Cross-reactive protection against influenza A virus infections by an NS1-specific CTL clone
Identifieur interne : 000E26 ( Istex/Checkpoint ); précédent : 000E25; suivant : 000E27Cross-reactive protection against influenza A virus infections by an NS1-specific CTL clone
Auteurs : Koichi Kuwano [États-Unis] ; Manabu Tamura [États-Unis] ; Francis A. Ennis [États-Unis]Source :
- Virology [ 0042-6822 ] ; 1990.
English descriptors
- Teeft :
- Adoptive, Adoptive transfer, Askonas, Braciale, Clone, Cytotoxic, Cytotoxlc, Fusion protein, Influenza, Influenza infection, Influenza virus, Influenza viruses, Kuwano, Lymphocyte, Lysis, Mdck cells, Nonstructural, Pulmonary virus titers, Recipient mice, Specific lysis, Spleen, Spleen cells, Synthetic peptides, Target cells, Virus, Virus challenge, Virus strains, Virus titers.
Abstract
Abstract: An influenza A subtype cross-reactive CTL clone (A-11) was established following stimulation of A/PR/8 virus-immune spleen cells of Balb/C (H-2d) mice. This T cell clone lysed target cells infected with influenza viruses of the H1, H2, or H3 subtypes, and recognizes a conserved epitope on the NS1 protein. The clone is restricted by the H-2Ld allele. Adoptive transfer of A-11 significantly reduced virus titers in the lungs of mice infected with influenza A viruses of the H1, H2, or H3 subtypes. These results suggest that the conserved epitope on NS1 which is recognized by A-11 may be a useful component to consider for inclusion in experimental cross-reactive influenza vaccines.
Url:
DOI: 10.1016/0042-6822(90)90391-4
Affiliations:
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Cross-reactive protection against influenza A virus infections by an NS1-specific CTL clone</title><author><name sortKey="Kuwano, Koichi" sort="Kuwano, Koichi" uniqKey="Kuwano K" first="Koichi" last="Kuwano">Koichi Kuwano</name></author><author><name sortKey="Tamura, Manabu" sort="Tamura, Manabu" uniqKey="Tamura M" first="Manabu" last="Tamura">Manabu Tamura</name></author><author><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. 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Ennis</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655</wicri:regionArea><wicri:noRegion>Massachusetts 01655</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Virology</title><title level="j" type="abbrev">YVIRO</title><idno type="ISSN">0042-6822</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1990">1990</date><biblScope unit="volume">178</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="174">174</biblScope><biblScope unit="page" to="179">179</biblScope></imprint><idno type="ISSN">0042-6822</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0042-6822</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adoptive</term><term>Adoptive transfer</term><term>Askonas</term><term>Braciale</term><term>Clone</term><term>Cytotoxic</term><term>Cytotoxlc</term><term>Fusion protein</term><term>Influenza</term><term>Influenza infection</term><term>Influenza virus</term><term>Influenza viruses</term><term>Kuwano</term><term>Lymphocyte</term><term>Lysis</term><term>Mdck cells</term><term>Nonstructural</term><term>Pulmonary virus titers</term><term>Recipient mice</term><term>Specific lysis</term><term>Spleen</term><term>Spleen cells</term><term>Synthetic peptides</term><term>Target cells</term><term>Virus</term><term>Virus challenge</term><term>Virus strains</term><term>Virus titers</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: An influenza A subtype cross-reactive CTL clone (A-11) was established following stimulation of A/PR/8 virus-immune spleen cells of Balb/C (H-2d) mice. This T cell clone lysed target cells infected with influenza viruses of the H1, H2, or H3 subtypes, and recognizes a conserved epitope on the NS1 protein. The clone is restricted by the H-2Ld allele. Adoptive transfer of A-11 significantly reduced virus titers in the lungs of mice infected with influenza A viruses of the H1, H2, or H3 subtypes. These results suggest that the conserved epitope on NS1 which is recognized by A-11 may be a useful component to consider for inclusion in experimental cross-reactive influenza vaccines.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Kuwano, Koichi" sort="Kuwano, Koichi" uniqKey="Kuwano K" first="Koichi" last="Kuwano">Koichi Kuwano</name></noRegion><name sortKey="Ennis, Francis A" sort="Ennis, Francis A" uniqKey="Ennis F" first="Francis A." last="Ennis">Francis A. Ennis</name><name sortKey="Tamura, Manabu" sort="Tamura, Manabu" uniqKey="Tamura M" first="Manabu" last="Tamura">Manabu Tamura</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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