The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection
Identifieur interne : 000D08 ( Istex/Corpus ); précédent : 000D07; suivant : 000D09The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection
Auteurs : R. Jennings ; C. M. Brand ; C. Mclaren ; Lynda Shepherd ; C. W. PotterSource :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 1974-11-01.
English descriptors
- Teeft :
- Antibody, Antibody response, Antibody titres, Detectable serum, Enhancement, Haemagglutinin, Haemagglutinin antigens, Haemagglutinins, Hamster, Heterotypic, Hong kong, Immune response, Immunization, Influenza, Influenza vaccines, Influenza virus, Influenza viruses, Split vaccine, Subsequent immunization, Titration vaccine, Vaccine, Vaccine virus, Virus, Whole virus vaccine.
Abstract
Abstract: The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.
Url:
DOI: 10.1007/BF02121445
Links to Exploration step
ISTEX:D45FFF912A6B7603CA798E5501036031F37C3293Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</title>
<author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name>
<affiliation><mods:affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Brand, C M" sort="Brand, C M" uniqKey="Brand C" first="C. M." last="Brand">C. M. Brand</name>
<affiliation><mods:affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Mclaren, C" sort="Mclaren, C" uniqKey="Mclaren C" first="C." last="Mclaren">C. Mclaren</name>
<affiliation><mods:affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Shepherd, Lynda" sort="Shepherd, Lynda" uniqKey="Shepherd L" first="Lynda" last="Shepherd">Lynda Shepherd</name>
<affiliation><mods:affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name>
<affiliation><mods:affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:D45FFF912A6B7603CA798E5501036031F37C3293</idno>
<date when="1974" year="1974">1974</date>
<idno type="doi">10.1007/BF02121445</idno>
<idno type="url">https://api.istex.fr/ark:/67375/1BB-W87HCM4C-R/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000D08</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000D08</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</title>
<author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name>
<affiliation><mods:affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Brand, C M" sort="Brand, C M" uniqKey="Brand C" first="C. M." last="Brand">C. M. Brand</name>
<affiliation><mods:affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Mclaren, C" sort="Mclaren, C" uniqKey="Mclaren C" first="C." last="Mclaren">C. Mclaren</name>
<affiliation><mods:affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Shepherd, Lynda" sort="Shepherd, Lynda" uniqKey="Shepherd L" first="Lynda" last="Shepherd">Lynda Shepherd</name>
<affiliation><mods:affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name>
<affiliation><mods:affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Medical Microbiology and Immunology</title>
<title level="j" type="abbrev">Med Microbiol Immunol</title>
<idno type="ISSN">0300-8584</idno>
<idno type="eISSN">1432-1831</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1974-11-01">1974-11-01</date>
<biblScope unit="volume">160</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="295">295</biblScope>
<biblScope unit="page" to="309">309</biblScope>
</imprint>
<idno type="ISSN">0300-8584</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0300-8584</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody</term>
<term>Antibody response</term>
<term>Antibody titres</term>
<term>Detectable serum</term>
<term>Enhancement</term>
<term>Haemagglutinin</term>
<term>Haemagglutinin antigens</term>
<term>Haemagglutinins</term>
<term>Hamster</term>
<term>Heterotypic</term>
<term>Hong kong</term>
<term>Immune response</term>
<term>Immunization</term>
<term>Influenza</term>
<term>Influenza vaccines</term>
<term>Influenza virus</term>
<term>Influenza viruses</term>
<term>Split vaccine</term>
<term>Subsequent immunization</term>
<term>Titration vaccine</term>
<term>Vaccine</term>
<term>Vaccine virus</term>
<term>Virus</term>
<term>Whole virus vaccine</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.</div>
</front>
</TEI>
<istex><corpusName>springer-journals</corpusName>
<keywords><teeft><json:string>hamster</json:string>
<json:string>vaccine</json:string>
<json:string>antibody response</json:string>
<json:string>influenza</json:string>
<json:string>influenza viruses</json:string>
<json:string>heterotypic</json:string>
<json:string>immunization</json:string>
<json:string>haemagglutinin</json:string>
<json:string>influenza virus</json:string>
<json:string>haemagglutinins</json:string>
<json:string>enhancement</json:string>
<json:string>subsequent immunization</json:string>
<json:string>virus</json:string>
<json:string>vaccine virus</json:string>
<json:string>hong kong</json:string>
<json:string>influenza vaccines</json:string>
<json:string>whole virus vaccine</json:string>
<json:string>immune response</json:string>
<json:string>titration vaccine</json:string>
<json:string>antibody titres</json:string>
<json:string>detectable serum</json:string>
<json:string>split vaccine</json:string>
<json:string>haemagglutinin antigens</json:string>
<json:string>antibody</json:string>
</teeft>
</keywords>
<author><json:item><name>R. Jennings</name>
<affiliations><json:string>Academic Division of Pathology, University of Sheffield, Sheffield</json:string>
</affiliations>
</json:item>
<json:item><name>C. M. Brand</name>
<affiliations><json:string>Academic Division of Pathology, University of Sheffield, Sheffield</json:string>
<json:string>Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England</json:string>
</affiliations>
</json:item>
<json:item><name>C. McLaren</name>
<affiliations><json:string>Academic Division of Pathology, University of Sheffield, Sheffield</json:string>
</affiliations>
</json:item>
<json:item><name>Lynda Shepherd</name>
<affiliations><json:string>Academic Division of Pathology, University of Sheffield, Sheffield</json:string>
</affiliations>
</json:item>
<json:item><name>C. W. Potter</name>
<affiliations><json:string>Academic Division of Pathology, University of Sheffield, Sheffield</json:string>
</affiliations>
</json:item>
</author>
<articleId><json:string>BF02121445</json:string>
<json:string>Art7</json:string>
</articleId>
<arkIstex>ark:/67375/1BB-W87HCM4C-R</arkIstex>
<language><json:string>eng</json:string>
</language>
<originalGenre><json:string>OriginalPaper</json:string>
</originalGenre>
<abstract>Abstract: The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.</abstract>
<qualityIndicators><score>9.16</score>
<pdfWordCount>5834</pdfWordCount>
<pdfCharCount>26138</pdfCharCount>
<pdfVersion>1.3</pdfVersion>
<pdfPageCount>15</pdfPageCount>
<pdfPageSize>432 x 648 pts</pdfPageSize>
<refBibsNative>false</refBibsNative>
<abstractWordCount>180</abstractWordCount>
<abstractCharCount>1228</abstractCharCount>
<keywordCount>0</keywordCount>
</qualityIndicators>
<title>The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</title>
<pmid><json:string>4449517</json:string>
</pmid>
<genre><json:string>research-article</json:string>
</genre>
<host><title>Medical Microbiology and Immunology</title>
<language><json:string>unknown</json:string>
</language>
<publicationDate>1974</publicationDate>
<copyrightDate>1974</copyrightDate>
<issn><json:string>0300-8584</json:string>
</issn>
<eissn><json:string>1432-1831</json:string>
</eissn>
<journalId><json:string>430</json:string>
</journalId>
<volume>160</volume>
<issue>4</issue>
<pages><first>295</first>
<last>309</last>
</pages>
<genre><json:string>journal</json:string>
</genre>
<subject><json:item><value>Immunology</value>
</json:item>
<json:item><value>Medical Microbiology</value>
</json:item>
</subject>
</host>
<namedEntities><unitex><date></date>
<geogName></geogName>
<orgName></orgName>
<orgName_funder></orgName_funder>
<orgName_provider></orgName_provider>
<persName></persName>
<placeName></placeName>
<ref_url></ref_url>
<ref_bibl></ref_bibl>
<bibl></bibl>
</unitex>
</namedEntities>
<ark><json:string>ark:/67375/1BB-W87HCM4C-R</json:string>
</ark>
<categories><wos><json:string>1 - science</json:string>
<json:string>2 - microbiology</json:string>
<json:string>2 - immunology</json:string>
</wos>
<scienceMetrix></scienceMetrix>
<scopus><json:string>1 - Health Sciences</json:string>
<json:string>2 - Medicine</json:string>
<json:string>3 - Microbiology (medical)</json:string>
<json:string>1 - Life Sciences</json:string>
<json:string>2 - Immunology and Microbiology</json:string>
<json:string>3 - Immunology</json:string>
<json:string>1 - Health Sciences</json:string>
<json:string>2 - Medicine</json:string>
<json:string>3 - General Medicine</json:string>
<json:string>1 - Health Sciences</json:string>
<json:string>2 - Medicine</json:string>
<json:string>3 - Immunology and Allergy</json:string>
</scopus>
<inist><json:string>1 - sciences appliquees, technologies et medecines</json:string>
<json:string>2 - sciences biologiques et medicales</json:string>
<json:string>3 - sciences medicales</json:string>
</inist>
</categories>
<publicationDate>1974</publicationDate>
<copyrightDate>1974</copyrightDate>
<doi><json:string>10.1007/BF02121445</json:string>
</doi>
<id>D45FFF912A6B7603CA798E5501036031F37C3293</id>
<score>1</score>
<fulltext><json:item><extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/ark:/67375/1BB-W87HCM4C-R/fulltext.pdf</uri>
</json:item>
<json:item><extension>zip</extension>
<original>false</original>
<mimetype>application/zip</mimetype>
<uri>https://api.istex.fr/ark:/67375/1BB-W87HCM4C-R/bundle.zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/1BB-W87HCM4C-R/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</title>
</titleStmt>
<publicationStmt><authority>ISTEX</authority>
<publisher scheme="https://scientific-publisher.data.istex.fr">Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<availability><licence><p>Springer-Verlag, 1974</p>
</licence>
<p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</p>
</availability>
<date>1974-07-26</date>
</publicationStmt>
<notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note>
<note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note>
</notesStmt>
<sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</title>
<author xml:id="author-0000"><persName><forename type="first">R.</forename>
<surname>Jennings</surname>
</persName>
<affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation>
</author>
<author xml:id="author-0001"><persName><forename type="first">C.</forename>
<surname>Brand</surname>
</persName>
<affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation>
<affiliation>Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England</affiliation>
</author>
<author xml:id="author-0002"><persName><forename type="first">C.</forename>
<surname>McLaren</surname>
</persName>
<affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation>
</author>
<author xml:id="author-0003"><persName><forename type="first">Lynda</forename>
<surname>Shepherd</surname>
</persName>
<affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation>
</author>
<author xml:id="author-0004"><persName><forename type="first">C.</forename>
<surname>Potter</surname>
</persName>
<affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation>
</author>
<idno type="istex">D45FFF912A6B7603CA798E5501036031F37C3293</idno>
<idno type="ark">ark:/67375/1BB-W87HCM4C-R</idno>
<idno type="DOI">10.1007/BF02121445</idno>
<idno type="article-id">BF02121445</idno>
<idno type="article-id">Art7</idno>
</analytic>
<monogr><title level="j">Medical Microbiology and Immunology</title>
<title level="j" type="abbrev">Med Microbiol Immunol</title>
<idno type="pISSN">0300-8584</idno>
<idno type="eISSN">1432-1831</idno>
<idno type="journal-ID">true</idno>
<idno type="issue-article-count">9</idno>
<idno type="volume-issue-count">4</idno>
<imprint><publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1974-11-01"></date>
<biblScope unit="volume">160</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="295">295</biblScope>
<biblScope unit="page" to="309">309</biblScope>
</imprint>
</monogr>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><creation><date>1974-07-26</date>
</creation>
<langUsage><language ident="en">en</language>
</langUsage>
<abstract xml:lang="en"><p>Abstract: The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.</p>
</abstract>
<textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head>
<item><term>Immunology</term>
</item>
<item><term>Medical Microbiology</term>
</item>
</list>
</keywords>
</textClass>
</profileDesc>
<revisionDesc><change when="1974-07-26">Created</change>
<change when="1974-11-01">Published</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item><extension>txt</extension>
<original>false</original>
<mimetype>text/plain</mimetype>
<uri>https://api.istex.fr/ark:/67375/1BB-W87HCM4C-R/fulltext.txt</uri>
</json:item>
</fulltext>
<metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration>
<istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType>
<istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName>
<PublisherLocation>Berlin/Heidelberg</PublisherLocation>
</PublisherInfo>
<Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>430</JournalID>
<JournalPrintISSN>0300-8584</JournalPrintISSN>
<JournalElectronicISSN>1432-1831</JournalElectronicISSN>
<JournalTitle>Medical Microbiology and Immunology</JournalTitle>
<JournalAbbreviatedTitle>Med Microbiol Immunol</JournalAbbreviatedTitle>
<JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject>
<JournalSubject Type="Secondary">Immunology</JournalSubject>
<JournalSubject Type="Secondary">Medical Microbiology</JournalSubject>
</JournalSubjectGroup>
</JournalInfo>
<Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>160</VolumeIDStart>
<VolumeIDEnd>160</VolumeIDEnd>
<VolumeIssueCount>4</VolumeIssueCount>
</VolumeInfo>
<Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>4</IssueIDStart>
<IssueIDEnd>4</IssueIDEnd>
<IssueArticleCount>9</IssueArticleCount>
<IssueHistory><CoverDate><DateString>15. XI. 1974</DateString>
<Year>1974</Year>
<Month>11</Month>
</CoverDate>
</IssueHistory>
<IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName>
<CopyrightYear>1974</CopyrightYear>
</IssueCopyright>
</IssueInfo>
<Article ID="Art7"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF02121445</ArticleID>
<ArticleDOI>10.1007/BF02121445</ArticleDOI>
<ArticleSequenceNumber>7</ArticleSequenceNumber>
<ArticleTitle Language="En">The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</ArticleTitle>
<ArticleFirstPage>295</ArticleFirstPage>
<ArticleLastPage>309</ArticleLastPage>
<ArticleHistory><RegistrationDate><Year>2005</Year>
<Month>8</Month>
<Day>10</Day>
</RegistrationDate>
<Received><Year>1974</Year>
<Month>7</Month>
<Day>26</Day>
</Received>
</ArticleHistory>
<ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName>
<CopyrightYear>1974</CopyrightYear>
</ArticleCopyright>
<ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant>
<AbstractGrant Grant="OpenAccess"></AbstractGrant>
<BodyPDFGrant Grant="Restricted"></BodyPDFGrant>
<BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant>
<BibliographyGrant Grant="Restricted"></BibliographyGrant>
<ESMGrant Grant="Restricted"></ESMGrant>
</ArticleGrants>
<ArticleContext><JournalID>430</JournalID>
<VolumeIDStart>160</VolumeIDStart>
<VolumeIDEnd>160</VolumeIDEnd>
<IssueIDStart>4</IssueIDStart>
<IssueIDEnd>4</IssueIDEnd>
</ArticleContext>
</ArticleInfo>
<ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>R.</GivenName>
<FamilyName>Jennings</FamilyName>
</AuthorName>
</Author>
<Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><GivenName>C.</GivenName>
<GivenName>M.</GivenName>
<FamilyName>Brand</FamilyName>
</AuthorName>
</Author>
<Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>C.</GivenName>
<FamilyName>McLaren</FamilyName>
</AuthorName>
</Author>
<Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Lynda</GivenName>
<FamilyName>Shepherd</FamilyName>
</AuthorName>
</Author>
<Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>C.</GivenName>
<GivenName>W.</GivenName>
<FamilyName>Potter</FamilyName>
</AuthorName>
</Author>
<Affiliation ID="Aff1"><OrgDivision>Academic Division of Pathology</OrgDivision>
<OrgName>University of Sheffield</OrgName>
<OrgAddress><City>Sheffield</City>
</OrgAddress>
</Affiliation>
<Affiliation ID="Aff2"><OrgName>Wellcome Research Laboratories</OrgName>
<OrgAddress><Street>Langley Court</Street>
<City>Beckenham</City>
<State>Kent</State>
<Country>England</Country>
</OrgAddress>
</Affiliation>
</AuthorGroup>
<Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading>
<Para>The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.</Para>
</Abstract>
</ArticleHeader>
<NoBody></NoBody>
</Article>
</Issue>
</Volume>
</Journal>
</Publisher>
</istex:document>
</istex:metadataXml>
<mods version="3.6"><titleInfo lang="en"><title>The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA"><title>The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</title>
</titleInfo>
<name type="personal"><namePart type="given">R.</namePart>
<namePart type="family">Jennings</namePart>
<affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C.</namePart>
<namePart type="given">M.</namePart>
<namePart type="family">Brand</namePart>
<affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation>
<affiliation>Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C.</namePart>
<namePart type="family">McLaren</namePart>
<affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Lynda</namePart>
<namePart type="family">Shepherd</namePart>
<affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C.</namePart>
<namePart type="given">W.</namePart>
<namePart type="family">Potter</namePart>
<affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre>
<originInfo><publisher>Springer-Verlag</publisher>
<place><placeTerm type="text">Berlin/Heidelberg</placeTerm>
</place>
<dateCreated encoding="w3cdtf">1974-07-26</dateCreated>
<dateIssued encoding="w3cdtf">1974-11-01</dateIssued>
<copyrightDate encoding="w3cdtf">1974</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<abstract lang="en">Abstract: The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.</abstract>
<relatedItem type="host"><titleInfo><title>Medical Microbiology and Immunology</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Med Microbiol Immunol</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<originInfo><publisher>Springer</publisher>
<dateIssued encoding="w3cdtf">1974-11-01</dateIssued>
<copyrightDate encoding="w3cdtf">1974</copyrightDate>
</originInfo>
<subject><genre>Biomedicine</genre>
<topic>Immunology</topic>
<topic>Medical Microbiology</topic>
</subject>
<identifier type="ISSN">0300-8584</identifier>
<identifier type="eISSN">1432-1831</identifier>
<identifier type="JournalID">430</identifier>
<identifier type="IssueArticleCount">9</identifier>
<identifier type="VolumeIssueCount">4</identifier>
<part><date>1974</date>
<detail type="volume"><number>160</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>4</number>
<caption>no.</caption>
</detail>
<extent unit="pages"><start>295</start>
<end>309</end>
</extent>
</part>
<recordInfo><recordOrigin>Springer-Verlag, 1974</recordOrigin>
</recordInfo>
</relatedItem>
<identifier type="istex">D45FFF912A6B7603CA798E5501036031F37C3293</identifier>
<identifier type="ark">ark:/67375/1BB-W87HCM4C-R</identifier>
<identifier type="DOI">10.1007/BF02121445</identifier>
<identifier type="ArticleID">BF02121445</identifier>
<identifier type="ArticleID">Art7</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1974</accessCondition>
<recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource>
<recordOrigin>Springer-Verlag, 1974</recordOrigin>
</recordInfo>
</mods>
<json:item><extension>json</extension>
<original>false</original>
<mimetype>application/json</mimetype>
<uri>https://api.istex.fr/ark:/67375/1BB-W87HCM4C-R/record.json</uri>
</json:item>
</metadata>
<serie></serie>
</istex>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D08 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000D08 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Istex |étape= Corpus |type= RBID |clé= ISTEX:D45FFF912A6B7603CA798E5501036031F37C3293 |texte= The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |