Do cytotoxic T lymphocytes clear some HIV/SIV infections?
Identifieur interne : 000589 ( Istex/Corpus ); précédent : 000588; suivant : 000590Do cytotoxic T lymphocytes clear some HIV/SIV infections?
Auteurs : Gordon AdaSource :
- Journal of Medical Primatology [ 0047-2565 ] ; 1996-06.
English descriptors
- Teeft :
- Antibody levels, Body fluids, Cell biology, Cell responses, Challenge infection, Control mice, Ctls, Cytotoxic, Different responses, Effector, Effector cells, Human immunodeficiency virus, Immune response, Immune responses, Immunol, Infection, Infectious dose, Infectious virus, Influenza, John curtin school, Lethal dose, Lymph nodes, Lymphocyte, Lymphoid organs, Major role, Medical research, Memory ctls, Neutralizing antibody, Replication, Vaccine, Vaccine design, Vaccine development, Viral, Viral infection, Viral infections, Virus.
Abstract
Early work on the roles of cytotoxic T lymphocytes (CTLs) in acute viral infections in animal models showed that i) the clearance of virus coincided with the increase in CTL activity rather than specific antibody levels, ii) transfer of CTLs after infection could protect from a lethal dose of virus, and iii) in primed, compared to naive, animals, CTL activity appeared 1–3 days earlier after a challenge infection. There is now a series of findings with individuals who have been exposed to HIV but are HIV‐seronegative that suggest a protective role for CTLs. Usually after in vitro culture, HIV‐specific CTLs have been isolated from i) infants born of infected mothers, ii) long‐time partners of HIV‐infected people, iii) some prostitutes in Africa, and iv). Most recently, 7/20 seronegative health care workers exposed once to HIV have been shown to possess HIV env‐specific CTLs. The findings suggest that CTLs (a type I T cell response) may rapidly clear a low dose of HIV. Experiments with SIV are proposed that may provide more direct supporting data for this possibility.
Url:
DOI: 10.1111/j.1600-0684.1996.tb00012.x
Links to Exploration step
ISTEX:4D3A9D2AF8CF66D7F59A71206B4822768DA7E61DLe document en format XML
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Experiments with SIV are proposed that may provide more direct supporting data for this possibility.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Do cytotoxic T lymphocytes clear some HIV/SIV infections?</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Do cytotoxic T lymphocytes clear some HIV/SIV infections?</title></titleInfo><name type="personal"><namePart type="given">Gordon</namePart><namePart type="family">Ada</namePart><affiliation>Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601</affiliation><affiliation>Correspondence address: Division of Immunology and Cell Biology, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, 2601</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1996-06</dateIssued><edition>Accepted for publication May 22, 1996</edition><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">33</extent><extent unit="linksCrossRef">2</extent></physicalDescription><abstract lang="en">Early work on the roles of cytotoxic T lymphocytes (CTLs) in acute viral infections in animal models showed that i) the clearance of virus coincided with the increase in CTL activity rather than specific antibody levels, ii) transfer of CTLs after infection could protect from a lethal dose of virus, and iii) in primed, compared to naive, animals, CTL activity appeared 1–3 days earlier after a challenge infection. There is now a series of findings with individuals who have been exposed to HIV but are HIV‐seronegative that suggest a protective role for CTLs. Usually after in vitro culture, HIV‐specific CTLs have been isolated from i) infants born of infected mothers, ii) long‐time partners of HIV‐infected people, iii) some prostitutes in Africa, and iv). Most recently, 7/20 seronegative health care workers exposed once to HIV have been shown to possess HIV env‐specific CTLs. The findings suggest that CTLs (a type I T cell response) may rapidly clear a low dose of HIV. 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