Specific changes in the M1 protein during adaptation of influenza virus to mouse
Identifieur interne : 000463 ( Istex/Corpus ); précédent : 000462; suivant : 000464Specific changes in the M1 protein during adaptation of influenza virus to mouse
Auteurs : A. C. WardSource :
- Archives of Virology [ 0304-8608 ] ; 1995-02-01.
English descriptors
- Teeft :
- Acid change, Acid substitution, Acid substitutions, Amino, Amino acids, Control virulence, Determinant, Direct sequencing, Gene, Gene sequences, Growth rate, Host range restriction, Influenza, Influenza virus, Matrix, Matrix protein, Mouse, Mouse brain, Mouse lung, Neurovirulent, Neurovirulent strains, Nucleic acids, Nucleotide, Nucleotide sequence, Other strains, Proc natl acad, Protein sequences, Royal melbourne hospital, Sequence changes, Substitution, Virol, Virology, Virulence, Virus.
Abstract
Summary: The matrix (M) gene of influenza virus has been implicated as a determinant of virulence for mouse brain and lung. Comparison of the M gene sequences of the mouse brain adapted variants A/NWS/33 and A/WSN/33 to their parent, A/WS/33, identified two specific amino acid substitutions in the M1 protein which correlated with virulence for mouse: Ala41 → Val and Thr139 → Ala.
Url:
DOI: 10.1007/BF01309872
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ISTEX:BF79D8BEBB869E08F46F122F05B8DB24463B9565Le document en format XML
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Ward</name><affiliation><mods:affiliation>Biomolecular Research Institute, Parkville, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, Australia</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Archives of Virology</title><title level="j" type="abbrev">Archives of Virology</title><idno type="ISSN">0304-8608</idno><idno type="eISSN">1432-8798</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1995-02-01">1995-02-01</date><biblScope unit="volume">140</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="383">383</biblScope><biblScope unit="page" to="389">389</biblScope></imprint><idno type="ISSN">0304-8608</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-8608</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acid change</term><term>Acid substitution</term><term>Acid substitutions</term><term>Amino</term><term>Amino acids</term><term>Control virulence</term><term>Determinant</term><term>Direct sequencing</term><term>Gene</term><term>Gene sequences</term><term>Growth rate</term><term>Host range restriction</term><term>Influenza</term><term>Influenza virus</term><term>Matrix</term><term>Matrix protein</term><term>Mouse</term><term>Mouse brain</term><term>Mouse lung</term><term>Neurovirulent</term><term>Neurovirulent strains</term><term>Nucleic acids</term><term>Nucleotide</term><term>Nucleotide sequence</term><term>Other strains</term><term>Proc natl acad</term><term>Protein sequences</term><term>Royal melbourne hospital</term><term>Sequence changes</term><term>Substitution</term><term>Virol</term><term>Virology</term><term>Virulence</term><term>Virus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: The matrix (M) gene of influenza virus has been implicated as a determinant of virulence for mouse brain and lung. Comparison of the M gene sequences of the mouse brain adapted variants A/NWS/33 and A/WSN/33 to their parent, A/WS/33, identified two specific amino acid substitutions in the M1 protein which correlated with virulence for mouse: Ala41 → Val and Thr139 → Ala.</div></front></TEI><istex><corpusName>springer-journals</corpusName><keywords><teeft><json:string>influenza</json:string><json:string>neurovirulent</json:string><json:string>virol</json:string><json:string>virology</json:string><json:string>influenza virus</json:string><json:string>mouse brain</json:string><json:string>gene sequences</json:string><json:string>mouse lung</json:string><json:string>determinant</json:string><json:string>matrix</json:string><json:string>nucleotide sequence</json:string><json:string>amino acids</json:string><json:string>amino</json:string><json:string>acid change</json:string><json:string>nucleic acids</json:string><json:string>sequence changes</json:string><json:string>virulence</json:string><json:string>royal melbourne hospital</json:string><json:string>direct sequencing</json:string><json:string>matrix protein</json:string><json:string>acid substitutions</json:string><json:string>protein sequences</json:string><json:string>proc natl acad</json:string><json:string>neurovirulent strains</json:string><json:string>other strains</json:string><json:string>host range restriction</json:string><json:string>acid substitution</json:string><json:string>control virulence</json:string><json:string>growth rate</json:string><json:string>nucleotide</json:string><json:string>substitution</json:string><json:string>gene</json:string><json:string>virus</json:string><json:string>mouse</json:string></teeft></keywords><author><json:item><name>A. 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Melbourne</OrgName><OrgAddress><City>Parkville</City><State>Victoria</State><Country>Australia</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>The matrix (M) gene of influenza virus has been implicated as a determinant of virulence for mouse brain and lung. Comparison of the M gene sequences of the mouse brain adapted variants A/NWS/33 and A/WSN/33 to their parent, A/WS/33, identified two specific amino acid substitutions in the M<Subscript>1</Subscript> protein which correlated with virulence for mouse: Ala<Superscript>41</Superscript> → Val and Thr<Superscript>139</Superscript> → Ala.</Para></Abstract></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Specific changes in the M1 protein during adaptation of influenza virus to mouse</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Specific changes in the M1 protein during adaptation of influenza virus to mouse</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="given">C.</namePart><namePart type="family">Ward</namePart><affiliation>Biomolecular Research Institute, Parkville, Australia</affiliation><affiliation>Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Victoria, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="BriefCommunication" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-S9SX2MFS-0">brief-communication</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Vienna</placeTerm></place><dateCreated encoding="w3cdtf">1994-05-10</dateCreated><dateIssued encoding="w3cdtf">1995-02-01</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: The matrix (M) gene of influenza virus has been implicated as a determinant of virulence for mouse brain and lung. 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