Perspectives on Pandemics: A Research Agenda
Identifieur interne : 000152 ( Istex/Corpus ); précédent : 000151; suivant : 000153Perspectives on Pandemics: A Research Agenda
Auteurs : Edwin D. KilbourneSource :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1997.
Abstract
During the 20th century, indisputable pandemics of influenza occurred in 1918, 1957, and 1968. The pandemics of 1957 (A/H2N2) and 1968 (A/H3N2) were associated with major antigenic changes in the virus, probably reflecting introduction by recombination of animal virus genes. The 1918 epidemic is beyond the reach of modern virology but, based on seroarcheology, appears to have been caused by a virus very similar to present swine (A/H1N1) influenza viruses. Changes in both principal antigens of the A/H1N1 subtype in 1947 resulted in total vaccine failure and pandemic spread of virus. On the basis of three periods of prevalence in the 20th century, A/H1N1 may be the “default” human virus, although the 39-year persistence of A/H3N2 to the present challenges this view. Only H1, H2, and H3 and N1 and N2 antigens have been found in human influenza viruses, but virologic history is too brief to preclude the contribution of other antigens to future pandemics.
Url:
DOI: 10.1086/514171
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ISTEX:5F5EA68C3E56147ABDCF5202BD57D6A34F5E0DC8Le document en format XML
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Kilbourne</name><affiliation><mods:affiliation>Department of Microbiology and Immunology, New York Medical College, Valhalla, New York</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Infectious Diseases</title><title level="j" type="abbrev">J Infect Dis.</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date when="1997-08">1997</date><biblScope unit="vol">176</biblScope><biblScope unit="issue">Supplemet_1</biblScope><biblScope unit="page" from="S29">S29</biblScope><biblScope unit="page" to="S31">S31</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">During the 20th century, indisputable pandemics of influenza occurred in 1918, 1957, and 1968. 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