/76-A/Victoria/75) Influenza Virus Vaccines</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>IgM and IgG Antibody Responses after Immunization of Children with Inactivated Monovalent (A/New Jersey/76) and Bivalent (A/New Jersey/76-A/Victoria/75) Influenza Virus Vaccines</title></titleInfo><name type="personal"><namePart type="given">Kenneth M.</namePart><namePart type="family">Boyer</namePart><affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">James D.</namePart><namePart type="family">Cherry</namePart><affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</affiliation><affiliation>Please address requests for reprints to Dr. James D. Cherry, Division of Infectious Diseases, Department of Pediatrics, UCLA Center for the Health Sciences, Los Angeles, California 90024.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robert C.</namePart><namePart type="family">Welliver</namePart><affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James P.</namePart><namePart type="family">Dudley</namePart><affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jaime Deseda</namePart><namePart type="family">Tous</namePart><affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John M.</namePart><namePart type="family">Zahradnik</namePart><affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter J</namePart><namePart type="family">Krause</namePart><affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mary J.</namePart><namePart type="family">Spencer</namePart><affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yvonne J.</namePart><namePart type="family">Bryson</namePart><affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alice J.</namePart><namePart type="family">Garakian</namePart><affiliation>Division of Infectious Diseases, Department Of Pediatrics, UCLA School Of Medicine, Los Angeles, California</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>The University of Chicago Press</publisher><dateIssued encoding="w3cdtf">1977-12</dateIssued><copyrightDate encoding="w3cdtf">1977</copyrightDate></originInfo><abstract>The character of the immune response to inactivated monovalent influenza A/New Jersey/76 and bivalent influenza A/New Jersey/76-A/Victoria/75 vaccines was studied in children six months to 18 years of age. Titers of hemagglutination-inhibiting antibody in sera taken after vaccination were measured before and after treatment with 2-mercaptoethanol. IgG antibody predominated in responses to the influenza A/Victoria/75 component of bivalent vaccines. In contrast, specific IgM antibody to influenza A/New Jersey/76 virus developed after administration of both monovalent and bivalent vaccines and appeared to characterize the immune response to this antigenic “shift” strain in children. Prevalences of IgM antibody against influenza A/New Jersey /76 virus did not differ significantly by age. This finding implies that type rather than extent of previous experience with influenza determines the IgM antibody response to an antigenic “shift.” Split-product vaccines produced significantly fewer IgM antibody responses to influenza A/New Jersey/76 virus than did whole-virus vaccines, a phenomenon that may correlate with their diminished reactogenicity and immunogenicity in children.</abstract><note type="author-notes">Please address requests for reprints to Dr. James D. 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