H2N2V1, Hal, Curation, bibRecord, 000315

Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community.

Identifieur interne : 000315 ( Hal/Curation ); précédent : 000314; suivant : 000316

Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community.

Auteurs : Leo L. M. Poon [République populaire de Chine] ; Kowk H. Chan [République populaire de Chine] ; Daniel K. W. Chu [République populaire de Chine] ; Cherry C. Y. Fung [République populaire de Chine] ; Calvin K. Y. Cheng [République populaire de Chine] ; Dennis K. M. Ip [République populaire de Chine] ; Gabriel M. Leung [République populaire de Chine] ; Joseph S. M. Peiris [République populaire de Chine] ; Benjamin J. Cowling [République populaire de Chine]

Source :

Journal of Clinical Virology [ 1386-6532 ] ; 2011-07-28.

RBID : Hal:pasteur-00614344

Abstract

BACKGROUND: There are few data in the literature on viral sequence variation between host generations/successive transmission events. Relatively little is known about the sequence heterogeneity of the influenza viruses transmitted within families. OBJECTIVES: To study the molecular epidemiology of influenza virus and to determine the sequence variation within an individual, a household and a community during the first wave of influenza pandemic in 2009. STUDY DESIGN: A prospective study of household transmission of influenza A in Hong Kong was conducted during the pandemic in 2009. The HA and NA sequences of pandemic and seasonal influenza A viral isolates identified in this household transmission study were sequences and analyzed. RESULTS: Our results indicated that there were multiple introductions of influenza viruses into Hong Kong. Sequence analysis of these isolates suggested that members of these family clusters acquired the infection by household transmissions. Interestingly, unlike those concluded from previous household transmission studies, we observed sequence variations between sequential samples from the same person and also within the same household. CONCLUSIONS: Family clusters of influenza A viral infection are predominantly the result of secondary transmission within a household. Our results also suggested that the intra-host viral sequence variation might be more common that than previously thought.

Url:

https://hal-riip.archives-ouvertes.fr/pasteur-00614344

DOI: 10.1016/j.jcv.2011.06.022

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Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>BACKGROUND: There are few data in the literature on viral sequence variation between host generations/successive transmission events. Relatively little is known about the sequence heterogeneity of the influenza viruses transmitted within families. OBJECTIVES: To study the molecular epidemiology of influenza virus and to determine the sequence variation within an individual, a household and a community during the first wave of influenza pandemic in 2009. STUDY DESIGN: A prospective study of household transmission of influenza A in Hong Kong was conducted during the pandemic in 2009. The HA and NA sequences of pandemic and seasonal influenza A viral isolates identified in this household transmission study were sequences and analyzed. RESULTS: Our results indicated that there were multiple introductions of influenza viruses into Hong Kong. Sequence analysis of these isolates suggested that members of these family clusters acquired the infection by household transmissions. Interestingly, unlike those concluded from previous household transmission studies, we observed sequence variations between sequential samples from the same person and also within the same household. CONCLUSIONS: Family clusters of influenza A viral infection are predominantly the result of secondary transmission within a household. Our results also suggested that the intra-host viral sequence variation might be more common that than previously thought.</p>
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<hal api="V3">          <titleStmt>            <title xml:lang="en">Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community.</title>
            <author role="crp">              <persName>                <forename type="first">Leo L. M.</forename>
                <surname>Poon</surname>
              </persName>
              <email type="md5">12dd69b4fc6098669afe833ac40b281b</email>
              <email type="domain">hkucc.hku.hk</email>
              <idno type="halauthorid">632330</idno>
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            </author>
            <author role="aut">              <persName>                <forename type="first">Kowk H.</forename>
                <surname>Chan</surname>
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              <idno type="halauthorid">632331</idno>
              <affiliation ref="#struct-136023"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Daniel K. W.</forename>
                <surname>Chu</surname>
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              <idno type="halauthorid">632332</idno>
              <affiliation ref="#struct-136023"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Cherry C. Y.</forename>
                <surname>Fung</surname>
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              <idno type="halauthorid">632333</idno>
              <affiliation ref="#struct-136023"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Calvin K. Y.</forename>
                <surname>Cheng</surname>
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              <idno type="halauthorid">632334</idno>
              <affiliation ref="#struct-164406"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Dennis K. M.</forename>
                <surname>Ip</surname>
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              <idno type="halauthorid">632335</idno>
              <affiliation ref="#struct-164406"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Gabriel M.</forename>
                <surname>Leung</surname>
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              <idno type="halauthorid">632336</idno>
              <affiliation ref="#struct-164406"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Joseph S. M.</forename>
                <surname>Peiris</surname>
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              <idno type="halauthorid">632337</idno>
              <affiliation ref="#struct-136023"></affiliation>
              <affiliation ref="#struct-55925"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Benjamin J.</forename>
                <surname>Cowling</surname>
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              <idno type="halauthorid">632338</idno>
              <affiliation ref="#struct-164406"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Francois</forename>
                <surname>Kien</surname>
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              <email type="md5">951560277f2910b0e3343e2504713733</email>
              <email type="domain">gmail.com</email>
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          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2011-08-11 05:30:37</date>
              <date type="whenModified">2018-10-08 17:44:06</date>
              <date type="whenReleased">2011-08-11 11:46:16</date>
              <date type="whenProduced">2011-07-28</date>
              <ref type="externalLink" target="http://europepmc.org/articles/pmc3175291?pdf=render"></ref>
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            <respStmt>              <resp>contributor</resp>
              <name key="157033">                <persName>                  <forename>Francois</forename>
                  <surname>Kien</surname>
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                <email type="md5">951560277f2910b0e3343e2504713733</email>
                <email type="domain">gmail.com</email>
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            <idno type="halId">pasteur-00614344</idno>
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            <idno type="halBibtex">poon:pasteur-00614344</idno>
            <idno type="halRefHtml">Journal of Clinical Virology, Elsevier, 2011, epub ahead of print. ⟨10.1016/j.jcv.2011.06.022⟩</idno>
            <idno type="halRef">Journal of Clinical Virology, Elsevier, 2011, epub ahead of print. ⟨10.1016/j.jcv.2011.06.022⟩</idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="RIIP">Institut Pasteur RIIP (Réseau International)</idno>
            <idno type="stamp" n="RIIP_HONGKONG" corresp="RIIP">Centre de Recherche Université de Hong-Kong-Pasteur</idno>
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          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community.</title>
                <author role="crp">                  <persName>                    <forename type="first">Leo L. M.</forename>
                    <surname>Poon</surname>
                  </persName>
                  <email type="md5">12dd69b4fc6098669afe833ac40b281b</email>
                  <email type="domain">hkucc.hku.hk</email>
                  <idno type="halauthorid">632330</idno>
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                </author>
                <author role="aut">                  <persName>                    <forename type="first">Kowk H.</forename>
                    <surname>Chan</surname>
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                  <idno type="halauthorid">632331</idno>
                  <affiliation ref="#struct-136023"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Daniel K. W.</forename>
                    <surname>Chu</surname>
                  </persName>
                  <idno type="halauthorid">632332</idno>
                  <affiliation ref="#struct-136023"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Cherry C. Y.</forename>
                    <surname>Fung</surname>
                  </persName>
                  <idno type="halauthorid">632333</idno>
                  <affiliation ref="#struct-136023"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Calvin K. Y.</forename>
                    <surname>Cheng</surname>
                  </persName>
                  <idno type="halauthorid">632334</idno>
                  <affiliation ref="#struct-164406"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Dennis K. M.</forename>
                    <surname>Ip</surname>
                  </persName>
                  <idno type="halauthorid">632335</idno>
                  <affiliation ref="#struct-164406"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Gabriel M.</forename>
                    <surname>Leung</surname>
                  </persName>
                  <idno type="halauthorid">632336</idno>
                  <affiliation ref="#struct-164406"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Joseph S. M.</forename>
                    <surname>Peiris</surname>
                  </persName>
                  <idno type="halauthorid">632337</idno>
                  <affiliation ref="#struct-136023"></affiliation>
                  <affiliation ref="#struct-55925"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Benjamin J.</forename>
                    <surname>Cowling</surname>
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                  <idno type="halauthorid">632338</idno>
                  <affiliation ref="#struct-164406"></affiliation>
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                <title level="j">Journal of Clinical Virology</title>
                <imprint>                  <publisher>Elsevier</publisher>
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                  <date type="datePub">2011-07-28</date>
                  <date type="dateEpub">2011-07-28</date>
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            <abstract xml:lang="en">              <p>BACKGROUND: There are few data in the literature on viral sequence variation between host generations/successive transmission events. Relatively little is known about the sequence heterogeneity of the influenza viruses transmitted within families. OBJECTIVES: To study the molecular epidemiology of influenza virus and to determine the sequence variation within an individual, a household and a community during the first wave of influenza pandemic in 2009. STUDY DESIGN: A prospective study of household transmission of influenza A in Hong Kong was conducted during the pandemic in 2009. The HA and NA sequences of pandemic and seasonal influenza A viral isolates identified in this household transmission study were sequences and analyzed. RESULTS: Our results indicated that there were multiple introductions of influenza viruses into Hong Kong. Sequence analysis of these isolates suggested that members of these family clusters acquired the infection by household transmissions. Interestingly, unlike those concluded from previous household transmission studies, we observed sequence variations between sequential samples from the same person and also within the same household. CONCLUSIONS: Family clusters of influenza A viral infection are predominantly the result of secondary transmission within a household. Our results also suggested that the intra-host viral sequence variation might be more common that than previously thought.</p>
            </abstract>
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Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community.

Viral genetic sequence variations in pandemic H1N1/2009 and seasonal H3N2 influenza viruses within an individual, a household and a community.

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