Development and characterization of cold-adapted viruses for use as live virus vaccines
Identifieur interne : 000587 ( Istex/Corpus ); précédent : 000586; suivant : 000588Development and characterization of cold-adapted viruses for use as live virus vaccines
Auteurs : H. F. Maassab ; Dan C. DebordeSource :
- Vaccine [ 0264-410X ] ; 1985.
English descriptors
- Teeft :
- Absent coryza, Academic press, Adaptation, Adult volunteers, Animal model system, Animal virus, Animal viruses, Application branch, Asian strain, Attenuated, Attenuated influenza, Attenuated phenotype, Attenuated strain, Attenuated strains, Attenuated type, Attenuated virus, Attenuation, Average duration, Biological properties, Chanock, Chick, Clone, Cold adaptation, Cold adaptation process, Cold mutants, Cold reassortant, Cold reassortants, Cold variant, Cold variant virus, Cold variants, Coldadapted, Coldadapted viruses, Constellation, Deborde, Deborde table, December, Defensive role, Different strains, Disease control, Donor line, Donor virus, Embryonated, Embryonated eggs, Encephalitis, Encephalitis virus vaccines, Fewer passages, Flow diagram, Gene, Gene composition, Gene constellation, Genes coding, Genetic, Genetic constitution, Genetic markers, Genetic stability, Genus, Growth characteristics, Hamster, Herpes simplex type, High temperature, Higher temperatures, Host cell, Host factors, Human volunteers, Immun, Immune serum, Incubation temperature, Infectious diseases, Infectivity, Influenza, Influenza reassortants, Influenza type, Influenza vaccine, Influenza virus, Influenza virus type, Influenza virus vaccine, Influenza virus vaccines, Influenza viruses, Inoculated, Inoculated intranasally, Intermediate temperature, Intranasal inoculation, Irregular boundary, Kendal, Lds0 titres, Lesion, Lower temperature, Lower temperatures, Maassab, Marker, Marker time postinfection, Master strain, Mdck cells, Monkey kidney cells, Mosquito, Mouse virulence, Multiple lesions, Mutant, National institute, Necrotic lesions, Negative strand viruses, Neutralizing antibody, Normal host, Optimal growth, Original strain, Parainfluenza, Parainfluenza type, Parainfluenza virus, Parainfluenza virus type, Parental, Parental lcmv, Parental virus, Passage history, Passaged, Personal communication, Phenotype, Pilot studies, Plaque, Plaque formation, Plaque morphology, Plaque size, Plaque titration, Pneumococcus type, Polio, Poliovirus, Poliovirus vaccines, Quail embryo fibroblasts, Rabies virus, Reactogenicity, Reassortant, Reassortants, Reassortment, Recombinant, Recombinant influenza, Replication, Reproductive capacity, Respiratory syncytial virus, Reversion, Rhabdovirus genus, Serial passage, Serial passages, Serially passaged, Several groups, Significant change, Simplex, Single genes, Successive passages, Suckling mice, Surface antigens, Syncytial virus, Temperature mutants, Temperature sensitivity, Temperatures passage, Tissue culture, Turbinate, Vaccine, Vaccine candidate, Vaccine line, Vaccine virus, Vaccinia virus, Variant, Various temperatures, Vesicular stomatitis virus, Vigorous growth, Viral replication, Virol, Virulence, Virulent, Virulent strains, Virus, Virus genera, Virus growth, Virus infectivity, Virus line, Virus strain, Virus vaccine, Virus vaccine candidates, Virus vaccine line, Virus vaccines, Wild type, Wild type parent, Wild type virus.
Abstract
Abstract: Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected. In addition, the starting virus should be a recent isolate not as yet adapted to a tissue culture host and the cold-adaptation process should then occur in a host heterologous to the virus' normal host. These viruses have been reviewed in the light of their cold-adaptation method and successful production of an attenuated line as virus vaccine candidate. Finally, detailed information is presented for the cold-adaptation process in influenza virus.
Url:
DOI: 10.1016/0264-410X(85)90124-0
Links to Exploration step
ISTEX:C607A98127712510DE16967DC2491F4D85790467Le document en format XML
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Maassab</name><affiliations><json:string>Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA</json:string></affiliations></json:item><json:item><name>Dan C. DeBorde</name><affiliations><json:string>Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Viruses</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>cold adaptation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>live virus vaccines</value></json:item></subject><arkIstex>ark:/67375/6H6-HXJ457L0-R</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected. In addition, the starting virus should be a recent isolate not as yet adapted to a tissue culture host and the cold-adaptation process should then occur in a host heterologous to the virus' normal host. These viruses have been reviewed in the light of their cold-adaptation method and successful production of an attenuated line as virus vaccine candidate. Finally, detailed information is presented for the cold-adaptation process in influenza virus.</abstract><qualityIndicators><score>8.812</score><pdfWordCount>11590</pdfWordCount><pdfCharCount>69312</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>15</pdfPageCount><pdfPageSize>648 x 864 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>151</abstractWordCount><abstractCharCount>978</abstractCharCount><keywordCount>3</keywordCount></qualityIndicators><title>Development and characterization of cold-adapted viruses for use as live virus vaccines</title><pmid><json:string>3909681</json:string></pmid><pii><json:string>0264-410X(85)90124-0</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Capacity of strains of pneumococcus type III to grow at 41°C and their virulence for rabbits</title><language><json:string>unknown</json:string></language><pages><first>7</first></pages></serie><host><title>Vaccine</title><language><json:string>unknown</json:string></language><publicationDate>1985</publicationDate><issn><json:string>0264-410X</json:string></issn><pii><json:string>S0264-410X(00)X0176-4</json:string></pii><volume>3</volume><issue>5</issue><pages><first>355</first><last>369</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1968</json:string><json:string>1975</json:string><json:string>1936</json:string><json:string>1976</json:string><json:string>1966</json:string><json:string>1960, 1965</json:string><json:string>1985</json:string></date><geogName></geogName><orgName><json:string>US Army Medical Research and Development</json:string><json:string>Sandoz Forschung Institute, Vienna, Austria</json:string><json:string>National Institute of Allergy and Infectious Diseases</json:string><json:string>Department of the Army, Contract Nos</json:string><json:string>Flow Laboratories</json:string><json:string>Laboratory of Infectious Diseases, Bethesda, MD, USA</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Results</json:string><json:string>Chanock</json:string><json:string>H.F. 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Allen</json:string></persName><placeName><json:string>Reactogenicity</json:string><json:string>Korea</json:string><json:string>Beijing</json:string><json:string>Pathogenicity</json:string><json:string>GA</json:string><json:string>Immunogenicity</json:string><json:string>Osaka Prefecture</json:string><json:string>Atlanta</json:string><json:string>USA</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Yoshida et al.</json:string><json:string>Hozinski et al.</json:string><json:string>Potash et al.</json:string><json:string>Gevaudan et al.</json:string><json:string>Friedewald et aL</json:string><json:string>Kendal et al.</json:string><json:string>Kendal et aL</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-HXJ457L0-R</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - medicine, research & experimental</json:string><json:string>2 - immunology</json:string></wos><scienceMetrix><json:string>1 - 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sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>1985</publicationDate><copyrightDate>1985</copyrightDate><doi><json:string>10.1016/0264-410X(85)90124-0</json:string></doi><id>C607A98127712510DE16967DC2491F4D85790467</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-HXJ457L0-R/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-HXJ457L0-R/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-HXJ457L0-R/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Development and characterization of cold-adapted viruses for use as live virus vaccines</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1985</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Development and characterization of cold-adapted viruses for use as live virus vaccines</title><author xml:id="author-0000"><persName><forename type="first">H.F.</forename><surname>Maassab</surname></persName><affiliation>Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Dan C.</forename><surname>DeBorde</surname></persName><affiliation>Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA</affiliation></author><idno type="istex">C607A98127712510DE16967DC2491F4D85790467</idno><idno type="ark">ark:/67375/6H6-HXJ457L0-R</idno><idno type="DOI">10.1016/0264-410X(85)90124-0</idno><idno type="PII">0264-410X(85)90124-0</idno></analytic><monogr><title level="j">Vaccine</title><title level="j" type="abbrev">JVAC</title><idno type="pISSN">0264-410X</idno><idno type="PII">S0264-410X(00)X0176-4</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985"></date><biblScope unit="volume">3</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="355">355</biblScope><biblScope unit="page" to="369">369</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1985</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected. In addition, the starting virus should be a recent isolate not as yet adapted to a tissue culture host and the cold-adaptation process should then occur in a host heterologous to the virus' normal host. These viruses have been reviewed in the light of their cold-adaptation method and successful production of an attenuated line as virus vaccine candidate. Finally, detailed information is presented for the cold-adaptation process in influenza virus.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Viruses</term></item><item><term>cold adaptation</term></item><item><term>live virus vaccines</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1985">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-HXJ457L0-R/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JVAC</jid><aid>85901240</aid><ce:pii>0264-410X(85)90124-0</ce:pii><ce:doi>10.1016/0264-410X(85)90124-0</ce:doi><ce:copyright type="unknown" year="1985"></ce:copyright></item-info><head><ce:title>Development and characterization of cold-adapted viruses for use as live virus vaccines</ce:title><ce:author-group><ce:author><ce:given-name>H.F.</ce:given-name><ce:surname>Maassab</ce:surname></ce:author><ce:author><ce:given-name>Dan C.</ce:given-name><ce:surname>DeBorde</ce:surname></ce:author><ce:affiliation><ce:textfn>Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA</ce:textfn></ce:affiliation></ce:author-group><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected. In addition, the starting virus should be a recent isolate not as yet adapted to a tissue culture host and the cold-adaptation process should then occur in a host heterologous to the virus' normal host. These viruses have been reviewed in the light of their cold-adaptation method and successful production of an attenuated line as virus vaccine candidate. Finally, detailed information is presented for the cold-adaptation process in influenza virus.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Viruses</ce:text></ce:keyword><ce:keyword><ce:text>cold adaptation</ce:text></ce:keyword><ce:keyword><ce:text>live virus vaccines</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Development and characterization of cold-adapted viruses for use as live virus vaccines</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Development and characterization of cold-adapted viruses for use as live virus vaccines</title></titleInfo><name type="personal"><namePart type="given">H.F.</namePart><namePart type="family">Maassab</namePart><affiliation>Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dan C.</namePart><namePart type="family">DeBorde</namePart><affiliation>Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48109, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1985</dateIssued><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the cold-adaptation phenotype and loss of virulence in the normal host whether animal or man. Overall, the best method of cold adaptation to develop a live virus vaccine line appeared to be a stepwise lowering of the growth temperature allowing time for multiple lesions to occur and/or be selected. In addition, the starting virus should be a recent isolate not as yet adapted to a tissue culture host and the cold-adaptation process should then occur in a host heterologous to the virus' normal host. These viruses have been reviewed in the light of their cold-adaptation method and successful production of an attenuated line as virus vaccine candidate. Finally, detailed information is presented for the cold-adaptation process in influenza virus.</abstract><subject><genre>Keywords</genre><topic>Viruses</topic><topic>cold adaptation</topic><topic>live virus vaccines</topic></subject><relatedItem type="host"><titleInfo><title>Vaccine</title></titleInfo><titleInfo type="abbreviated"><title>JVAC</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1985</dateIssued></originInfo><identifier type="ISSN">0264-410X</identifier><identifier type="PII">S0264-410X(00)X0176-4</identifier><part><date>1985</date><detail type="volume"><number>3</number><caption>vol.</caption></detail><detail type="issue"><number>5</number><caption>no.</caption></detail><extent unit="issue-pages"><start>353</start><end>424</end></extent><extent unit="pages"><start>355</start><end>369</end></extent></part></relatedItem><identifier type="istex">C607A98127712510DE16967DC2491F4D85790467</identifier><identifier type="ark">ark:/67375/6H6-HXJ457L0-R</identifier><identifier type="DOI">10.1016/0264-410X(85)90124-0</identifier><identifier type="PII">0264-410X(85)90124-0</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-HXJ457L0-R/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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