H2N2V1, Istex, Corpus, bibRecord, 000657

Comparison of US Inactivated Split-Virus and Russian Live Attenuated, Cold-Adapted Trivalent Influenza Vaccines in Russian Schoolchildren

Identifieur interne : 000657 ( Istex/Corpus ); précédent : 000656; suivant : 000658

Comparison of US Inactivated Split-Virus and Russian Live Attenuated, Cold-Adapted Trivalent Influenza Vaccines in Russian Schoolchildren

Auteurs : A. S. Khan ; F. Polezhaev ; R. Vasiljeva ; V. Drinevsky ; J. Buffington ; H. Gary ; A. Sominina ; W. Keitel ; H. Regnery ; N. L. Lonskaya ; E. Doroshenko ; A. Gavrilov ; I. Ivakhov ; N. Arden ; L. B. Schonberger ; R. Couch ; A. Kendal ; N. Cox

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1996.

RBID : ISTEX:10B4A6B7E0EA291F36AE73D24FEA1B83B8ED88AD

Abstract

In a blinded, placebo-controlled study, the reactogenicity, immunogenicity, and clinical efficacy of single doses of US inactivated split-virus and Russian live attenuated, cold-adapted influenza vaccines were compared in 555 schoolchildren in Vologda, Russia. Serial serum samples were collected and school absenteeism was assessed. Systemic reactions were rare, but local reactions (primarily erythema at the injection site) were observed in 27% of the inactivated vaccine group, and coryza (12%) and sore throat (8%) were observed in the attenuated vaccine group. At 4 weeks after vaccination, a ⩾4-fold rise in titer of hemagglutination inhibition antibody to A (H1N1), A (H3N2), and B was noted, respectively, among 78%, 88%, and 53% of children who received inactivated vaccine and among 55%, 79%, and 30% of children who received attenuated vaccine. The vaccine efficacy for preventing school absenteeism due to acute respiratory illness during the period of peak influenza activity was 56% for inactivated vaccine and 47% for attenuated vaccine.

Url:

https://api.istex.fr/ark:/67375/HXZ-5MPSVHKF-T/fulltext.pdf

DOI: 10.1093/infdis/173.2.453

Links to Exploration step

ISTEX:10B4A6B7E0EA291F36AE73D24FEA1B83B8ED88AD

Le document en format XML

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<front><div type="abstract">In a blinded, placebo-controlled study, the reactogenicity, immunogenicity, and clinical efficacy of single doses of US inactivated split-virus and Russian live attenuated, cold-adapted influenza vaccines were compared in 555 schoolchildren in Vologda, Russia. Serial serum samples were collected and school absenteeism was assessed. Systemic reactions were rare, but local reactions (primarily erythema at the injection site) were observed in 27% of the inactivated vaccine group, and coryza (12%) and sore throat (8%) were observed in the attenuated vaccine group. At 4 weeks after vaccination, a ⩾4-fold rise in titer of hemagglutination inhibition antibody to A (H1N1), A (H3N2), and B was noted, respectively, among 78%, 88%, and 53% of children who received inactivated vaccine and among 55%, 79%, and 30% of children who received attenuated vaccine. The vaccine efficacy for preventing school absenteeism due to acute respiratory illness during the period of peak influenza activity was 56% for inactivated vaccine and 47% for attenuated vaccine.</div>
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<affiliation role="corresp">Reprints or correspondence: Dr. Ali S. Khan, Centers for Disease Control and Prevention, Mailstop A-26, 1600 Clifton Rd., NE, Atlanta, GA 30333.</affiliation>
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<affiliation><orgName type="institution">Research Institute of Influenza</orgName>
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<affiliation><orgName type="institution">Baylor College of Medicine</orgName>
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<affiliation><orgName type="institution">Research Institute of Influenza</orgName>
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<author xml:id="author-0005"><persName><surname>Gary</surname>
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<affiliation><orgName type="institution">Research Institute of Influenza</orgName>
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<orgName>St Petersburg</orgName>
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<orgName>St Petersburg</orgName>
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<author xml:id="author-0009"><persName><surname>Lonskaya</surname>
<forename type="first">N. L.</forename>
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<orgName>St Petersburg</orgName>
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<profileDesc><abstract><p>In a blinded, placebo-controlled study, the reactogenicity, immunogenicity, and clinical efficacy of single doses of US inactivated split-virus and Russian live attenuated, cold-adapted influenza vaccines were compared in 555 schoolchildren in Vologda, Russia. Serial serum samples were collected and school absenteeism was assessed. Systemic reactions were rare, but local reactions (primarily erythema at the injection site) were observed in 27% of the inactivated vaccine group, and coryza (12%) and sore throat (8%) were observed in the attenuated vaccine group. At 4 weeks after vaccination, a ⩾4-fold rise in titer of hemagglutination inhibition antibody to A (H1N1), A (H3N2), and B was noted, respectively, among 78%, 88%, and 53% of children who received inactivated vaccine and among 55%, 79%, and 30% of children who received attenuated vaccine. The vaccine efficacy for preventing school absenteeism due to acute respiratory illness during the period of peak influenza activity was 56% for inactivated vaccine and 47% for attenuated vaccine.</p>
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<journal-title>Journal of Infectious Diseases</journal-title>

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<article-title>Comparison of US Inactivated Split-Virus and Russian Live Attenuated, Cold-Adapted Trivalent Influenza Vaccines in Russian Schoolchildren</article-title>

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<name>

<surname>Khan</surname>

<given-names>A. S.</given-names>

</name>

<xref ref-type="corresp" rid="cor1"></xref>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Polezhaev</surname>

<given-names>F.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Vasiljeva</surname>

<given-names>R.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Drinevsky</surname>

<given-names>V.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Buffington</surname>

<given-names>J.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Gary</surname>

<given-names>H.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Sominina</surname>

<given-names>A.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Keitel</surname>

<given-names>W.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Regnery</surname>

<given-names>H.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Lonskaya</surname>

<given-names>N. L.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Doroshenko</surname>

<given-names>E.</given-names>

</name>

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<contrib contrib-type="author">

<name>

<surname>Gavrilov</surname>

<given-names>A.</given-names>

</name>

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<contrib contrib-type="author">

<name>

<surname>Ivakhov</surname>

<given-names>I.</given-names>

</name>

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<contrib contrib-type="author">

<name>

<surname>Arden</surname>

<given-names>N.</given-names>

</name>

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<contrib contrib-type="author">

<name>

<surname>Schonberger</surname>

<given-names>L. B.</given-names>

</name>

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<contrib contrib-type="author">

<name>

<surname>Couch</surname>

<given-names>R.</given-names>

</name>

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<contrib contrib-type="author">

<name>

<surname>Kendal</surname>

<given-names>A.</given-names>

</name>

</contrib>

<contrib contrib-type="author">

<name>

<surname>Cox</surname>

<given-names>N.</given-names>

</name>

</contrib>

<aff><institution>Centers for Disease Control and Prevention</institution>
, <addr-line>Atlanta, Georgia</addr-line>
</aff>

<aff><institution>Baylor College of Medicine, Acute Respiratory Disease Unit</institution>
, <addr-line>Houston, Texas</addr-line>
</aff>

<aff><institution>Research Institute of Influenza, St. Petersburg, and Tarasyevich State Institute for Control of Biological Products</institution>
, <addr-line>Moscow, Russia</addr-line>
</aff>

</contrib-group>

<author-notes>

<fn fn-type="presented-at">

<p>Presented in part: Options for the Control of Influenza Il, 26 September to 2 October 1992, Courchevel, France. Parents or guardians of all study subjects gave consent. These studies were conducted under the auspices of the Joint Health Science Agreement between the United States and Russia in the area of viral infections other than HIV.</p>

</fn>

<corresp id="cor1">Reprints or correspondence: Dr. Ali S. Khan, Centers for Disease Control and Prevention, Mailstop A-26, 1600 Clifton Rd., NE, Atlanta, GA 30333.</corresp>

</author-notes>

<pub-date pub-type="ppub">

<month>2</month>

<year>1996</year>

</pub-date>

<volume>173</volume>

<issue>2</issue>

<fpage>453</fpage>

<lpage>456</lpage>

<history>

<date date-type="received">

<day>10</day>

<month>3</month>

<year>1995</year>

</date>

<date date-type="rev-recd">

<day>28</day>

<month>9</month>

<year>1995</year>

</date>

</history>

<copyright-statement>© 1996 by The University of Chicago</copyright-statement>

<copyright-year>1996</copyright-year>

<abstract>

<p>In a blinded, placebo-controlled study, the reactogenicity, immunogenicity, and clinical efficacy of single doses of US inactivated split-virus and Russian live attenuated, cold-adapted influenza vaccines were compared in 555 schoolchildren in Vologda, Russia. Serial serum samples were collected and school absenteeism was assessed. Systemic reactions were rare, but local reactions (primarily erythema at the injection site) were observed in 27% of the inactivated vaccine group, and coryza (12%) and sore throat (8%) were observed in the attenuated vaccine group. At 4 weeks after vaccination, a ⩾4-fold rise in titer of hemagglutination inhibition antibody to A (H1N1), A (H3N2), and B was noted, respectively, among 78%, 88%, and 53% of children who received inactivated vaccine and among 55%, 79%, and 30% of children who received attenuated vaccine. The vaccine efficacy for preventing school absenteeism due to acute respiratory illness during the period of peak influenza activity was 56% for inactivated vaccine and 47% for attenuated vaccine.</p>

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<note type="footnotes">Presented in part: Options for the Control of Influenza Il, 26 September to 2 October 1992, Courchevel, France. Parents or guardians of all study subjects gave consent. These studies were conducted under the auspices of the Joint Health Science Agreement between the United States and Russia in the area of viral infections other than HIV.</note>
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Comparison of US Inactivated Split-Virus and Russian Live Attenuated, Cold-Adapted Trivalent Influenza Vaccines in Russian Schoolchildren

Comparison of US Inactivated Split-Virus and Russian Live Attenuated, Cold-Adapted Trivalent Influenza Vaccines in Russian Schoolchildren

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