The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection
Identifieur interne : 000D08 ( Istex/Corpus ); précédent : 000D07; suivant : 000D09The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection
Auteurs : R. Jennings ; C. M. Brand ; C. Mclaren ; Lynda Shepherd ; C. W. PotterSource :
- Medical Microbiology and Immunology [ 0300-8584 ] ; 1974-11-01.
English descriptors
- Teeft :
- Antibody, Antibody response, Antibody titres, Detectable serum, Enhancement, Haemagglutinin, Haemagglutinin antigens, Haemagglutinins, Hamster, Heterotypic, Hong kong, Immune response, Immunization, Influenza, Influenza vaccines, Influenza virus, Influenza viruses, Split vaccine, Subsequent immunization, Titration vaccine, Vaccine, Vaccine virus, Virus, Whole virus vaccine.
Abstract
Abstract: The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.
Url:
DOI: 10.1007/BF02121445
Links to Exploration step
ISTEX:D45FFF912A6B7603CA798E5501036031F37C3293Le document en format XML
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Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. 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Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. 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XI. 1974</DateString><Year>1974</Year><Month>11</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1974</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art7"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF02121445</ArticleID><ArticleDOI>10.1007/BF02121445</ArticleDOI><ArticleSequenceNumber>7</ArticleSequenceNumber><ArticleTitle Language="En">The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</ArticleTitle><ArticleFirstPage>295</ArticleFirstPage><ArticleLastPage>309</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>8</Month><Day>10</Day></RegistrationDate><Received><Year>1974</Year><Month>7</Month><Day>26</Day></Received></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1974</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>430</JournalID><VolumeIDStart>160</VolumeIDStart><VolumeIDEnd>160</VolumeIDEnd><IssueIDStart>4</IssueIDStart><IssueIDEnd>4</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>R.</GivenName><FamilyName>Jennings</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><GivenName>C.</GivenName><GivenName>M.</GivenName><FamilyName>Brand</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>C.</GivenName><FamilyName>McLaren</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Lynda</GivenName><FamilyName>Shepherd</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>C.</GivenName><GivenName>W.</GivenName><FamilyName>Potter</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Academic Division of Pathology</OrgDivision><OrgName>University of Sheffield</OrgName><OrgAddress><City>Sheffield</City></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgName>Wellcome Research Laboratories</OrgName><OrgAddress><Street>Langley Court</Street><City>Beckenham</City><State>Kent</State><Country>England</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The immune response of hamsters to purified haemagglutinins and whole influenza virus vaccines following live influenza virus infection</title></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Jennings</namePart><affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="given">M.</namePart><namePart type="family">Brand</namePart><affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation><affiliation>Wellcome Research Laboratories, Langley Court, Beckenham, Kent, England</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">McLaren</namePart><affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Lynda</namePart><namePart type="family">Shepherd</namePart><affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="given">W.</namePart><namePart type="family">Potter</namePart><affiliation>Academic Division of Pathology, University of Sheffield, Sheffield</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1974-07-26</dateCreated><dateIssued encoding="w3cdtf">1974-11-01</dateIssued><copyrightDate encoding="w3cdtf">1974</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: The ability of several, live type A influenza viruses to enhance the serum haemagglutination-inhibiting (HI) antibody response of hamsters to subsequent immunization with inactivated, heterotypic influenza virus vaccines was examined. Live influenza viruses were found to vary in their priming ability for a given vaccine, and a given virus was not able to prime for all inactivated vaccines to an equal extent. Common determinants in the haemagglutinin antigens of the priming virus and the vaccine virus were suggested as responsible for the enhancement of the antibody response to some of the vaccines, but for other pairs of viruses the haemagglutinin antigens were distinct. Thus, enhancement in these instances cannot be due to cross-reacting haemagglutinins. Pre-infection of hamsters by several influenza type A viruses was employed in an attempt to enhance the serum HI antibody response to purified, haemagglutinin antigens prepared from A/PR/8/34 and the MRC-2 recombinant strain of A/England/42/72 viruses. Although prior infection enhanced the antibody response to whole virus, this was not demonstrable for the purified haemagglutinin components of the virus. The possible reasons for this are discussed.</abstract><relatedItem type="host"><titleInfo><title>Medical Microbiology and Immunology</title></titleInfo><titleInfo type="abbreviated"><title>Med Microbiol Immunol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1974-11-01</dateIssued><copyrightDate encoding="w3cdtf">1974</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Immunology</topic><topic>Medical Microbiology</topic></subject><identifier type="ISSN">0300-8584</identifier><identifier type="eISSN">1432-1831</identifier><identifier type="JournalID">430</identifier><identifier type="IssueArticleCount">9</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>1974</date><detail type="volume"><number>160</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="pages"><start>295</start><end>309</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1974</recordOrigin></recordInfo></relatedItem><identifier type="istex">D45FFF912A6B7603CA798E5501036031F37C3293</identifier><identifier type="ark">ark:/67375/1BB-W87HCM4C-R</identifier><identifier type="DOI">10.1007/BF02121445</identifier><identifier type="ArticleID">BF02121445</identifier><identifier type="ArticleID">Art7</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1974</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Springer-Verlag, 1974</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-W87HCM4C-R/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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