Genetic reassortment in pandemic and interpandemic influenza viruses
Identifieur interne : 000083 ( Istex/Corpus ); précédent : 000082; suivant : 000084Genetic reassortment in pandemic and interpandemic influenza viruses
Auteurs : L. P. Shu ; G. B. Sharp ; Y. P. Lin ; E. C. J. Claas ; S. L. Krauss ; K. F. Shortridge ; R. G. WebsterSource :
- European Journal of Epidemiology [ 0393-2990 ] ; 1996-02-01.
English descriptors
- KwdEn :
- Teeft :
- Antigenic, Avian, Avian genes, Avian influenza virus genes, Avian influenza viruses, Avian origin, Avian virus probes, Avian viruses, Blot hybridization, Clin microbiol, Disease control, Diverse collection, Dotblot analysis, Equivocal results, European pigs, Fatal case, Fatal cases, Gene, Gene sequences, Genetic analysis, Genetic reassortment, Genetic relatedness, Highest homology, Homology, Hong kong, Human influenza, Human influenza strains, Human influenza viruses, Human origin, Human population, Human populations, Human strains, Human virus, Human virus probe, Human viruses, Hybridization, Influenza, Influenza virus, Influenza viruses, Influenza wisconsin, Internal gene segments, Internal genes, Interpandemic, Interpandemic influenza, Interpandemic influenza viruses, Interpandemic periods, Interspecies transmission, Jude research hospital, Kawaoka, Limited spread, Neuraminidase genes, Outbreak, Pandemic, Pandemic strain, Pandemic strains, Personal communication, Phylogenetic, Phylogenetic analysis, Phylogenetic tree, Pig, Porcine origin, Proc natl acad, Reassortant, Reassortant virus, Reassortant viruses, Reassortants, Reassortment, Sequence analysis, Serological evidence, Sick pigs, Southern china, Such genes, Such infections, Such viruses, Survival advantage, Swine, Swine influenza, Swine influenza virus, Swine influenza virus infections, Swine origin, Swine virus, Swine virus probes, Swine viruses, Virol, Virology, Virus.
Abstract
Abstract: The human influenza pandemics of 1957 and 1968 were caused by reassortant viruses that possessed internal gene segments from avian and human strains. Whether genetic reassortment of human and avian influenza viruses occurs during interpandemic periods and how often humans are infected with such reassortants is not known. To provide this information, we used dot-blot hybridization, partial nucleotide sequencing and subsequent phylogenetic analysis to examine the 6 internal genes of 122 viruses isolated in humans between 1933 and 1992 primarily from Asia, Europe, and the Americas. The internal genes of A/New Jersey/11/76 isolated from a human fatality at Fort Dix, New Jersey in 1976 were found to be of porcine origin. Although none of the geographically and temporally diverse collection of 122 viruses was an avian-human or other reassortant, cognizance was made of the fact that there were two isolates from children from amongst 546 influenza A isolates obtained from The Netherlands from 1989–1994 which were influenza reassortants containing genes of avian origin, viruses which have infected European pigs since 1983–1985. Thus, genetic reassortment between avian and human influenza strains does occur in the emergence of pandemic and interpandemic influenza A viruses. However, in the interpandemic periods the reassortants have no survival advantage, and the circulating interpandemic influenza viruses in humans do not appear to accumulate avian influenza virus genes.
Url:
DOI: 10.1007/BF00144430
Links to Exploration step
ISTEX:CBE126895F4D385047138777679C94B02D3CCB53Le document en format XML
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Whether genetic reassortment of human and avian influenza viruses occurs during interpandemic periods and how often humans are infected with such reassortants is not known. To provide this information, we used dot-blot hybridization, partial nucleotide sequencing and subsequent phylogenetic analysis to examine the 6 internal genes of 122 viruses isolated in humans between 1933 and 1992 primarily from Asia, Europe, and the Americas. The internal genes of A/New Jersey/11/76 isolated from a human fatality at Fort Dix, New Jersey in 1976 were found to be of porcine origin. Although none of the geographically and temporally diverse collection of 122 viruses was an avian-human or other reassortant, cognizance was made of the fact that there were two isolates from children from amongst 546 influenza A isolates obtained from The Netherlands from 1989–1994 which were influenza reassortants containing genes of avian origin, viruses which have infected European pigs since 1983–1985. Thus, genetic reassortment between avian and human influenza strains does occur in the emergence of pandemic and interpandemic influenza A viruses. However, in the interpandemic periods the reassortants have no survival advantage, and the circulating interpandemic influenza viruses in humans do not appear to accumulate avian influenza virus genes.</div></front></TEI><istex><corpusName>springer-journals</corpusName><keywords><teeft><json:string>avian</json:string><json:string>influenza</json:string><json:string>virology</json:string><json:string>reassortment</json:string><json:string>internal genes</json:string><json:string>phylogenetic</json:string><json:string>reassortants</json:string><json:string>kawaoka</json:string><json:string>influenza viruses</json:string><json:string>hybridization</json:string><json:string>virol</json:string><json:string>reassortant</json:string><json:string>homology</json:string><json:string>antigenic</json:string><json:string>avian origin</json:string><json:string>human influenza</json:string><json:string>swine</json:string><json:string>virus</json:string><json:string>genetic reassortment</json:string><json:string>interpandemic</json:string><json:string>avian genes</json:string><json:string>hong kong</json:string><json:string>pandemic</json:string><json:string>human origin</json:string><json:string>phylogenetic analysis</json:string><json:string>swine influenza</json:string><json:string>gene</json:string><json:string>human influenza viruses</json:string><json:string>swine influenza virus</json:string><json:string>pandemic strain</json:string><json:string>jude research hospital</json:string><json:string>interpandemic periods</json:string><json:string>neuraminidase genes</json:string><json:string>disease control</json:string><json:string>gene sequences</json:string><json:string>reassortant viruses</json:string><json:string>avian influenza viruses</json:string><json:string>sequence analysis</json:string><json:string>swine viruses</json:string><json:string>human virus probe</json:string><json:string>european pigs</json:string><json:string>phylogenetic tree</json:string><json:string>interspecies transmission</json:string><json:string>avian viruses</json:string><json:string>such viruses</json:string><json:string>such infections</json:string><json:string>fatal case</json:string><json:string>outbreak</json:string><json:string>pig</json:string><json:string>porcine origin</json:string><json:string>diverse collection</json:string><json:string>influenza virus</json:string><json:string>blot hybridization</json:string><json:string>internal gene segments</json:string><json:string>genetic relatedness</json:string><json:string>human strains</json:string><json:string>human influenza strains</json:string><json:string>genetic analysis</json:string><json:string>human viruses</json:string><json:string>human populations</json:string><json:string>interpandemic influenza</json:string><json:string>swine virus probes</json:string><json:string>avian virus probes</json:string><json:string>survival advantage</json:string><json:string>equivocal results</json:string><json:string>dotblot analysis</json:string><json:string>highest homology</json:string><json:string>human virus</json:string><json:string>fatal cases</json:string><json:string>sick pigs</json:string><json:string>interpandemic influenza viruses</json:string><json:string>such genes</json:string><json:string>limited spread</json:string><json:string>avian influenza virus genes</json:string><json:string>human population</json:string><json:string>serological evidence</json:string><json:string>personal communication</json:string><json:string>southern china</json:string><json:string>swine virus</json:string><json:string>influenza wisconsin</json:string><json:string>clin microbiol</json:string><json:string>proc natl acad</json:string><json:string>swine influenza virus infections</json:string><json:string>reassortant virus</json:string><json:string>pandemic strains</json:string><json:string>swine origin</json:string></teeft></keywords><author><json:item><name>L. P. Shu</name><affiliations><json:string>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</json:string></affiliations></json:item><json:item><name>G. B. Sharp</name><affiliations><json:string>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</json:string><json:string>Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</json:string></affiliations></json:item><json:item><name>Y. P. Lin</name><affiliations><json:string>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</json:string><json:string>Department of Microbiology, The University of Hong Kong, Pathology Building, Queen Mary Hospital Compound, Hong Kong</json:string></affiliations></json:item><json:item><name>E. C. J. Claas</name><affiliations><json:string>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</json:string><json:string>Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands</json:string></affiliations></json:item><json:item><name>S. L. Krauss</name><affiliations><json:string>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</json:string></affiliations></json:item><json:item><name>K. F. Shortridge</name><affiliations><json:string>Department of Microbiology, The University of Hong Kong, Pathology Building, Queen Mary Hospital Compound, Hong Kong</json:string></affiliations></json:item><json:item><name>R. G. Webster</name><affiliations><json:string>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Influenza A viruses</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Genetic reassortment</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Interspecies transmission</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Pandemic</value></json:item></subject><articleId><json:string>BF00144430</json:string><json:string>Art12</json:string></articleId><arkIstex>ark:/67375/1BB-1546CMN3-0</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: The human influenza pandemics of 1957 and 1968 were caused by reassortant viruses that possessed internal gene segments from avian and human strains. Whether genetic reassortment of human and avian influenza viruses occurs during interpandemic periods and how often humans are infected with such reassortants is not known. To provide this information, we used dot-blot hybridization, partial nucleotide sequencing and subsequent phylogenetic analysis to examine the 6 internal genes of 122 viruses isolated in humans between 1933 and 1992 primarily from Asia, Europe, and the Americas. The internal genes of A/New Jersey/11/76 isolated from a human fatality at Fort Dix, New Jersey in 1976 were found to be of porcine origin. Although none of the geographically and temporally diverse collection of 122 viruses was an avian-human or other reassortant, cognizance was made of the fact that there were two isolates from children from amongst 546 influenza A isolates obtained from The Netherlands from 1989–1994 which were influenza reassortants containing genes of avian origin, viruses which have infected European pigs since 1983–1985. Thus, genetic reassortment between avian and human influenza strains does occur in the emergence of pandemic and interpandemic influenza A viruses. However, in the interpandemic periods the reassortants have no survival advantage, and the circulating interpandemic influenza viruses in humans do not appear to accumulate avian influenza virus genes.</abstract><qualityIndicators><score>9.434</score><pdfWordCount>4782</pdfWordCount><pdfCharCount>29822</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>598 x 843 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>221</abstractWordCount><abstractCharCount>1496</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Genetic reassortment in pandemic and interpandemic influenza viruses</title><pmid><json:string>8817180</json:string></pmid><genre><json:string>research-article</json:string></genre><host><title>European Journal of 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xml:lang="en">A study of 122 viruses infecting humans</title><author xml:id="author-0000"><persName><forename type="first">L.</forename><surname>Shu</surname></persName><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation></author><author xml:id="author-0001"><persName><forename type="first">G.</forename><surname>Sharp</surname></persName><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation><affiliation>Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Y.</forename><surname>Lin</surname></persName><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation><affiliation>Department of Microbiology, The University of Hong Kong, Pathology Building, Queen Mary Hospital Compound, Hong Kong</affiliation></author><author xml:id="author-0003"><persName><forename type="first">E.</forename><surname>Claas</surname></persName><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation><affiliation>Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands</affiliation></author><author xml:id="author-0004"><persName><forename type="first">S.</forename><surname>Krauss</surname></persName><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation></author><author xml:id="author-0005"><persName><forename type="first">K.</forename><surname>Shortridge</surname></persName><affiliation>Department of Microbiology, The University of Hong Kong, Pathology Building, Queen Mary Hospital Compound, Hong Kong</affiliation></author><author xml:id="author-0006" corresp="yes"><persName><forename type="first">R.</forename><surname>Webster</surname></persName><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation></author><idno type="istex">CBE126895F4D385047138777679C94B02D3CCB53</idno><idno type="ark">ark:/67375/1BB-1546CMN3-0</idno><idno type="DOI">10.1007/BF00144430</idno><idno type="article-id">BF00144430</idno><idno type="article-id">Art12</idno></analytic><monogr><title level="j">European Journal of Epidemiology</title><title level="j" type="abbrev">Eur J Epidemiol</title><idno type="pISSN">0393-2990</idno><idno type="eISSN">1573-7284</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">20</idno><idno type="volume-issue-count">6</idno><imprint><publisher>Kluwer Academic Publishers</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="1996-02-01"></date><biblScope unit="volume">12</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="63">63</biblScope><biblScope unit="page" to="70">70</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The human influenza pandemics of 1957 and 1968 were caused by reassortant viruses that possessed internal gene segments from avian and human strains. Whether genetic reassortment of human and avian influenza viruses occurs during interpandemic periods and how often humans are infected with such reassortants is not known. To provide this information, we used dot-blot hybridization, partial nucleotide sequencing and subsequent phylogenetic analysis to examine the 6 internal genes of 122 viruses isolated in humans between 1933 and 1992 primarily from Asia, Europe, and the Americas. The internal genes of A/New Jersey/11/76 isolated from a human fatality at Fort Dix, New Jersey in 1976 were found to be of porcine origin. Although none of the geographically and temporally diverse collection of 122 viruses was an avian-human or other reassortant, cognizance was made of the fact that there were two isolates from children from amongst 546 influenza A isolates obtained from The Netherlands from 1989–1994 which were influenza reassortants containing genes of avian origin, viruses which have infected European pigs since 1983–1985. Thus, genetic reassortment between avian and human influenza strains does occur in the emergence of pandemic and interpandemic influenza A viruses. However, in the interpandemic periods the reassortants have no survival advantage, and the circulating interpandemic influenza viruses in humans do not appear to accumulate avian influenza virus genes.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>Influenza A viruses</term></item><item><term>Genetic reassortment</term></item><item><term>Interspecies transmission</term></item><item><term>Pandemic</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>Medicine & Public Health</head><item><term>Public Health/Gesundheitswesen</term></item><item><term>Cardiology</term></item><item><term>Infectious Diseases</term></item><item><term>Oncology</term></item><item><term>Epidemiology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996-02-01">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-1546CMN3-0/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus springer-journals not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Kluwer Academic Publishers</PublisherName><PublisherLocation>Dordrecht</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>10654</JournalID><JournalPrintISSN>0393-2990</JournalPrintISSN><JournalElectronicISSN>1573-7284</JournalElectronicISSN><JournalTitle>European Journal of Epidemiology</JournalTitle><JournalAbbreviatedTitle>Eur J Epidemiol</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Medicine & Public Health</JournalSubject><JournalSubject Type="Secondary">Public Health/Gesundheitswesen</JournalSubject><JournalSubject Type="Secondary">Cardiology</JournalSubject><JournalSubject Type="Secondary">Infectious Diseases</JournalSubject><JournalSubject Type="Secondary">Oncology</JournalSubject><JournalSubject Type="Secondary">Epidemiology</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>12</VolumeIDStart><VolumeIDEnd>12</VolumeIDEnd><VolumeIssueCount>6</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd><IssueArticleCount>20</IssueArticleCount><IssueHistory><CoverDate><Year>1996</Year><Month>2</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Kluwer Academic Publishers</CopyrightHolderName><CopyrightYear>1996</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art12"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00144430</ArticleID><ArticleDOI>10.1007/BF00144430</ArticleDOI><ArticleSequenceNumber>12</ArticleSequenceNumber><ArticleTitle Language="En">Genetic reassortment in pandemic and interpandemic influenza viruses</ArticleTitle><ArticleSubTitle Language="En">A study of 122 viruses infecting humans</ArticleSubTitle><ArticleFirstPage>63</ArticleFirstPage><ArticleLastPage>70</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>6</Month><Day>14</Day></RegistrationDate><Accepted><Year>1995</Year><Month>10</Month><Day>12</Day></Accepted></ArticleHistory><ArticleCopyright><CopyrightHolderName>Kluwer Academic Publishers</CopyrightHolderName><CopyrightYear>1996</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>10654</JournalID><VolumeIDStart>12</VolumeIDStart><VolumeIDEnd>12</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>L.</GivenName><GivenName>P.</GivenName><FamilyName>Shu</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1 Aff2"><AuthorName DisplayOrder="Western"><GivenName>G.</GivenName><GivenName>B.</GivenName><FamilyName>Sharp</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1 Aff3"><AuthorName DisplayOrder="Western"><GivenName>Y.</GivenName><GivenName>P.</GivenName><FamilyName>Lin</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1 Aff4"><AuthorName DisplayOrder="Western"><GivenName>E.</GivenName><GivenName>C.</GivenName><GivenName>J.</GivenName><FamilyName>Claas</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>S.</GivenName><GivenName>L.</GivenName><FamilyName>Krauss</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff3"><AuthorName DisplayOrder="Western"><GivenName>K.</GivenName><GivenName>F.</GivenName><FamilyName>Shortridge</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff4"><AuthorName DisplayOrder="Western"><GivenName>R.</GivenName><GivenName>G.</GivenName><FamilyName>Webster</FamilyName></AuthorName><Contact><Phone>(901) 495 3400</Phone><Fax>(901) 523 2622</Fax></Contact></Author><Affiliation ID="Aff1"><OrgDivision>Department of Virology & Molecular Biology</OrgDivision><OrgName>St. Jude Children's Research Hospital</OrgName><OrgAddress><City>Memphis</City><State>Tennessee</State><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Hematology/Oncology</OrgDivision><OrgName>St. Jude Children's Research Hospital</OrgName><OrgAddress><City>Memphis</City><State>Tennessee</State><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Department of Microbiology</OrgDivision><OrgName>The University of Hong Kong</OrgName><OrgAddress><Street>Pathology Building, Queen Mary Hospital Compound</Street><Country>Hong Kong</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgDivision>Department of Virology and WHO National Influenza Centre</OrgDivision><OrgName>Erasmus University</OrgName><OrgAddress><City>Rotterdam</City><Country>The Netherlands</Country></OrgAddress></Affiliation><Affiliation ID="Aff5"><OrgDivision>Department of Virology & Molecular Biology</OrgDivision><OrgName>St. Jude's Children's Research Hospital</OrgName><OrgAddress><Street>332 N. Lauderdale</Street><Postbox>P.O. Box 318</Postbox><Postcode>38101</Postcode><City>Memphis</City><State>TN</State><Country>USA</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>The human influenza pandemics of 1957 and 1968 were caused by reassortant viruses that possessed internal gene segments from avian and human strains. Whether genetic reassortment of human and avian influenza viruses occurs during interpandemic periods and how often humans are infected with such reassortants is not known. To provide this information, we used dot-blot hybridization, partial nucleotide sequencing and subsequent phylogenetic analysis to examine the 6 internal genes of 122 viruses isolated in humans between 1933 and 1992 primarily from Asia, Europe, and the Americas. The internal genes of A/New Jersey/11/76 isolated from a human fatality at Fort Dix, New Jersey in 1976 were found to be of porcine origin. Although none of the geographically and temporally diverse collection of 122 viruses was an avian-human or other reassortant, cognizance was made of the fact that there were two isolates from children from amongst 546 influenza A isolates obtained from The Netherlands from 1989–1994 which were influenza reassortants containing genes of avian origin, viruses which have infected European pigs since 1983–1985. Thus, genetic reassortment between avian and human influenza strains does occur in the emergence of pandemic and interpandemic influenza A viruses. However, in the interpandemic periods the reassortants have no survival advantage, and the circulating interpandemic influenza viruses in humans do not appear to accumulate avian influenza virus genes.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Influenza A viruses</Keyword><Keyword>Genetic reassortment</Keyword><Keyword>Interspecies transmission</Keyword><Keyword>Pandemic</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Genetic reassortment in pandemic and interpandemic influenza viruses</title><subTitle>A study of 122 viruses infecting humans</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Genetic reassortment in pandemic and interpandemic influenza viruses</title></titleInfo><name type="personal"><namePart type="given">L.</namePart><namePart type="given">P.</namePart><namePart type="family">Shu</namePart><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="given">B.</namePart><namePart type="family">Sharp</namePart><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation><affiliation>Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Y.</namePart><namePart type="given">P.</namePart><namePart type="family">Lin</namePart><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation><affiliation>Department of Microbiology, The University of Hong Kong, Pathology Building, Queen Mary Hospital Compound, Hong Kong</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="given">C.</namePart><namePart type="given">J.</namePart><namePart type="family">Claas</namePart><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation><affiliation>Department of Virology and WHO National Influenza Centre, Erasmus University, Rotterdam, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="given">L.</namePart><namePart type="family">Krauss</namePart><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="given">F.</namePart><namePart type="family">Shortridge</namePart><affiliation>Department of Microbiology, The University of Hong Kong, Pathology Building, Queen Mary Hospital Compound, Hong Kong</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">R.</namePart><namePart type="given">G.</namePart><namePart type="family">Webster</namePart><affiliation>Department of Virology & Molecular Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Kluwer Academic Publishers</publisher><place><placeTerm type="text">Dordrecht</placeTerm></place><dateIssued encoding="w3cdtf">1996-02-01</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Abstract: The human influenza pandemics of 1957 and 1968 were caused by reassortant viruses that possessed internal gene segments from avian and human strains. Whether genetic reassortment of human and avian influenza viruses occurs during interpandemic periods and how often humans are infected with such reassortants is not known. To provide this information, we used dot-blot hybridization, partial nucleotide sequencing and subsequent phylogenetic analysis to examine the 6 internal genes of 122 viruses isolated in humans between 1933 and 1992 primarily from Asia, Europe, and the Americas. The internal genes of A/New Jersey/11/76 isolated from a human fatality at Fort Dix, New Jersey in 1976 were found to be of porcine origin. Although none of the geographically and temporally diverse collection of 122 viruses was an avian-human or other reassortant, cognizance was made of the fact that there were two isolates from children from amongst 546 influenza A isolates obtained from The Netherlands from 1989–1994 which were influenza reassortants containing genes of avian origin, viruses which have infected European pigs since 1983–1985. Thus, genetic reassortment between avian and human influenza strains does occur in the emergence of pandemic and interpandemic influenza A viruses. However, in the interpandemic periods the reassortants have no survival advantage, and the circulating interpandemic influenza viruses in humans do not appear to accumulate avian influenza virus genes.</abstract><subject lang="en"><genre>Key words</genre><topic>Influenza A viruses</topic><topic>Genetic reassortment</topic><topic>Interspecies transmission</topic><topic>Pandemic</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Epidemiology</title></titleInfo><titleInfo type="abbreviated"><title>Eur J Epidemiol</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>Springer</publisher><dateIssued encoding="w3cdtf">1996-02-01</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><subject><genre>Medicine & Public Health</genre><topic>Public Health/Gesundheitswesen</topic><topic>Cardiology</topic><topic>Infectious Diseases</topic><topic>Oncology</topic><topic>Epidemiology</topic></subject><identifier type="ISSN">0393-2990</identifier><identifier type="eISSN">1573-7284</identifier><identifier type="JournalID">10654</identifier><identifier type="IssueArticleCount">20</identifier><identifier type="VolumeIssueCount">6</identifier><part><date>1996</date><detail type="volume"><number>12</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="pages"><start>63</start><end>70</end></extent></part><recordInfo><recordOrigin>Kluwer Academic Publishers, 1996</recordOrigin></recordInfo></relatedItem><identifier type="istex">CBE126895F4D385047138777679C94B02D3CCB53</identifier><identifier type="ark">ark:/67375/1BB-1546CMN3-0</identifier><identifier type="DOI">10.1007/BF00144430</identifier><identifier type="ArticleID">BF00144430</identifier><identifier type="ArticleID">Art12</identifier><accessCondition type="use and reproduction" contentType="copyright">Kluwer Academic Publishers, 1996</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-3XSW68JL-F">springer</recordContentSource><recordOrigin>Kluwer Academic Publishers, 1996</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/1BB-1546CMN3-0/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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