Can human viruses infect porcine xenografts?
Identifieur interne : 000D26 ( Istex/Corpus ); précédent : 000D25; suivant : 000D27Can human viruses infect porcine xenografts?
Auteurs : Anne Laure Millard ; Nicolas J. MuellerSource :
- Xenotransplantation [ 0908-665X ] ; 2010-01.
English descriptors
- Teeft :
- Adenovirus, Biochem biophys, Cell cultures, Cellular machinery, Chronic hepatitis, Clinical trials, Cytomegalovirus, Defective entry, Gnotobiotic pigs, Graft function, Hepatitis, Herpes simplex virus, Herpesviruses, Hospital epidemiology, Human cells, Human cytomegalovirus, Human noroviruses, Human pathogens, Human viruses, Immune suppression, Immunosuppressed patients, Infant pigs, Infection, Infectious diseases, Infective progeny, Islet, Mueller, Nipah, Nipah virus, Pathogen, Permanent porcine cell lines, Porcine, Porcine cell lines, Porcine cells, Porcine islets, Porcine lung epithelial cells, Porcine origin, Porcine tissues, Porcine xenograft, Porcine xenografts, Productive infection, Receptor, Replication, Respiratory tract, Transplantation, University hospital zurich, Unknown pathogens, Unpredictable consequences, Viral, Viral proteins, Viral strains, Virol, Virus, Virus infection, Xenograft, Xenograft infection, Xenotransplantation.
Abstract
Millard AL, Mueller NJ. Can human viruses infect porcine xenografts? Xenotransplantation 2010; 17: 6–10. © 2010 John Wiley & Sons A/S. Abstract: Xenotransplantation exposes the recipient to known and unknown pathogens of the donor pig (donor‐derived xenosis). A major effort has been undertaken to minimize the risk of transmission from the donor using specialized breeding techniques. With the exception of endogenous retroviruses and porcine lymphotropic herpesvirus, exclusion of known pathogens was successful and has eliminated a majority of donor pathogens. In the recipient, enhanced replication of many pathogens will be stimulated by the immune responses induced by transplantation and by the immune suppression used to prevent graft rejection. Infection of the graft may occur with unpredictable consequences due to the cross‐species situation. Infectivity may be decreased as entry or replication is altered by missing receptors or inability to use the cellular machinery. Replication of organisms in the xenograft and the inability of the human host to respond to human pathogens in the context of a xenograft infection due to immune suppression, or the presentation of such pathogens in the context of pig instead of human major histocompatibility complex (MHC) could impair control of such infections. Recent data suggest that some human herpesviruses infections, such as human cytomegalovirus, may infect porcine tissue and are associated with a pro‐inflammatory phenotype. This review focuses on human or recipient‐derived pathogens and their potential harmful role in xenograft infection.
Url:
DOI: 10.1111/j.1399-3089.2009.00566.x
Links to Exploration step
ISTEX:AF34C4D6C09A1509B5868737E9E511898538AED8Le document en format XML
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Can human viruses infect porcine xenografts? Xenotransplantation 2010; 17: 6–10. © 2010 John Wiley & Sons A/S. Abstract: Xenotransplantation exposes the recipient to known and unknown pathogens of the donor pig (donor‐derived xenosis). A major effort has been undertaken to minimize the risk of transmission from the donor using specialized breeding techniques. With the exception of endogenous retroviruses and porcine lymphotropic herpesvirus, exclusion of known pathogens was successful and has eliminated a majority of donor pathogens. In the recipient, enhanced replication of many pathogens will be stimulated by the immune responses induced by transplantation and by the immune suppression used to prevent graft rejection. Infection of the graft may occur with unpredictable consequences due to the cross‐species situation. Infectivity may be decreased as entry or replication is altered by missing receptors or inability to use the cellular machinery. Replication of organisms in the xenograft and the inability of the human host to respond to human pathogens in the context of a xenograft infection due to immune suppression, or the presentation of such pathogens in the context of pig instead of human major histocompatibility complex (MHC) could impair control of such infections. Recent data suggest that some human herpesviruses infections, such as human cytomegalovirus, may infect porcine tissue and are associated with a pro‐inflammatory phenotype. 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Can human viruses infect porcine xenografts? Xenotransplantation 2010; 17: 6–10. © 2010 John Wiley & Sons A/S. Abstract: Xenotransplantation exposes the recipient to known and unknown pathogens of the donor pig (donor‐derived xenosis). A major effort has been undertaken to minimize the risk of transmission from the donor using specialized breeding techniques. With the exception of endogenous retroviruses and porcine lymphotropic herpesvirus, exclusion of known pathogens was successful and has eliminated a majority of donor pathogens. In the recipient, enhanced replication of many pathogens will be stimulated by the immune responses induced by transplantation and by the immune suppression used to prevent graft rejection. Infection of the graft may occur with unpredictable consequences due to the cross‐species situation. Infectivity may be decreased as entry or replication is altered by missing receptors or inability to use the cellular machinery. Replication of organisms in the xenograft and the inability of the human host to respond to human pathogens in the context of a xenograft infection due to immune suppression, or the presentation of such pathogens in the context of pig instead of human major histocompatibility complex (MHC) could impair control of such infections. Recent data suggest that some human herpesviruses infections, such as human cytomegalovirus, may infect porcine tissue and are associated with a pro‐inflammatory phenotype. 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[15]</json:string><json:string>[19,20]</json:string><json:string>[9]</json:string><json:string>[1,2]</json:string><json:string>[11,12]</json:string><json:string>[13]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-7RVNHJS4-X</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - transplantation</json:string><json:string>2 - medicine, research & experimental</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - surgery</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Transplantation</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - 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Infection of the graft may occur with unpredictable consequences due to the cross‐species situation. Infectivity may be decreased as entry or replication is altered by missing receptors or inability to use the cellular machinery. Replication of organisms in the xenograft and the inability of the human host to respond to human pathogens in the context of a xenograft infection due to immune suppression, or the presentation of such pathogens in the context of pig instead of human major histocompatibility complex (MHC) could impair control of such infections. Recent data suggest that some human herpesviruses infections, such as human cytomegalovirus, may infect porcine tissue and are associated with a pro‐inflammatory phenotype. This review focuses on human or recipient‐derived pathogens and their potential harmful role in xenograft infection.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">coxsackievirus‐B5</term><term xml:id="k2">hepatitis C virus</term><term xml:id="k3">herpes simplex virus 1 and 2</term><term xml:id="k4">host‐derived infection</term><term xml:id="k5">human adenovirus</term><term xml:id="k6">human cytomegaolvirus</term><term xml:id="k7">human herpesviruses</term><term xml:id="k8">human influenza virus</term><term xml:id="k9">transplantation</term><term xml:id="k10">xenotransplantation</term></keywords><keywords rend="tocHeading1"><term>Review Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-7RVNHJS4-X/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1399-3089</doi><issn type="print">0908-665X</issn><issn type="electronic">1399-3089</issn><idGroup><id type="product" value="XEN"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="XENOTRANSPLANTATION">Xenotransplantation</title></titleGroup></publicationMeta><publicationMeta level="part" position="01001"><doi origin="wiley">10.1111/xen.2010.17.issue-1</doi><numberingGroup><numbering type="journalVolume" number="17">17</numbering><numbering type="journalIssue" number="1">1</numbering></numberingGroup><coverDate startDate="2010-01">January/February 2010</coverDate></publicationMeta><publicationMeta level="unit" type="reviewArticle" position="3" status="forIssue"><doi origin="wiley">10.1111/j.1399-3089.2009.00566.x</doi><idGroup><id type="unit" value="XEN566"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">R<sc>eview</sc> A<sc>rticles</sc></title></titleGroup><copyright>© 2010 John Wiley & Sons A/S</copyright><eventGroup><event type="firstOnline" date="2010-02-07"></event><event type="publishedOnlineFinalForm" date="2010-02-07"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-02"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-10"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-04"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="6">6</numbering><numbering type="pageLast" number="10">10</numbering></numberingGroup><correspondenceTo>Address reprint requests to Nicolas Mueller, MD, Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital Zurich, Rämistrasse 100/RAE U 70, CH‐8091 Zürich, Switzerland
(E‐mail: <email>nicolas.mueller@usz.ch</email>)</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:XEN.XEN566.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 1 September 2009; Accepted 26 October 2009</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="1"></count></countGroup><titleGroup><title type="main">Can human viruses infect porcine xenografts?</title><title type="shortAuthors"><b>Millard and Mueller</b></title><title type="short"><b>Host‐derived viruses and xenotransplantation</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#aff-1-1"><personName><givenNames>Anne Laure</givenNames><familyName>Millard</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#aff-1-1"><personName><givenNames>Nicolas J.</givenNames><familyName>Mueller</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="aff-1-1" countryCode="CH"><unparsedAffiliation>Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital Zürich, Zurich, Switzerland</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">coxsackievirus‐B5</keyword><keyword xml:id="k2">hepatitis C virus</keyword><keyword xml:id="k3">herpes simplex virus 1 and 2</keyword><keyword xml:id="k4">host‐derived infection</keyword><keyword xml:id="k5">human adenovirus</keyword><keyword xml:id="k6">human cytomegaolvirus</keyword><keyword xml:id="k7">human herpesviruses</keyword><keyword xml:id="k8">human influenza virus</keyword><keyword xml:id="k9">transplantation</keyword><keyword xml:id="k10">xenotransplantation</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Millard AL, Mueller NJ. Can human viruses infect porcine xenografts? Xenotransplantation 2010; 17: 6–10. © 2010 John Wiley & Sons A/S.</p><p><b>Abstract: </b> Xenotransplantation exposes the recipient to known and unknown pathogens of the donor pig (donor‐derived xenosis). A major effort has been undertaken to minimize the risk of transmission from the donor using specialized breeding techniques. With the exception of endogenous retroviruses and porcine lymphotropic herpesvirus, exclusion of known pathogens was successful and has eliminated a majority of donor pathogens. In the recipient, enhanced replication of many pathogens will be stimulated by the immune responses induced by transplantation and by the immune suppression used to prevent graft rejection. Infection of the graft may occur with unpredictable consequences due to the cross‐species situation. Infectivity may be decreased as entry or replication is altered by missing receptors or inability to use the cellular machinery. Replication of organisms in the xenograft and the inability of the human host to respond to human pathogens in the context of a xenograft infection due to immune suppression, or the presentation of such pathogens in the context of pig instead of human major histocompatibility complex (MHC) could impair control of such infections. Recent data suggest that some human herpesviruses infections, such as human cytomegalovirus, may infect porcine tissue and are associated with a pro‐inflammatory phenotype. This review focuses on human or recipient‐derived pathogens and their potential harmful role in xenograft infection.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Can human viruses infect porcine xenografts?</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Host‐derived viruses and xenotransplantation</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Can human viruses infect porcine xenografts?</title></titleInfo><name type="personal"><namePart type="given">Anne Laure</namePart><namePart type="family">Millard</namePart><affiliation>Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital Zürich, Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicolas J.</namePart><namePart type="family">Mueller</namePart><affiliation>Division of Infectious Diseases and Hospital Epidemiology, Department of Medicine, University Hospital Zürich, Zurich, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="reviewArticle" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2010-01</dateIssued><edition>Received 1 September 2009; Accepted 26 October 2009</edition><copyrightDate encoding="w3cdtf">2010</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">1</extent></physicalDescription><abstract lang="en">Millard AL, Mueller NJ. Can human viruses infect porcine xenografts? Xenotransplantation 2010; 17: 6–10. © 2010 John Wiley & Sons A/S. Abstract: Xenotransplantation exposes the recipient to known and unknown pathogens of the donor pig (donor‐derived xenosis). A major effort has been undertaken to minimize the risk of transmission from the donor using specialized breeding techniques. With the exception of endogenous retroviruses and porcine lymphotropic herpesvirus, exclusion of known pathogens was successful and has eliminated a majority of donor pathogens. In the recipient, enhanced replication of many pathogens will be stimulated by the immune responses induced by transplantation and by the immune suppression used to prevent graft rejection. Infection of the graft may occur with unpredictable consequences due to the cross‐species situation. Infectivity may be decreased as entry or replication is altered by missing receptors or inability to use the cellular machinery. Replication of organisms in the xenograft and the inability of the human host to respond to human pathogens in the context of a xenograft infection due to immune suppression, or the presentation of such pathogens in the context of pig instead of human major histocompatibility complex (MHC) could impair control of such infections. Recent data suggest that some human herpesviruses infections, such as human cytomegalovirus, may infect porcine tissue and are associated with a pro‐inflammatory phenotype. This review focuses on human or recipient‐derived pathogens and their potential harmful role in xenograft infection.</abstract><subject lang="en"><genre>keywords</genre><topic>coxsackievirus‐B5</topic><topic>hepatitis C virus</topic><topic>herpes simplex virus 1 and 2</topic><topic>host‐derived infection</topic><topic>human adenovirus</topic><topic>human cytomegaolvirus</topic><topic>human herpesviruses</topic><topic>human influenza virus</topic><topic>transplantation</topic><topic>xenotransplantation</topic></subject><relatedItem type="host"><titleInfo><title>Xenotransplantation</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0908-665X</identifier><identifier type="eISSN">1399-3089</identifier><identifier type="DOI">10.1111/(ISSN)1399-3089</identifier><identifier type="PublisherID">XEN</identifier><part><date>2010</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>6</start><end>10</end><total>5</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3‐galactosyltransferase gene‐knockout donors and the cotransplantation of vascularized thymic tissue</title></titleInfo><name type="personal"><namePart type="given">K</namePart><namePart type="family">Yamada</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K</namePart><namePart type="family">Yazawa</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A</namePart><namePart type="family">Shimizu</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Yamada K, Yazawa K, Shimizu A et al. 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