Principle of cold-adaptation in the derivation of live attenuated respiratory virus vaccines
Identifieur interne : 000130 ( Istex/Corpus ); précédent : 000129; suivant : 000131Principle of cold-adaptation in the derivation of live attenuated respiratory virus vaccines
Auteurs : H. F. MaassabSource :
Abstract
Abstract: Adaptation of selected human respiratory viruses to grow at suboptimal temperatures has provided a valuable tool for use in the development of live respiratory virus vaccines in man. The early report that live influenza virus vaccines can be made suitable for administration to children and young adults by passage at 25°C, stimulated our interest in deterring whether cold-adaptation can be used regularly to obtain attenuated vaccines that were well tolerated by and immunogenic for humans of all ages.1,2 This chapter describes the development, characterization and evaluation of the cold-adapted respiratory viruses in animals and also in limited testing in man.
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DOI: 10.1007/978-3-642-58607-1_7
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vaccines in man. The early report that live influenza virus vaccines can be made suitable for administration to children and young adults by passage at 25°C, stimulated our interest in deterring whether cold-adaptation can be used regularly to obtain attenuated vaccines that were well tolerated by and immunogenic for humans of all ages.<Superscript>1,2</Superscript> This chapter describes the development, characterization and evaluation of the cold-adapted respiratory viruses in animals and also in limited testing in man.</Para></Abstract></ChapterHeader><NoBody></NoBody></Chapter></Part></Book></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Principle of cold-adaptation in the derivation of live attenuated respiratory virus vaccines</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Principle of cold-adaptation in the derivation of live attenuated respiratory virus vaccines</title></titleInfo><name type="personal"><namePart type="given">H.</namePart><namePart type="given">F.</namePart><namePart type="family">Maassab</namePart><affiliation>School of Public Health, Department of Epidemology, University of Michigan, 109 Observatory Street, 48109, Ann Arbor, Michigan, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Professor</namePart><namePart type="given">Rosa</namePart><namePart type="family">Margesin</namePart><affiliation>Institute of Microbiology, University of Innsbruck, Technikerstraße 25, A-6020, Innsbruck, Austria</affiliation><affiliation>E-mail: rosa.margesin@uibk.ac.at</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Professor</namePart><namePart type="given">Franz</namePart><namePart type="family">Schinner</namePart><affiliation>Institute of Microbiology, University of Innsbruck, Technikerstraße 25, A-6020, Innsbruck, Austria</affiliation><affiliation>E-mail: franz.schinner@uibk.ac.at</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="chapter" displayLabel="chapter" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-CGT4WMJM-6"></genre><originInfo><publisher>Springer Berlin Heidelberg</publisher><place><placeTerm type="text">Berlin, Heidelberg</placeTerm></place><dateIssued encoding="w3cdtf">1999</dateIssued><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: Adaptation of selected human respiratory viruses to grow at suboptimal temperatures has provided a valuable tool for use in the development of live respiratory virus vaccines in man. 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