Human immune responses to influenza virus vaccines administered by systemic or mucosal routes
Identifieur interne : 000A89 ( Istex/Checkpoint ); précédent : 000A88; suivant : 000A90Human immune responses to influenza virus vaccines administered by systemic or mucosal routes
Auteurs : Z. Moldoveanu [États-Unis] ; M. L. Clements [États-Unis] ; S. J. Prince [États-Unis] ; B. R. Murphy [États-Unis] ; J. Mestecky [États-Unis]Source :
- Vaccine [ 0264-410X ] ; 1995.
English descriptors
- Teeft :
- Antibody, Antibody isotype, Antibodysecreting cells, Attenuated, Attenuated virus, Boca raton, Calibration curves, Cells secreting, Common mucosal, Curr, Days post, Elispot assay, Experimental challenge, External secretions, Hlnl, Immun, Immune responses, Immunization, Immunization figure, Immunization protocols, Immunization route, Infectious diseases, Influenza, Influenza type, Influenza vaccine, Influenza virus, Influenza virus vaccine, Influenza virus vaccines, Intramuscular injection, Intranasal, Intranasal administration, Intranasal application, Intranasal immunization, Intranasally, Isotype, Isotypes, Johns hopkins university school, Large doses, Lavage, Lymphoid cells, Mestecky, Moldoveanu, Mucosal, Mucosal immunization, Mucosal surfaces, Nasal, Nasal lavage, Nasal lavage fluid, Nasal lavages, Nasal mucosa, Nasal secretions, National institute, Oral administration, Oral immunization, Oral influenza immunization, Other reports, Parotid saliva, Peak response, Peripheral blood, Peroral immunization, Reassortant virus, Room temperature, Salivary glands, Secreting, Secretion, Secretory, Secretory antibody responses, Secretory immunity, Serum antibodies, Serum antibody, Significant increase, Specific antibodies, Spectfic antibodies, Systemic, Systemic immunization, Systemically, Total number, Vaccine, Vaccine administration, Viral, Virus, Virus vaccine.
Abstract
Abstract: Healthy adult volunteers were immunized by parenteral or oral routes with trivalent inactivated influenza vaccine (A/Chile/1/83 (H1N1), A/Mississippi/1/85 (H3N2), and B/Ann Arbor/1/86), or intranasally with live attenuated, cold-adapted influenza type A/Texas/1/85 (H1N1) reassortant virus. In all volunteers, cells spontaneously secreting IgA, IgG or IgM antibodies specific to influenza virus were detected in peripheral blood on days 6–13 after immunization, and specific IgA, IgG and IgM antibodies to influenza vaccine were measured in sera and external secretions (saliva and nasal lavage). Following systemic immunization, a raise in specific antibodies of all isotypes was observed in sera beginning on day 13. Although small variations in IgA and IgM antibodies in saliva and nasal lavages were detected, antigen-specific IgG significantly increased between days 13 and 27. Intranasal administration of attenuated virus induced IgA and IgG antibodies in serum as well as in secretions. Serum antibodies were not substantially influenced by oral immunization, only a small increase in all isotypes was observed in volunteers' sera 21 days after ingestion of vaccine. However, in secretions, antigen-specific IgA and IgG responses were detected one week after immunization and reached a peak response on day 20. These studies show that different routes of immunization can be effective for the induction of specific antibodies, and support the concept of the common mucosal immune system in humans by demonstrating that the oral or intranasal administration of antigen-induced specific antibodies of IgA isotype in external secretions, preceded by the transient appearance in peripheral blood of specific antibody-producing cells.
Url:
DOI: 10.1016/0264-410X(95)00016-T
Affiliations:
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<term>Attenuated virus</term>
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<term>Specific antibodies</term>
<term>Spectfic antibodies</term>
<term>Systemic</term>
<term>Systemic immunization</term>
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<front><div type="abstract" xml:lang="en">Abstract: Healthy adult volunteers were immunized by parenteral or oral routes with trivalent inactivated influenza vaccine (A/Chile/1/83 (H1N1), A/Mississippi/1/85 (H3N2), and B/Ann Arbor/1/86), or intranasally with live attenuated, cold-adapted influenza type A/Texas/1/85 (H1N1) reassortant virus. In all volunteers, cells spontaneously secreting IgA, IgG or IgM antibodies specific to influenza virus were detected in peripheral blood on days 6–13 after immunization, and specific IgA, IgG and IgM antibodies to influenza vaccine were measured in sera and external secretions (saliva and nasal lavage). Following systemic immunization, a raise in specific antibodies of all isotypes was observed in sera beginning on day 13. Although small variations in IgA and IgM antibodies in saliva and nasal lavages were detected, antigen-specific IgG significantly increased between days 13 and 27. Intranasal administration of attenuated virus induced IgA and IgG antibodies in serum as well as in secretions. Serum antibodies were not substantially influenced by oral immunization, only a small increase in all isotypes was observed in volunteers' sera 21 days after ingestion of vaccine. However, in secretions, antigen-specific IgA and IgG responses were detected one week after immunization and reached a peak response on day 20. These studies show that different routes of immunization can be effective for the induction of specific antibodies, and support the concept of the common mucosal immune system in humans by demonstrating that the oral or intranasal administration of antigen-induced specific antibodies of IgA isotype in external secretions, preceded by the transient appearance in peripheral blood of specific antibody-producing cells.</div>
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