Egg-grown and tissue-culture-grown variants of influenza A (H3N2) virus with special attention to their use as antigens in seroepidemiology
Identifieur interne : 000B88 ( Istex/Corpus ); précédent : 000B87; suivant : 000B89Egg-grown and tissue-culture-grown variants of influenza A (H3N2) virus with special attention to their use as antigens in seroepidemiology
Auteurs : R. Pyh L ; L. Pyh L ; M. Valle ; K. AhoSource :
- Epidemiology and Infection [ 0950-2688 ] ; 1987-12.
Abstract
A field strain of influenza A (H3N2) virus isolated in embryonated eggs during the 1984–5 influenza outbreak (A/Finland/13/85E) was compared in an antigenic analysis with virus from the same clinical specimen isolated in MDCK cell cultures (A/Finland/13/85M). The M-virus appeared to be more sensitive to haemagglutination-inhibiting antibodies against heterologous viruses than did the Evirus. The results of propagation and plaque purification experiments support the hypothesis that a single clinical specimen may consist of distinct antigenic variant subpopulations promoted selectively by the host during isolation procedures. Receptor-binding properties are discussed as a possible explanation for this selectivity. A set of 471 paired sera consisting of pre-epidemic and post-epidemic specimens taken from the same subjects in 1984–5 was studied for haemagglutinationinhibiting antibodies to six influenza A (H3N2) virus strains, including the E-virus and the M-virus from A/Finland/13/85. Of the antigens used, the M-virus detected significant antibody increases more frequently than did the E-virus (10·0 v. 5·9%). The superiority of the M-virus may rest primarily in its ability to pick out anamnestic antibody responses. Irrespective of this cross-reactivity, preepidemic antibody to the M-virus was fairly well associated with protection. In the set of sera (230 specimens) collected in summer 1985 to represent different age groups, the antibody status against the M-virus was significantly better than the status against the E-virus. The results suggest that, at least in some instances, antibody to MDCK-grown virus is a more accurate indicator of the immune status of a community than antibodies to egg-grown virus variants.
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DOI: 10.1017/S0950268800066607
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Egg-grown and tissue-culture-grown variants of influenza A (H3N2) virus with special attention to their use as antigens in seroepidemiology</title><author><name sortKey="Pyh L, R" sort="Pyh L, R" uniqKey="Pyh L R" first="R." last="Pyh L">R. Pyh L</name><affiliation><mods:affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Pyh L, L" sort="Pyh L, L" uniqKey="Pyh L L" first="L." last="Pyh L">L. Pyh L</name><affiliation><mods:affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Valle, M" sort="Valle, M" uniqKey="Valle M" first="M." last="Valle">M. Valle</name><affiliation><mods:affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Aho, K" sort="Aho, K" uniqKey="Aho K" first="K." last="Aho">K. Aho</name><affiliation><mods:affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A3ED2BA2788C5A21645B1CE8503C3EE4E655B964</idno><date when="1987" year="1987">1987</date><idno type="doi">10.1017/S0950268800066607</idno><idno type="url">https://api.istex.fr/ark:/67375/6GQ-90BBPBNJ-Q/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000B88</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B88</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Egg-grown and tissue-culture-grown variants of influenza A (H3N2) virus with special attention to their use as antigens in seroepidemiology</title><author><name sortKey="Pyh L, R" sort="Pyh L, R" uniqKey="Pyh L R" first="R." last="Pyh L">R. Pyh L</name><affiliation><mods:affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Pyh L, L" sort="Pyh L, L" uniqKey="Pyh L L" first="L." last="Pyh L">L. Pyh L</name><affiliation><mods:affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Valle, M" sort="Valle, M" uniqKey="Valle M" first="M." last="Valle">M. Valle</name><affiliation><mods:affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</mods:affiliation></affiliation></author><author><name sortKey="Aho, K" sort="Aho, K" uniqKey="Aho K" first="K." last="Aho">K. Aho</name><affiliation><mods:affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Epidemiology and Infection</title><title level="j" type="abbrev">Epidemiol. Infect.</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1987-12">1987-12</date><biblScope unit="volume">99</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="745">745</biblScope><biblScope unit="page" to="753">753</biblScope></imprint><idno type="ISSN">0950-2688</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0950-2688</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">A field strain of influenza A (H3N2) virus isolated in embryonated eggs during the 1984–5 influenza outbreak (A/Finland/13/85E) was compared in an antigenic analysis with virus from the same clinical specimen isolated in MDCK cell cultures (A/Finland/13/85M). The M-virus appeared to be more sensitive to haemagglutination-inhibiting antibodies against heterologous viruses than did the Evirus. The results of propagation and plaque purification experiments support the hypothesis that a single clinical specimen may consist of distinct antigenic variant subpopulations promoted selectively by the host during isolation procedures. Receptor-binding properties are discussed as a possible explanation for this selectivity. A set of 471 paired sera consisting of pre-epidemic and post-epidemic specimens taken from the same subjects in 1984–5 was studied for haemagglutinationinhibiting antibodies to six influenza A (H3N2) virus strains, including the E-virus and the M-virus from A/Finland/13/85. Of the antigens used, the M-virus detected significant antibody increases more frequently than did the E-virus (10·0 v. 5·9%). The superiority of the M-virus may rest primarily in its ability to pick out anamnestic antibody responses. Irrespective of this cross-reactivity, preepidemic antibody to the M-virus was fairly well associated with protection. In the set of sera (230 specimens) collected in summer 1985 to represent different age groups, the antibody status against the M-virus was significantly better than the status against the E-virus. The results suggest that, at least in some instances, antibody to MDCK-grown virus is a more accurate indicator of the immune status of a community than antibodies to egg-grown virus variants.</div></front></TEI><istex><corpusName>cambridge</corpusName><author><json:item><name>R. Pyhälä</name><affiliations><json:string>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</json:string></affiliations></json:item><json:item><name>L. Pyhälä</name><affiliations><json:string>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</json:string></affiliations></json:item><json:item><name>M. Valle</name><affiliations><json:string>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</json:string></affiliations></json:item><json:item><name>K. Aho</name><affiliations><json:string>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</json:string></affiliations></json:item></author><articleId><json:string>06660</json:string></articleId><arkIstex>ark:/67375/6GQ-90BBPBNJ-Q</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>A field strain of influenza A (H3N2) virus isolated in embryonated eggs during the 1984–5 influenza outbreak (A/Finland/13/85E) was compared in an antigenic analysis with virus from the same clinical specimen isolated in MDCK cell cultures (A/Finland/13/85M). The M-virus appeared to be more sensitive to haemagglutination-inhibiting antibodies against heterologous viruses than did the Evirus. The results of propagation and plaque purification experiments support the hypothesis that a single clinical specimen may consist of distinct antigenic variant subpopulations promoted selectively by the host during isolation procedures. Receptor-binding properties are discussed as a possible explanation for this selectivity. A set of 471 paired sera consisting of pre-epidemic and post-epidemic specimens taken from the same subjects in 1984–5 was studied for haemagglutinationinhibiting antibodies to six influenza A (H3N2) virus strains, including the E-virus and the M-virus from A/Finland/13/85. Of the antigens used, the M-virus detected significant antibody increases more frequently than did the E-virus (10·0 v. 5·9%). The superiority of the M-virus may rest primarily in its ability to pick out anamnestic antibody responses. Irrespective of this cross-reactivity, preepidemic antibody to the M-virus was fairly well associated with protection. In the set of sera (230 specimens) collected in summer 1985 to represent different age groups, the antibody status against the M-virus was significantly better than the status against the E-virus. The results suggest that, at least in some instances, antibody to MDCK-grown virus is a more accurate indicator of the immune status of a community than antibodies to egg-grown virus variants.</abstract><qualityIndicators><score>8.29</score><pdfWordCount>3314</pdfWordCount><pdfCharCount>20880</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>514.8 x 752.4 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>248</abstractWordCount><abstractCharCount>1740</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Egg-grown and tissue-culture-grown variants of influenza A (H3N2) virus with special attention to their use as antigens in seroepidemiology</title><pii><json:string>S0950268800066607</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Epidemiology and Infection</title><language><json:string>unknown</json:string></language><issn><json:string>0950-2688</json:string></issn><eissn><json:string>1469-4409</json:string></eissn><publisherId><json:string>HYG</json:string></publisherId><volume>99</volume><issue>3</issue><pages><first>745</first><last>753</last><total>9</total></pages><genre><json:string>journal</json:string></genre></host><ark><json:string>ark:/67375/6GQ-90BBPBNJ-Q</json:string></ark><categories><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1987</publicationDate><copyrightDate>1987</copyrightDate><doi><json:string>10.1017/S0950268800066607</json:string></doi><id>A3ED2BA2788C5A21645B1CE8503C3EE4E655B964</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-90BBPBNJ-Q/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-90BBPBNJ-Q/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6GQ-90BBPBNJ-Q/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Egg-grown and tissue-culture-grown variants of influenza A (H3N2) virus with special attention to their use as antigens in seroepidemiology</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><availability><licence><p>Copyright © Cambridge University Press 1987</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</p></availability><date>1987</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Egg-grown and tissue-culture-grown variants of influenza A (H3N2) virus with special attention to their use as antigens in seroepidemiology</title><author xml:id="author-0000"><persName><forename type="first">R.</forename><surname>Pyhälä</surname></persName><affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</affiliation></author><author xml:id="author-0001"><persName><forename type="first">L.</forename><surname>Pyhälä</surname></persName><affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</affiliation></author><author xml:id="author-0002"><persName><forename type="first">M.</forename><surname>Valle</surname></persName><affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</affiliation></author><author xml:id="author-0003"><persName><forename type="first">K.</forename><surname>Aho</surname></persName><affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki, Finland</affiliation></author><idno type="istex">A3ED2BA2788C5A21645B1CE8503C3EE4E655B964</idno><idno type="ark">ark:/67375/6GQ-90BBPBNJ-Q</idno><idno type="DOI">10.1017/S0950268800066607</idno><idno type="PII">S0950268800066607</idno><idno type="article-id">06660</idno></analytic><monogr><title level="j">Epidemiology and Infection</title><title level="j" type="abbrev">Epidemiol. Infect.</title><idno type="pISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><idno type="publisher-id">HYG</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1987-12"></date><biblScope unit="volume">99</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="745">745</biblScope><biblScope unit="page" to="753">753</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1987</date></creation><langUsage><language ident="en">en</language></langUsage><abstract style="normal"><p>A field strain of influenza A (H3N2) virus isolated in embryonated eggs during the 1984–5 influenza outbreak (A/Finland/13/85E) was compared in an antigenic analysis with virus from the same clinical specimen isolated in MDCK cell cultures (A/Finland/13/85M). The M-virus appeared to be more sensitive to haemagglutination-inhibiting antibodies against heterologous viruses than did the Evirus. The results of propagation and plaque purification experiments support the hypothesis that a single clinical specimen may consist of distinct antigenic variant subpopulations promoted selectively by the host during isolation procedures. Receptor-binding properties are discussed as a possible explanation for this selectivity. A set of 471 paired sera consisting of pre-epidemic and post-epidemic specimens taken from the same subjects in 1984–5 was studied for haemagglutinationinhibiting antibodies to six influenza A (H3N2) virus strains, including the E-virus and the M-virus from A/Finland/13/85. Of the antigens used, the M-virus detected significant antibody increases more frequently than did the E-virus (10·0 v. 5·9%). The superiority of the M-virus may rest primarily in its ability to pick out anamnestic antibody responses. Irrespective of this cross-reactivity, preepidemic antibody to the M-virus was fairly well associated with protection. In the set of sera (230 specimens) collected in summer 1985 to represent different age groups, the antibody status against the M-virus was significantly better than the status against the E-virus. The results suggest that, at least in some instances, antibody to MDCK-grown virus is a more accurate indicator of the immune status of a community than antibodies to egg-grown virus variants.</p></abstract></profileDesc><revisionDesc><change when="1987-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-90BBPBNJ-Q/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus cambridge not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="US-ASCII"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.2 20060430//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article dtd-version="2.2" article-type="research-article"><front><journal-meta><journal-id journal-id-type="publisher-id">HYG</journal-id><journal-title>Epidemiology and Infection</journal-title><abbrev-journal-title>Epidemiol. Infect.</abbrev-journal-title><issn pub-type="ppub">0950-2688</issn><issn pub-type="epub">1469-4409</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1017/S0950268800066607</article-id><article-id pub-id-type="pii">S0950268800066607</article-id><article-id pub-id-type="publisher-id">06660</article-id><title-group><article-title>Egg-grown and tissue-culture-grown variants of influenza A (H3N2) virus with special attention to their use as antigens in seroepidemiology</article-title><alt-title alt-title-type="left-running">R. Pyhälä and others</alt-title><alt-title alt-title-type="right-running">Egg-grown and MDCK-grown influenza viruses</alt-title></title-group><contrib-group><contrib><name><surname>Pyhälä</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib><name><surname>Pyhälä</surname><given-names>L.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib><name><surname>Valle</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib><name><surname>Aho</surname><given-names>K.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib></contrib-group><aff id="aff1"><institution>National Public Health Institute</institution>, <addr-line>Mannerheimintie 166</addr-line>, <addr-line>SF-00280 Helsinki</addr-line>, <addr-line>Finland</addr-line></aff><pub-date pub-type="ppub"><month>12</month><year>1987</year></pub-date><volume>99</volume><issue>3</issue><fpage seq="22">745</fpage><lpage>753</lpage><history><date date-type="accepted"><day>23</day><month>06</month><year>1987</year></date></history><permissions><copyright-statement>Copyright © Cambridge University Press 1987</copyright-statement><copyright-year>1987</copyright-year><copyright-holder>Cambridge University Press</copyright-holder></permissions><abstract abstract-type="normal"><title>SUMMARY</title><p>A field strain of influenza A (H3N2) virus isolated in embryonated eggs during the 1984–5 influenza outbreak (A/Finland/13/85E) was compared in an antigenic analysis with virus from the same clinical specimen isolated in MDCK cell cultures (A/Finland/13/85M). The M-virus appeared to be more sensitive to haemagglutination-inhibiting antibodies against heterologous viruses than did the Evirus. The results of propagation and plaque purification experiments support the hypothesis that a single clinical specimen may consist of distinct antigenic variant subpopulations promoted selectively by the host during isolation procedures. Receptor-binding properties are discussed as a possible explanation for this selectivity.</p><p>A set of 471 paired sera consisting of pre-epidemic and post-epidemic specimens taken from the same subjects in 1984–5 was studied for haemagglutinationinhibiting antibodies to six influenza A (H3N2) virus strains, including the E-virus and the M-virus from A/Finland/13/85. Of the antigens used, the M-virus detected significant antibody increases more frequently than did the E-virus (10·0 <italic>v</italic>. 5·9%). The superiority of the M-virus may rest primarily in its ability to pick out anamnestic antibody responses. Irrespective of this cross-reactivity, preepidemic antibody to the M-virus was fairly well associated with protection. In the set of sera (230 specimens) collected in summer 1985 to represent different age groups, the antibody status against the M-virus was significantly better than the status against the E-virus. The results suggest that, at least in some instances, antibody to MDCK-grown virus is a more accurate indicator of the immune status of a community than antibodies to egg-grown virus variants.</p></abstract><counts><page-count count="9"></page-count></counts><custom-meta-wrap><custom-meta><meta-name>pdf</meta-name><meta-value>S0950268800066607a.pdf</meta-value></custom-meta></custom-meta-wrap></article-meta></front><back><ref-list><title>REFERENCES</title><ref><citation id="ref001" citation-type="journal"><name><surname>Beyer</surname><given-names>W. E. 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The M-virus appeared to be more sensitive to haemagglutination-inhibiting antibodies against heterologous viruses than did the Evirus. The results of propagation and plaque purification experiments support the hypothesis that a single clinical specimen may consist of distinct antigenic variant subpopulations promoted selectively by the host during isolation procedures. Receptor-binding properties are discussed as a possible explanation for this selectivity. A set of 471 paired sera consisting of pre-epidemic and post-epidemic specimens taken from the same subjects in 1984–5 was studied for haemagglutinationinhibiting antibodies to six influenza A (H3N2) virus strains, including the E-virus and the M-virus from A/Finland/13/85. Of the antigens used, the M-virus detected significant antibody increases more frequently than did the E-virus (10·0 v. 5·9%). The superiority of the M-virus may rest primarily in its ability to pick out anamnestic antibody responses. Irrespective of this cross-reactivity, preepidemic antibody to the M-virus was fairly well associated with protection. In the set of sera (230 specimens) collected in summer 1985 to represent different age groups, the antibody status against the M-virus was significantly better than the status against the E-virus. The results suggest that, at least in some instances, antibody to MDCK-grown virus is a more accurate indicator of the immune status of a community than antibodies to egg-grown virus variants.</abstract><relatedItem type="host"><titleInfo><title>Epidemiology and Infection</title></titleInfo><titleInfo type="abbreviated"><title>Epidemiol. Infect.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0950-2688</identifier><identifier type="eISSN">1469-4409</identifier><identifier type="PublisherID">HYG</identifier><part><date>1987</date><detail type="volume"><caption>vol.</caption><number>99</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>745</start><end>753</end><total>9</total></extent></part></relatedItem><identifier type="istex">A3ED2BA2788C5A21645B1CE8503C3EE4E655B964</identifier><identifier type="ark">ark:/67375/6GQ-90BBPBNJ-Q</identifier><identifier type="DOI">10.1017/S0950268800066607</identifier><identifier type="PII">S0950268800066607</identifier><identifier type="ArticleID">06660</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © Cambridge University Press 1987</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</recordContentSource><recordOrigin>Copyright © Cambridge University Press 1987</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-90BBPBNJ-Q/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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