Induction of homotypic and heterotypic T- and B-cell immunity with influenza A virus in mice
Identifieur interne : 000128 ( Istex/Corpus ); précédent : 000127; suivant : 000129Induction of homotypic and heterotypic T- and B-cell immunity with influenza A virus in mice
Auteurs : D. Armerding ; E. LiehlSource :
- Cellular Immunology [ 0008-8749 ] ; 1981.
English descriptors
- Teeft :
- Academic press, Allantoic fluid, Antibody titers, Armerding, Assay, Assay system, Attenuated, Attenuated virus strains, Attenuated viruses, Cold recombinants, Culture supernatants, Cytolytic, Cytolytic activity, Cytotoxic, Cytotoxicity assay, Different results, Effector, Effector cells, First series, Heterologous, Heterologous influenza substrains, Heterologous virus, Heterotypic, Heterotypic influenza, Heterotypic protection, Heterotypic virus, Honl, Honl virus, Hswlnl, Hswlnl hznz, Immunity, Immunol, Immunological memory, Infectious virus, Influenza, Influenza subtype, Influenza virus, Influenza viruses, Killer responses, Latter case, Liehl, Lymphocyte, Mice unprimed, Microtiter method, Mouse, Normal mice, Normal rabbit serum, Other viruses, Presensitized mice, Primary response, Primary responses, Primary sensitization, Procedural guide, Respective influenza, Same route, Schild, Secondary responses, Sensitizing virus, Specific honi, Spleen cells, Substrain specificity, Substrains, Subtypes, Such antisera, Target cell infection, Target cells, Target virus, Unprimed mice, Virus, Virus infection, Virus preparation, Virus preparations, Virus strain, Virus strains, Virus substrains, Virus subtypes, Vivo, Vivo induction, Vivo systems.
Abstract
Abstract: Infection of mice with live influenza A virus induces cytolytic T lymphocytes (CTL) as well as B cells capable of reacting with target cells infected with the appropriate virus subtypes. In Balb/c mice CTL reveal a broad cross-reactivity against all influenza A substrains known. In contrast B-cell responses are restricted to virus subtypes which are identical in regard to the hemagglutinin (HA) of the sensitizing virus. Reinfection with homologous live influenza virus within 6–7 months results in no or in a drastically diminished B-cell response as compared to a priming situation and fails to induce CTL. Inability to induce secondary immunity to homologous influenza virus was correlated with the presence of circulating antibodies specific for the sensitizing virus subtype. Cross-boosting with heterologous live influenza A virus induces homotypic and heterotypic CTL and B-cell immunity with characteristics of secondary responses. Preparations of inactivated intact influenza virus are unable to reactivate CTL memory in vivo but induce B-cell activity. B-cell responses stimulated by this procedure are restricted to the boosting virus. Attenuated viruses, which are produced by recombination of wild strains with cold-adapted strains, are also efficient in stimulating in vivo CTL memory if used for cross-boosting.
Url:
DOI: 10.1016/0008-8749(81)90253-7
Links to Exploration step
ISTEX:3E8FD3E7636E64207A5D7B3F314AC67F11FAF549Le document en format XML
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Liehl</name><affiliation><mods:affiliation>Sandoz Research Institute, Vienna, Austria</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3E8FD3E7636E64207A5D7B3F314AC67F11FAF549</idno><date when="1981" year="1981">1981</date><idno type="doi">10.1016/0008-8749(81)90253-7</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-T7WVMFNK-J/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000128</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000128</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Induction of homotypic and heterotypic T- and B-cell immunity with influenza A virus in mice</title><author><name sortKey="Armerding, D" sort="Armerding, D" uniqKey="Armerding D" first="D." last="Armerding">D. 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In Balb/c mice CTL reveal a broad cross-reactivity against all influenza A substrains known. In contrast B-cell responses are restricted to virus subtypes which are identical in regard to the hemagglutinin (HA) of the sensitizing virus. Reinfection with homologous live influenza virus within 6–7 months results in no or in a drastically diminished B-cell response as compared to a priming situation and fails to induce CTL. Inability to induce secondary immunity to homologous influenza virus was correlated with the presence of circulating antibodies specific for the sensitizing virus subtype. Cross-boosting with heterologous live influenza A virus induces homotypic and heterotypic CTL and B-cell immunity with characteristics of secondary responses. Preparations of inactivated intact influenza virus are unable to reactivate CTL memory in vivo but induce B-cell activity. B-cell responses stimulated by this procedure are restricted to the boosting virus. 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Armerding</name><affiliations><json:string>Sandoz Research Institute, Vienna, Austria</json:string></affiliations></json:item><json:item><name>E. Liehl</name><affiliations><json:string>Sandoz Research Institute, Vienna, Austria</json:string></affiliations></json:item></author><articleId><json:string>81902537</json:string></articleId><arkIstex>ark:/67375/6H6-T7WVMFNK-J</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Infection of mice with live influenza A virus induces cytolytic T lymphocytes (CTL) as well as B cells capable of reacting with target cells infected with the appropriate virus subtypes. In Balb/c mice CTL reveal a broad cross-reactivity against all influenza A substrains known. In contrast B-cell responses are restricted to virus subtypes which are identical in regard to the hemagglutinin (HA) of the sensitizing virus. Reinfection with homologous live influenza virus within 6–7 months results in no or in a drastically diminished B-cell response as compared to a priming situation and fails to induce CTL. Inability to induce secondary immunity to homologous influenza virus was correlated with the presence of circulating antibodies specific for the sensitizing virus subtype. Cross-boosting with heterologous live influenza A virus induces homotypic and heterotypic CTL and B-cell immunity with characteristics of secondary responses. Preparations of inactivated intact influenza virus are unable to reactivate CTL memory in vivo but induce B-cell activity. B-cell responses stimulated by this procedure are restricted to the boosting virus. Attenuated viruses, which are produced by recombination of wild strains with cold-adapted strains, are also efficient in stimulating in vivo CTL memory if used for cross-boosting.</abstract><qualityIndicators><score>9.352</score><pdfWordCount>5385</pdfWordCount><pdfCharCount>34096</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>17</pdfPageCount><pdfPageSize>468 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>196</abstractWordCount><abstractCharCount>1339</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Induction of homotypic and heterotypic T- and B-cell immunity with influenza A virus in mice</title><pmid><json:string>6972261</json:string></pmid><pii><json:string>0008-8749(81)90253-7</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Immunological Series No. 6</title><language><json:string>unknown</json:string></language><pages><first>25</first></pages></serie><host><title>Cellular Immunology</title><language><json:string>unknown</json:string></language><publicationDate>1981</publicationDate><issn><json:string>0008-8749</json:string></issn><pii><json:string>S0008-8749(00)X0393-0</json:string></pii><volume>60</volume><issue>1</issue><pages><first>119</first><last>135</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1981</json:string></date><geogName></geogName><orgName><json:string>Bomholtgard Ltd.</json:string><json:string>United States Department of Health</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>S. 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In Balb/c mice CTL reveal a broad cross-reactivity against all influenza A substrains known. In contrast B-cell responses are restricted to virus subtypes which are identical in regard to the hemagglutinin (HA) of the sensitizing virus. Reinfection with homologous live influenza virus within 6–7 months results in no or in a drastically diminished B-cell response as compared to a priming situation and fails to induce CTL. Inability to induce secondary immunity to homologous influenza virus was correlated with the presence of circulating antibodies specific for the sensitizing virus subtype. Cross-boosting with heterologous live influenza A virus induces homotypic and heterotypic CTL and B-cell immunity with characteristics of secondary responses. Preparations of inactivated intact influenza virus are unable to reactivate CTL memory in vivo but induce B-cell activity. B-cell responses stimulated by this procedure are restricted to the boosting virus. Attenuated viruses, which are produced by recombination of wild strains with cold-adapted strains, are also efficient in stimulating in vivo CTL memory if used for cross-boosting.</p></abstract></profileDesc><revisionDesc><change when="1981">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-T7WVMFNK-J/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla" xml:lang="en"><item-info><jid>YCIMM</jid><aid>81902537</aid><ce:pii>0008-8749(81)90253-7</ce:pii><ce:doi>10.1016/0008-8749(81)90253-7</ce:doi><ce:copyright type="unknown" year="1981"></ce:copyright></item-info><head><ce:title>Induction of homotypic and heterotypic T- and B-cell immunity with influenza A virus in mice</ce:title><ce:author-group><ce:author><ce:given-name>D.</ce:given-name><ce:surname>Armerding</ce:surname></ce:author><ce:author><ce:given-name>E.</ce:given-name><ce:surname>Liehl</ce:surname></ce:author><ce:affiliation><ce:textfn>Sandoz Research Institute, Vienna, Austria</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="15" month="8" year="1980"></ce:date-received><ce:date-accepted day="30" month="9" year="1980"></ce:date-accepted><ce:abstract class="author"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">Infection of mice with live influenza A virus induces cytolytic T lymphocytes (CTL) as well as B cells capable of reacting with target cells infected with the appropriate virus subtypes. In Balb/c mice CTL reveal a broad cross-reactivity against all influenza A substrains known. In contrast B-cell responses are restricted to virus subtypes which are identical in regard to the hemagglutinin (HA) of the sensitizing virus. Reinfection with homologous live influenza virus within 6–7 months results in no or in a drastically diminished B-cell response as compared to a priming situation and fails to induce CTL. Inability to induce secondary immunity to homologous influenza virus was correlated with the presence of circulating antibodies specific for the sensitizing virus subtype. Cross-boosting with heterologous live influenza A virus induces homotypic and heterotypic CTL and B-cell immunity with characteristics of secondary responses. Preparations of inactivated intact influenza virus are unable to reactivate CTL memory <ce:italic>in vivo</ce:italic> but induce B-cell activity. B-cell responses stimulated by this procedure are restricted to the boosting virus. Attenuated viruses, which are produced by recombination of wild strains with cold-adapted strains, are also efficient in stimulating <ce:italic>in vivo</ce:italic> CTL memory if used for cross-boosting.</ce:simple-para></ce:abstract-sec></ce:abstract></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Induction of homotypic and heterotypic T- and B-cell immunity with influenza A virus in mice</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Induction of homotypic and heterotypic T- and B-cell immunity with influenza A virus in mice</title></titleInfo><name type="personal"><namePart type="given">D.</namePart><namePart type="family">Armerding</namePart><affiliation>Sandoz Research Institute, Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Liehl</namePart><affiliation>Sandoz Research Institute, Vienna, Austria</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1981</dateIssued><copyrightDate encoding="w3cdtf">1981</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Infection of mice with live influenza A virus induces cytolytic T lymphocytes (CTL) as well as B cells capable of reacting with target cells infected with the appropriate virus subtypes. In Balb/c mice CTL reveal a broad cross-reactivity against all influenza A substrains known. In contrast B-cell responses are restricted to virus subtypes which are identical in regard to the hemagglutinin (HA) of the sensitizing virus. Reinfection with homologous live influenza virus within 6–7 months results in no or in a drastically diminished B-cell response as compared to a priming situation and fails to induce CTL. Inability to induce secondary immunity to homologous influenza virus was correlated with the presence of circulating antibodies specific for the sensitizing virus subtype. Cross-boosting with heterologous live influenza A virus induces homotypic and heterotypic CTL and B-cell immunity with characteristics of secondary responses. Preparations of inactivated intact influenza virus are unable to reactivate CTL memory in vivo but induce B-cell activity. B-cell responses stimulated by this procedure are restricted to the boosting virus. Attenuated viruses, which are produced by recombination of wild strains with cold-adapted strains, are also efficient in stimulating in vivo CTL memory if used for cross-boosting.</abstract><relatedItem type="host"><titleInfo><title>Cellular Immunology</title></titleInfo><titleInfo type="abbreviated"><title>YCIMM</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1981</dateIssued></originInfo><identifier type="ISSN">0008-8749</identifier><identifier type="PII">S0008-8749(00)X0393-0</identifier><part><date>1981</date><detail type="volume"><number>60</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>249</end></extent><extent unit="pages"><start>119</start><end>135</end></extent></part></relatedItem><identifier type="istex">3E8FD3E7636E64207A5D7B3F314AC67F11FAF549</identifier><identifier type="ark">ark:/67375/6H6-T7WVMFNK-J</identifier><identifier type="DOI">10.1016/0008-8749(81)90253-7</identifier><identifier type="PII">0008-8749(81)90253-7</identifier><identifier type="ArticleID">81902537</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-T7WVMFNK-J/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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