A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity
Identifieur interne : 000237 ( Istex/Corpus ); précédent : 000236; suivant : 000238A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity
Auteurs : A. Clark ; C. W. Potter ; R. Jennings ; J. P. Nicholl ; A. F. Langrick ; G. C. Schild ; J. M. Wood ; D. A. J. TyrrellSource :
- Journal of Hygiene [ 0022-1724 ] ; 1983-06.
Abstract
Groups of volunteers were immunized subcutaneously with one of three inacti vated influenza virus A/USSR/77 (HlNl) vaccine preparations; a whole virus vaccine, a surface-antigen subunit adsorbed vaccine, or an aqueous surface-antigen subunit vaccine. The reactions to immunization were recorded, and the antibody response was measured 1 month later. A fourth group of volunteers were inoculated intranasally with live attentuated A/USSR/77 (H1N1) influenza virus; the reactions and antibody response of these volunteers were also measured. One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.
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DOI: 10.1017/S0022172400028989
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Jennings</name><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation></affiliation></author><author><name sortKey="Nicholl, J P" sort="Nicholl, J P" uniqKey="Nicholl J" first="J. P." last="Nicholl">J. P. Nicholl</name><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation></affiliation></author><author><name sortKey="Langrick, A F" sort="Langrick, A F" uniqKey="Langrick A" first="A. F." last="Langrick">A. F. Langrick</name><affiliation><mods:affiliation>Health Centre, University of Birmingham, Birmingham, B15 2TJ</mods:affiliation></affiliation></author><author><name sortKey="Schild, G C" sort="Schild, G C" uniqKey="Schild G" first="G. C." last="Schild">G. C. Schild</name><affiliation><mods:affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</mods:affiliation></affiliation></author><author><name sortKey="Wood, J M" sort="Wood, J M" uniqKey="Wood J" first="J. M." last="Wood">J. M. Wood</name><affiliation><mods:affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</mods:affiliation></affiliation></author><author><name sortKey="Tyrrell, D A J" sort="Tyrrell, D A J" uniqKey="Tyrrell D" first="D. A. J." last="Tyrrell">D. A. J. Tyrrell</name><affiliation><mods:affiliation>Division of Communicable Diseases, Medical Research Council, Clinical Research Centre, Watford Road, Harrow, HA1 3UJ</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:17AB2A8F735A009E850C3C45FB0BE450F917DDB5</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1017/S0022172400028989</idno><idno type="url">https://api.istex.fr/ark:/67375/6GQ-WDVTG962-1/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000237</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000237</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity</title><author><name sortKey="Clark, A" sort="Clark, A" uniqKey="Clark A" first="A." last="Clark">A. Clark</name><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation></affiliation></author><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation></affiliation></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation></affiliation></author><author><name sortKey="Nicholl, J P" sort="Nicholl, J P" uniqKey="Nicholl J" first="J. P." last="Nicholl">J. P. Nicholl</name><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation></affiliation></author><author><name sortKey="Langrick, A F" sort="Langrick, A F" uniqKey="Langrick A" first="A. F." last="Langrick">A. F. Langrick</name><affiliation><mods:affiliation>Health Centre, University of Birmingham, Birmingham, B15 2TJ</mods:affiliation></affiliation></author><author><name sortKey="Schild, G C" sort="Schild, G C" uniqKey="Schild G" first="G. C." last="Schild">G. C. Schild</name><affiliation><mods:affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</mods:affiliation></affiliation></author><author><name sortKey="Wood, J M" sort="Wood, J M" uniqKey="Wood J" first="J. M." last="Wood">J. M. Wood</name><affiliation><mods:affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</mods:affiliation></affiliation></author><author><name sortKey="Tyrrell, D A J" sort="Tyrrell, D A J" uniqKey="Tyrrell D" first="D. A. J." last="Tyrrell">D. A. J. Tyrrell</name><affiliation><mods:affiliation>Division of Communicable Diseases, Medical Research Council, Clinical Research Centre, Watford Road, Harrow, HA1 3UJ</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. Hyg.</title><idno type="ISSN">0022-1724</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1983-06">1983-06</date><biblScope unit="volume">90</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="351">351</biblScope><biblScope unit="page" to="359">359</biblScope></imprint><idno type="ISSN">0022-1724</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1724</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Groups of volunteers were immunized subcutaneously with one of three inacti vated influenza virus A/USSR/77 (HlNl) vaccine preparations; a whole virus vaccine, a surface-antigen subunit adsorbed vaccine, or an aqueous surface-antigen subunit vaccine. The reactions to immunization were recorded, and the antibody response was measured 1 month later. A fourth group of volunteers were inoculated intranasally with live attentuated A/USSR/77 (H1N1) influenza virus; the reactions and antibody response of these volunteers were also measured. One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.</div></front></TEI><istex><corpusName>cambridge</corpusName><author><json:item><name>A. Clark</name><affiliations><json:string>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</json:string></affiliations></json:item><json:item><name>C. W. Potter</name><affiliations><json:string>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</json:string></affiliations></json:item><json:item><name>R. Jennings</name><affiliations><json:string>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</json:string></affiliations></json:item><json:item><name>J. P. Nicholl</name><affiliations><json:string>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</json:string></affiliations></json:item><json:item><name>A. F. Langrick</name><affiliations><json:string>Health Centre, University of Birmingham, Birmingham, B15 2TJ</json:string></affiliations></json:item><json:item><name>G. C. Schild</name><affiliations><json:string>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</json:string></affiliations></json:item><json:item><name>J. M. Wood</name><affiliations><json:string>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</json:string></affiliations></json:item><json:item><name>D. A. J. 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One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.</abstract><qualityIndicators><score>7.241</score><pdfWordCount>3513</pdfWordCount><pdfCharCount>21939</pdfCharCount><pdfVersion>1.5</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>523.44 x 769.68 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>144</abstractWordCount><abstractCharCount>1030</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity</title><pii><json:string>S0022172400028989</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Journal of Hygiene</title><language><json:string>unknown</json:string></language><issn><json:string>0022-1724</json:string></issn><publisherId><json:string>HYG</json:string></publisherId><volume>90</volume><issue>3</issue><pages><first>351</first><last>359</last><total>9</total></pages><genre><json:string>journal</json:string></genre></host><ark><json:string>ark:/67375/6GQ-WDVTG962-1</json:string></ark><categories><wos></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Public Health, Environmental and Occupational Health</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Immunology and Microbiology</json:string><json:string>3 - Immunology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1983</publicationDate><copyrightDate>1983</copyrightDate><doi><json:string>10.1017/S0022172400028989</json:string></doi><id>17AB2A8F735A009E850C3C45FB0BE450F917DDB5</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-WDVTG962-1/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-WDVTG962-1/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6GQ-WDVTG962-1/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><availability><licence><p>Copyright © Cambridge University Press 1983</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</p></availability><date>1983</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity</title><author xml:id="author-0000"><persName><forename type="first">A.</forename><surname>Clark</surname></persName><affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</affiliation></author><author xml:id="author-0001"><persName><forename type="first">C. W.</forename><surname>Potter</surname></persName><affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</affiliation></author><author xml:id="author-0002"><persName><forename type="first">R.</forename><surname>Jennings</surname></persName><affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</affiliation></author><author xml:id="author-0003"><persName><forename type="first">J. P.</forename><surname>Nicholl</surname></persName><affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</affiliation></author><author xml:id="author-0004"><persName><forename type="first">A. F.</forename><surname>Langrick</surname></persName><affiliation>Health Centre, University of Birmingham, Birmingham, B15 2TJ</affiliation></author><author xml:id="author-0005"><persName><forename type="first">G. C.</forename><surname>Schild</surname></persName><affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</affiliation></author><author xml:id="author-0006"><persName><forename type="first">J. M.</forename><surname>Wood</surname></persName><affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</affiliation></author><author xml:id="author-0007"><persName><forename type="first">D. A. J.</forename><surname>Tyrrell</surname></persName><affiliation>Division of Communicable Diseases, Medical Research Council, Clinical Research Centre, Watford Road, Harrow, HA1 3UJ</affiliation></author><idno type="istex">17AB2A8F735A009E850C3C45FB0BE450F917DDB5</idno><idno type="ark">ark:/67375/6GQ-WDVTG962-1</idno><idno type="DOI">10.1017/S0022172400028989</idno><idno type="PII">S0022172400028989</idno><idno type="article-id">02898</idno></analytic><monogr><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. Hyg.</title><idno type="pISSN">0022-1724</idno><idno type="publisher-id">HYG</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1983-06"></date><biblScope unit="volume">90</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="351">351</biblScope><biblScope unit="page" to="359">359</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1983</date></creation><langUsage><language ident="en">en</language></langUsage><abstract style="normal"><p>Groups of volunteers were immunized subcutaneously with one of three inacti vated influenza virus A/USSR/77 (HlNl) vaccine preparations; a whole virus vaccine, a surface-antigen subunit adsorbed vaccine, or an aqueous surface-antigen subunit vaccine. The reactions to immunization were recorded, and the antibody response was measured 1 month later. A fourth group of volunteers were inoculated intranasally with live attentuated A/USSR/77 (H1N1) influenza virus; the reactions and antibody response of these volunteers were also measured. One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.</p></abstract></profileDesc><revisionDesc><change when="1983-06">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-WDVTG962-1/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus cambridge not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="US-ASCII"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.2 20060430//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article dtd-version="2.2" article-type="research-article"><front><journal-meta><journal-id journal-id-type="publisher-id">HYG</journal-id><journal-title>Journal of Hygiene</journal-title><abbrev-journal-title>J. Hyg.</abbrev-journal-title><issn pub-type="ppub">0022-1724</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1017/S0022172400028989</article-id><article-id pub-id-type="pii">S0022172400028989</article-id><article-id pub-id-type="publisher-id">02898</article-id><title-group><article-title>A comparison of live and inactivated influenza A (H1N1) virus vaccines: Short-term immunity</article-title><alt-title alt-title-type="left-running">A. Clark and others</alt-title><alt-title alt-title-type="right-running">Influenza A virus vaccines. 1</alt-title></title-group><contrib-group><contrib><name><surname>Clark</surname><given-names>A.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib><name><surname>Potter</surname><given-names>C. W.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib><name><surname>Jennings</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib><name><surname>Nicholl</surname><given-names>J. P.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib><name><surname>Langrick</surname><given-names>A. F.</given-names></name><xref ref-type="aff" rid="aff2"></xref></contrib><contrib><name><surname>Schild</surname><given-names>G. C.</given-names></name><xref ref-type="aff" rid="aff3"></xref></contrib><contrib><name><surname>Wood</surname><given-names>J. M.</given-names></name><xref ref-type="aff" rid="aff3"></xref></contrib><contrib><name><surname>Tyrrell</surname><given-names>D. A. J.</given-names></name><xref ref-type="aff" rid="aff4"></xref></contrib></contrib-group><aff id="aff1"><addr-line>Departments of Medical Microbiology</addr-line>, <addr-line>Virology and Community Medicine</addr-line>, <institution>University of Sheffield Medical School</institution>, <addr-line>Beech Hill Road, Sheffield, 510 2RX</addr-line></aff><aff id="aff2"><addr-line>Health Centre</addr-line>, <institution>University of Birmingham</institution>, <addr-line>Birmingham</addr-line>, <addr-line>B15 2TJ</addr-line></aff><aff id="aff3"><addr-line>Division of Viral Products</addr-line>, <institution>National Institute for Biological Standardization and Control</institution>, <addr-line>Holly Hill</addr-line>, <addr-line>Hampstead</addr-line>, <addr-line>London</addr-line>, <addr-line>NW3 6RB</addr-line></aff><aff id="aff4"><addr-line>Division of Communicable Diseases</addr-line>, <addr-line>Medical Research Council</addr-line>, <addr-line>Clinical Research Centre</addr-line>, <addr-line>Watford Road</addr-line>, <addr-line>Harrow</addr-line>, <addr-line>HA1 3UJ</addr-line></aff><pub-date pub-type="ppub"><month>06</month><year>1983</year></pub-date><volume>90</volume><issue>3</issue><fpage seq="5">351</fpage><lpage>359</lpage><history><date date-type="received"><day>14</day><month>12</month><year>1982</year></date><date date-type="accepted"><day>11</day><month>01</month><year>1983</year></date></history><permissions><copyright-statement>Copyright © Cambridge University Press 1983</copyright-statement><copyright-year>1983</copyright-year><copyright-holder>Cambridge University Press</copyright-holder></permissions><abstract abstract-type="normal"><title>SUMMARY</title><p>Groups of volunteers were immunized subcutaneously with one of three inacti vated influenza virus A/USSR/77 (HlNl) vaccine preparations; a whole virus vaccine, a surface-antigen subunit adsorbed vaccine, or an aqueous surface-antigen subunit vaccine. The reactions to immunization were recorded, and the antibody response was measured 1 month later. A fourth group of volunteers were inoculated intranasally with live attentuated A/USSR/77 (H1N1) influenza virus; the reactions and antibody response of these volunteers were also measured. One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.</p></abstract><counts><page-count count="9"></page-count></counts><custom-meta-wrap><custom-meta><meta-name>pdf</meta-name><meta-value>S0022172400028989a.pdf</meta-value></custom-meta></custom-meta-wrap></article-meta></front><back><ref-list><title>REFERENCES</title><ref><citation id="ref001" citation-type="journal"><name><surname>Aymard-Henry</surname><given-names>M.</given-names></name>, <name><surname>Coleman</surname><given-names>M. T.</given-names></name>, <name><surname>Dowdle</surname><given-names>W. R.</given-names></name>, <name><surname>Layer</surname><given-names>W. G.</given-names></name> & <name><surname>Webster</surname><given-names>R. 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W.</namePart><namePart type="family">Potter</namePart><affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Jennings</namePart><affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. P.</namePart><namePart type="family">Nicholl</namePart><affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. F.</namePart><namePart type="family">Langrick</namePart><affiliation>Health Centre, University of Birmingham, Birmingham, B15 2TJ</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G. C.</namePart><namePart type="family">Schild</namePart><affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. M.</namePart><namePart type="family">Wood</namePart><affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. A. J.</namePart><namePart type="family">Tyrrell</namePart><affiliation>Division of Communicable Diseases, Medical Research Council, Clinical Research Centre, Watford Road, Harrow, HA1 3UJ</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Cambridge University Press</publisher><place><placeTerm type="text">Cambridge, UK</placeTerm></place><dateIssued encoding="w3cdtf">1983-06</dateIssued><copyrightDate encoding="w3cdtf">1983</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract type="normal">Groups of volunteers were immunized subcutaneously with one of three inacti vated influenza virus A/USSR/77 (HlNl) vaccine preparations; a whole virus vaccine, a surface-antigen subunit adsorbed vaccine, or an aqueous surface-antigen subunit vaccine. The reactions to immunization were recorded, and the antibody response was measured 1 month later. A fourth group of volunteers were inoculated intranasally with live attentuated A/USSR/77 (H1N1) influenza virus; the reactions and antibody response of these volunteers were also measured. One month after immunization, the incidence of infection by challenge with homologous live attentuated virus was determined for all groups of volunteers. The results showed that all four vaccines used were relatively non-reactogenic, and that inactivated vaccines induced higher titres of serum antibody than the live attenuated vaccine. All the vaccines induced significant protection against challenge virus infection which was directly related to the level of serum HI antibody response.</abstract><relatedItem type="host"><titleInfo><title>Journal of Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>J. Hyg.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-1724</identifier><identifier type="PublisherID">HYG</identifier><part><date>1983</date><detail type="volume"><caption>vol.</caption><number>90</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>351</start><end>359</end><total>9</total></extent></part></relatedItem><identifier type="istex">17AB2A8F735A009E850C3C45FB0BE450F917DDB5</identifier><identifier type="ark">ark:/67375/6GQ-WDVTG962-1</identifier><identifier type="DOI">10.1017/S0022172400028989</identifier><identifier type="PII">S0022172400028989</identifier><identifier type="ArticleID">02898</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © Cambridge University Press 1983</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</recordContentSource><recordOrigin>Copyright © Cambridge University Press 1983</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-WDVTG962-1/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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