A Polyphenolic Extract from Geranium Sanguineum L. Inhibits Influenza Virus Protein Expression
Identifieur interne : 000A65 ( Istex/Checkpoint ); précédent : 000A64; suivant : 000A66A Polyphenolic Extract from Geranium Sanguineum L. Inhibits Influenza Virus Protein Expression
Auteurs : Julia Serkedjieva [Bulgarie]Source :
- Phytotherapy Research [ 0951-418X ] ; 1996-08.
English descriptors
- Teeft :
- Antiviral, Antiviral action, Antiviral activity, Bulgarian, Bulgarian academy, Calf serum, Cell cultures, Cell monolayers, Cell surface, Elisa, Equine influenza viruses, Geranium, Geranium sanguineurn, Influenza, Influenza viruses, Inhibitory effect, Manolova, Mdck, Medicinal plant geranium sanguineum, Mill hill, Monoclonal antibodies, Monolayers, Plant polyphenolic, Polyphenolic, Polyphenolic acids, Polyphenolic substances, Protein synthesis, Replication, Rostock, Sanguineum, Sanguineurn, Serkedjieva, Sofia, Uglrnl figure, Vanden berghe, Viral, Viral infection, Viral protein synthesis, Viral proteins, Virus inoculum.
Abstract
A polyphenolic complex (PC) with antiviral activity has been isolated from the Bulgarian medicinal plant Geranium sanguineum L. Its antiviral activity was studied with respect to the effect of the substance on the expression of influenza virus proteins on infected cell surface. ELISA with monoclonal antibodies to haemagglutinin, neuraminidase and nucleoprotein was used. By studying various strains of human, avian and equine influenza viruses it was shown that the inhibitory effect was strain‐related, and consistent with a selective antiviral action. The effect depended also on the dose of PC and the virus inoculum.
Url:
DOI: 10.1002/(SICI)1099-1573(199608)10:5<441::AID-PTR867>3.0.CO;2-9
Affiliations:
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<wicri:regionArea>Institute of Microbiology, Bulgarian Academy of Science, Acad. Georgy Bonchev str., bl. 26, 1113 Sofia</wicri:regionArea>
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<wicri:regionArea>Correspondence address: Institute of Microbiology, Bulgarian Academy of Science, Acad. Georgy Bonchev str., bl. 26, 1113 Sofia</wicri:regionArea>
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<series><title level="j" type="main">Phytotherapy Research</title>
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<idno type="ISSN">0951-418X</idno>
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<publisher>John Wiley & Sons, Ltd.</publisher>
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<profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antiviral</term>
<term>Antiviral action</term>
<term>Antiviral activity</term>
<term>Bulgarian</term>
<term>Bulgarian academy</term>
<term>Calf serum</term>
<term>Cell cultures</term>
<term>Cell monolayers</term>
<term>Cell surface</term>
<term>Elisa</term>
<term>Equine influenza viruses</term>
<term>Geranium</term>
<term>Geranium sanguineurn</term>
<term>Influenza</term>
<term>Influenza viruses</term>
<term>Inhibitory effect</term>
<term>Manolova</term>
<term>Mdck</term>
<term>Medicinal plant geranium sanguineum</term>
<term>Mill hill</term>
<term>Monoclonal antibodies</term>
<term>Monolayers</term>
<term>Plant polyphenolic</term>
<term>Polyphenolic</term>
<term>Polyphenolic acids</term>
<term>Polyphenolic substances</term>
<term>Protein synthesis</term>
<term>Replication</term>
<term>Rostock</term>
<term>Sanguineum</term>
<term>Sanguineurn</term>
<term>Serkedjieva</term>
<term>Sofia</term>
<term>Uglrnl figure</term>
<term>Vanden berghe</term>
<term>Viral</term>
<term>Viral infection</term>
<term>Viral protein synthesis</term>
<term>Viral proteins</term>
<term>Virus inoculum</term>
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<front><div type="abstract" xml:lang="en">A polyphenolic complex (PC) with antiviral activity has been isolated from the Bulgarian medicinal plant Geranium sanguineum L. Its antiviral activity was studied with respect to the effect of the substance on the expression of influenza virus proteins on infected cell surface. ELISA with monoclonal antibodies to haemagglutinin, neuraminidase and nucleoprotein was used. By studying various strains of human, avian and equine influenza viruses it was shown that the inhibitory effect was strain‐related, and consistent with a selective antiviral action. The effect depended also on the dose of PC and the virus inoculum.</div>
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