The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus
Identifieur interne : 000711 ( Istex/Corpus ); précédent : 000710; suivant : 000712The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus
Auteurs : Y. Komatsu ; Y. Nawa ; J. MarbrookSource :
- Immunology Letters [ 0165-2478 ] ; 1982.
English descriptors
- Teeft :
- Clonal analysis, Clone, Contingency table, Dimple, Equal aliquots, Individual clones, Influenza, Influenza cells, Influenza virus, Lysis, Lyzed, Present address, Primary response, Specific clones, Specific lysis, Spleen, Spleen cells, Spontaneous release, Stimulator, Stimulator cells, Stimulator spleen cells, Target cells, Tissue culture, Total dimples, Total number, Uninfected cells.
Abstract
Abstract: CBA spleen cells have been stimulated in vitro with A/Jap influenza virus-infected CBA spleen cells to generate a ‘primary’ cytotoxic lymphocyte (CL) response. The culture conditions were devised to allow the segregation of individual clones of CL and cytotoxicity measured by the lysis of infected or non-infected L-929 cells. The specificity was assessed by splitting clones and measuring the ability of the clones to discriminate between pairs of targets. Influenza A/FMI and A/Jap strains were used. Subsets of clones were detected which could lyze either A/Jap-infected or A/FMI-infected target cells. In addition CL clones were found which lyzed uninfected L-929 cells and a fourth category were clones which could not discriminate between A/FMI- and A/Jap-infected targets.
Url:
DOI: 10.1016/0165-2478(82)90127-4
Links to Exploration step
ISTEX:530F4D7361F0588AB286B246DD4C0A36F5D7DE4BLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus</title><author><name sortKey="Komatsu, Y" sort="Komatsu, Y" uniqKey="Komatsu Y" first="Y." last="Komatsu">Y. Komatsu</name><affiliation><mods:affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</mods:affiliation></affiliation></author><author><name sortKey="Nawa, Y" sort="Nawa, Y" uniqKey="Nawa Y" first="Y." last="Nawa">Y. Nawa</name><affiliation><mods:affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</mods:affiliation></affiliation></author><author><name sortKey="Marbrook, J" sort="Marbrook, J" uniqKey="Marbrook J" first="J." last="Marbrook">J. Marbrook</name><affiliation><mods:affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:530F4D7361F0588AB286B246DD4C0A36F5D7DE4B</idno><date when="1982" year="1982">1982</date><idno type="doi">10.1016/0165-2478(82)90127-4</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-L9WC949G-G/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000711</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000711</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus</title><author><name sortKey="Komatsu, Y" sort="Komatsu, Y" uniqKey="Komatsu Y" first="Y." last="Komatsu">Y. Komatsu</name><affiliation><mods:affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</mods:affiliation></affiliation></author><author><name sortKey="Nawa, Y" sort="Nawa, Y" uniqKey="Nawa Y" first="Y." last="Nawa">Y. Nawa</name><affiliation><mods:affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</mods:affiliation></affiliation></author><author><name sortKey="Marbrook, J" sort="Marbrook, J" uniqKey="Marbrook J" first="J." last="Marbrook">J. Marbrook</name><affiliation><mods:affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Immunology Letters</title><title level="j" type="abbrev">IMLET</title><idno type="ISSN">0165-2478</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1982">1982</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="351">351</biblScope><biblScope unit="page" to="355">355</biblScope></imprint><idno type="ISSN">0165-2478</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0165-2478</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Clonal analysis</term><term>Clone</term><term>Contingency table</term><term>Dimple</term><term>Equal aliquots</term><term>Individual clones</term><term>Influenza</term><term>Influenza cells</term><term>Influenza virus</term><term>Lysis</term><term>Lyzed</term><term>Present address</term><term>Primary response</term><term>Specific clones</term><term>Specific lysis</term><term>Spleen</term><term>Spleen cells</term><term>Spontaneous release</term><term>Stimulator</term><term>Stimulator cells</term><term>Stimulator spleen cells</term><term>Target cells</term><term>Tissue culture</term><term>Total dimples</term><term>Total number</term><term>Uninfected cells</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: CBA spleen cells have been stimulated in vitro with A/Jap influenza virus-infected CBA spleen cells to generate a ‘primary’ cytotoxic lymphocyte (CL) response. The culture conditions were devised to allow the segregation of individual clones of CL and cytotoxicity measured by the lysis of infected or non-infected L-929 cells. The specificity was assessed by splitting clones and measuring the ability of the clones to discriminate between pairs of targets. Influenza A/FMI and A/Jap strains were used. Subsets of clones were detected which could lyze either A/Jap-infected or A/FMI-infected target cells. In addition CL clones were found which lyzed uninfected L-929 cells and a fourth category were clones which could not discriminate between A/FMI- and A/Jap-infected targets.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>clone</json:string><json:string>dimple</json:string><json:string>target cells</json:string><json:string>lysis</json:string><json:string>stimulator</json:string><json:string>specific lysis</json:string><json:string>stimulator cells</json:string><json:string>lyzed</json:string><json:string>influenza</json:string><json:string>individual clones</json:string><json:string>spleen cells</json:string><json:string>contingency table</json:string><json:string>uninfected cells</json:string><json:string>total number</json:string><json:string>influenza virus</json:string><json:string>spleen</json:string><json:string>clonal analysis</json:string><json:string>spontaneous release</json:string><json:string>primary response</json:string><json:string>specific clones</json:string><json:string>influenza cells</json:string><json:string>present address</json:string><json:string>tissue culture</json:string><json:string>stimulator spleen cells</json:string><json:string>total dimples</json:string><json:string>equal aliquots</json:string></teeft></keywords><author><json:item><name>Y. Komatsu</name><affiliations><json:string>Department of Cell Biology, University of Auckland, Auckland, New Zealand</json:string></affiliations></json:item><json:item><name>Y. Nawa</name><affiliations><json:string>Department of Cell Biology, University of Auckland, Auckland, New Zealand</json:string></affiliations></json:item><json:item><name>J. Marbrook</name><affiliations><json:string>Department of Cell Biology, University of Auckland, Auckland, New Zealand</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>in vitro immune response</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>murine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cytotoxic lymphocyte</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>influenza A virus</value></json:item></subject><arkIstex>ark:/67375/6H6-L9WC949G-G</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: CBA spleen cells have been stimulated in vitro with A/Jap influenza virus-infected CBA spleen cells to generate a ‘primary’ cytotoxic lymphocyte (CL) response. The culture conditions were devised to allow the segregation of individual clones of CL and cytotoxicity measured by the lysis of infected or non-infected L-929 cells. The specificity was assessed by splitting clones and measuring the ability of the clones to discriminate between pairs of targets. Influenza A/FMI and A/Jap strains were used. Subsets of clones were detected which could lyze either A/Jap-infected or A/FMI-infected target cells. In addition CL clones were found which lyzed uninfected L-929 cells and a fourth category were clones which could not discriminate between A/FMI- and A/Jap-infected targets.</abstract><qualityIndicators><score>6.166</score><pdfWordCount>2762</pdfWordCount><pdfCharCount>16091</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>526 x 735 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>117</abstractWordCount><abstractCharCount>790</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus</title><pmid><json:string>6984690</json:string></pmid><pii><json:string>0165-2478(82)90127-4</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Immunology Letters</title><language><json:string>unknown</json:string></language><publicationDate>1982</publicationDate><issn><json:string>0165-2478</json:string></issn><pii><json:string>S0165-2478(00)X0133-2</json:string></pii><volume>5</volume><issue>6</issue><pages><first>351</first><last>355</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1982</json:string></date><geogName></geogName><orgName><json:string>National Institute for Medical Research, Mill Hill, London</json:string><json:string>Australian Laboratory Services</json:string><json:string>Influenza Center</json:string><json:string>Juntendo University</json:string><json:string>Department of Anatomy, Kumamoto University Medical School, Kumamoto,Japan</json:string><json:string>Medical Research Council of New Zealand</json:string></orgName><orgName_funder><json:string>Medical Research Council of New Zealand</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>J. Exp</json:string><json:string>The</json:string><json:string>E. D. Kilboourne</json:string><json:string>Yukio Shiomi</json:string><json:string>J. J. Skehel</json:string><json:string>El Ds</json:string><json:string>J. Immunol</json:string></persName><placeName><json:string>Ennis</json:string><json:string>Japan</json:string><json:string>Auckland</json:string><json:string>Tokyo</json:string><json:string>York</json:string><json:string>Cambridge</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[12]</json:string><json:string>[18]</json:string><json:string>Accepted October 22nd, 1982</json:string><json:string>[8]</json:string><json:string>[17]</json:string><json:string>[ 12]</json:string><json:string>[1]</json:string><json:string>[10]</json:string><json:string>[10,13]</json:string><json:string>[3]</json:string><json:string>[10,16]</json:string><json:string>[17,20]</json:string><json:string>[4-7]</json:string><json:string>[10,12]</json:string><json:string>[14]</json:string><json:string>[21,22,23]</json:string><json:string>[9]</json:string><json:string>[1,2]</json:string><json:string>[19]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-L9WC949G-G</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - immunology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Immunology and Allergy</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string><json:string>4 - agronomie. sciences du sol et productions vegetales</json:string></inist></categories><publicationDate>1982</publicationDate><copyrightDate>1982</copyrightDate><doi><json:string>10.1016/0165-2478(82)90127-4</json:string></doi><id>530F4D7361F0588AB286B246DD4C0A36F5D7DE4B</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-L9WC949G-G/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-L9WC949G-G/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-L9WC949G-G/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1982</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus</title><author xml:id="author-0000"><persName><forename type="first">Y.</forename><surname>Komatsu</surname></persName><note type="biography">Present address: Dept. of Tissue Culture and Virology, Juntendo University, School of Medicine, Hongo Bunkyo-ku, Tokyo, Japan.</note><affiliation>Present address: Dept. of Tissue Culture and Virology, Juntendo University, School of Medicine, Hongo Bunkyo-ku, Tokyo, Japan.</affiliation><affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Y.</forename><surname>Nawa</surname></persName><note type="biography">Present address: Department of Anatomy, Kumamoto University Medical School, Kumamoto, Japan.</note><affiliation>Present address: Department of Anatomy, Kumamoto University Medical School, Kumamoto, Japan.</affiliation><affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</affiliation></author><author xml:id="author-0002"><persName><forename type="first">J.</forename><surname>Marbrook</surname></persName><affiliation>To whom correspondence should be addressed</affiliation><affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</affiliation></author><idno type="istex">530F4D7361F0588AB286B246DD4C0A36F5D7DE4B</idno><idno type="ark">ark:/67375/6H6-L9WC949G-G</idno><idno type="DOI">10.1016/0165-2478(82)90127-4</idno><idno type="PII">0165-2478(82)90127-4</idno></analytic><monogr><title level="j">Immunology Letters</title><title level="j" type="abbrev">IMLET</title><idno type="pISSN">0165-2478</idno><idno type="PII">S0165-2478(00)X0133-2</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1982"></date><biblScope unit="volume">5</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="351">351</biblScope><biblScope unit="page" to="355">355</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1982</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: CBA spleen cells have been stimulated in vitro with A/Jap influenza virus-infected CBA spleen cells to generate a ‘primary’ cytotoxic lymphocyte (CL) response. The culture conditions were devised to allow the segregation of individual clones of CL and cytotoxicity measured by the lysis of infected or non-infected L-929 cells. The specificity was assessed by splitting clones and measuring the ability of the clones to discriminate between pairs of targets. Influenza A/FMI and A/Jap strains were used. Subsets of clones were detected which could lyze either A/Jap-infected or A/FMI-infected target cells. In addition CL clones were found which lyzed uninfected L-929 cells and a fourth category were clones which could not discriminate between A/FMI- and A/Jap-infected targets.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>in vitro immune response</term></item><item><term>murine</term></item><item><term>cytotoxic lymphocyte</term></item><item><term>influenza A virus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1982">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-L9WC949G-G/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>IMLET</jid><aid>82901274</aid><ce:pii>0165-2478(82)90127-4</ce:pii><ce:doi>10.1016/0165-2478(82)90127-4</ce:doi><ce:copyright type="unknown" year="1982"></ce:copyright></item-info><head><ce:title>The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus</ce:title><ce:author-group><ce:author><ce:given-name>Y.</ce:given-name><ce:surname>Komatsu</ce:surname><ce:cross-ref refid="FN1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Y.</ce:given-name><ce:surname>Nawa</ce:surname><ce:cross-ref refid="FN2"><ce:sup>∗∗</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Marbrook</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗∗∗</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Department of Cell Biology, University of Auckland, Auckland, New Zealand</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗∗∗</ce:label><ce:text>To whom correspondence should be addressed</ce:text></ce:correspondence><ce:footnote id="FN1"><ce:label>∗</ce:label><ce:note-para>Present address: Dept. of Tissue Culture and Virology, Juntendo University, School of Medicine, Hongo Bunkyo-ku, Tokyo, Japan.</ce:note-para></ce:footnote><ce:footnote id="FN2"><ce:label>∗∗</ce:label><ce:note-para>Present address: Department of Anatomy, Kumamoto University Medical School, Kumamoto, Japan.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="10" month="10" year="1982"></ce:date-received><ce:date-accepted day="22" month="10" year="1982"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>CBA spleen cells have been stimulated in vitro with A/Jap influenza virus-infected CBA spleen cells to generate a ‘primary’ cytotoxic lymphocyte (CL) response. The culture conditions were devised to allow the segregation of individual clones of CL and cytotoxicity measured by the lysis of infected or non-infected L-929 cells. The specificity was assessed by splitting clones and measuring the ability of the clones to discriminate between pairs of targets. Influenza A/FMI and A/Jap strains were used. Subsets of clones were detected which could lyze either A/Jap-infected or A/FMI-infected target cells. In addition CL clones were found which lyzed uninfected L-929 cells and a fourth category were clones which could not discriminate between A/FMI- and A/Jap-infected targets.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>in vitro immune response</ce:text></ce:keyword><ce:keyword><ce:text>murine</ce:text></ce:keyword><ce:keyword><ce:text>cytotoxic lymphocyte</ce:text></ce:keyword><ce:keyword><ce:text>influenza A virus</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus</title></titleInfo><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Komatsu</namePart><affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</affiliation><description>Present address: Dept. of Tissue Culture and Virology, Juntendo University, School of Medicine, Hongo Bunkyo-ku, Tokyo, Japan.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="family">Nawa</namePart><affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</affiliation><description>Present address: Department of Anatomy, Kumamoto University Medical School, Kumamoto, Japan.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Marbrook</namePart><affiliation>Department of Cell Biology, University of Auckland, Auckland, New Zealand</affiliation><description>To whom correspondence should be addressed</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1982</dateIssued><copyrightDate encoding="w3cdtf">1982</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: CBA spleen cells have been stimulated in vitro with A/Jap influenza virus-infected CBA spleen cells to generate a ‘primary’ cytotoxic lymphocyte (CL) response. The culture conditions were devised to allow the segregation of individual clones of CL and cytotoxicity measured by the lysis of infected or non-infected L-929 cells. The specificity was assessed by splitting clones and measuring the ability of the clones to discriminate between pairs of targets. Influenza A/FMI and A/Jap strains were used. Subsets of clones were detected which could lyze either A/Jap-infected or A/FMI-infected target cells. In addition CL clones were found which lyzed uninfected L-929 cells and a fourth category were clones which could not discriminate between A/FMI- and A/Jap-infected targets.</abstract><subject><genre>Keywords</genre><topic>in vitro immune response</topic><topic>murine</topic><topic>cytotoxic lymphocyte</topic><topic>influenza A virus</topic></subject><relatedItem type="host"><titleInfo><title>Immunology Letters</title></titleInfo><titleInfo type="abbreviated"><title>IMLET</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1982</dateIssued></originInfo><identifier type="ISSN">0165-2478</identifier><identifier type="PII">S0165-2478(00)X0133-2</identifier><part><date>1982</date><detail type="volume"><number>5</number><caption>vol.</caption></detail><detail type="issue"><number>6</number><caption>no.</caption></detail><extent unit="issue-pages"><start>285</start><end>367</end></extent><extent unit="pages"><start>351</start><end>355</end></extent></part></relatedItem><identifier type="istex">530F4D7361F0588AB286B246DD4C0A36F5D7DE4B</identifier><identifier type="ark">ark:/67375/6H6-L9WC949G-G</identifier><identifier type="DOI">10.1016/0165-2478(82)90127-4</identifier><identifier type="PII">0165-2478(82)90127-4</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-L9WC949G-G/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000711 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000711 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:530F4D7361F0588AB286B246DD4C0A36F5D7DE4B
|texte= The segregation of specific clones of cytotoxic lymphocytes in an in vitro primary response against influenza virus
}}
| This area was generated with Dilib version V0.6.33. |  |