Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses
Identifieur interne : 000001 ( Istex/Corpus ); précédent : 000000; suivant : 000002Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses
Auteurs : R. Pyh LSource :
- Journal of Hygiene [ 0022-1724 ] ; 1985-10.
Abstract
The incidence of haemagglutination inhibition (HI) antibody (titre ≥ 12) to influenza A/Singapore/1/57(H2N2) in sera collected from a Finnish population in the summer of 1981 was 58%. Subjects born after 1968 were essentially seronegative, and a comparable low HI antibody status was also recorded among the elderly, lowest being in people born during the period 1901–10. A small increase in antibody titre to the H2N2 virus was observed in the different age groups after infections with the H3N2, but not the H1N1, subtype influenza A viruses. The heterotypic response, which could be due to HI or NA antibodies, was restricted almost exclusively to subjects already exhibiting this antibody in acute phase sera. Moreover, the anamnestic boosting was not as strong as that described in earlier studies from samples collected at the beginning of the present era of H3N2 viruses.At population level, the HI antibody status to H2N2 was about the same at the beginning and end of the follow-up period which covered eight epidemic seasons. The results are discussed with respect to the doctrine of ‘original antigenic sin’ and to the threat of re-emergence of the H2N2 viruses.
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DOI: 10.1017/S0022172400062860
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses</title><author><name sortKey="Pyh L, R" sort="Pyh L, R" uniqKey="Pyh L R" first="R." last="Pyh L">R. Pyh L</name><affiliation><mods:affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki 28, Finland</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A07AE19D19C086FCC38B3409ABCD8CEA9A27CED9</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1017/S0022172400062860</idno><idno type="url">https://api.istex.fr/ark:/67375/6GQ-LFQX7L0M-M/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000001</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000001</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses</title><author><name sortKey="Pyh L, R" sort="Pyh L, R" uniqKey="Pyh L R" first="R." last="Pyh L">R. Pyh L</name><affiliation><mods:affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki 28, Finland</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. Hyg.</title><idno type="ISSN">0022-1724</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1985-10">1985-10</date><biblScope unit="volume">95</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="437">437</biblScope><biblScope unit="page" to="445">445</biblScope></imprint><idno type="ISSN">0022-1724</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1724</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">The incidence of haemagglutination inhibition (HI) antibody (titre ≥ 12) to influenza A/Singapore/1/57(H2N2) in sera collected from a Finnish population in the summer of 1981 was 58%. Subjects born after 1968 were essentially seronegative, and a comparable low HI antibody status was also recorded among the elderly, lowest being in people born during the period 1901–10. A small increase in antibody titre to the H2N2 virus was observed in the different age groups after infections with the H3N2, but not the H1N1, subtype influenza A viruses. The heterotypic response, which could be due to HI or NA antibodies, was restricted almost exclusively to subjects already exhibiting this antibody in acute phase sera. Moreover, the anamnestic boosting was not as strong as that described in earlier studies from samples collected at the beginning of the present era of H3N2 viruses.At population level, the HI antibody status to H2N2 was about the same at the beginning and end of the follow-up period which covered eight epidemic seasons. The results are discussed with respect to the doctrine of ‘original antigenic sin’ and to the threat of re-emergence of the H2N2 viruses.</div></front></TEI><istex><corpusName>cambridge</corpusName><author><json:item><name>R. Pyhälä</name><affiliations><json:string>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki 28, Finland</json:string></affiliations></json:item></author><articleId><json:string>06286</json:string></articleId><arkIstex>ark:/67375/6GQ-LFQX7L0M-M</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>The incidence of haemagglutination inhibition (HI) antibody (titre ≥ 12) to influenza A/Singapore/1/57(H2N2) in sera collected from a Finnish population in the summer of 1981 was 58%. Subjects born after 1968 were essentially seronegative, and a comparable low HI antibody status was also recorded among the elderly, lowest being in people born during the period 1901–10. A small increase in antibody titre to the H2N2 virus was observed in the different age groups after infections with the H3N2, but not the H1N1, subtype influenza A viruses. The heterotypic response, which could be due to HI or NA antibodies, was restricted almost exclusively to subjects already exhibiting this antibody in acute phase sera. Moreover, the anamnestic boosting was not as strong as that described in earlier studies from samples collected at the beginning of the present era of H3N2 viruses.At population level, the HI antibody status to H2N2 was about the same at the beginning and end of the follow-up period which covered eight epidemic seasons. The results are discussed with respect to the doctrine of ‘original antigenic sin’ and to the threat of re-emergence of the H2N2 viruses.</abstract><qualityIndicators><score>7.562</score><pdfWordCount>3306</pdfWordCount><pdfCharCount>19469</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>9</pdfPageCount><pdfPageSize>478.08 x 697.68 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>188</abstractWordCount><abstractCharCount>1173</abstractCharCount><keywordCount>0</keywordCount></qualityIndicators><title>Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses</title><pii><json:string>S0022172400062860</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Journal of Hygiene</title><language><json:string>unknown</json:string></language><issn><json:string>0022-1724</json:string></issn><publisherId><json:string>HYG</json:string></publisherId><volume>95</volume><issue>2</issue><pages><first>437</first><last>445</last><total>9</total></pages><genre><json:string>journal</json:string></genre></host><ark><json:string>ark:/67375/6GQ-LFQX7L0M-M</json:string></ark><categories><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - pathologie infectieuse</json:string></inist></categories><publicationDate>1985</publicationDate><copyrightDate>1985</copyrightDate><doi><json:string>10.1017/S0022172400062860</json:string></doi><id>A07AE19D19C086FCC38B3409ABCD8CEA9A27CED9</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-LFQX7L0M-M/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-LFQX7L0M-M/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6GQ-LFQX7L0M-M/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><availability><licence><p>Copyright © Cambridge University Press 1985</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</p></availability><date>1985</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses</title><author xml:id="author-0000"><persName><forename type="first">R.</forename><surname>Pyhälä</surname></persName><affiliation>National Public Health Institute, Mannerheimintie 166, SF-00280 Helsinki 28, Finland</affiliation></author><idno type="istex">A07AE19D19C086FCC38B3409ABCD8CEA9A27CED9</idno><idno type="ark">ark:/67375/6GQ-LFQX7L0M-M</idno><idno type="DOI">10.1017/S0022172400062860</idno><idno type="PII">S0022172400062860</idno><idno type="article-id">06286</idno></analytic><monogr><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. Hyg.</title><idno type="pISSN">0022-1724</idno><idno type="publisher-id">HYG</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1985-10"></date><biblScope unit="volume">95</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="437">437</biblScope><biblScope unit="page" to="445">445</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1985</date></creation><langUsage><language ident="en">en</language></langUsage><abstract style="normal"><p>The incidence of haemagglutination inhibition (HI) antibody (titre ≥ 12) to influenza A/Singapore/1/57(H2N2) in sera collected from a Finnish population in the summer of 1981 was 58%. Subjects born after 1968 were essentially seronegative, and a comparable low HI antibody status was also recorded among the elderly, lowest being in people born during the period 1901–10. A small increase in antibody titre to the H2N2 virus was observed in the different age groups after infections with the H3N2, but not the H1N1, subtype influenza A viruses. The heterotypic response, which could be due to HI or NA antibodies, was restricted almost exclusively to subjects already exhibiting this antibody in acute phase sera. Moreover, the anamnestic boosting was not as strong as that described in earlier studies from samples collected at the beginning of the present era of H3N2 viruses.At population level, the HI antibody status to H2N2 was about the same at the beginning and end of the follow-up period which covered eight epidemic seasons. The results are discussed with respect to the doctrine of ‘original antigenic sin’ and to the threat of re-emergence of the H2N2 viruses.</p></abstract></profileDesc><revisionDesc><change when="1985-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-LFQX7L0M-M/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus cambridge not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="US-ASCII"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.2 20060430//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article dtd-version="2.2" article-type="research-article"><front><journal-meta><journal-id journal-id-type="publisher-id">HYG</journal-id><journal-title>Journal of Hygiene</journal-title><abbrev-journal-title>J. Hyg.</abbrev-journal-title><issn pub-type="ppub">0022-1724</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1017/S0022172400062860</article-id><article-id pub-id-type="pii">S0022172400062860</article-id><article-id pub-id-type="publisher-id">06286</article-id><title-group><article-title>Antibody status to influenza A/Singapore/1/57(H2N2) in Finland during a period of outbreaks caused by H3N2 and H1N1 subtype viruses</article-title><alt-title alt-title-type="left-running">R. Pyhälä</alt-title><alt-title alt-title-type="right-running">Antibody status to an H2N2 influenza A virus</alt-title></title-group><contrib-group><contrib><name><surname>Pyhälä</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib></contrib-group><aff id="aff1"><addr-line>National Public Health Institute</addr-line>, <addr-line>Mannerheimintie 166</addr-line>, <addr-line>SF-00280 Helsinki 28</addr-line>, <country>Finland</country></aff><pub-date pub-type="ppub"><month>10</month><year>1985</year></pub-date><volume>95</volume><issue>2</issue><fpage seq="25">437</fpage><lpage>445</lpage><history><date date-type="received"><day>04</day><month>12</month><year>1984</year></date><date date-type="accepted"><day>25</day><month>03</month><year>1984</year></date></history><permissions><copyright-statement>Copyright © Cambridge University Press 1985</copyright-statement><copyright-year>1985</copyright-year><copyright-holder>Cambridge University Press</copyright-holder></permissions><abstract abstract-type="normal"><title>SUMMARY</title><p>The incidence of haemagglutination inhibition (HI) antibody (titre ≥ 12) to influenza A/Singapore/1/57(H2N2) in sera collected from a Finnish population in the summer of 1981 was 58%. Subjects born after 1968 were essentially seronegative, and a comparable low HI antibody status was also recorded among the elderly, lowest being in people born during the period 1901–10. A small increase in antibody titre to the H2N2 virus was observed in the different age groups after infections with the H3N2, but not the H1N1, subtype influenza A viruses. The heterotypic response, which could be due to HI or NA antibodies, was restricted almost exclusively to subjects already exhibiting this antibody in acute phase sera. Moreover, the anamnestic boosting was not as strong as that described in earlier studies from samples collected at the beginning of the present era of H3N2 viruses.At population level, the HI antibody status to H2N2 was about the same at the beginning and end of the follow-up period which covered eight epidemic seasons. The results are discussed with respect to the doctrine of ‘original antigenic sin’ and to the threat of re-emergence of the H2N2 viruses.</p></abstract><counts><page-count count="9"></page-count></counts><custom-meta-wrap><custom-meta><meta-name>pdf</meta-name><meta-value>S0022172400062860a.pdf</meta-value></custom-meta></custom-meta-wrap></article-meta></front><back><ref-list><title>REFERENCES</title><ref><citation id="ref001" citation-type="journal"><name><surname>Al-Khayatt</surname><given-names>R.</given-names></name>, <name><surname>Jennings</surname><given-names>R.</given-names></name> & <name><surname>Potter</surname><given-names>C. 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Subjects born after 1968 were essentially seronegative, and a comparable low HI antibody status was also recorded among the elderly, lowest being in people born during the period 1901–10. A small increase in antibody titre to the H2N2 virus was observed in the different age groups after infections with the H3N2, but not the H1N1, subtype influenza A viruses. The heterotypic response, which could be due to HI or NA antibodies, was restricted almost exclusively to subjects already exhibiting this antibody in acute phase sera. Moreover, the anamnestic boosting was not as strong as that described in earlier studies from samples collected at the beginning of the present era of H3N2 viruses.At population level, the HI antibody status to H2N2 was about the same at the beginning and end of the follow-up period which covered eight epidemic seasons. The results are discussed with respect to the doctrine of ‘original antigenic sin’ and to the threat of re-emergence of the H2N2 viruses.</abstract><relatedItem type="host"><titleInfo><title>Journal of Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>J. Hyg.</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0022-1724</identifier><identifier type="PublisherID">HYG</identifier><part><date>1985</date><detail type="volume"><caption>vol.</caption><number>95</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>437</start><end>445</end><total>9</total></extent></part></relatedItem><identifier type="istex">A07AE19D19C086FCC38B3409ABCD8CEA9A27CED9</identifier><identifier type="ark">ark:/67375/6GQ-LFQX7L0M-M</identifier><identifier type="DOI">10.1017/S0022172400062860</identifier><identifier type="PII">S0022172400062860</identifier><identifier type="ArticleID">06286</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © Cambridge University Press 1985</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-G3RCRD03-V">cambridge</recordContentSource><recordOrigin>Copyright © Cambridge University Press 1985</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6GQ-LFQX7L0M-M/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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