The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Virulence for Infants and Children
Identifieur interne : 000948 ( Istex/Corpus ); précédent : 000947; suivant : 000949The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Virulence for Infants and Children
Auteurs : Mark C. Steinhoff ; Neal A. Halsey ; Louis F. Fries ; Modena H. Wilson ; James King ; Barbara A. Burns ; Roberta K. Samorodin ; Victoria Perkis ; Brian R. Murphy ; Mary Lou ClementsSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1991.
Abstract
Characteristics of avian-human (ab) and cold-adapted (ca) influenza A/Kawasaki/9/86 (H1N1) reassortant vaccine viruses were compared in 37 seronegative adults and 122 seronegative infants and children. The 50% human infectious dose (HID50) in infants and children was 102.9 and 102.6 TCID50 for the ab and ca vaccine, respectively. The ah influenza A/Kawasaki/9/86 reassortant was reactogenic: 24% of infants and children infected with ⩾100 HID50 had fever ⩾39.4°C. Since H3N2 ah vaccines were previously shown to be adequately attenuated, it is reasonable to suggest that the genes that code for hemagglutinin and neuraminidase of the H1N1 virus apparently influence the reactogenicity of reassort antviruses derived from the avian influenza A/Mallard/NewYork/6750/78 donor virus. Because this avian virus does not reproducibly confer a satisfactory level of attenuation to each subtype of influenza A virus, it is not a suitable donor virus for attenuation of wild-typeinfluenza viruses. In contrast, the ca A/AnnArbor/6/60 donor virus reliably confers attenuation characteristics to a variety of H1N1 and H3N2 influenza A viruses.
Url:
DOI: 10.1093/infdis/163.5.1023
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Broadway, Baltimore, MD 21205.</mods:affiliation></affiliation></author><author><name sortKey="Halsey, Neal A" sort="Halsey, Neal A" uniqKey="Halsey N" first="Neal A." last="Halsey">Neal A. Halsey</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Fries, Louis F" sort="Fries, Louis F" uniqKey="Fries L" first="Louis F." last="Fries">Louis F. 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Steinhoff</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation><affiliation><mods:affiliation>Reprints or correspondence: Dr. Mark C. Steinhoff, Johns Hopkins University, Center for Immunization Research, Hampton House, Room 125, 624 N. Broadway, Baltimore, MD 21205.</mods:affiliation></affiliation></author><author><name sortKey="Halsey, Neal A" sort="Halsey, Neal A" uniqKey="Halsey N" first="Neal A." last="Halsey">Neal A. Halsey</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Fries, Louis F" sort="Fries, Louis F" uniqKey="Fries L" first="Louis F." last="Fries">Louis F. Fries</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Wilson, Modena H" sort="Wilson, Modena H" uniqKey="Wilson M" first="Modena H." last="Wilson">Modena H. Wilson</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="King, James" sort="King, James" uniqKey="King J" first="James" last="King">James King</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Burns, Barbara A" sort="Burns, Barbara A" uniqKey="Burns B" first="Barbara A." last="Burns">Barbara A. Burns</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Samorodin, Roberta K" sort="Samorodin, Roberta K" uniqKey="Samorodin R" first="Roberta K." last="Samorodin">Roberta K. Samorodin</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Perkis, Victoria" sort="Perkis, Victoria" uniqKey="Perkis V" first="Victoria" last="Perkis">Victoria Perkis</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Murphy, Brian R" sort="Murphy, Brian R" uniqKey="Murphy B" first="Brian R." last="Murphy">Brian R. Murphy</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation></author><author><name sortKey="Clements, Mary Lou" sort="Clements, Mary Lou" uniqKey="Clements M" first="Mary Lou" last="Clements">Mary Lou Clements</name><affiliation><mods:affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University Chicago Press</publisher><date when="1991-05">1991</date><biblScope unit="vol">163</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="1023">1023</biblScope><biblScope unit="page" to="1028">1028</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Characteristics of avian-human (ab) and cold-adapted (ca) influenza A/Kawasaki/9/86 (H1N1) reassortant vaccine viruses were compared in 37 seronegative adults and 122 seronegative infants and children. The 50% human infectious dose (HID50) in infants and children was 102.9 and 102.6 TCID50 for the ab and ca vaccine, respectively. The ah influenza A/Kawasaki/9/86 reassortant was reactogenic: 24% of infants and children infected with ⩾100 HID50 had fever ⩾39.4°C. Since H3N2 ah vaccines were previously shown to be adequately attenuated, it is reasonable to suggest that the genes that code for hemagglutinin and neuraminidase of the H1N1 virus apparently influence the reactogenicity of reassort antviruses derived from the avian influenza A/Mallard/NewYork/6750/78 donor virus. Because this avian virus does not reproducibly confer a satisfactory level of attenuation to each subtype of influenza A virus, it is not a suitable donor virus for attenuation of wild-typeinfluenza viruses. In contrast, the ca A/AnnArbor/6/60 donor virus reliably confers attenuation characteristics to a variety of H1N1 and H3N2 influenza A viruses.</div></front></TEI><istex><corpusName>oup</corpusName><keywords><teeft><json:string>reassortant</json:string><json:string>vaccine</json:string><json:string>seronegative</json:string><json:string>attenuated</json:string><json:string>influenza</json:string><json:string>tcidso</json:string><json:string>hini</json:string><json:string>reassortant virus</json:string><json:string>reassortants</json:string><json:string>vaccinee</json:string><json:string>placebo</json:string><json:string>viral</json:string><json:string>attenuation</json:string><json:string>vaccine virus</json:string><json:string>hidso</json:string><json:string>hinl</json:string><json:string>maassab</json:string><json:string>responder</json:string><json:string>glycoprotein</json:string><json:string>antibody response</json:string><json:string>reciprocal titer</json:string><json:string>exact test</json:string><json:string>virus vaccine</json:string><json:string>seronegative infant</json:string><json:string>clin microbiol</json:string><json:string>peak titer</json:string><json:string>national institute</json:string><json:string>virus</json:string><json:string>attenuated influenza</json:string><json:string>placebo recipient</json:string><json:string>dose response</json:string><json:string>nasal wash antibody response</json:string><json:string>infectious disease</json:string><json:string>seronegative adult</json:string><json:string>adult volunteer</json:string><json:string>nasal</json:string><json:string>datum</json:string><json:string>squirrel monkey</json:string><json:string>reassortant virus vaccine</json:string><json:string>phenotypic stability</json:string><json:string>tcidso dose</json:string><json:string>seronegative individual</json:string><json:string>lower respiratory tract</json:string><json:string>satisfactory attenuation</json:string><json:string>virus infection</json:string><json:string>donor virus</json:string><json:string>young child</json:string><json:string>attenuating gene</json:string><json:string>viral isolation</json:string><json:string>attenuated influenza vaccine</json:string><json:string>nasal wash</json:string><json:string>influenza virus</json:string><json:string>inoculation</json:string><json:string>clements</json:string><json:string>titer</json:string><json:string>vaccine recipient</json:string><json:string>vaccine responder</json:string><json:string>nasal wash specimen</json:string><json:string>immunologic response</json:string><json:string>greater rise</json:string><json:string>high fever</json:string><json:string>viral culture</json:string><json:string>serum antibody response virus</json:string><json:string>reassortant vaccine</json:string><json:string>susceptible infant</json:string><json:string>consecutive day</json:string><json:string>rise elisa</json:string><json:string>first dose</json:string><json:string>candidate vaccine virus</json:string><json:string>adventitious agent</json:string><json:string>influenza reassortants</json:string><json:string>surface glycoprotein</json:string><json:string>seronegative child</json:string><json:string>attenuated donor virus</json:string><json:string>influenza reassortant</json:string><json:string>john hopkins university school</json:string><json:string>immunization research</json:string><json:string>serum antibody titer</json:string><json:string>seronegative adult volunteer</json:string><json:string>human influenza</json:string></teeft></keywords><author><json:item><name>Mark C. Steinhoff</name><affiliations><json:string>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</json:string><json:string>Reprints or correspondence: Dr. Mark C. Steinhoff, Johns Hopkins University, Center for Immunization Research, Hampton House, Room 125, 624 N. Broadway, Baltimore, MD 21205.</json:string></affiliations></json:item><json:item><name>Neal A. Halsey</name><affiliations><json:string>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>Louis F. Fries</name><affiliations><json:string>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>Modena H. Wilson</name><affiliations><json:string>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>James King</name><affiliations><json:string>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>Barbara A. Burns</name><affiliations><json:string>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>Roberta K. Samorodin</name><affiliations><json:string>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>Victoria Perkis</name><affiliations><json:string>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>Brian R. Murphy</name><affiliations><json:string>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</json:string></affiliations></json:item><json:item><name>Mary Lou Clements</name><affiliations><json:string>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</json:string></affiliations></json:item></author><arkIstex>ark:/67375/HXZ-G6F3HD0G-Q</arkIstex><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Characteristics of avian-human (ab) and cold-adapted (ca) influenza A/Kawasaki/9/86 (H1N1) reassortant vaccine viruses were compared in 37 seronegative adults and 122 seronegative infants and children. The 50% human infectious dose (HID50) in infants and children was 102.9 and 102.6 TCID50 for the ab and ca vaccine, respectively. The ah influenza A/Kawasaki/9/86 reassortant was reactogenic: 24% of infants and children infected with ⩾100 HID50 had fever ⩾39.4°C. Since H3N2 ah vaccines were previously shown to be adequately attenuated, it is reasonable to suggest that the genes that code for hemagglutinin and neuraminidase of the H1N1 virus apparently influence the reactogenicity of reassort antviruses derived from the avian influenza A/Mallard/NewYork/6750/78 donor virus. Because this avian virus does not reproducibly confer a satisfactory level of attenuation to each subtype of influenza A virus, it is not a suitable donor virus for attenuation of wild-typeinfluenza viruses. In contrast, the ca A/AnnArbor/6/60 donor virus reliably confers attenuation characteristics to a variety of H1N1 and H3N2 influenza A viruses.</abstract><qualityIndicators><score>6.8</score><pdfWordCount>4177</pdfWordCount><pdfCharCount>29750</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>581.04 x 770.94 pts</pdfPageSize><pdfWordsPerPage>696</pdfWordsPerPage><pdfText>true</pdfText><refBibsNative>false</refBibsNative><abstractWordCount>163</abstractWordCount><abstractCharCount>1133</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Virulence for Infants and Children</title><pmid><json:string>2019751</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>Journal of Infectious Diseases</title><language><json:string>unknown</json:string></language><issn><json:string>0022-1899</json:string></issn><eissn><json:string>1537-6613</json:string></eissn><publisherId><json:string>jid</json:string></publisherId><volume>163</volume><issue>5</issue><pages><first>1023</first><last>1028</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1988</json:string><json:string>67S</json:string><json:string>1991</json:string></date><geogName></geogName><orgName><json:string>JohnsHopkins University, Center</json:string><json:string>Immunization Research, Hampton House, Room</json:string><json:string>Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health</json:string><json:string>Johns Hopkins University</json:string><json:string>National Institutes of Health, Tokyo</json:string><json:string>and Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases</json:string><json:string>National Institute of Allergy and Infectious Diseases</json:string><json:string>National Institutes of Health</json:string><json:string>National Institutes of Health, Bethesda, Maryland Characteristics</json:string><json:string>US Departmentof Human Services, the Joint Committeefor Clinical Investigation of the Johns Hopkins University Schoolof Medicine</json:string><json:string>University of Chicago</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Neal A. Halsey</json:string><json:string>Karen Christina</json:string><json:string>Alan Leach</json:string><json:string>Ruth Karron</json:string><json:string>John Maassab</json:string><json:string>Louis F. Fries</json:string><json:string>Tina Speaks</json:string><json:string>Barbara A. Burns</json:string><json:string>Any Associated</json:string><json:string>H. Snyder</json:string><json:string>MarkC</json:string><json:string>Mark C. Steinhoff</json:string><json:string>James King</json:string><json:string>Ann Arbor</json:string><json:string>John Modlin</json:string><json:string>Brian R. Murphy</json:string><json:string>Stephanie Boddie</json:string><json:string>Victoria Perkis</json:string><json:string>H. Wilson</json:string><json:string>Robert Black</json:string><json:string>Roberta K. Samorodin</json:string><json:string>Robert Chanock</json:string></persName><placeName><json:string>NewYork</json:string><json:string>Modena</json:string><json:string>Los Angeles</json:string><json:string>Baltimore</json:string><json:string>Kawasaki</json:string><json:string>MD</json:string><json:string>York</json:string><json:string>New Yorkl</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[33-36]</json:string><json:string>[11]</json:string><json:string>[39]</json:string><json:string>[11, 21-23]</json:string><json:string>[32]</json:string><json:string>[1-4]</json:string><json:string>[38]</json:string><json:string>[31]</json:string><json:string>[18, 20]</json:string><json:string>[5]</json:string><json:string>[37]</json:string><json:string>[12-20]</json:string><json:string>[30]</json:string><json:string>[20,28, 29]</json:string><json:string>[20, 21]</json:string><json:string>[24-26]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/HXZ-G6F3HD0G-Q</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - microbiology</json:string><json:string>2 - infectious diseases</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - microbiology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Infectious Diseases</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - pathologie infectieuse</json:string></inist></categories><publicationDate>1991</publicationDate><copyrightDate>1991</copyrightDate><doi><json:string>10.1093/infdis/163.5.1023</json:string></doi><id>D6F40AA0B98E981622A2A7C9177CE75592A0B434</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-G6F3HD0G-Q/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-G6F3HD0G-Q/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/HXZ-G6F3HD0G-Q/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Virulence for Infants and Children</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>The University Chicago Press</publisher><availability><licence>© 1991 by The University of Chicago</licence></availability><date type="Copyright" when="1991">1991</date><date when="1991-05">1991</date></publicationStmt><notesStmt><note type="content-type" source="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="publication-type" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Virulence for Infants and Children</title><author xml:id="author-0000" role="corresp"><persName><surname>Steinhoff</surname><forename type="first">Mark C.</forename></persName><affiliation><orgName type="institution">Center for Immunization Research</orgName><orgName type="department">Department of International Health</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><orgName type="department">and Departments of Pediatrics and Medicine</orgName><orgName type="institution">Johns Hopkins University School of Medicine</orgName><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><address><addrLine>Baltimore</addrLine><addrLine>Bethesda, Maryland</addrLine></address></affiliation><affiliation role="corresp">Reprints or correspondence: Dr. Mark C. Steinhoff, Johns Hopkins University, Center for Immunization Research, Hampton House, Room 125, 624 N. Broadway, Baltimore, MD 21205.</affiliation></author><author xml:id="author-0001"><persName><surname>Halsey</surname><forename type="first">Neal A.</forename></persName><affiliation><orgName type="institution">Center for Immunization Research</orgName><orgName type="department">Department of International Health</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><orgName type="department">and Departments of Pediatrics and Medicine</orgName><orgName type="institution">Johns Hopkins University School of Medicine</orgName><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><address><addrLine>Baltimore</addrLine><addrLine>Bethesda, Maryland</addrLine></address></affiliation></author><author xml:id="author-0002"><persName><surname>Fries</surname><forename type="first">Louis F.</forename></persName><affiliation><orgName type="institution">Center for Immunization Research</orgName><orgName type="department">Department of International Health</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><orgName type="department">and Departments of Pediatrics and Medicine</orgName><orgName type="institution">Johns Hopkins University School of Medicine</orgName><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><address><addrLine>Baltimore</addrLine><addrLine>Bethesda, Maryland</addrLine></address></affiliation></author><author xml:id="author-0003"><persName><surname>Wilson</surname><forename type="first">Modena H.</forename></persName><affiliation><orgName type="institution">Center for Immunization Research</orgName><orgName type="department">Department of International Health</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><orgName type="department">and Departments of Pediatrics and Medicine</orgName><orgName type="institution">Johns Hopkins University School of Medicine</orgName><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><address><addrLine>Baltimore</addrLine><addrLine>Bethesda, Maryland</addrLine></address></affiliation></author><author xml:id="author-0004"><persName><surname>King</surname><forename type="first">James</forename></persName><affiliation><orgName type="institution">Center for Immunization Research</orgName><orgName type="department">Department of International Health</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><orgName type="department">and Departments of Pediatrics and Medicine</orgName><orgName type="institution">Johns Hopkins University School of Medicine</orgName><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><address><addrLine>Baltimore</addrLine><addrLine>Bethesda, Maryland</addrLine></address></affiliation></author><author xml:id="author-0005"><persName><surname>Burns</surname><forename type="first">Barbara A.</forename></persName><affiliation><orgName type="institution">Center for Immunization Research</orgName><orgName type="department">Department of International Health</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><orgName type="department">and Departments of Pediatrics and Medicine</orgName><orgName type="institution">Johns Hopkins University School of Medicine</orgName><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><address><addrLine>Baltimore</addrLine><addrLine>Bethesda, Maryland</addrLine></address></affiliation></author><author xml:id="author-0006"><persName><surname>Samorodin</surname><forename type="first">Roberta K.</forename></persName><affiliation><orgName type="institution">Center for Immunization Research</orgName><orgName type="department">Department of International Health</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><orgName type="department">and Departments of Pediatrics and Medicine</orgName><orgName type="institution">Johns Hopkins University School of Medicine</orgName><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and Infectious Diseases</orgName><orgName type="institution">National Institutes of Health</orgName><address><addrLine>Baltimore</addrLine><addrLine>Bethesda, Maryland</addrLine></address></affiliation></author><author xml:id="author-0007"><persName><surname>Perkis</surname><forename type="first">Victoria</forename></persName><affiliation><orgName type="institution">Center for Immunization Research</orgName><orgName type="department">Department of International Health</orgName><orgName type="institution">Johns Hopkins University School of Hygiene and Public Health</orgName><orgName type="department">and Departments of Pediatrics and Medicine</orgName><orgName type="institution">Johns Hopkins University School of Medicine</orgName><orgName type="laboratory">Laboratory of Infectious Diseases</orgName><orgName type="institution">National Institute of Allergy and 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<ref target="http://www.tei-c.org/">We use TEI</ref></desc></application></appInfo></encodingDesc><profileDesc><abstract><p>Characteristics of avian-human (ab) and cold-adapted (ca) influenza A/Kawasaki/9/86 (H1N1) reassortant vaccine viruses were compared in 37 seronegative adults and 122 seronegative infants and children. The 50% human infectious dose (HID<hi rend="subscript">50</hi>) in infants and children was 10<hi rend="superscript">2.9</hi> and 10<hi rend="superscript">2.6</hi> TCID<hi rend="subscript">50</hi> for the ab and <hi rend="italic">ca</hi> vaccine, respectively. The ah influenza A/Kawasaki/9/86 reassortant was reactogenic: 24% of infants and children infected with ⩾100 HID<hi rend="subscript">50</hi> had fever ⩾39.4°C. Since H3N2 ah vaccines were previously shown to be adequately attenuated, it is reasonable to suggest that the genes that code for hemagglutinin and neuraminidase of the H1N1 virus apparently influence the reactogenicity of reassort antviruses derived from the avian influenza A/Mallard/NewYork/6750/78 donor virus. Because this avian virus does not reproducibly confer a satisfactory level of attenuation to each subtype of influenza A virus, it is not a suitable donor virus for attenuation of wild-typeinfluenza viruses. In contrast, the <hi rend="italic">ca</hi> A/AnnArbor/6/60 donor virus reliably confers attenuation characteristics to a variety of H1N1 and H3N2 influenza A viruses.</p></abstract><textClass ana="subject"><keywords scheme="heading"><term>Major Articles</term></keywords></textClass><langUsage><language ident="EN"></language></langUsage></profileDesc><revisionDesc><change when="2019-12-09" who="#istex" xml:id="pub2tei">formatting</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2019-12-11">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-G6F3HD0G-Q/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article">
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<journal-title>Journal of Infectious Diseases</journal-title>
<abbrev-journal-title>J Infect Dis.</abbrev-journal-title>
<issn pub-type="ppub">0022-1899</issn>
<issn pub-type="epub">1537-6613</issn>
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<publisher-name>The University Chicago Press</publisher-name>
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<title-group>
<article-title>The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Virulence for Infants and Children</article-title>
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<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Steinhoff</surname><given-names>Mark C.</given-names>
</name><xref ref-type="corresp" rid="COR1"></xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Halsey</surname><given-names>Neal A.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Fries</surname><given-names>Louis F.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wilson</surname><given-names>Modena H.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>King</surname><given-names>James</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Burns</surname><given-names>Barbara A.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Samorodin</surname><given-names>Roberta K.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Perkis</surname><given-names>Victoria</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Murphy</surname><given-names>Brian R.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Clements</surname><given-names>Mary Lou</given-names>
</name>
</contrib>
<aff><institution>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine</institution>, <addr-line>Baltimore</addr-line>, and <institution>Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health</institution>, <addr-line>Bethesda, Maryland</addr-line></aff>
</contrib-group>
<author-notes>
<corresp id="COR1">Reprints or correspondence: Dr. Mark C. Steinhoff, Johns Hopkins University, Center for Immunization Research, Hampton House, Room 125, 624 N. Broadway, Baltimore, MD 21205.</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>5</month>
<year>1991</year>
</pub-date>
<volume>163</volume>
<issue>5</issue>
<fpage>1023</fpage>
<lpage>1028</lpage>
<history>
<date date-type="received">
<day>18</day>
<month>7</month>
<year>1990</year>
</date>
<date date-type="rev-recd">
<day>2</day>
<month>1</month>
<year>1991</year>
</date>
</history>
<copyright-statement>© 1991 by The University of Chicago</copyright-statement>
<copyright-year>1991</copyright-year>
<abstract>
<p>Characteristics of avian-human (ab) and cold-adapted (ca) influenza A/Kawasaki/9/86 (H1N1) reassortant vaccine viruses were compared in 37 seronegative adults and 122 seronegative infants and children. The 50% human infectious dose (HID<sub>50</sub>) in infants and children was 10<sup>2.9</sup> and 10<sup>2.6</sup> TCID<sub>50</sub> for the ab and <italic>ca</italic> vaccine, respectively. The ah influenza A/Kawasaki/9/86 reassortant was reactogenic: 24% of infants and children infected with ⩾100 HID<sub>50</sub> had fever ⩾39.4°C. Since H3N2 ah vaccines were previously shown to be adequately attenuated, it is reasonable to suggest that the genes that code for hemagglutinin and neuraminidase of the H1N1 virus apparently influence the reactogenicity of reassort antviruses derived from the avian influenza A/Mallard/NewYork/6750/78 donor virus. Because this avian virus does not reproducibly confer a satisfactory level of attenuation to each subtype of influenza A virus, it is not a suitable donor virus for attenuation of wild-typeinfluenza viruses. In contrast, the <italic>ca</italic> A/AnnArbor/6/60 donor virus reliably confers attenuation characteristics to a variety of H1N1 and H3N2 influenza A viruses.</p>
</abstract>
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</front>
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</istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Virulence for Infants and Children</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Virulence for Infants and Children</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Mark C.</namePart><namePart type="family">Steinhoff</namePart><affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</affiliation><affiliation>Reprints or correspondence: Dr. Mark C. Steinhoff, Johns Hopkins University, Center for Immunization Research, Hampton House, Room 125, 624 N. Broadway, Baltimore, MD 21205.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Neal A.</namePart><namePart type="family">Halsey</namePart><affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Louis F.</namePart><namePart type="family">Fries</namePart><affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Modena H.</namePart><namePart type="family">Wilson</namePart><affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">James</namePart><namePart type="family">King</namePart><affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara A.</namePart><namePart type="family">Burns</namePart><affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roberta K.</namePart><namePart type="family">Samorodin</namePart><affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Victoria</namePart><namePart type="family">Perkis</namePart><affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brian R.</namePart><namePart type="family">Murphy</namePart><affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mary Lou</namePart><namePart type="family">Clements</namePart><affiliation>Center for Immunization Research, Department of International Health, Johns Hopkins University School of Hygiene and Public Health, and Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, Bethesda, Maryland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>The University Chicago Press</publisher><dateIssued encoding="w3cdtf">1991-05</dateIssued><copyrightDate encoding="w3cdtf">1991</copyrightDate></originInfo><abstract>Characteristics of avian-human (ab) and cold-adapted (ca) influenza A/Kawasaki/9/86 (H1N1) reassortant vaccine viruses were compared in 37 seronegative adults and 122 seronegative infants and children. The 50% human infectious dose (HID50) in infants and children was 102.9 and 102.6 TCID50 for the ab and ca vaccine, respectively. The ah influenza A/Kawasaki/9/86 reassortant was reactogenic: 24% of infants and children infected with ⩾100 HID50 had fever ⩾39.4°C. Since H3N2 ah vaccines were previously shown to be adequately attenuated, it is reasonable to suggest that the genes that code for hemagglutinin and neuraminidase of the H1N1 virus apparently influence the reactogenicity of reassort antviruses derived from the avian influenza A/Mallard/NewYork/6750/78 donor virus. Because this avian virus does not reproducibly confer a satisfactory level of attenuation to each subtype of influenza A virus, it is not a suitable donor virus for attenuation of wild-typeinfluenza viruses. In contrast, the ca A/AnnArbor/6/60 donor virus reliably confers attenuation characteristics to a variety of H1N1 and H3N2 influenza A viruses.</abstract><note type="author-notes">Reprints or correspondence: Dr. Mark C. Steinhoff, Johns Hopkins University, Center for Immunization Research, Hampton House, Room 125, 624 N. Broadway, Baltimore, MD 21205.</note><relatedItem type="host"><titleInfo><title>Journal of Infectious Diseases</title></titleInfo><titleInfo type="abbreviated"><title>J Infect Dis.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-1899</identifier><identifier type="eISSN">1537-6613</identifier><identifier type="PublisherID">jid</identifier><identifier type="PublisherID-hwp">jinfdis</identifier><part><date>1991</date><detail type="volume"><caption>vol.</caption><number>163</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>1023</start><end>1028</end></extent></part></relatedItem><identifier type="istex">D6F40AA0B98E981622A2A7C9177CE75592A0B434</identifier><identifier type="ark">ark:/67375/HXZ-G6F3HD0G-Q</identifier><identifier type="DOI">10.1093/infdis/163.5.1023</identifier><accessCondition type="use and reproduction" contentType="copyright">© 1991 by The University of Chicago</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-GTWS0RDP-M">oup</recordContentSource><recordOrigin>Converted from (version 1.2.0) to MODS version 3.6.</recordOrigin><recordCreationDate encoding="w3cdtf">2019-12-09</recordCreationDate></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-G6F3HD0G-Q/record.json</uri></json:item></metadata><covers><json:item><extension>tiff</extension><original>true</original><mimetype>image/tiff</mimetype><uri>https://api.istex.fr/document/D6F40AA0B98E981622A2A7C9177CE75592A0B434/covers/tiff</uri></json:item></covers><annexes><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/HXZ-G6F3HD0G-Q/annexes.pdf</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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