H2N2V1, Istex, Corpus, bibRecord, 000244

Long-term stability of the anti-influenza A compounds—amantadine and rimantadine

Identifieur interne : 000244 ( Istex/Corpus ); précédent : 000243; suivant : 000245

Long-term stability of the anti-influenza A compounds—amantadine and rimantadine

Auteurs : Christoph Scholtissek ; Robert G. Webster

Source :

Antiviral Research [ 0166-3542 ] ; 1998.

RBID : ISTEX:B10FB66A27914B132AE647C094BB6970C7A5EF9F

English descriptors

KwdEn :
- Amantadine, Anti-influenza compounds, Rimantadine.
Teeft :
- Amantadine, Amantadine hydrochloride, Antiviral activity, Channel activity, Compounds amantadine, Drug preparations, Elsevier science, Forest pharmaceuticals, Giessen, Hydrochloride, Jude research hospital, Plaque, Plaque formation, Rimantadine, Rimantadine hydrochloride, Room temperature, Webster anti6iral research.

Abstract

Abstract: Amantadine and rimantadine hydrochloride were tested for stability after storage at different temperatures and under different conditions for extended periods of time. Both compounds were quite stable after storage for at least 25 years at ambient temperature; they both retained full antiviral activity after long-term storage or after boiling and holding at 65–85°C for several days. Thus, amantadine and rimantadine could be synthesized in large quantities and stored for at least one generation without loss of activity in preparation for the next influenza A pandemic in humans.

Url:

https://api.istex.fr/ark:/67375/6H6-PBSVFZWR-S/fulltext.pdf

DOI: 10.1016/S0166-3542(98)00015-1

Links to Exploration step

ISTEX:B10FB66A27914B132AE647C094BB6970C7A5EF9F

Le document en format XML

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Long-term stability of the anti-influenza A compounds—amantadine and rimantadine

Long-term stability of the anti-influenza A compounds—amantadine and rimantadine

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