Dose‐Response Assessment for Influenza A Virus Based on Data Sets of Infection with its Live Attenuated Reassortants
Identifieur interne : 000B56 ( Istex/Corpus ); précédent : 000B55; suivant : 000B57Dose‐Response Assessment for Influenza A Virus Based on Data Sets of Infection with its Live Attenuated Reassortants
Auteurs : Toru Watanabe ; Timothy A. Bartrand ; Tatsuo Omura ; Charles N. HaasSource :
- Risk Analysis [ 0272-4332 ] ; 2012-03.
Abstract
Reported data sets on infection of volunteers challenged with wild‐type influenza A virus at graded doses are few. Alternatively, we aimed at developing a dose‐response assessment for this virus based on the data sets for its live attenuated reassortants. Eleven data sets for live attenuated reassortants that were fit to beta‐Poisson and exponential dose‐response models. Dose‐response relationships for those reassortants were characterized by pooling analysis of the data sets with respect to virus subtype (H1N1 or H3N2), attenuation method (cold‐adapted or avian‐human gene reassortment), and human age (adults or children). Furthermore, by comparing the above data sets to a limited number of reported data sets for wild‐type virus, we quantified the degree of attenuation of wild‐type virus with gene reassortment and estimated its infectivity. As a result, dose‐response relationships of all reassortants were best described by a beta‐Poisson model. Virus subtype and human age were significant factors determining the dose‐response relationship, whereas attenuation method affected only the relationship of H1N1 virus infection to adults. The data sets for H3N2 wild‐type virus could be pooled with those for its reassortants on the assumption that the gene reassortment attenuates wild‐type virus by at least 63 times and most likely 1,070 times. Considering this most likely degree of attenuation, 10% infectious dose of H3N2 wild‐type virus for adults was estimated at 18 TCID50 (95% CI = 8.8–35 TCID50). The infectivity of wild‐type H1N1 virus remains unknown as the data set pooling was unsuccessful.
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DOI: 10.1111/j.1539-6924.2011.01680.x
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Haas</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:24AAEA67582981A1F212E0E904914F2328A0E576</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1111/j.1539-6924.2011.01680.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-487J50ZZ-H/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000B56</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Dose‐Response Assessment for Influenza A Virus Based on Data Sets of Infection with its Live Attenuated Reassortants</title><author><name sortKey="Watanabe, Toru" sort="Watanabe, Toru" uniqKey="Watanabe T" first="Toru" last="Watanabe">Toru Watanabe</name></author><author><name sortKey="Bartrand, Timothy A" sort="Bartrand, Timothy A" uniqKey="Bartrand T" first="Timothy A." last="Bartrand">Timothy A. Bartrand</name></author><author><name sortKey="Omura, Tatsuo" sort="Omura, Tatsuo" uniqKey="Omura T" first="Tatsuo" last="Omura">Tatsuo Omura</name></author><author><name sortKey="Haas, Charles N" sort="Haas, Charles N" uniqKey="Haas C" first="Charles N." last="Haas">Charles N. Haas</name></author></analytic><monogr></monogr><series><title level="j" type="main">Risk Analysis</title><title level="j" type="alt">RISK ANALYSIS</title><idno type="ISSN">0272-4332</idno><idno type="eISSN">1539-6924</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="555">555</biblScope><biblScope unit="page" to="565">565</biblScope><biblScope unit="page-count">11</biblScope><publisher>Blackwell Publishing Inc</publisher><pubPlace>Malden, USA</pubPlace><date type="published" when="2012-03">2012-03</date></imprint><idno type="ISSN">0272-4332</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0272-4332</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Reported data sets on infection of volunteers challenged with wild‐type influenza A virus at graded doses are few. Alternatively, we aimed at developing a dose‐response assessment for this virus based on the data sets for its live attenuated reassortants. Eleven data sets for live attenuated reassortants that were fit to beta‐Poisson and exponential dose‐response models. Dose‐response relationships for those reassortants were characterized by pooling analysis of the data sets with respect to virus subtype (H1N1 or H3N2), attenuation method (cold‐adapted or avian‐human gene reassortment), and human age (adults or children). Furthermore, by comparing the above data sets to a limited number of reported data sets for wild‐type virus, we quantified the degree of attenuation of wild‐type virus with gene reassortment and estimated its infectivity. As a result, dose‐response relationships of all reassortants were best described by a beta‐Poisson model. Virus subtype and human age were significant factors determining the dose‐response relationship, whereas attenuation method affected only the relationship of H1N1 virus infection to adults. The data sets for H3N2 wild‐type virus could be pooled with those for its reassortants on the assumption that the gene reassortment attenuates wild‐type virus by at least 63 times and most likely 1,070 times. Considering this most likely degree of attenuation, 10% infectious dose of H3N2 wild‐type virus for adults was estimated at 18 TCID50 (95% CI = 8.8–35 TCID50). The infectivity of wild‐type H1N1 virus remains unknown as the data set pooling was unsuccessful.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>attenuated</json:string><json:string>datum set</json:string><json:string>reassortants</json:string><json:string>datum</json:string><json:string>attenuation</json:string><json:string>reassortant</json:string><json:string>infectivity</json:string><json:string>influenza</json:string><json:string>attenuated reassortants</json:string><json:string>vaccine</json:string><json:string>attenuation method</json:string><json:string>adult volunteer</json:string><json:string>influenza virus</json:string><json:string>virus subtype</json:string><json:string>reassortment</json:string><json:string>infectious disease</json:string><json:string>attenuated reassortant</json:string><json:string>exponential model</json:string><json:string>glycoprotein</json:string><json:string>null hypothesis</json:string><json:string>watanabe</json:string><json:string>gene reassortment</json:string><json:string>model fitting</json:string><json:string>attenuation factor</json:string><json:string>reassortant virus</json:string><json:string>human infection</json:string><json:string>virus</json:string><json:string>exponential</json:string><json:string>attenuated virus</json:string><json:string>dose response</json:string><json:string>virus vaccine</json:string><json:string>internal gene</json:string><json:string>human volunteer</json:string><json:string>other hand</json:string><json:string>local antibody</json:string><json:string>subtype</json:string><json:string>dos</json:string><json:string>maximum likelihood method</json:string><json:string>environmental engineering</json:string><json:string>reassortant virus vaccine</json:string><json:string>clinical microbiology</json:string><json:string>infectious dose</json:string><json:string>vaccine development</json:string><json:string>more susceptible</json:string><json:string>statistical significance</json:string><json:string>human influenza</json:string><json:string>vaccine virus</json:string><json:string>seronegative adult volunteer</json:string><json:string>wildtype virus</json:string><json:string>doseresponse model</json:string><json:string>model parameter</json:string><json:string>infection</json:string></teeft></keywords><author><json:item><name>Toru Watanabe</name></json:item><json:item><name>Timothy A. 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Toru Watanabe, Department of Food, Life and Environmental Sciences, Yamagata University, 1–23 Wakaba‐Machi, Tsuruoka, Yamagata 997‐8555, Japan; tel: +81‐235‐28‐2907; fax: +81‐235‐28‐2907; <email normalForm="to-ru@tds1.tr.yamagata-u.ac.jp">to‐ru@tds1.tr.yamagata‐u.ac.jp</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:RISA.RISA1680.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="5"></count><count type="tableTotal" number="4"></count><count type="formulaTotal" number="11"></count><count type="referenceTotal" number="32"></count><count type="linksCrossRef" number="61"></count></countGroup><titleGroup><title type="main">Dose‐Response Assessment for Influenza A Virus Based on Data Sets of Infection with its Live Attenuated Reassortants</title><title type="shortAuthors"><b>Watanabe <i>et al.</i></b></title><title type="short"><b>Dose‐Response Assessment for Influenza A Virus</b></title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" noteRef="#fn1"><personName><givenNames>Toru</givenNames><familyName>Watanabe</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" noteRef="#fn2"><personName><givenNames>Timothy A.</givenNames><familyName>Bartrand</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" noteRef="#fn3"><personName><givenNames>Tatsuo</givenNames><familyName>Omura</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" noteRef="#fn2"><personName><givenNames>Charles N.</givenNames><familyName>Haas</familyName></personName></creator></creators><keywordGroup xml:lang="en"><keyword xml:id="k1">Dose‐response model</keyword><keyword xml:id="k2">influenza A virus</keyword><keyword xml:id="k3">live attenuated reassortants</keyword><keyword xml:id="k4">pooling analysis</keyword><keyword xml:id="k5">wild‐type strains</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Reported data sets on infection of volunteers challenged with wild‐type influenza A virus at graded doses are few. Alternatively, we aimed at developing a dose‐response assessment for this virus based on the data sets for its live attenuated reassortants. Eleven data sets for live attenuated reassortants that were fit to beta‐Poisson and exponential dose‐response models. Dose‐response relationships for those reassortants were characterized by pooling analysis of the data sets with respect to virus subtype (H1N1 or H3N2), attenuation method (cold‐adapted or avian‐human gene reassortment), and human age (adults or children). Furthermore, by comparing the above data sets to a limited number of reported data sets for wild‐type virus, we quantified the degree of attenuation of wild‐type virus with gene reassortment and estimated its infectivity. As a result, dose‐response relationships of all reassortants were best described by a beta‐Poisson model. Virus subtype and human age were significant factors determining the dose‐response relationship, whereas attenuation method affected only the relationship of H1N1 virus infection to adults. The data sets for H3N2 wild‐type virus could be pooled with those for its reassortants on the assumption that the gene reassortment attenuates wild‐type virus by at least 63 times and most likely 1,070 times. Considering this most likely degree of attenuation, 10% infectious dose of H3N2 wild‐type virus for adults was estimated at 18 TCID<sub>50</sub> (95% CI = 8.8–35 TCID<sub>50</sub>). The infectivity of wild‐type H1N1 virus remains unknown as the data set pooling was unsuccessful.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Department of Food, Life and Environmental Sciences, Yamagata University, Yamagata, Japan.</p></note><note xml:id="fn2"><p>Department of Civil, Architectural and Environmental Engineering, Drexel University, USA.</p></note><note xml:id="fn3"><p>Department of Civil and Environmental Engineering, Tohoku University, Japan.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Dose‐Response Assessment for Influenza A Virus Based on Data Sets of Infection with its Live Attenuated Reassortants</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Dose‐Response Assessment for Influenza A Virus</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Dose‐Response Assessment for Influenza A Virus Based on Data Sets of Infection with its Live Attenuated Reassortants</title></titleInfo><name type="personal"><namePart type="given">Toru</namePart><namePart type="family">Watanabe</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Timothy A.</namePart><namePart type="family">Bartrand</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Tatsuo</namePart><namePart type="family">Omura</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Charles N.</namePart><namePart type="family">Haas</namePart><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Inc</publisher><place><placeTerm type="text">Malden, USA</placeTerm></place><dateIssued encoding="w3cdtf">2012-03</dateIssued><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">5</extent><extent unit="tables">4</extent><extent unit="formulas">11</extent><extent unit="references">32</extent><extent unit="linksCrossRef">61</extent></physicalDescription><abstract lang="en">Reported data sets on infection of volunteers challenged with wild‐type influenza A virus at graded doses are few. Alternatively, we aimed at developing a dose‐response assessment for this virus based on the data sets for its live attenuated reassortants. Eleven data sets for live attenuated reassortants that were fit to beta‐Poisson and exponential dose‐response models. Dose‐response relationships for those reassortants were characterized by pooling analysis of the data sets with respect to virus subtype (H1N1 or H3N2), attenuation method (cold‐adapted or avian‐human gene reassortment), and human age (adults or children). Furthermore, by comparing the above data sets to a limited number of reported data sets for wild‐type virus, we quantified the degree of attenuation of wild‐type virus with gene reassortment and estimated its infectivity. As a result, dose‐response relationships of all reassortants were best described by a beta‐Poisson model. Virus subtype and human age were significant factors determining the dose‐response relationship, whereas attenuation method affected only the relationship of H1N1 virus infection to adults. The data sets for H3N2 wild‐type virus could be pooled with those for its reassortants on the assumption that the gene reassortment attenuates wild‐type virus by at least 63 times and most likely 1,070 times. Considering this most likely degree of attenuation, 10% infectious dose of H3N2 wild‐type virus for adults was estimated at 18 TCID50 (95% CI = 8.8–35 TCID50). The infectivity of wild‐type H1N1 virus remains unknown as the data set pooling was unsuccessful.</abstract><subject lang="en"><genre>keywords</genre><topic>Dose‐response model</topic><topic>influenza A virus</topic><topic>live attenuated reassortants</topic><topic>pooling analysis</topic><topic>wild‐type strains</topic></subject><relatedItem type="host"><titleInfo><title>Risk Analysis</title><subTitle>An International Journal</subTitle></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0272-4332</identifier><identifier type="eISSN">1539-6924</identifier><identifier type="DOI">10.1111/(ISSN)1539-6924</identifier><identifier type="PublisherID">RISA</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>32</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>555</start><end>565</end><total>11</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>The pathology of influenza virus infections</title></titleInfo><name type="personal"><namePart type="given">JK</namePart><namePart type="family">Taubenberger</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DM</namePart><namePart type="family">Morens</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Taubenberger JK, Morens DM. 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