H2N2V1, Istex, Corpus, bibRecord, 000274

Local Immunity to Influenza Virus in Chicken Tracheal Organ Cultures

Identifieur interne : 000274 ( Istex/Corpus ); précédent : 000273; suivant : 000275

Local Immunity to Influenza Virus in Chicken Tracheal Organ Cultures

Auteurs : R. C. Schmidt ; H. F. Maassab

Source :

Journal of Infectious Diseases [ 0022-1899 ] ; 1974.

RBID : ISTEX:1A9BF5201E907DBA26F0C343007250A280564F6D

Abstract

Immunity to influenza A virus was demonstrated in tracheal organ cultures by parallel titration of challenge virus in replicate cultures prepared from control and virus-inoculated chickens. Five to 10 times more virus was required to infect 50% of cultures from chickens inoculated intranasally and intratracheally with active virus than from control chickens or from chickens with serum antibody induced by intramuscular and intraperitoneal inoculation of inactivated virus. Viral yield from resistant cultures was reduced. Cultures from chickens immunized with either of two antigenically distinct influenza A viruses were resistant to homotypic virus but susceptible to the heterotypic strain. Medium from such cultures contained virus-specific HAI and neutralizing activity. Cultures from some chickens inoculated up to 31 days previously were resistant. The immune state became undetectable between the first and fourth days of culturing. Results suggest that a secretory immunologic system was at least partially responsible for the immunity of the organ cultures.

Url:

https://api.istex.fr/ark:/67375/HXZ-N89RCC2T-D/fulltext.pdf

DOI: 10.1093/infdis/129.6.637

Links to Exploration step

ISTEX:1A9BF5201E907DBA26F0C343007250A280564F6D

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<surname>Maassab</surname>

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<aff>From the <institution>Department of Epidemiology, School of Public Health, The University of Michigan</institution>
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<fn fn-type="supported-by">

<p>This investigation was supported in part by training grant no. 2-TO1-AI-00060-11 and research fellowships no. I-FO2-AI-46718-01 and no. 2-FO2-AI-46718-02 from the National Institute of Allergy and Infectious Diseases (to R.C.S.) and under the auspices of the Commission on Influenza, Armed Forces Epidemiological Board, by research contract no. DADA17-70-C-0050 from the Office of the U.S. Army Medical Research and Development Command.</p>

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<fn fn-type="presented-at">

<p>This paper was presented in part at the 71st annual meeting of the American Society for Microbiology, May 4, 1971, Minneapolis, Minnesota.</p>

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<fn fn-type="other">

<p>Please address requests for reprints to Dr. R. C. Schmidt, Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan 48104.</p>

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<p>Immunity to influenza A virus was demonstrated in tracheal organ cultures by parallel titration of challenge virus in replicate cultures prepared from control and virus-inoculated chickens. Five to 10 times more virus was required to infect 50% of cultures from chickens inoculated intranasally and intratracheally with active virus than from control chickens or from chickens with serum antibody induced by intramuscular and intraperitoneal inoculation of inactivated virus. Viral yield from resistant cultures was reduced. Cultures from chickens immunized with either of two antigenically distinct influenza A viruses were resistant to homotypic virus but susceptible to the heterotypic strain. Medium from such cultures contained virus-specific HAI and neutralizing activity. Cultures from some chickens inoculated up to 31 days previously were resistant. The immune state became undetectable between the first and fourth days of culturing. Results suggest that a secretory immunologic system was at least partially responsible for the immunity of the organ cultures.</p>

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<abstract>Immunity to influenza A virus was demonstrated in tracheal organ cultures by parallel titration of challenge virus in replicate cultures prepared from control and virus-inoculated chickens. Five to 10 times more virus was required to infect 50% of cultures from chickens inoculated intranasally and intratracheally with active virus than from control chickens or from chickens with serum antibody induced by intramuscular and intraperitoneal inoculation of inactivated virus. Viral yield from resistant cultures was reduced. Cultures from chickens immunized with either of two antigenically distinct influenza A viruses were resistant to homotypic virus but susceptible to the heterotypic strain. Medium from such cultures contained virus-specific HAI and neutralizing activity. Cultures from some chickens inoculated up to 31 days previously were resistant. The immune state became undetectable between the first and fourth days of culturing. Results suggest that a secretory immunologic system was at least partially responsible for the immunity of the organ cultures.</abstract>
<note type="footnotes">This investigation was supported in part by training grant no. 2-TO1-AI-00060-11 and research fellowships no. I-FO2-AI-46718-01 and no. 2-FO2-AI-46718-02 from the National Institute of Allergy and Infectious Diseases (to R.C.S.) and under the auspices of the Commission on Influenza, Armed Forces Epidemiological Board, by research contract no. DADA17-70-C-0050 from the Office of the U.S. Army Medical Research and Development Command.</note>
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<part><date>1974</date>
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<number>129</number>
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<extent unit="pages"><start>637</start>
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<accessCondition type="use and reproduction" contentType="copyright">© 1974 by the University of Chicago</accessCondition>
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Local Immunity to Influenza Virus in Chicken Tracheal Organ Cultures

Local Immunity to Influenza Virus in Chicken Tracheal Organ Cultures

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