An epidemiological study of influenza viruses among Chinese farm families with household ducks and pigs
Identifieur interne : 000356 ( Istex/Corpus ); précédent : 000355; suivant : 000357An epidemiological study of influenza viruses among Chinese farm families with household ducks and pigs
Auteurs : L. L. Shu ; N. N. Zhou ; G. B. Sharp ; S. Q. He ; T. J. Zhang ; W. W. Zou ; R. G. WebsterSource :
- Epidemiology and Infection [ 0950-2688 ] ; 1996-08.
Abstract
To examine the possibility of interspecies transmission and genetic reassortment of influenza viruses on farms in Southern China, we surveyed 20 farm families living outside the city of Nanchang who raised pigs and ducks in their homes. Weekly interviews of family members and virus isolation studies of throat swabs and faecal samples, collected from September 1992 to September 1993, established the seasonal pattern of respiratory tract infections in these families and identified 11 influenza viruses (6 in humans and 5 in ducks). Most of the human isolates were type A of H3N2 subtype. Serologic studies of farm pigs indicated infection by the same human viruses circulating in family members, but there was no evidence that either swine or avian viruses had been transmitted to pigs. Eight of 156 human serum samples inhibited the neuraminidase activity of two of the duck isolates, raising the possibility of interspecies transmission of these avian viruses. Genotype analysis of duck and human isolates provided no evidence for reassortment. Our findings support the concept that intermingling of humans, pigs and ducks on Chinese farms is favourable to the generation of new, potentially hazardous strains of influenza virus.
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DOI: 10.1017/S0950268800001291
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Box 318, Memphis, TN 38101, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</mods:affiliation></affiliation></author><author><name sortKey="Sharp, G B" sort="Sharp, G B" uniqKey="Sharp G" first="G. B." last="Sharp">G. B. Sharp</name><affiliation><mods:affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Hematology/ Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</mods:affiliation></affiliation></author><author><name sortKey="He, S Q" sort="He, S Q" uniqKey="He S" first="S. Q." last="He">S. Q. He</name><affiliation><mods:affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</mods:affiliation></affiliation></author><author><name sortKey="Zhang, T J" sort="Zhang, T J" uniqKey="Zhang T" first="T. J." last="Zhang">T. J. Zhang</name><affiliation><mods:affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</mods:affiliation></affiliation></author><author><name sortKey="Zou, W W" sort="Zou, W W" uniqKey="Zou W" first="W. W." last="Zou">W. W. Zou</name><affiliation><mods:affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</mods:affiliation></affiliation></author><author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name><affiliation><mods:affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E2F1B94CB8367BF00A01D1013C77074FF861CB84</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1017/S0950268800001291</idno><idno type="url">https://api.istex.fr/ark:/67375/6GQ-TH4ZL4NB-M/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000356</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000356</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">An epidemiological study of influenza viruses among Chinese farm families with household ducks and pigs</title><author><name sortKey="Shu, L L" sort="Shu, L L" uniqKey="Shu L" first="L. L." last="Shu">L. L. Shu</name><affiliation><mods:affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</mods:affiliation></affiliation></author><author><name sortKey="Zhou, N N" sort="Zhou, N N" uniqKey="Zhou N" first="N. N." last="Zhou">N. N. Zhou</name><affiliation><mods:affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</mods:affiliation></affiliation></author><author><name sortKey="Sharp, G B" sort="Sharp, G B" uniqKey="Sharp G" first="G. B." last="Sharp">G. B. Sharp</name><affiliation><mods:affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Hematology/ Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</mods:affiliation></affiliation></author><author><name sortKey="He, S Q" sort="He, S Q" uniqKey="He S" first="S. Q." last="He">S. Q. He</name><affiliation><mods:affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</mods:affiliation></affiliation></author><author><name sortKey="Zhang, T J" sort="Zhang, T J" uniqKey="Zhang T" first="T. J." last="Zhang">T. J. Zhang</name><affiliation><mods:affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</mods:affiliation></affiliation></author><author><name sortKey="Zou, W W" sort="Zou, W W" uniqKey="Zou W" first="W. W." last="Zou">W. W. Zou</name><affiliation><mods:affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</mods:affiliation></affiliation></author><author><name sortKey="Webster, R G" sort="Webster, R G" uniqKey="Webster R" first="R. G." last="Webster">R. G. Webster</name><affiliation><mods:affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Epidemiology and Infection</title><title level="j" type="abbrev">Epidemiol. Infect.</title><idno type="ISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1996-08">1996-08</date><biblScope unit="volume">117</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="179">179</biblScope><biblScope unit="page" to="188">188</biblScope></imprint><idno type="ISSN">0950-2688</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0950-2688</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine the possibility of interspecies transmission and genetic reassortment of influenza viruses on farms in Southern China, we surveyed 20 farm families living outside the city of Nanchang who raised pigs and ducks in their homes. Weekly interviews of family members and virus isolation studies of throat swabs and faecal samples, collected from September 1992 to September 1993, established the seasonal pattern of respiratory tract infections in these families and identified 11 influenza viruses (6 in humans and 5 in ducks). Most of the human isolates were type A of H3N2 subtype. Serologic studies of farm pigs indicated infection by the same human viruses circulating in family members, but there was no evidence that either swine or avian viruses had been transmitted to pigs. Eight of 156 human serum samples inhibited the neuraminidase activity of two of the duck isolates, raising the possibility of interspecies transmission of these avian viruses. Genotype analysis of duck and human isolates provided no evidence for reassortment. Our findings support the concept that intermingling of humans, pigs and ducks on Chinese farms is favourable to the generation of new, potentially hazardous strains of influenza virus.</div></front></TEI><istex><corpusName>cambridge</corpusName><author><json:item><name>L. L. Shu</name><affiliations><json:string>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</json:string></affiliations></json:item><json:item><name>N. N. Zhou</name><affiliations><json:string>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</json:string><json:string>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</json:string></affiliations></json:item><json:item><name>G. B. Sharp</name><affiliations><json:string>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</json:string><json:string>Department of Hematology/ Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</json:string></affiliations></json:item><json:item><name>S. Q. He</name><affiliations><json:string>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</json:string></affiliations></json:item><json:item><name>T. J. Zhang</name><affiliations><json:string>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</json:string></affiliations></json:item><json:item><name>W. W. Zou</name><affiliations><json:string>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</json:string></affiliations></json:item><json:item><name>R. G. Webster</name><affiliations><json:string>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</json:string></affiliations></json:item></author><articleId><json:string>00129</json:string></articleId><arkIstex>ark:/67375/6GQ-TH4ZL4NB-M</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>To examine the possibility of interspecies transmission and genetic reassortment of influenza viruses on farms in Southern China, we surveyed 20 farm families living outside the city of Nanchang who raised pigs and ducks in their homes. Weekly interviews of family members and virus isolation studies of throat swabs and faecal samples, collected from September 1992 to September 1993, established the seasonal pattern of respiratory tract infections in these families and identified 11 influenza viruses (6 in humans and 5 in ducks). Most of the human isolates were type A of H3N2 subtype. Serologic studies of farm pigs indicated infection by the same human viruses circulating in family members, but there was no evidence that either swine or avian viruses had been transmitted to pigs. Eight of 156 human serum samples inhibited the neuraminidase activity of two of the duck isolates, raising the possibility of interspecies transmission of these avian viruses. Genotype analysis of duck and human isolates provided no evidence for reassortment. Our findings support the concept that intermingling of humans, pigs and ducks on Chinese farms is favourable to the generation of new, potentially hazardous strains of influenza virus.</abstract><qualityIndicators><score>8.545</score><pdfWordCount>4253</pdfWordCount><pdfCharCount>27108</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>595.44 x 841.68 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>191</abstractWordCount><abstractCharCount>1234</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>An epidemiological study of influenza viruses among Chinese farm families with household ducks and pigs</title><pii><json:string>S0950268800001291</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Epidemiology and Infection</title><language><json:string>unknown</json:string></language><issn><json:string>0950-2688</json:string></issn><eissn><json:string>1469-4409</json:string></eissn><publisherId><json:string>HYG</json:string></publisherId><volume>117</volume><issue>1</issue><pages><first>179</first><last>188</last><total>10</total></pages><genre><json:string>journal</json:string></genre></host><ark><json:string>ark:/67375/6GQ-TH4ZL4NB-M</json:string></ark><categories><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>1996</publicationDate><copyrightDate>1996</copyrightDate><doi><json:string>10.1017/S0950268800001291</json:string></doi><id>E2F1B94CB8367BF00A01D1013C77074FF861CB84</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-TH4ZL4NB-M/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-TH4ZL4NB-M/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6GQ-TH4ZL4NB-M/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">An epidemiological study of influenza viruses among Chinese farm families with household ducks and pigs</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><availability><licence><p>Copyright © Cambridge University Press 1996</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</p></availability><date>1996</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>* Corresponding author.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">An epidemiological study of influenza viruses among Chinese farm families with household ducks and pigs</title><author xml:id="author-0000"><persName><forename type="first">L. L.</forename><surname>Shu</surname></persName><affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">N. N.</forename><surname>Zhou</surname></persName><affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</affiliation><affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</affiliation></author><author xml:id="author-0002"><persName><forename type="first">G. B.</forename><surname>Sharp</surname></persName><affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</affiliation><affiliation>Department of Hematology/ Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</affiliation></author><author xml:id="author-0003"><persName><forename type="first">S. Q.</forename><surname>He</surname></persName><affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</affiliation></author><author xml:id="author-0004"><persName><forename type="first">T. J.</forename><surname>Zhang</surname></persName><affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</affiliation></author><author xml:id="author-0005"><persName><forename type="first">W. W.</forename><surname>Zou</surname></persName><affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</affiliation></author><author xml:id="author-0006"><persName><forename type="first">R. G.</forename><surname>Webster</surname></persName><affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</affiliation></author><idno type="istex">E2F1B94CB8367BF00A01D1013C77074FF861CB84</idno><idno type="ark">ark:/67375/6GQ-TH4ZL4NB-M</idno><idno type="DOI">10.1017/S0950268800001291</idno><idno type="PII">S0950268800001291</idno><idno type="article-id">00129</idno></analytic><monogr><title level="j">Epidemiology and Infection</title><title level="j" type="abbrev">Epidemiol. Infect.</title><idno type="pISSN">0950-2688</idno><idno type="eISSN">1469-4409</idno><idno type="publisher-id">HYG</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1996-08"></date><biblScope unit="volume">117</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="179">179</biblScope><biblScope unit="page" to="188">188</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en" style="normal"><p>To examine the possibility of interspecies transmission and genetic reassortment of influenza viruses on farms in Southern China, we surveyed 20 farm families living outside the city of Nanchang who raised pigs and ducks in their homes. Weekly interviews of family members and virus isolation studies of throat swabs and faecal samples, collected from September 1992 to September 1993, established the seasonal pattern of respiratory tract infections in these families and identified 11 influenza viruses (6 in humans and 5 in ducks). Most of the human isolates were type A of H3N2 subtype. Serologic studies of farm pigs indicated infection by the same human viruses circulating in family members, but there was no evidence that either swine or avian viruses had been transmitted to pigs. Eight of 156 human serum samples inhibited the neuraminidase activity of two of the duck isolates, raising the possibility of interspecies transmission of these avian viruses. Genotype analysis of duck and human isolates provided no evidence for reassortment. Our findings support the concept that intermingling of humans, pigs and ducks on Chinese farms is favourable to the generation of new, potentially hazardous strains of influenza virus.</p></abstract></profileDesc><revisionDesc><change when="1996-08">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-TH4ZL4NB-M/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus cambridge not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.2 20060430//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article" dtd-version="2.2" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="publisher-id">HYG</journal-id><journal-title>Epidemiology and Infection</journal-title><abbrev-journal-title>Epidemiol. Infect.</abbrev-journal-title><issn pub-type="ppub">0950-2688</issn><issn pub-type="epub">1469-4409</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1017/S0950268800001291</article-id><article-id pub-id-type="pii">S0950268800001291</article-id><article-id pub-id-type="publisher-id">00129</article-id><title-group><article-title>An epidemiological study of influenza viruses among Chinese farm families with household ducks and pigs</article-title><alt-title alt-title-type="left-running">L. L. Shu and others</alt-title><alt-title alt-title-type="right-running">Influenza in a village in China</alt-title></title-group><contrib-group><contrib><name name-style="western"><surname>Shu</surname><given-names>L. L.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib><name name-style="western"><surname>Zhou</surname><given-names>N. N.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib><name name-style="western"><surname>Sharp</surname><given-names>G. B.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib><name name-style="western"><surname>He</surname><given-names>S. Q.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib><name name-style="western"><surname>Zhang</surname><given-names>T. J.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib><name name-style="western"><surname>Zou</surname><given-names>W. W.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib><name name-style="western"><surname>Webster</surname><given-names>R. G.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1"><label><sup>1</sup></label><addr-line>Department of Virology/Molecular Biology</addr-line>, <institution>St. Jude Children's Research Hospital</institution>, <addr-line>332 North Lauderdale</addr-line>, <addr-line>P. O. Box 318</addr-line>, <addr-line>Memphis</addr-line>, <addr-line>TN 38101</addr-line>, <country>USA</country></aff><aff id="aff2"><label><sup>2</sup></label><addr-line>Department of Microbiology</addr-line>, <institution>Jiangxi Medical College</institution>, <addr-line>162 Ba Yi Road</addr-line>, <addr-line>Nanchang</addr-line>, <addr-line>Jiangxi</addr-line>, <addr-line>China</addr-line></aff><aff id="aff3"><label><sup>3</sup></label><addr-line>Department of Hematology/ Oncology</addr-line>, <institution>St. Jude Children's Research Hospital</institution>, <addr-line>332 North Lauderdale</addr-line>, <addr-line>P. O. Box 318</addr-line>, <addr-line>Memphis</addr-line>, <addr-line>TN 38101</addr-line>, <country>USA</country></aff><author-notes><corresp id="cor1"><label>*</label> Corresponding author.</corresp></author-notes><pub-date pub-type="ppub"><month>08</month><year>1996</year></pub-date><volume>117</volume><issue>1</issue><fpage seq="26">179</fpage><lpage>188</lpage><history><date date-type="accepted"><day>18</day><month>01</month><year>1996</year></date></history><permissions><copyright-statement>Copyright © Cambridge University Press 1996</copyright-statement><copyright-year>1996</copyright-year><copyright-holder>Cambridge University Press</copyright-holder></permissions><abstract abstract-type="normal"><title>Summary</title><p>To examine the possibility of interspecies transmission and genetic reassortment of influenza viruses on farms in Southern China, we surveyed 20 farm families living outside the city of Nanchang who raised pigs and ducks in their homes. Weekly interviews of family members and virus isolation studies of throat swabs and faecal samples, collected from September 1992 to September 1993, established the seasonal pattern of respiratory tract infections in these families and identified 11 influenza viruses (6 in humans and 5 in ducks). Most of the human isolates were type A of H3N2 subtype. Serologic studies of farm pigs indicated infection by the same human viruses circulating in family members, but there was no evidence that either swine or avian viruses had been transmitted to pigs. Eight of 156 human serum samples inhibited the neuraminidase activity of two of the duck isolates, raising the possibility of interspecies transmission of these avian viruses. Genotype analysis of duck and human isolates provided no evidence for reassortment. Our findings support the concept that intermingling of humans, pigs and ducks on Chinese farms is favourable to the generation of new, potentially hazardous strains of influenza virus.</p></abstract><counts><page-count count="10"></page-count></counts><custom-meta-wrap><custom-meta><meta-name>pdf</meta-name><meta-value>S0950268800001291a.pdf</meta-value></custom-meta></custom-meta-wrap></article-meta></front><back><ref-list><title>References</title><ref><citation citation-type="book" id="ref001"><label>1.</label> <name name-style="western"><surname>Lamb</surname><given-names>RA</given-names></name>. <source>The influenza virus RNA segments and their encoded proteins</source>. In: <name name-style="western"><surname>Palese</surname><given-names>P</given-names></name>, <name name-style="western"><surname>Kingsbury</surname><given-names>DW</given-names></name>, ed. 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L.</namePart><namePart type="family">Shu</namePart><affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N. N.</namePart><namePart type="family">Zhou</namePart><affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</affiliation><affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. B.</namePart><namePart type="family">Sharp</namePart><affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</affiliation><affiliation>Department of Hematology/ Oncology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S. Q.</namePart><namePart type="family">He</namePart><affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T. J.</namePart><namePart type="family">Zhang</namePart><affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W. W.</namePart><namePart type="family">Zou</namePart><affiliation>Department of Microbiology, Jiangxi Medical College, 162 Ba Yi Road, Nanchang, Jiangxi, China</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R. G.</namePart><namePart type="family">Webster</namePart><affiliation>Department of Virology/Molecular Biology, St. Jude Children's Research Hospital, 332 North Lauderdale, P. O. Box 318, Memphis, TN 38101, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Cambridge University Press</publisher><place><placeTerm type="text">Cambridge, UK</placeTerm></place><dateIssued encoding="w3cdtf">1996-08</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract type="normal" lang="en">To examine the possibility of interspecies transmission and genetic reassortment of influenza viruses on farms in Southern China, we surveyed 20 farm families living outside the city of Nanchang who raised pigs and ducks in their homes. Weekly interviews of family members and virus isolation studies of throat swabs and faecal samples, collected from September 1992 to September 1993, established the seasonal pattern of respiratory tract infections in these families and identified 11 influenza viruses (6 in humans and 5 in ducks). Most of the human isolates were type A of H3N2 subtype. Serologic studies of farm pigs indicated infection by the same human viruses circulating in family members, but there was no evidence that either swine or avian viruses had been transmitted to pigs. Eight of 156 human serum samples inhibited the neuraminidase activity of two of the duck isolates, raising the possibility of interspecies transmission of these avian viruses. Genotype analysis of duck and human isolates provided no evidence for reassortment. Our findings support the concept that intermingling of humans, pigs and ducks on Chinese farms is favourable to the generation of new, potentially hazardous strains of influenza virus.</abstract><note type="author-notes">* Corresponding author.</note><relatedItem type="host"><titleInfo><title>Epidemiology and Infection</title></titleInfo><titleInfo type="abbreviated"><title>Epidemiol. Infect.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0950-2688</identifier><identifier type="eISSN">1469-4409</identifier><identifier type="PublisherID">HYG</identifier><part><date>1996</date><detail type="volume"><caption>vol.</caption><number>117</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>179</start><end>188</end><total>10</total></extent></part></relatedItem><identifier type="istex">E2F1B94CB8367BF00A01D1013C77074FF861CB84</identifier><identifier type="ark">ark:/67375/6GQ-TH4ZL4NB-M</identifier><identifier type="DOI">10.1017/S0950268800001291</identifier><identifier type="PII">S0950268800001291</identifier><identifier type="ArticleID">00129</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © Cambridge University Press 1996</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</recordContentSource><recordOrigin>Copyright © Cambridge University Press 1996</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-TH4ZL4NB-M/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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